Article
Otorhinolaryngology
Yin Ren, Bridget MacDonald, Kareem O. Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: Clinical predictors of facial nerve outcomes after microsurgical resection of vestibular schwannoma were identified, indicating excellent outcomes can be achieved with this procedure. Gross total resection and >= 100-mu V intraoperative FN electromyographic response were found to predict excellent FN outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Michael A. Silva, Henry Chang, Ashish H. Shah, Nickalus R. Khan, Clifford S. Brown, Christine T. Dinh, Adrien A. Eshraghi, Fred F. Telischi, Simon Angeli, Jacques J. Morcos
Summary: Intracisternal papaverine irrigation during vestibular schwannoma resection can safely improve immediate postoperative facial nerve outcomes, maintain similar long-term facial nerve outcomes, and is not associated with a significant increase in complications.
WORLD NEUROSURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Gang Xiao, Bin Huang, Ming Guo, Chaoxin Long, Pingan Li, Bin Zhong, Chuncheng Guan
Summary: BRCAT54 is an anti-tumor lncRNA that is downregulated in lung cancer and its role in vestibular schwannoma (VS) is unclear. This study found that BRCAT54 interacts with miR-21 and suppresses cell proliferation in VS.
Article
Otorhinolaryngology
Catherine Sobieski, Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: Facial nerve outcomes one year after microsurgical resection are poorer in patients with NF2 tumors compared to sporadic tumors, particularly for tumors with a volume greater than 3 cm³ and those classified as NF2 tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Felix Arlt, Johannes Kasper, Dirk Winkler, Katja Jaehne, Michael Karl Fehrenbach, Juergen Meixensberger, Caroline Sander
Summary: Intraoperative neurophysiological monitoring is crucial in vestibular schwannoma surgery to prevent nerve injury. Repeated direct nerve stimulation and a detected decreased amplitude might show facial nerve function deterioration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Michel Heide Talebnasab, Dan Dupont Hougaard
Summary: Vestibular schwannoma is the most common type of intracranial schwannoma, accounting for about 8% of all intracranial tumors in adults with an estimated incidence rate of around 1.3/100,000. The incidence rates of facial nerve schwannomas and cochlear nerve schwannomas are not well-documented. These three types of nerve tumors often present with unilateral hearing loss, tinnitus, and disequilibrium. Facial nerve palsy is common in facial nerve schwannomas but rare in vestibular schwannomas. The symptoms are usually persistent and progressive, leading to interventions that may cause significant morbidity such as deafness and imbalance.
Article
Clinical Neurology
Robert J. Macielak, Christine M. Lohse, Katherine P. Wallerius, Skye K. Lawlor, Brian A. Neff, Maria Peris Celda, Jamie J. Van Gompel, Colin L. W. Driscoll, Michael J. Link, Matthew L. Carlson
Summary: Younger age and better immediate postoperative HB grade were found to be significantly associated with complete recovery of facial nerve function to HB Grade I after microsurgical resection of sporadic vestibular schwannoma.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Otorhinolaryngology
Zdenek Fik, Josef Kraus, Zdenek Cada, Martin Chovanec, Alzbeta Fikova, Eduard Zverina, Jan Betka, Jan Plzak
Summary: The study demonstrates the utility of electromyographic follow-up in facial nerve reconstruction, with hemihypoglossal-facial anastomosis being an optimal solution for restoring facial function. Electromyography can predict initial reinnervation activity after reconstructive procedures, aiding in identifying insufficiently recovering patients during follow-up.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: The study revealed that patients with tumor volume >3 cm(3) had worse facial nerve outcomes 12 months following surgical resection. Tumor volume was identified as a key factor affecting facial nerve function outcomes.
Article
Otorhinolaryngology
Sophia Tran, Daniel E. Killeen, Shafeen Qazi, Sanjana Balachandra, Jacob B. Hunter
Summary: This study assessed the impact of medication use, specifically statin, metformin, and aspirin, on the growth of vestibular schwannomas (VSs), and found that metformin is associated with reduced VS growth.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Multidisciplinary Sciences
Jonathan Shapey, Aaron Kujawa, Reuben Dorent, Guotai Wang, Alexis Dimitriadis, Diana Grishchuk, Ian Paddick, Neil Kitchen, Robert Bradford, Shakeel R. Saeed, Sotirios Bisdas, Sebastien Ourselin, Tom Vercauteren
Summary: The study introduces the first publicly-available imaging dataset of vestibular schwannomas, consisting of 484 MR images and detailed treatment information. A novel artificial intelligence framework based on a 2.5D convolutional neural network was utilized, achieving results equivalent to those of an independent human annotator.
Article
Oncology
Giuseppe Di Perna, Raffaele De Marco, Bianca Maria Baldassarre, Enrico Lo Bue, Fabio Cofano, Pietro Zeppa, Luca Ceroni, Federica Penner, Antonio Melcarne, Diego Garbossa, Michele Maria Lanotte, Francesco Zenga
Summary: This retrospective study aimed to investigate the impact of morphologic and neurophysiological factors on the short- and long-term facial nerve function after vestibular schwannoma resection. A multiparametric score, Facial Nerve Outcome Score (FNOS), was developed and shown to be a reliable predictor of facial nerve function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Xueyun Deng, Lihua Liu, Jiuhong Li, Hui Yao, Shuai He, Zhiwei Guo, Jiayu Sun, Wenke Liu, Xuhui Hui
Summary: Patients with acoustic neuroma show cognitive impairments in various domains, including memory, executive function, attention, and processing speed compared to healthy controls. Changes in the structural brain network, especially the efficiency of subnetworks and fiber connections, are associated with cognitive impairments in these patients. Including neuropsychological aspects in clinical evaluation and appropriate treatments may help improve the life quality of patients with acoustic neuroma.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Bridget MacDonald, Yin Ren, Bita Shahrvini, Kareem O. Tawfik, Omid Moshtaghi, Marc S. Schwartz, Rick A. Friedman
Summary: This study aimed to analyze the characteristics and functional changes of delayed facial nerve palsy following resection of vestibular schwannoma (VS). The results showed that intraoperative electromyographic facial nerve response, tumor size, surgical approach, and extent of resection may play a role in the development of delayed facial nerve palsy. Most patients were able to recover near-normal function after experiencing delayed facial nerve palsy.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
John W. Rutland, Francesco Padormo, Cindi K. Yim, Amy Yao, Annie Arrighi-Allisan, Kuang-Han Huang, Hung-Mo Lin, James Chelnis, Bradley N. Delman, Raj K. Shrivastava, Priti Balchandani
JOURNAL OF NEUROSURGERY
(2020)
Review
Clinical Neurology
J. W. Rutland, B. N. Delman, C. M. Gill, C. Zhu, R. K. Shrivastava, P. Balchandani
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Clinical Neurology
Rebecca Emily Feldman, Lara Vanessa Marcuse, Gaurav Verma, Stephanie Sian Gabriella Brown, Alexandru Rus, John Watson Rutland, Bradley Neil Delman, Priti Balchandani, Madeline Cara Fields
Article
Radiology, Nuclear Medicine & Medical Imaging
Amy Yao, John W. Rutland, Gaurav Verma, Amir Banihashemi, Francesco Padormo, Nadejda M. Tsankova, Bradley N. Delman, Raj K. Shrivastava, Priti Balchandani
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Dara L. Dickstein, Rita De Gasperi, Miguel A. Gama Sosa, Georgina Perez-Garcia, Jennifer A. Short, Heidi Sosa, Gissel M. Perez, Anna E. Tschiffely, Kristen Dams-O'Connor, Mariel Y. Pullman, Karin Knesaurek, Andrew Knutsen, Dzung L. Pham, Lale Soleimani, Barry D. Jordan, Wayne A. Gordon, Bradley N. Delman, Gleb Shumyatsky, Pashtun-Poh Shahim, Steven T. DeKosky, James R. Stone, Elaine Peskind, Kaj Blennow, Henrik Zetterberg, Steven A. Chance, Mario Torso, Lale Kostakoglu, Mary Sano, Patrick R. Hof, Stephen T. Ahlers, Sam Gandy, Gregory A. Elder
Summary: Traumatic brain injury is a risk factor for neurodegenerative diseases, particularly chronic traumatic encephalopathy. This study identified biomarker signatures associated with chronic anxiety traits and behavioral, cognitive, and memory complaints in individuals exposed to blast injuries.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
John W. Rutland, Puneet Pawha, Puneet Belani, Bradley N. Delman, Corey M. Gill, Teresa Brown, Khadeen Cheesman, Raj K. Shrivastava, Priti Balchandani
Article
Medicine, General & Internal
Rebecca Smith-Bindman, Philip Chu, Yifei Wang, Robert Chung, Naomi Lopez-Solano, Andrew J. Einstein, Leif Solberg, Luisa F. Cervantes, Thomas Yellen-Nelson, William Boswell, Bradley N. Delman, Phuong-Anh Duong, Allen R. Goode, Nima Kasraie, Ryan K. Lee, Rebecca Neill, Anokh Pahwa, Pavlina Pike, Jodi Roehm, Sebastian Schindera, Jay Starkey, Saravanabavaan Suntharalingam, Cecile R. L. P. N. Jeukens, Diana Miglioretti
JAMA INTERNAL MEDICINE
(2020)
Article
Clinical Neurology
P. Belani, J. Schefflein, S. Kihira, B. Rigney, B. N. Delman, K. Mahmoudi, J. Mocco, S. Majidi, J. Yeckley, A. Aggarwal, D. Lefton, A. H. Doshi
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Clinical Neurology
S. Kihira, B. N. Delman, P. Belani, L. Stein, A. Aggarwal, B. Rigney, J. Schefflein, A. H. Doshi, P. S. Pawha
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Daryl T. Goldman, Himanshu Sharma, Mark Finkelstein, Timothy Carlon, Brett Marinelli, Amish H. Doshi, Bradley N. Delman, Robert Lookstein
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Clinical Neurology
I. C. George, A. Arrighi-Allisan, B. N. Delman, P. Balchandani, S. Horng, R. Feldman
Summary: In multiple sclerosis, the accumulation of inflammatory cells within perivascular spaces is significant. However, the use of perivascular spaces as biomarkers remains uncertain due to inconsistencies in anatomy. Specific imaging techniques, such as susceptibility-weighted imaging at 7T, are being explored to better differentiate between venular and arteriolar perivascular spaces.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Letter
Clinical Neurology
Stavros Matsoukas, Susmita Chennareddy, Roshini Kalagara, Jacopo Scaggiante, Colton J. Smith, Maximilian J. Bazil, Emma Reford, Kayla Liu, Bradley N. Delman, Magdy H. Selim, J. Mocco, Johanna T. Fifi, Christopher P. Kellner
Article
Clinical Neurology
Matthew T. Carr, Gianina C. Hernandez-Marquez, Meenakshi Vij, Xing Chin, Bradley N. Delman, Melissa Umphlett, Isabelle M. Germano
Summary: This study provides a systematic review of third ventricular subependymomas (TVSE), finding that these tumors present with symptoms such as headache, memory disturbances, and vomitus. Timely diagnosis and treatment are crucial, and surgical resection of the tumor can lead to the best clinical outcomes and improvement.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Annie E. Arrighi-Allisan, Bradley N. Delman, John W. Rutland, Amy Yao, Judy Alper, Kuang-Han Huang, Priti Balchandani, Raj K. Shrivastava
WORLD NEUROSURGERY
(2020)
Article
Neurosciences
Stephanie S. G. Brown, John W. Rutland, Gaurav Verma, Rebecca E. Feldman, Molly Schneider, Bradley N. Delman, James M. Murrough, Priti Balchandani
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2020)