The Gut Microbiome in Neuromyelitis Optica

Expansion of IL-6 + Th17-like cells expressing TLRs correlates with microbial translocation and neurological disabilities in NMOSD patients

(2017) Priscila O. Barros et al.   JOURNAL OF NEUROIMMUNOLOGY

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into Clostridium perfringens epsilon toxin activation and action on the brain during enterotoxemia

(2016) John C. Freedman et al.   ANAEROBE

Gut microbiome analysis in neuromyelitis optica reveals overabundance ofClostridium perfringens

(2016) Bruce A. C. Cree et al.   ANNALS OF NEUROLOGY

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

(2016) Helen Tremlett et al.   BMC Neurology

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

(2016) Helen Tremlett et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The human intestinal B-cell response

(2016) J Spencer et al.   Mucosal Immunology

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

(2016) Sharon A. Sagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

(2015) Jacqueline A. Hubbard et al.   ASN Neuro

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Intestinal M cells

(2015) Hiroshi Ohno   JOURNAL OF BIOCHEMISTRY

Association of circulating follicular helper T cells with disease course of NMO spectrum disorders

(2015) Yu-Jing Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica

(2015) Melina V Jones et al.   Acta Neuropathologica Communications

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Microbial view of central nervous system autoimmunity

(2014) Kerstin Berer et al.   FEBS LETTERS

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Rheumatic Fever, Autoimmunity, and Molecular Mimicry: The Streptococcal Connection

(2014) Madeleine W. Cunningham   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease

(2014) Romana Höftberger et al.   Multiple Sclerosis Journal

Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis

(2014) Bianca van den Berg et al.   Nature Reviews Neurology

Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders

(2014) D. K. Sato et al.   NEUROLOGY

Neuromyelitis Optica Spectrum Disorders With Aquaporin-4 and Myelin-Oligodendrocyte Glycoprotein Antibodies

(2014) Joanna Kitley et al.   JAMA Neurology

The Pathology of an Autoimmune Astrocytopathy: Lessons Learned from Neuromyelitis Optica

(2013) Claudia F. Lucchinetti et al.   BRAIN PATHOLOGY

High in vitro immune reactivity to Escherichia coli in neuromyelitis optica patients is correlated with both neurological disabilities and elevated plasma lipopolysaccharide levels

(2013) Priscila O. Barros et al.   HUMAN IMMUNOLOGY

Aquaporin 4 molecular mimicry and implications for neuromyelitis optica

(2013) Radhika A. Vaishnav et al.   JOURNAL OF NEUROIMMUNOLOGY

Aquaporin 4, Helicobacter pylori and potential implications for neuromyelitis optica

(2013) Jannis Kountouras et al.   JOURNAL OF NEUROIMMUNOLOGY

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characteristic Cerebrospinal Fluid Cytokine/Chemokine Profiles in Neuromyelitis Optica, Relapsing Remitting or Primary Progressive Multiple Sclerosis

(2013) Takuya Matsushita et al.   PLoS One

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease

(2013) Kareem Rashid Rumah et al.   PLoS One

Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognizeClostridiumABC transporter

(2012) Michel Varrin-Doyer et al.   ANNALS OF NEUROLOGY

The Ex Vivo Production of IL-6 and IL-21 by CD4+ T Cells is Directly Associated with Neurological Disability in Neuromyelitis Optica Patients

(2012) Ulisses C. Linhares et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cross-Immunoreactivity between Bacterial Aquaporin-Z and Human Aquaporin-4: Potential Relevance to Neuromyelitis Optica

(2012) Zhihua Ren et al.   JOURNAL OF IMMUNOLOGY

The human microbiome: at the interface of health and disease

(2012) Ilseung Cho et al.   NATURE REVIEWS GENETICS

T-cell reactivity against AQP4 in neuromyelitis optica

(2012) A. Vaknin-Dembinsky et al.   NEUROLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica

(2011) N. Matsuya et al.   INTERNATIONAL IMMUNOLOGY

Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

(2010) Javier Ochoa-Repáraz et al.   ANNALS OF NEUROLOGY

Novel insights into the epidemiology of Clostridium perfringens type A food poisoning

(2010) Miia Lindström et al.   FOOD MICROBIOLOGY

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Homology between Klebsiella pneumoniae and human aquaporin-4: no evidence for cross-reactivity in neuromyelitis optica. A study on 114 patients

(2010) S. Jarius et al.   JOURNAL OF NEUROLOGY

Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population

(2010) R Deschamps et al.   Multiple Sclerosis Journal

Diet, gut microbiota and immune responses

(2010) Kendle M Maslowski et al.   NATURE IMMUNOLOGY

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Phylogenomic analyses of clostridia and identification of novel protein signatures that are specific to the genus Clostridium sensu stricto (cluster I)

(2009) R. S. Gupta et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes

(2009) Johann Sellner et al.   JOURNAL OF AUTOIMMUNITY

HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis

(2009) Doralina Guimaraães Brum et al.   Multiple Sclerosis Journal

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

(2009) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of theHLA-DPB1*0501allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders

(2009) T. Matsushita et al.   TISSUE ANTIGENS

Clostridium perfringens toxin genotypes in the feces of healthy North Americans

(2008) Robert J. Carman et al.   ANAEROBE

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Binding of ɛ-toxin from Clostridium perfringens in the nervous system

(2008) Jonatan Dorca-Arévalo et al.   VETERINARY MICROBIOLOGY