Article
Microbiology
Marjo Helander, Aditya Jeevannavar, Kimmo Kaakinen, Suni A. Mathew, Kari Saikkonen, Benjamin Fuchs, Pere Puigbo, Olli J. Loukola, Manu Tamminen
Summary: Pollinator decline is a serious issue, with the overuse of pesticides, particularly glyphosate, being a potential cause. This study found that glyphosate negatively affects the gut microbiota of bumblebees, reducing diversity and decreasing the abundance of sensitive bacterial species. These findings suggest that the heavy use of glyphosate-based herbicides may have implications for bees and ecosystems.
FEMS MICROBIOLOGY ECOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jana Niedobova, Jana Ourednickova, Radek Michalko, Michal Skalsky
Summary: Glyphosate-based herbicides, commonly used worldwide, may have different effects on predatory activity of spiders, indicating the importance of considering formulation toxicity in pesticide evaluations.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Review
Pharmacology & Pharmacy
Ambra Maddalon, Valentina Galbiati, Claudio Colosio, Stefan Mandic-Rajcevic, Emanuela Corsini
Summary: Glyphosate, the active ingredient of widely used herbicides, is being debated due to emerging studies indicating its potential hazard and toxicity on non-target organisms. While evidence suggests potential endocrine disruption by Glyphosate-based herbicides targeting sex and thyroid hormones, studies on immunotoxicity are limited but highlight possible harmful effects. Further research is needed to investigate the safety profile of Glyphosate-based herbicides and their potential impact on human exposure.
Article
Neurosciences
Qun Lu, Haitao Xiang, Haojie Zhu, Yifan Chen, Xu Lu, Chao Huang
Summary: Intranasal administration of LPS prior to stress exposure can prevent chronic social defeat stress-induced depression and anxiety-like behaviors, as well as reduce neuroinflammatory responses in the hippocampus and prefrontal cortex. This suggests that innate immune stimulation via intranasal administration could be a potential approach for the prevention of depression and anxiety.
Review
Environmental Sciences
Germano A. B. Lanzarin, Luis M. Felix, Antonio Fontainhas-Fernandes, Sandra Mariza Monteiro, Carlos Venancio
Summary: A critical review was conducted to investigate the toxicity of glyphosate and glyphosate-based herbicides on zebrafish. The results showed that both substances can cause damage to zebrafish, compromising their survival, reproduction, and maintenance. These findings may be applicable to other fish species and aquatic ecosystems.
Article
Plant Sciences
Alexandra R. Golt, Lisa J. Wood
Summary: Glyphosate-based herbicides have a significant impact on the reproductive morphology of understory shrubs, reducing pollen viability and causing changes in floral morphology. Residues of glyphosate can still be detected in floral tissues two years after application, highlighting the long-term effects on forest vegetation and the importance of understanding and managing these impacts to preserve biodiversity in boreal forest ecosystems.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Endocrinology & Metabolism
Renata Marino Romano, Jeane Maria de Oliveira, Viviane Matoso de Oliveira, Isabela Medeiros de Oliveira, Yohandra Reyes Torres, Paula Bargi-Souza, Anderson Joel Martino Andrade, Marco Aurelio Romano
Summary: This article discusses the impact of glyphosate and glyphosate-based herbicides on the balance of HPT axis and thyroid hormone levels, exploring the molecular mechanisms that may contribute to the increased incidence of thyroid diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Lua Reis, Marilena Raciti, Patricia Gonzalez Rodriguez, Bertrand Joseph, Ibrahim Al Rayyes, Per Uhlen, Anna Falk, Suzana Telles da Cunha Lima, Sandra Ceccatelli
Summary: This study evaluated the long-term effects of subcytotoxic concentrations of GBH and GLY on the differentiation of human neuroepithelial stem cells (NES). It was found that GBH induced abnormal cellular differentiation, including immature neuronal profiles and a shift towards glial cell fate. These effects were associated with dysregulation of key genes involved in neurogenesis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biology
Sergey K. Sudakov, Natalia G. Bogdanova, Galina A. Nazarova
Summary: This research investigates the influence of epigenetic events at conception on the formation of behavioral features in adult rats. The study examines the first generational inheritance of activity level, anxiety-like behavior, and learning ability. The results show that offspring of parents who mated in the presence of males with high motor activity display higher activity levels, but anxiety-like behavior and learning ability are not inherited in the same way. This discovery may be important for maintaining a specific population's activity levels and counteracting natural selection.
Article
Chemistry, Inorganic & Nuclear
Alessandra Garau, Giacomo Picci, Andrea Bencini, Claudia Caltagirone, Luca Conti, Vito Lippolis, Paola Paoli, Giammarco Maria Romano, Patrizia Rossi, Mariano Andrea Scorciapino
Summary: This study describes the binding abilities of Zn(II) complexes of [12]aneN(4)-(L1) and [9]aneN(3)-based receptors (L2, L3) towards the herbicides and their metabolites. The results show that the L2/Zn(II) system exhibits strong coordination ability and high binding affinity for H(3)PMG.
DALTON TRANSACTIONS
(2022)
Article
Behavioral Sciences
Kylie A. Wright, Rebecca Polk, Tian Lin, David Feifel, Natalie C. Ebner
Summary: Neuropeptide oxytocin (OT) plays a critical role in modulating social cognition and behavior. This study found that chronic intranasal administration of OT can reduce attachment avoidance in older women, thus positively influencing their adult relationships.
HORMONES AND BEHAVIOR
(2023)
Article
Environmental Sciences
Julieta Peluso, Agustina Furio Lanuza, Cristina S. Perez Coll, Carolina M. Aronzon
Summary: The study found that glyphosate was significantly more toxic to Rhinella arenarum larvae than 2,4-D, with toxicity varying over time. The equitoxic mixture showed additive toxicity at 48 hours and became antagonistic at LC10 and LC50 effect levels after 96 hours. The non-equitoxic mixture exhibited additive toxicity at LC10 effect level from 48 to 168 hours, and synergistic effect from 240 hours.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jianzhong Hu, Corina Lesseur, Yu Miao, Fabiana Manservisi, Simona Panzacchi, Daniele Mandrioli, Fiorella Belpoggi, Jia Chen, Lauren Petrick
Summary: The study found that exposure to glyphosate-based herbicides can significantly alter the urine metabolite profiles of rat dams and pups, with differences observed between female and male pups. There was a significant increase in homocysteine in both Roundup and glyphosate exposed pups, but only in males. Additionally, correlation analysis indicated a negative relationship between the gut microbiome Prevotella and homocysteine levels.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Mengling Liu, Siying Lu, Chuanzhen Yang, Dalei Zhang, Jun Zhu, Jiting Yin, Hongru Zhao, Bei Yang, Haibin Kuang
Summary: This study aimed to investigate the effects and mechanisms of glyphosate-based herbicides (GBHs) exposure on placental development in vivo during pregnancy in mice. The results showed that GBHs administration led to increased resorption of fetuses, decreased fetal and placental weight, inhibited placental growth, and altered expression of related proteins and genes. Further study revealed that GBHs exposure induced oxidative stress in placental tissue. In conclusion, maternal exposure to GBHs can impair placental development through the activation of endoplasmic reticulum stress-mediated signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amir H. Rezvani, Corinne Wells, Andrew Hawkey, Graham Blair, Reese Koburov, Ashley Ko, Andrea Schwartz, Veronica J. Kim, Edward D. Levin
Summary: Female rats exhibit a considerable range in self-administration of remifentanil, while offspring from parents with different levels of remifentanil self-administration show significant differences in specific behavioral functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ezequiela Adrover, Maria Eugenia Pallares, Carlos Javier Baier, Melisa C. Monteleone, Fernando A. Giuliani, Helle S. Waagepetersen, Marcela A. Brocco, Ricardo Cabrera, Ursula Sonnewald, Arne Schousboe, Marta C. Antonelli
NEUROCHEMISTRY INTERNATIONAL
(2015)
Article
Behavioral Sciences
Carlos J. Baier, Maria E. Pallares, Ezequiela Adrover, Melisa C. Monteleone, Marcela A. Brocco, Francisco J. Barrantes, Marta C. Antonelli
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2015)
Article
Biochemistry & Molecular Biology
Jacques Fantini, Coralie Di Scala, Carlos J. Baier, Francisco J. Barrantes
CHEMISTRY AND PHYSICS OF LIPIDS
(2016)
Article
Neurosciences
Cristina Eugenia Gallegos, Carlos Javier Baier, Mariana Bartos, Cristina Bras, Sergio Dominguez, Nina Monaco, Fernanda Gumilar, Maria Sofia Gimenez, Alejandra Minetti
NEUROTOXICITY RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Natalia P. Alza, Victoria Richmond, Carlos J. Baier, Eleonora Freire, Ricardo Baggio, Ana Paula Murray
BIOORGANIC & MEDICINAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Maria Eugenia Pallares, Carlos Javier Baier, Ezequiela Adrover, Melisa Carolina Monteleone, Marcela Adriana Brocco, Marta Cristina Antonelli
NEUROCHEMICAL RESEARCH
(2013)
Article
Neurosciences
M. E. Pallares, E. Adrover, M. Imsen, D. Gonzalez, B. Fabre, V. Mesch, C. J. Baier, M. C. Antonelli
Article
Neurosciences
C. J. Baier, D. L. Franco, C. E. Gallegos, L. A. Mongiat, L. Dionisio, C. Bouzat, P. Caviedes, F. J. Barrantes
Review
Neurosciences
Carlos J. Baier, Maria R. Katunar, Ezequiela Adrover, Maria Eugenia Pallares, Marta C. Antonelli
NEUROTOXICITY RESEARCH
(2012)
Article
Neurosciences
Carlos J. Baier, Maria Eugenia Pallares, Ezequiela Adrover, Maria R. Katunar, Rita Raisman-Vozari, Marta C. Antonelli
NEUROTOXICITY RESEARCH
(2014)
Article
Behavioral Sciences
Maria Eugenia Pallares, Ezequiela Adrover, Carlos Javier Baier, Nadia S. Bourguignon, Melisa C. Monteleone, Marcela A. Brocco, Silvia I. Gonzalez-Calvar, Marta C. Antonelli
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2013)
Article
Plant Sciences
V. Cavallaro, C. J. Baier, M. G. Murray, A. Estevez-Braun, A. P. Murray
SOUTH AFRICAN JOURNAL OF BOTANY
(2018)
Article
Neurosciences
Cristina Eugenia Gallegos, Mariana Bartos, Fernanda Gumilar, Rita Raisman-Vozari, Alejandra Minetti, Carlos Javier Baier
Article
Neurosciences
Brunella Biscussi, Victoria Richmond, Carlos Javier Baier, Pau Arroyo Manez, Ana Paula Murray
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2020)