Article
Pharmacology & Pharmacy
Hebaallah Mamdouh Hashiesh, Niraj Kumar Jha, Charu Sharma, Piyush Kumar Gupta, Saurabh Kumar Jha, Chandragouda R. Patil, Sameer N. Goyal, Shreesh K. Ojha
Summary: The pharmacological activation of CB2R, particularly by the compound JWH133, has shown promising neuroprotective and anti-inflammatory effects in various neurological disorders, making it a potential candidate for drug development in neurotherapeutics. Further regulatory toxicology and pharmacokinetic studies are needed to evaluate its safety for clinical use.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Ignacio Fernandez-Moncada, Abel Eraso-Pichot, Tommaso Dalla Tor, Berenice Fortunato-Marsol, Giovanni Marsicano
Summary: Neurodegenerative disorders are debilitating conditions with unclear origins and mechanisms. However, studies have shown that the endocannabinoid system (ECS) and its main receptor, the type-1 cannabinoid (CB1) receptor, are altered in diseases such as Alzheimer's, Parkinson's, and Huntington's. This review summarizes the findings and highlights the importance of understanding the role of ECS and CB1 receptor signaling in neurodegeneration, specifically in astrocyte function. More research is required to fully comprehend the impact of ECS defects in these disorders.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Medicinal
Ioannis P. Papanastasiou, Markos-Orestis Georgiadis, Christos Iliopoulos-Tsoutsouvas, Carol A. Paronis, Christina A. Brust, Ngan K. Tran, Lipin Ji, Xiaoyu Ma, JodiAnne T. Wood, Nikolai Zvonok, Fei Tong, Laura M. Bohn, Spyros P. Nikas, Alexandros Makriyannis
Summary: This study merged the features of nabilone and AM2389 and optimized the C3 side chain. Among the nabilone analogs, AM8936 exhibited balanced and potent agonist activity on the CB1 receptor, making it a potential candidate for further development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Ana Tadijan, Ignacija Vlasic, Josipa Vlainic, Domagoj Dikic, Nada Orsolic, Maja Jazvinscak Jembrek
Summary: Cannabinoids have shown antioxidative and neuroprotective effects in the treatment of neurodegenerative conditions, with complex mechanisms involving multiple receptors and signaling pathways.
Article
Plant Sciences
Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng
Summary: This study evaluated the anti-inflammatory effect of Saikosaponin B2 (SSB2) in LPS-induced primary microglia and CUMS-induced mice model of depression, and elucidated the underlying molecular mechanisms. The results showed that SSB2 attenuated LPS-induced ferroptosis and relieved central neuroinflammation through the TLR4/NF-κB pathway in a GPX4-dependent manner. SSB2 treatment also maintained calcium homeostasis, relieved endoplasmic reticulum stress, and improved symptoms of depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Xiao Fan Xu, Meng Meng Shi, Ming Ying Luo, Dan Dan Liu, Dong Ming Guo, Ling Chen, Xiao Lin Zhong, Yang Xu, Wen Yu Cao
Summary: Neuroinflammation plays a key role in the development of depression-like behaviors, and endoplasmic reticulum stress is suggested to collaborate with inflammation process to drive sustained neuroinflammation. This study found that targeting the PERK pathway can improve LPS-induced depression-like behaviors, indicating that targeting PERK pathway may be a promising antidepressant and anti-inflammatory drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Christian Grinan-Ferre, Julia Jarne-Ferrer, Aina Bellver-Sanchis, Sandra Codony, Dolors Puigoriol-Illamola, Coral Sanfeliu, Yumin Oh, Seulki Lee, Santiago Vazquez, Merce Pallas
Summary: This study found that inhibiting soluble epoxide hydrolase (sEH) is helpful in combating neuroinflammation, and it can achieve neuroprotection by modulating the eIF2 alpha/CHOP pathway, which is of potential significance for the treatment of Alzheimer's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Tibor M. Brunt, Matthijs G. Bossong
Summary: The endocannabinoid system is a complex neuronal system involved in various biological functions, and its understanding has been driven by the potential therapeutic benefits of cannabinoid ligands. This review provides an overview of the neuropharmacology of cannabinoid receptor ligands, including endocannabinoids, herbal cannabis, and synthetic cannabinoids, focusing on their modulatory actions through other neurotransmitter systems. The effects of cannabinoid ligands on neurotransmitter systems such as dopamine, serotonin, glutamate, noradrenaline, opioid, and GABA are discussed, as well as their therapeutic potential and adverse effects.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Laise P. A. Chiari, Aldineia P. da Silva, Kathia M. Honorio, Alberico B. F. da Silva
Summary: This study used quantum and chemometric methods to investigate the relationship between the structure and psychoactivity of 50 cannabinoid compounds. QSAR models were successfully built to predict the biological activities of these compounds, and compounds Ic14, Ic18, and Ic19 showed higher predicted biological activities than the main cannabinoid compounds Delta 9-THC and Delta 8-THC. Compound Ic21 stood out as having the highest predicted biological activity in interaction with the CB2 receptor.
JOURNAL OF MOLECULAR MODELING
(2023)
Review
Psychiatry
Srinagesh Mannekote Thippaiah, Sloka S. Iyengar, K. Yaragudri Vinod
Summary: Cannabis has been recognized for thousands of years, but recent research has highlighted the crucial role of the endocannabinoid system in regulating mood, impulsivity, and decision-making, with dysfunction potentially increasing the risk of negative mood and cognitive impairments. The literature suggests that targeting the endocannabinoid system could be a viable approach for treating various neuropsychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Hongyu Yi, Yali Duan, Renjie Song, Yibo Zhou, Yating Cui, Chao Liu, Zhi Mao, Jie Hu, Feihu Zhou
Summary: The activation of GLP-1R with Liraglutide can inhibit ER stress, inflammation, and apoptosis in microglia, improving the pathological process of SAE. In vivo experiments confirmed the benefits of Liraglutide in regulating microglial activation and improving survival rate and cognitive dysfunction in septic mice.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maite L. Docampo-Palacios, Giovanni A. Ramirez, Tesfay T. Tesfatsion, Alex Okhovat, Monica Pittiglio, Kyle P. Ray, Westley Cruces
Summary: This article describes the discovery of natural and non-natural hexahydrocannabinols (HHC) by Adam in 1940 and its emergence in the drug market in the United States and some European countries in late 2021. The article provides background information on the synthesis and pharmacology studies of hydrogenated and saturated cannabinoids and discusses the cannabinoid receptor affinities of different types of saturated cannabinoids. The effects of HHC treatment have been studied in vitro and in several animal species in vivo, showing similarities to Δ9-tetrahydrocannabinol (Δ9-THC), but no studies have been conducted in humans to establish its biological profile.
Article
Pharmacology & Pharmacy
Zhiyang Huang, Jiahong Gong, Wen Lin, Zhiyi Feng, Yirou Ma, Yurong Tu, Xiong Cai, Jianhua Liu, Chang Lv, Xinru Lv, Qiuji Wu, Wenjie Lu, Juan Zhao, Yibo Ying, Shengcun Li, Wenfei Ni, Haili Chen
Summary: CAT can inhibit neuronal apoptosis in SCI by reducing endoplasmic reticulum stress and activating the Caspase3/Bax/Bcl-2 pathway, and it has the potential to be a therapeutic drug for SCI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xinming Li, Zongxin Cheng, Xiaohong Chen, Dejiang Yang, Huanhuan Li, Youqing Deng
Summary: This study found that Purpurogallin (PPG) has neuroprotective effects on cerebral ischemia/reperfusion (I/R) injury. PPG attenuates brain I/R damage by suppressing endoplasmic reticulum (ER) stress and neuroinflammation via inactivation of the TLR4/NF-kappa B pathway. PPG may be a potential candidate drug for treating cerebral I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Jose Luis Cortes-Altamirano, Ariadna Yanez-Pizana, Samuel Reyes-Long, Gonzalez-Maciel Angelica, Cindy Bandala, Herlinda Bonilla-Jaime, Alfonso Alfaro-Rodriguez
Summary: This review discusses the neurological manifestations that may result from SARS-CoV-2 infection and explores the potential use of cannabinoids as a neuroprotective treatment. The activation of the endocannabinoid system has shown promising results in reducing viral replication and pro-inflammatory cytokines in the central nervous system.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Psychiatry
Danielle Gouvea-Junqueira, Ana Caroline Brambilla Falvella, Andre Saraiva Leao Marcelo Antunes, Gabriela Seabra, Caroline Brandao-Teles, Daniel Martins-de-Souza, Fernanda Crunfli
FRONTIERS IN PSYCHIATRY
(2020)
Article
Cell Biology
Ana Campos Codo, Gustavo Gastao Davanzo, Lauar de Brito Monteiro, Gabriela Fabiano de Souza, Stefanie Primon Muraro, Joao Victor Virgilio-da-Silva, Juliana Silveira Prodonoff, Victor Corasolla Carregari, Carlos Alberto Oliveira de Biagi Junior, Fernanda Crunfli, Jeffersson Leandro Jimenez Restrepo, Pedro Henrique Vendramini, Guilherme Reis-de-Oliveira, Karina Bispo dos Santos, Daniel A. Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Rafael Elias Marques, Helison R. Carmo, Alexandre Borin, Lais Durco Coimbra, Vinicius O. Boldrini, Natalia S. Brunetti, Andre S. Vieira, Eli Mansour, Raisa G. Ulaf, Ana F. Bernardes, Thyago A. Nunes, Luciana C. Ribeiro, Andre C. Palma, Marcus Agrela, Maria Luiza Moretti, Andrei C. Sposito, Fabricio Biscaro Pereira, Licio Augusto Velloso, Marco Aurelio Ramirez Vinolo, Andre Damasio, Jose Luiz Proenca-Modena, Robson Francisco Carvalho, Marcelo A. Mori, Daniel Martins-de-Souza, Helder Nakaya, Alessandro S. Farias, Pedro M. Moraes-Vieira
Article
Multidisciplinary Sciences
Gabriela Seabra, Valeria de Almeida, Guilherme Reis-de-Oliveira, Fernanda Crunfli, Andre Saraiva Leao Marcelo Antunes, Daniel Martins-de-Souza
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Talita A. M. Vrechi, Anderson H. F. F. Leao, Ingrid B. M. Morais, Vanessa C. Abilio, Antonio W. Zuardi, Jaime Eduardo C. Hallak, Jose Alexandre Crippa, Claudia Bincoletto, Rodrigo P. Ureshino, Soraya S. Smaili, Gustavo J. S. Pereira
Summary: CBD activates autophagy through ERK1/2 activation and AKT suppression, dependent on ULK1 but independent of mTORC1, suggesting a potential non-canonical pathway and highlighting CBD as a potential therapeutic target for neurodegenerative disorders.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Gustavo Jose da Silva Pereira, Anderson Henrique Franca Figueredo Leao, Adolfo Garcia Erustes, Ingrid Beatriz de Melo Morais, Talita Aparecida de Moraes Vrechi, Lucas dos Santos Zamarioli, Cassia Arruda Souza Pereira, Lais de Oliveira Marchioro, Leticia Paulino Sperandio, Isis Valeska Freire Lins, Mauro Piacentini, Gian Maria Fimia, Patricia Reckziegel, Soraya Soubhi Smaili, Claudia Bincoletto
Summary: This review discusses the potential of targeting the autophagy machinery of host cells to combat COVID-19, with a focus on clinically used drugs that can affect different stages of autophagy. Specific compounds that modulate autophagy and show antiviral properties are identified, with the aim of identifying novel or off-label drugs to effectively treat patients infected with SARS-CoV-2 and reduce mortality risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychiatry
Andre S. L. M. Antunes, Veronica M. Saia-Cereda, Fernanda Crunfli, Daniel Martins-de-Souza
Summary: The 14-3-3 family is involved in various processes in neurological disorders, particularly in relation to dopamine and glutamate theories in schizophrenia. However, a more comprehensive understanding of their role is still needed.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Review
Geriatrics & Gerontology
Camila A. E. F. Cardinali, Yandara A. Martins, Andrea S. Torrao
Summary: The systematic review aimed to investigate the relationship between HT use in postmenopausal women and the risk of developing or treating AD symptoms. Findings revealed that while some studies suggested an improvement in cognitive function and a decrease in AD risk with HT, others did not show any association or even indicated an increased risk of AD.
Review
Endocrinology & Metabolism
Paulina Belen Sepulveda Figueroa, Ana Flavia Fernandes Ferreira, Luiz Roberto Britto, Arlette Patricia Doussoulin, Andrea da Silva Torrao
Summary: Studies have shown alterations in TH and circadian rhythm in AD patients, with TH deficits correlated with behavior, cognition, cerebral blood flow, and glucose consumption. The causal relationship between thyroid dysfunctions and AD remains inconclusive, but there is enough evidence in the literature to support a relationship between TH and AD. Further research in this field is needed to better understand the potential impact of TH on AD.
METABOLIC BRAIN DISEASE
(2021)
Article
Neurosciences
Ana Caroline Brambilla Falvella, Bradley Joseph Smith, Licia C. Silva-Costa, Aline G. F. Valenca, Fernanda Crunfli, Antonio W. Zuardi, Jaime E. Hallak, Jose A. Crippa, Valeria de Almeida, Daniel Martins-de-Souza
Summary: The study found that cannabidiol shares similarities in molecular pathways with clozapine and benztropine, exhibiting characteristics of atypical antipsychotic drugs. These drugs affect metabolic and gene expression pathways, and post-cuprizone-induced toxicity, cannabidiol, benztropine, and clozapine modulated cell proliferation and apoptosis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Correction
Neurosciences
Ana Caroline Brambilla Falvella, Bradley Joseph Smith, Licia C. Silva-Costa, Aline G. F. Valenca, Fernanda Crunfli, Antonio W. Zuardi, Jaime E. Hallak, Jose A. Crippa, Valeria de Almeida, Daniel Martins-de-Souza
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Pedro Yamamoto, Victor Corasolla Carregari, Fernanda Crunfli, Guilherme Reis-de-Oliveira, Licia Costa, Pedro Henrique Vendramini, Erica Almeida Duque, Nilton Barreto dos Santos, Egidi Mayara Firmino, Isadora Marques Paiva, Glaucia Maria Almeida, Adriano Sebollela, Carolina Manganeli Polonio, Nagela Ghabdan Zanluqui, Marilia Garcia de Oliveira, Patrick da Silva, Gustavo Gastao Davanzo, Marina Cacador Ayupe, Caio Loureiro Salgado, Antonio Francisco de Souza Filho, Marcelo Valdemir de Araujo, Taiana Taina Silva-Pereira, Angelica Cristine de Almeida Campos, Luiz Gustavo Bentim Goes, Marielton dos Passos Cunha, Elia Garcia Caldini, Maria Regina D'Imperio Lima, Denise Morais Fonseca, Ana Marcia de Sa Guimaraes, Paola Camargo Minoprio, Carolina Demarchi Munhoz, Claudia Madalena Cabrera Mori, Pedro Manoel Moraes-Vieira, Thiago Mattar Cunha, Daniel Martins-de-Souza, Jean Pierre Schatzmann Peron
Summary: COVID-19 infection alters the immune metabolism and disrupts the balance of important metabolic molecules and neurotransmitters in astrocytes, which may contribute to neurological impairment observed during the disease.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Juliana Minardi Nascimento, Danielle Gouvea-Junqueira, Giuliana S. Zuccoli, Carolina da Silva Gouveia Pedrosa, Caroline Brandao-Teles, Fernanda Crunfli, Andre S. L. M. Antunes, Juliana S. Cassoli, Karina Karmirian, Jose Alexandre Salerno, Gabriela Fabiano de Souza, Stefanie Primon Muraro, Jose Luiz Proenca-Modena, Luiza M. Higa, Amilcar Tanuri, Patricia P. Garcez, Stevens K. Rehen, Daniel Martins-de-Souza
Summary: This study investigates the proteomic alterations induced by the Brazilian and African strains of Zika virus as well as the molecular responses to dengue virus. The results reveal that both Zika virus and dengue virus lead to biological effects such as cell death, cell cycle dysregulation, and neurogenesis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Fernanda Crunfli, Victor C. Carregari, Flavio P. Veras, Lucas S. Silva, Mateus Henrique Nogueira, Andre Saraiva Leao Marcelo Antunes, Pedro Henrique Vendramini, Aline Gazzola Fragnani Valenca, Caroline Brandao-Teles, Giuliana da Silva Zuccoli, Guilherme Reis-de-Oliveira, Licia C. Silva-Costa, Veronica Monteiro Saia-Cereda, Bradley J. Smith, Ana Campos Codo, Gabriela F. de Souza, Stefanie P. Muraro, Pierina Lorencini Parise, Daniel A. Toledo-Teixeira, Icaro Maia Santos de Castro, Bruno Marcel Melo, Glaucia M. Almeida, Egidi Mayara Silva Firmino, Isadora Marques Paiva, Bruna Manuella Souza Silva, Rafaela Mano Guimaraes, Niele D. Mendes, Raissa L. Ludwig, Gabriel P. Ruiz, Thiago L. Knittel, Gustavo G. Davanzo, Jaqueline Aline Gerhardt, Patricia Brito Rodrigues, Julia Forato, Mariene Ribeiro Amorim, Natalia S. Brunetti, Matheus Cavalheiro Martini, Maira Nilson Benatti, Sabrina S. Batah, Li Siyuan, Rafael B. Joao, Italo K. Aventurato, Mariana Rabelo de Brito, Maria J. Mendes, Beatriz A. da Costa, Marina K. M. Alvim, Jose Roberto da Silva Junior, Livia L. Damiao, Ieda Maria P. de Sousa, Elessandra D. da Rocha, Solange M. Goncalves, Luiz H. Lopes da Silva, Vanessa Bettini, Brunno M. Campos, Guilherme Ludwig, Lucas Alves Tavares, Marjorie Cornejo Pontelli, Rosa Maria Mendes Viana, Ronaldo B. Martins, Andre Schwambach Vieira, Jose Carlos Alves-Filho, Eurico Arruda, Guilherme Gozzoli Podolsky-Gondim, Marcelo Volpon Santos, Luciano Neder, Andre Damasio, Stevens Rehen, Marco Aurelio Ramirez Vinolo, Carolina Demarchi Munhoz, Paulo Louzada-Junior, Rene Donizeti Oliveira, Fernando Q. Cunha, Helder I. Nakaya, Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff, Paulo Hilario Nascimento Saldiva, Alessandro S. Farias, Fernando Cendes, Pedro Manoel M. Moraes-Vieira, Alexandre T. Fabro, Adriano Sebollela, Jose L. Proenca-Modena, Clarissa L. Yasuda, Marcelo A. Mori, Thiago M. Cunha, Daniel Martins-de-Souza
Summary: Research indicates that neuropsychiatric dysfunction can occur in individuals with mild COVID-19 infections, and the SARS-CoV-2 virus can infect astrocytes in the brain, leading to neuronal death or dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Ruan Carlos de Mace, Gabriely Cristina Alves Lima, Camila Aparecida Erreiras Fernandes Cardinali, Alisson Carvalho Gonsalves, Guilherme Vannucchi Portari, Elvira Maria Guerra-Shinohara, Antoine Leboucher, Jose Donato Junior, Andrea Kleinridders, Andrea da Silva Torrao
Summary: Benfotiamine treatment shows potential as a therapeutic approach for hypothalamic dysfunction and metabolic disturbances associated with sporadic AD.
Article
Cell Biology
Patricia Brito Rodrigues, Giovanni Freitas Gomes, Monara K. S. C. Angelim, Gabriela F. Souza, Stefanie Primon Muraro, Daniel A. Toledo-Teixeira, Bruna Amanda Cruz Rattis, Amanda Stephane Passos, Lais Passarielo Pral, Vinicius de Rezende Rodovalho, Arilson Bernardo dos Santos P. Gomes, Valquiria Aparecida Matheus, Andre Saraiva Leao Marcelo Antunes, Fernanda Crunfli, Krist Helen Antunes, Ana Paula Duarte de Souza, Silvio Roberto Consonni, Luiz Osorio Leiria, Jose Carlos Alves-Filho, Thiago M. Cunha, Pedro M. M. Moraes-Vieira, Jose Luiz Proenca-Modena, Marco Aurelio R. Vinolo
Summary: Clinical and experimental data suggest that SARS-CoV-2 infection leads to changes in gut microbiota. However, the relevance of these changes remains unclear. This study examined the impact of microbiota depletion on the clinical and immunological responses of mice to SARS-CoV-2 infection. The results showed that microbiota depletion had no effect on the infection.