Article
Polymer Science
Thi Lien Nguyen, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: The self-assembly of pH-responsive random and block copolymers composed of 2-(N,N-diisopropylamino)ethyl methacrylate and 2-methacryloyloxyethyl phosphorylcholine was studied in aqueous media. The copolymers existed as single polymer chains in an acidic environment, but formed separated micelles in a basic environment.
Article
Materials Science, Biomaterials
Dongxu Zhou, Zhixiong Fei, Lunqiang Jin, Peng Zhou, Chenxi Li, Xiaoling Liu, Changsheng Zhao
Summary: Multi stimuli-responsive polymersomes designed via self-assembly can serve as smart drug carriers, enabling separate control over the release of multiple drug pairs. They show promising potential for tumor combination chemotherapy by taking effect for a relatively longer period in a simulated tumor microenvironment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Pharmacology & Pharmacy
Eirik A. L. Rustad, Susannah von Hofsten, Robin Kumar, Eirik A. Laensman, Gerd Berge, Natasa Skalko-Basnet
Summary: Nanomedicine has been successful in developing superior anticancer therapies, but there are still challenges in treating certain tumors, such as glioblastoma. In this study, pH-responsive liposomes were used to deliver drugs to glioblastoma cells, taking advantage of the acidic extracellular environment. The results showed improved intracellular uptake of drugs in glioblastoma cells compared to non-pH-responsive liposomes, regardless of the length of PEG.
Article
Chemistry, Applied
Min Li, Yinan Zhao, Jiao Sun, Huiying Chen, Zhanbiao Liu, Kexin Lin, Pengfei Ma, Wenjun Zhang, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: Polymer-based prodrug nanocarriers with tumor-targeting and controlled-release properties are highly desirable for improving cancer treatment. Hyaluronic acid (HA), known for its excellent biocompatibility and targeting ability for CD44, has been suggested as a carrier for delivering drugs with poor solubility and high toxicity. In this study, podophyllotoxin (PPT) was conjugated to HA through ester and disulfide linkages to create a pH and reduction-responsive prodrug (HA-S-S-PPT). Micelles self-assembled from HA-S-S-PPT efficiently accumulated at the tumor site due to HA receptor-mediated endocytosis. These micelles exhibited 33.1% higher cumulative release compared to HA-NH-CO-PPT micelles, which were only sensitive to pH. HA-S-S-PPT micelles demonstrated excellent antitumor activity in vivo, with a tumor inhibition rate of 92%, significantly higher than that of HA-NH-CO-PPT micelles (65%), and minimal systemic toxicity. This controllable-targeting nanoparticle system presents a potential platform for the clinical application of PPT.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
Shudi Yang, Weiliang Chen, Wei Li, Jingcheng Song, Yue Gao, Wenhui Si, Xiaoping Li, Baowei Cui, Tongtong Yu
Summary: The study prepared CD44-targeted pH-responsive micelles for efficient delivery and release of doxorubicin based on the overexpressed CD44 receptor and mild acidic microenvironment of tumor cells. These micelles exhibited enhanced cellular uptake and cytotoxicity, as well as excellent tumor-targeting effects in vitro and improved anti-tumor effects with reduced side effects in vivo.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Shufen Li, Qiang Wang, Xiao Duan, Zhen Pei, Zhipeng He, Wei Guo, Lingna Han
Summary: A GSH-responsive nanogel conjugated with Dox was developed, which demonstrated potential application in inhibiting tumor growth and reducing side effects based on in vitro and in vivo experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Lakshmi Priya Datta
Summary: Careful design can integrate chemical enrichment, stimuli responsiveness, and targeted delivery within compartmentalized models to enhance therapeutic efficacy.
Article
Polymer Science
Zahn Stanvliet, Yiyi Deng, Dietmar Appelhans, Silvia Moreno, Susanne Boye, Jens Gaitzsch, Albena Lederer
Summary: This study investigates the temperature sensitivity of polymeric nanoparticles based on tertiary amine methacrylate block copolymers. The research shows that these nanoparticles can undergo a reversible morphological transformation in response to changes in pH and temperature. The findings also demonstrate the ability to lock their intermediate self-assembly structures through cross-linking and validate the morphology transition using analytical tools, which opens up new possibilities for responsive nanocarriers.
Article
Engineering, Biomedical
Yu-Han Wen, Po-I Hsieh, Hsin-Cheng Chiu, Chil-Wei Chiang, Chun-Liang Lo, Yi-Ting Chiang
Summary: This study developed dual pH-sensitive and tumor microenvironment-active targeting micelles for combining immunotherapy and chemotherapy, which effectively inhibited tumor cell growth, exhibited high tumor accumulation, and reduced adverse effects in a mouse model.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Shumin Hu, Qiuli Cheng, Yulu Shang, Zhihao Wang, Rui Zhu, Leitao Zhang, Wenlan Wu, Shouren Zhang, Junbo Li
Summary: A zwitterionic polymer containing quaternary ammonium cation and sulfonamide anion was synthesized and coated onto gold nanoparticles for pH-responsive behavior in tumors. The modified nanoparticles exhibited high sensitivity and reversible positive charge conversion at tumor acidic microenvironment, leading to enhanced cellular uptake and tumor accumulation. This pH-responsive polymer holds great potential for cancer nanomedicine applications.
BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Analytical
Dheeraj K. Agrohia, Peidong Wu, Uyen Huynh, S. Thayumanavan, Richard W. Vachet
Summary: This article introduces a metal-coded mass tagging approach that enables the multiplexed quantification of the PNC uptake in cells using mass spectrometry. The conjugation of different metals to the PNCs allows the simultaneous multiplexed analysis of multiple distinct PNCs, which should improve the design and optimization of PNCs.
ANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Polymer Science
Priya Rajdev, Pradip Dey, Indranil Ghosh, Rajesh Khamrui, Joy Kar, Siddhartha Sankar Jana, Suhrit Ghosh
Summary: Cellular uptake of nanostructures is greatly influenced by the shape of the aggregate, with polymersomes showing the most efficient uptake compared to spherical or cylindrical micelles. The observed difference in cellular uptake can be attributed to the shape difference rather than intrinsic chemical structure. Further studies are needed to validate the impact of aggregate shape on cellular uptake in different cell lines.
Article
Biophysics
Huan Li, Zexin Gao, Jingjing Xu, Wu Sun, Jianrong Wu, Li Zhu, Minjie Gao, Xiaobei Zhan
Summary: An amphiphilic polymer based on octenyl succinic anhydride-modified curdlan oligosaccharide (MCOS) was synthesized, which self-assembled into spherical micelles with pH-responsive property. It exhibited high loading capacity for polyphenols and showed sustained release in the simulated intestinal fluid, demonstrating potential for colon-targeted delivery of hydrophobic polyphenols.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Won Jung Kim, Eu Hyun Lee, Yong-Jin Kwon, Sang-Kyu Ye, Kyu Oh Kim
Summary: An amphipathic PAA-POSS@DOX drug delivery system that is sensitive to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). This system has high loading efficiency and can quickly release the drug to the target area, as confirmed by cell death in the MDA-MB-231 breast cancer line.
Article
Polymer Science
Shuai Li, Yuanyuan Cai, Jun Cao, Mengtan Cai, Yuanwei Chen, Xianglin Luo
Article
Nanoscience & Nanotechnology
Zhenwu Wang, Haijun Cui, Shuai Li, Xiaowei Feng, Jasmin Aghassi-Hagmann, Saeid Azizian, Pavel A. Levkin
Summary: The study introduces a simple and efficient strategy to fabricate conductive polymer microelectrodes using surface-tension-confined liquid patterns, which shows universality for various oxidizers and conductive polymers, high resolution, stability, and favorable compatibility with different surfaces and materials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Johannes M. Scheiger, Shuai Li, Marius Brehm, Andreas Bartschat, Patrick Theato, Pavel A. Levkin
Summary: Organogels, soft materials based on polymeric networks swollen in organic solvents, are hydrophobic and have high solvent content. Control of shape and surface structure is necessary for functional organogels. Poly(methacrylate) organogels have inherent UV photodegradability, with low UV absorbance and high swelling ability of the solvent infusing the organogel contributing to fast photodegradation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shuai Li, Johannes M. Scheiger, Zhenwu Wang, Zheqin Dong, Alexander Welle, Vanessa Trouillet, Pavel A. Levkin
Summary: The article introduces a simple and substrate-independent strategy for surface functionalization and patterning, combining the advantages of polydopamine coating, gas phase silanization, and thiol-ene photoclick reaction. It has demonstrated efficient functionalization and patterning of diverse materials, showing the potential for controlled chemical removal of patterns for re-modification or re-patterning of substrates. This universal and powerful approach can significantly assist in the development of novel functional materials and devices for various applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
F. Behboodi-Sadabad, S. Li, W. Lei, Y. Liu, T. Sommer, P. Friederich, C. Sobek, P. B. Messersmith, P. A. Levkin
Summary: Investigated oxidation behavior and coating formation ability of 45 phenolic compounds and catecholamines, discovered non-additive behavior of binary mixtures. Used high-throughput strategy to screen 2523 spots with various coating precursors combinations, evaluated machine learning models and discontinuous dewetting. Found 30 stable combinations for exploring nanocoatings in a cost-effective manner.
MATERIALS TODAY BIO
(2021)
Article
Chemistry, Multidisciplinary
Zihan Ma, Lishuang Wang, Tingting Chen, Guangning Wang
Summary: In this study, two kinds of 3D self-doped (N/O) lilac-based and coriander-based porous carbons with high performance have been prepared.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qin Wang, Yun-Fan Yan, Jiao-Lin Weng, Ying Huang, Fu Yang, Hao-Hui Xie, Fei Tan, Fa-Kun Zheng, Jian-Gang Xu
Summary: Balancing energy and mechanical sensitivities is a challenging issue in the field of energetic materials. This study constructed a 3D energetic metal-organic framework with nitrogen-rich ligand and NO3- anions. The framework demonstrated high stability, energy density, and excellent mechanical sensitivities, making it a potential insensitive energetic material.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Marrium Saeed, Urooj Kamran, Amina Khan, Md Irfanul Haque Siddiqui, Hasan Jamal, Haq Nawaz Bhatti
Summary: In this study, magnesium-aluminum layered double hydroxides (Mg-Al-LDH) were synthesized using an environmentally friendly hydrothermal technique for adsorbing the dye reactive green 5 (RG5). To improve the adsorption capability, composites were prepared by combining Mg-Al-LDH with low-cost Mangifera indica stone biomass (MISB). The results showed that the composites had high adsorption capacities for RG5 dye and could be regenerated.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Xuanlin Zhan, Xiaojie Li, Yunyan Zeng, Siyan Jiang, Chao Pan, Shiyu Pan, Jiaquan Huang, Heqian Zhang, Zhiwei Qin
Summary: This study reports on the potential prospects of natural products derived from the rhizosphere for the development of antibiotics and herbicides, as well as the advancements in cultivating a mutant strain that produces a substantial quantity of lydicamycins, a potent family for herbicide development.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jie Zhu, Jiangtao Yu, Linhua Zhu, Xiaoxiao Yu, Jixing Liu, Yanhong Chao, Jingzhou Yin, Peiwen Wu, Jian Liu, Wenshuai Zhu
Summary: This study successfully demonstrates the 3D printing of attapulgite monoliths and investigates the influence of thermal treatment on their properties. The thermal treated monoliths show superior catalytic performance at low temperatures.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yanzhu Ye, Yixiang Ye, Jiannan Cai, Zhongshui Li, Shen Lin
Summary: In this paper, a novel Pt/CoP/C photo-electro synergistic catalyst was successfully synthesized and its performance was investigated. The catalyst exhibited excellent photo-electro catalytic performance, with significantly higher hydrogen production compared to a commercial catalyst. The introduction of cobalt phosphide and the existence of Co3O4 were identified as key factors for enhancing the catalytic activity.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nurul Hidayah Abu Bakar, Wan Norfazilah Wan Ismail, Hartina Mohd Yusop, Noreen Farzuhana Mohd Zulkifli
Summary: Hydrophobic coatings inspired by the lotus effect have gained popularity for their ability to solve various problems. The sol-gel method, utilizing silica, alumina, and titania, is explored as an environmentally friendly approach to produce water-based hydrophobic coatings. This study focuses on producing water-based hydrophobic coatings for cotton and polyester fabrics using a one-step sol-gel method. The coated fabrics exhibited improved hydrophobic properties, altered surface morphologies, and lower air permeability compared to uncoated fabrics. TEOS-PDMS coating provides a promising approach for enhancing the hydrophobic and surface properties of cotton and polyester fabrics.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nikita Belko, Hanna Maltanava, Anatol Lugovski, Polina Shabunya, Sviatlana Fatykhava, Evgeny Bondarenko, Pavel Chulkin, Sergey Poznyak, Michael Samtsov
Summary: This study investigates the difference in electrochemical behavior between rhodamine B hydrazide and rhodamine B acylhydrazone, and finds that rhodamine B acylhydrazone exhibits higher reversibility in electrooxidation. These results can be applied for developing new sensors with desired electrochemical properties.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Showket Ahmad Bhat, Mohd Ikram
Summary: In this study, 0-3 particulate multiferroic composites were synthesized and characterized. The composites exhibited excellent ferroelectric and ferromagnetic properties, as well as high piezoelectric strain and magnetoelectric coupling effects.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Carla Gomes, Mariana Costa, Susana M. M. Lopes, Bernardo Albuquerque Nogueira, Rui Fausto, Jose A. Paixao, Teresa M. V. D. e Melo, Luisa M. D. R. S. Martins, Marta Pineiro
Summary: The development of sustainable processes requires the integration of green chemistry principles. In this study, a solvent-free synthesis method was developed to prepare new copper catalysts, which efficiently catalyze cycloaddition reactions under solvent-free mechanochemical conditions. Through this process, the principles of atom economy, reduction of solvents and auxiliaries, design for energy efficiency, and reduction of derivatives and catalysis are combined.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Zhihua Liu, Jinzhe Li, Jianguo Zhou
Summary: This study demonstrates the enhancement of photoelectrochemical activity of BiFeO3 photoelectrodes through ion modification, which increases visible light absorption and active area, leading to improved PEC water splitting performance.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yisheng Zhang, Wensong Li, Jing Li, Fang Li, Wei Xue, Xinqiang Zhao, Yanji Wang
Summary: Pt/C and SO42-/ZrO2 were used as catalysts for the synthesis of p-aminophenol through the catalytic transfer hydrogenation of nitrobenzene in water with formic acid as the hydrogen source. The optimal Pt loading for PAP selectivity was found to be 1 wt%. The presence of different valence states of Pt affected both the nitrobenzene hydrogenation and formic acid decomposition. Among different solid acid catalysts tested, SO42-/ZrO2 exhibited the highest catalytic activity for p-aminophenol formation. Under the optimized reaction conditions, the conversion of nitrobenzene reached 80.0%, with a selectivity of 47.6% for p-aminophenol.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Pradyota Kumar Behera, Papita Behera, Amlan Swain, Santosh Kumar Sahu, Ajeena Sahoo, Laxmidhar Rout
Summary: We have developed a simple and direct method for the synthesis of diaryl ether using an oxygen bridged bimetallic CuMoO4 nanocatalyst under mild reaction conditions. The catalyst exhibited tolerance towards a wide range of substrates with various functional groups. It is efficient and recyclable. This methodology allows easy access to nitrofen derivatives (herbicides) from unactivated 2,4-dichlorophenol, which are important for agriculture and pharmaceuticals.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yihua Fu, Yan Zhang, Changwei Hu, Zhishan Su
Summary: The mechanism of the reaction between CO2 and styrene oxide for cyclic carbonate was revealed using density functional theory calculations. The noncatalytic reaction occurred via a concerted mechanism, while in the presence of guanidine and tetrabutylammonium iodide (TBAI) co-catalysts, the epoxide ring-opening by nucleophilic attack of an iodide anion was predicted to be the rate-determining step. Guanidine acted as the H-bond donor to activate styrene oxide, facilitating the reaction with a lower activation barrier.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Saikat Khamarui, Sirshendu Ghosh
Summary: Copper nanorods (Cu-NRs) exhibit significant plasmonic behavior and can act as efficient catalysts in redox processes and coupling. A benign decarboxylative approach, utilizing localized surface plasmon resonance (LSPR) assisted catalysis with Cu-NRs, has been developed for the production of alkane analogues from alkyl carboxylic acids under visible light. The catalyst shows a broad substrate scope and high functional group tolerance, without the need for an external oxidant or proton source. A plausible mechanism for this recyclable nano-catalyst has also been proposed based on control experiments.
NEW JOURNAL OF CHEMISTRY
(2024)