PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS

Poly (ADP-Ribose) Polymerase Inhibitors: Recent Advances and Future Development

(2015) Clare L. Scott et al.   JOURNAL OF CLINICAL ONCOLOGY

Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells

(2015) Vijesh J. Bhute et al.   Metabolomics

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors

(2015) Albert A. Antolín et al.   Oncotarget

Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules

(2014) J Murray et al.   BRITISH JOURNAL OF CANCER

Detection of cerebral NAD+byin vivo1H NMR spectroscopy

(2014) Robin A. de Graaf et al.   NMR IN BIOMEDICINE

Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis

(2013) Nady Braidy et al.   BRAIN RESEARCH

Intracellular redox state revealed by in vivo31P MRS measurement of NAD+and NADH contents in brains

(2013) Ming Lu et al.   MAGNETIC RESONANCE IN MEDICINE

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

(2012) Ilirjana Bajrami et al.   EMBO Molecular Medicine

Poly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment

(2012) Laura Orlando et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

(2012) Elisabet Wahlberg et al.   NATURE BIOTECHNOLOGY

The clinical development of inhibitors of poly(ADP-ribose) polymerase

(2011) H. Calvert et al.   ANNALS OF ONCOLOGY

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Poly ADP-ribose polymerase-1 and health

(2010) James B Kirkland   EXPERIMENTAL BIOLOGY AND MEDICINE

Nitrosative stress, protein tyrosine nitration, PARP activation and NAD depletion in the kidneys of rats after single dose of cyclophosphamide

(2009) Premila Abraham et al.   Clinical and Experimental Nephrology

Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo?

(2009) M. Ali et al.   CLINICAL CANCER RESEARCH

Development of PARP inhibitors in oncology

(2008) Jordi Rodon et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Benzo[a]pyrene-induced necrosis in the HepG2 cells via PARP-1 activation and NAD+ depletion

(2008) T. Lin et al.   TOXICOLOGY