Article
Biochemistry & Molecular Biology
Lucia Caffino, Francesca Mottarlini, Sabrine Bilel, Giorgia Targa, Micaela Tirri, Coralie Maggi, Matteo Marti, Fabio Fumagalli
Summary: The study reveals that the expression of neuroplastic markers in the brain can be altered by low doses of MDPV or alpha-PVP, suggesting the widespread impact of these cathinones on brain plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychology, Multidisciplinary
Anastasia Morandi-Raikova, Uwe Mayer
Summary: This review discusses the functional equivalence of the avian and mammalian hippocampus, focusing on research in domestic chicks. While the hippocampus plays a central role in processing spatial information in both birds and mammals, the structure of this area shows remarkable differences.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Physiology
Francesca Protti-Sanchez, Carlos DanielCorrales Parada, Uwe Mayer, Hannah M. Rowland
Summary: This study reports the short-term taste behavior of chickens towards umami and bitter taste solutions and the associated neural activity. The results show that chickens prefer umami taste and have a stronger reaction to bitter taste. This differential response is lateralized at the neural level.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Behavioral Sciences
Sofia Leal Santos, Briana K. Chen, Guilherme R. Pereira, Vananh Pham, Christine A. Denny
Summary: Altered fear learning is a significant component of anxiety disorders, and the noradrenergic signaling system plays an important role in regulating stress responses and fear learning processes. Propranolol has been shown to reduce exaggerated fear responses and can impact the activity of the dentate gyrus and hilar layer. These findings contribute to our understanding of the neural mechanisms underlying anxiety disorders and provide a new possibility for improving treatment efficacy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Hibiki Okamura, Shinnosuke Yasugaki, Haruka Suzuki-Abe, Yoshifumi Arai, Katsuyasu Sakurai, Masashi Yanagisawa, Hotaka Takizawa, Yu Hayashi
Summary: Understanding the long-term effects of stress on brain function is crucial for understanding the mechanisms of depression. This study investigated the effects of repeated social defeat stress (SDS) on behavior and brain activity in BALB/c mice over subsequent weeks. The results revealed the long-term effects of social stress on behavior and brain activity, providing insight into the underlying mechanisms of related diseases.
Article
Multidisciplinary Sciences
Stephen R. Morairty, Yu Sun, Lawrence Toll, Michael R. Bruchas, Thomas S. Kilduff
Summary: This study evaluated the effects of two NOPR agonists on sleep/wake in rats, mice, and Cynomolgus macaques. The results showed that these agonists increased non-Rapid Eye Movement sleep and electroencephalogram slow wave activity, while suppressing Rapid Eye Movement sleep in all three species. These findings suggest that the N/OFQ-NOPR system may have a previously unrecognized role in sleep/wake control and could be a potential therapeutic target for insomnia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Jose Mario Prati, Evelyn Maria Guilherme, Thiago Luiz de Russo, Anna Carolyna Lepesteur Gianlorenco
Summary: The cerebellum is not only involved in motor functions such as balance and movement, but also in non-motor functions like emotional control, memory, and language. Different cerebellar areas and other brain structures showed varying levels of neuronal activation in response to exposure to different behavioral models, indicating distinct circuits for motor and non-motor functions.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Shin Hayase, Chengru Shao, Masahiko Kobayashi, Chihiro Mori, Wan-Chun Liu, Kazuhiro Wada
Summary: The study revealed that neural activity-dependent genes in songbirds are induced by singing and correlated with the level of vocal plasticity, regardless of age. Different gene regulation patterns were observed in songbirds during different seasons, indicating a complex relationship between singing and vocal plasticity. This suggests that the correlation between vocal plasticity and the singing-driven expression of neural activity-dependent genes in the robust nucleus of the arcopallium (RA) is consistent across different seasons and ages.
Article
Neurosciences
Fabrizio Sanna, Maria Pina Serra, Marianna Boi, Jessica Bratzu, Laura Poddighe, Francesco Sanna, Antonella Carta, Maria Giuseppa Corda, Osvaldo Giorgi, Maria Rosaria Melis, Antonio Argiolas, Marina Quartu
Summary: Sexual activity causes differential changes in the expression of markers of neural activation and plasticity in the hippocampus of Roman rats, which are influenced by sexual experience level, hippocampal partition, marker type, and rat line.
Article
Behavioral Sciences
David Lorincz, Hannah R. Drury, Doug W. Smith, Rebecca Lim, Alan M. Brichta
Summary: The study examined the relationship between motion sickness and brainstem efferent vestibular nucleus (EVN) neurons, showing that young adult WT and transgenic mice exhibit motion sickness symptoms and activation of EVN neurons, while aged WT mice do not show symptoms or changes in c-Fos expression when exposed to the same provocative stimulus.
BRAIN AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Hiroaki Ohishi, Seiru Shimada, Satoshi Uchino, Jieru Li, Yuko Sato, Manabu Shintani, Hitoshi Owada, Yasuyuki Ohkawa, Alexandros Pertsinidis, Takashi Yamamoto, Hiroshi Kimura, Hiroshi Ochiai
Summary: The authors developed a new tool called STREAMING-tag that can reveal the relationship between transcriptional activity and protein clusters, which is useful for quantitatively understanding transcriptional regulation in living cells.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Jannik M. Buettner, Leonie Sowoidnich, Florian Gerstner, Beatriz Blanco-Redondo, Stefan Hallermann, Christian M. Simon
Summary: The activation of the p53 pathway is associated with neuronal degeneration in various neurological disorders, including SMA. Aberrant expression of p53 leads to the selective death of motor neurons in SMA. In this study, the expression of p53 downstream targets c-fos, perp, and fas was investigated in vulnerable motor neurons of SMA mice. Nuclear upregulation of c-Fos protein was observed in degenerating motor neurons in different mouse models of SMA, suggesting that it may serve as a readout for therapeutic approaches targeting neuronal death in SMA and other p53-dependent neurodegenerative diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Yu Ri Kim, Sun Young Lee, So Min Lee, Insop Shim, Mi Young Lee
Summary: The study results suggest that the extract of Hibiscus syriacus Linnaeus flower (HSF) and its active constituent saponarin have desirable effects on anxiety, wake times, REM sleep time, and the expression of cortical GABA(A) receptor alpha 1 (GABAAR alpha 1) and c-Fos in the ventrolateral preoptic nucleus (VLPO). HSF extract and saponarin also restored sleep rate and sleep bout duration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Behavioral Sciences
Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study investigated changes in neuronal activity in brain regions associated with motivation in mice during different intensities of rotation on running wheels. The results suggest that subareas of the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) may play a critical role in the motivational effects of running wheel rotations.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Environmental Sciences
S. P. Keerthana, R. Yuvakkumar, G. Ravi, Abd El-Zaher M. A. Mustafa, Abdullah Ahmed Al-Ghamdi, Mohamed Soliman Elshikh, Dhayalan Velauthapillai
Summary: The translated text highlights the urgency of wastewater treatment, the method and experimental results of photocatalytic dye degradation, and ultimately proposes that the 2% PVP-(Mn-CdS) sample is a promising candidate for wastewater treatment.
Article
Pharmacology & Pharmacy
Andrea Ossato, Roberto Tessari, Carlotta Trabucchi, Teresa Zuppini, Nicola Realdon, Francesca Marchesini
Summary: This study investigated the adverse events following vaccination with the Comirnaty vaccine in individuals who were previously infected with COVID-19 and those who were not. The results showed that participants who had previously been infected experienced more side effects after the first dose, but fewer side effects after the second dose, compared to those who had not been previously infected. Most of the side effects identified in this study were consistent with reports from the manufacturer and the US Food and Drug Administration.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
Francesca Mottarlini, Giorgia Targa, Giorgia Bottan, Benedetta Tarenzi, Fabio Fumagalli, Lucia Caffino
Summary: Patients with anorexia nervosa show altered neural activity and connectivity in the fronto-striatal circuit. Low glutamatergic transmission and abnormal excitability in the mPFC may contribute to cognitive deficits. After recovery, ABA rats still exhibit reduced synaptic stability associated with cognitive dysfunction.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemical Research Methods
Marta Massano, Enrico Gerace, Martina Borsari, Matteo Marti, Micaela Tirri, Christina Ververi, Eugenio Alladio, Marco Vincenti, Alberto Salomone
Summary: This study investigated the distribution of the dissociative drug MXPr and its metabolites in body fluids and fur of mice. The main metabolite identified in urine was Desmethyl-MXPr-glucoronide, and norMXPr was also present in urine, plasma, and fur. These findings can contribute to the toxicological screening and extending the detection window of MXPr.
DRUG TESTING AND ANALYSIS
(2023)
Article
Neurosciences
Giorgia Corli, Micaela Tirri, Raffaella Arfe, Beatrice Marchetti, Tatiana Bernardi, Martina Borsari, Sara Odoardi, Serena Mestria, Sabina Strano-Rossi, Margherita Neri, Rosa Maria Gaudio, Sabrine Bilel, Matteo Marti
Summary: Synthetic cathinones, including MTTA, are becoming increasingly popular in the illicit drug market, particularly among young adults, due to their ability to replicate the effects of traditional psychostimulant drugs. However, there is limited data available on the in vivo pharmaco-toxicology of these substances. This study examined the effects of repeated administration of MTTA in mice and found that it caused sensory and physiological changes, as well as histological alterations in the heart, kidney, and liver, suggesting potential toxicity.
Article
Pharmacology & Pharmacy
Sabrine Bilel, Erica Zamberletti, Lucia Caffino, Micaela Tirri, Francesca Mottarlini, Raffaella Arfe, Mario Barbieri, Sarah Beggiato, Federica Boccuto, Tatiana Bernardi, Sara Casati, Anna T. Brini, Daniela Parolaro, Tiziana Rubino, Luca Ferraro, Fabio Fumagalli, Matteo Marti
Summary: This study investigates the long-lasting effects of repeated exposure to synthetic cannabinoid JWH-018, and finds that it leads to the manifestation of psychotic-like symptoms accompanied by alterations in neuroplasticity and changes in the endocannabinoid system.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Substance Abuse
Giorgia Corli, Micaela Tirri, Sabrine Bilel, Arianna Giorgetti, Tatiana Bernardi, Federica Boccuto, Martina Borsari, Raffaele Giorgetti, Matteo Marti
Summary: This study investigates the acute effects of co-administration of JWH-018 and ethanol on sensorimotor and motor responses, grip strength, and memory functions in mice. The results show that the combination of JWH-018 and ethanol leads to worsened cognitive and sensorimotor disruptions.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Biochemistry & Molecular Biology
Monia Lenzi, Sofia Gasperini, Giorgia Corli, Matteo Marti, Patrizia Hrelia
Summary: MTTA, a novel psychoactive substance with a similar structure to cathinone, has not been extensively studied for its pharmaco-toxicological profile and genotoxic potential. This study aimed to evaluate its genotoxicity on TK6 cells by assessing its ability to induce chromosomal aberrations using the In Vitro Mammalian Cell Micronucleus (MN) test. The results showed no statistically significant increase in the frequency of micronuclei, except at a concentration of 50 μM after long-term treatment (26 hours).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Beatrice Marchetti, Sabrine Bilel, Micaela Tirri, Giorgia Corli, Elisa Roda, Carlo Alessandro Locatelli, Elena Cavarretta, Fabio De-Giorgio, Matteo Marti
Summary: JWH-018 is a known compound used for its psychoactive effects, but it also has toxic effects on the cardiovascular and respiratory systems. This study investigated the effects of different antidotes on the cardiovascular and respiratory responses to JWH-018 in male mice. The results showed that while all tested antidotes reduced tachycardia and tachyarrhythmia and improved breathing functions, only atropine completely reversed the heart rate and pulse distension. These findings provide valuable information for the treatment of intoxicated patients in emergency clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Andrea Ossato, Valeria Mezzadrelli, Giulia Montagner, Diletta Trojan, Giuseppe Giovagnoni, Michele Giannini, Carlotta Trabucchi, Chiara Angelini, Francesca Realdon, Lorenza Cipriano, Nicola Realdon, Teresa Zuppini, Roberto Tessari
Summary: The Fondazione Banca dei Tessuti del Veneto (FBTV) stopped sending thawed and ready to be transplanted cadaveric human tissues to hospitals. The hospital pharmacy developed a new centralized service for thawing and washing human tissues, resulting in a significant reduction in wasted tissues and economic loss for the hospital.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Review
Oncology
Andrea Messori, Vera Damuzzo, Melania Rivano, Luca Cancanelli, Lorenzo Di Spazio, Andrea Ossato, Marco Chiumente, Daniele Mengato
Summary: The IPDfromKM-Shiny method is an innovative approach for conducting comparative research in evidence-based medicine, particularly in oncology. It uses reconstructed patient data from previous trials to perform indirect comparisons and determine the most appropriate treatments based on individual characteristics. This method shows promising results and deserves further investigation.
Article
Oncology
Andrea Ossato, Daniele Mengato, Marco Chiumente, Andrea Messori, Vera Damuzzo
Summary: This study compared the efficacy of combination therapies based on PD-1 and VEGF inhibitors for advanced renal cell carcinoma using an innovative method that reconstructed individual patient data. Pembrolizumab + lenvatinib showed the best progression-free survival and was expected to determine the longest overall survival. Pembrolizumab + axitinib, nivolumab + cabozantinib, and nivolumab + ipilimumab showed similar progression-free survival, but pembrolizumab + axitinib also demonstrated better overall survival. Subgroup analysis showed significant improvements in overall survival with pembrolizumab + axitinib and nivolumab + ipilimumab compared to sunitinib in intermediate-poor risk patients. This innovative method provided indirect comparisons of these treatment regimens in the absence of real comparative trials.
Article
Biochemistry & Molecular Biology
Giorgia Targa, Francesca Mottarlini, Beatrice Rizzi, Damiana Leo, Lucia Caffino, Fabio Fumagalli
Summary: Dopamine overactivity reduces the translation and localization of cortical AMPA receptors through altered vesicular sorting. The decreased expression of anchoring proteins and structural markers indicates synaptic instability. Hyperdopaminergia significantly alters the homeostatic plasticity of AMPA receptors, leading to a destabilized and depotentiated AMPA-mediated glutamatergic neurotransmission in the prefrontal cortex.
Article
Cell Biology
Andrea Ossato, Carlo Gasperoni, Michela Stella, Giulia Montagner, Diletta Trojan, Giuseppe Giovagnoni, Michele Giannini, Francesca Realdon, Valeria Mezzadrelli, Nicola Realdon, Teresa Zuppini, Roberto Tessari
Summary: This study describes the design and execution of an adapted Media Fill Test to demonstrate aseptic thawing and washing of musculoskeletal allografts. The study successfully completed all tests and provides insights for health professionals interested in implementing this service.
CELL AND TISSUE BANKING
(2023)
Article
Substance Abuse
Raffaella Arfe, Sabrine Bilel, Micaela Tirri, Giorgia Corli, Eva Bergamin, Giovanni Serpelloni, Marta Bassi, Martina Borsari, Federica Boccuto, Tatiana Bernardi, Lorenzo Caruso, Alaaldin M. Alkilany, Ousama Rachid, Francesco Botre, Fabio De-Giorgio, Matteo Marti
Summary: This study investigated the effects of gamma-valerolactone (GVL) on mice and compared it to gamma-hydroxybutyric acid (GHB). The results showed that GVL inhibits sensorimotor and motor responses and induces cardiorespiratory depression in a dose-dependent manner. The study suggests that GVL could be used as a substitute for GHB and should be included in forensic toxicology screenings.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Review
Neurosciences
Sabrine Bilel, Arianna Giorgetti, Micaela Tirri, Raffaella Arfe, Virginia Cristofori, Beatrice Marchetti, Giorgia Corli, Lorenzo Caruso, Giorgio Zauli, Raffaele Giorgetti, Matteo Marti
Summary: Driving is a complex task that requires coordination of cognitive functions and psychomotor skills. The effects of novel psychoactive substances (NPS) and novel synthetic opioids (NSO) on driving ability are still unclear. This study presents a literature review on the psychomotor impairing effects of Fentanyl (FENT) and three analogues in humans. Experimental studies on both humans and mice showed that FENT and its analogues dose-dependently decreased visual and sensory responses, suggesting that these synthetic opioids may impair psychomotor performance, particularly in driving.
CURRENT NEUROPHARMACOLOGY
(2023)
