Journal
NEUROSURGERY
Volume 82, Issue 4, Pages 491-495Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuros/nyx226
Keywords
Aneurysm; Cerebrovascular circulation; Subarachnoid hemorrhage; Morphology; Cerebral aneurysm; Hemorrhagic stroke; Natural history; Unruptured
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Funding
- National Institute of Neurological Disorders and Stroke [NS068092, NS028492]
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BACKGROUND: There are conflicting data between natural history studies suggesting a very low risk of rupture for small, unruptured intracranial aneurysms and retrospective studies that have identified a much higher frequency of small, ruptured aneurysms than expected. OBJECTIVE: To use the prospective International Study of Unruptured Intracranial Aneurysms cohort to identify morphological characteristics predictive of unruptured intracranial aneurysm rupture. METHODS: A case-control design was used to analyze morphological characteristics associated with aneurysm rupture in the International Study of Unruptured Intracranial Aneurysms database. Fifty-seven patientswith ruptured aneurysms during follow-upwere matched (by size and location) with 198 patients with unruptured intracranial aneurysms without rupture during follow-up. Twelve morphological metrics were measured from cerebral angiograms in a blinded fashion. RESULTS: Perpendicular height (P =. 008) and size ratio (ratio of maximum diameter to the parent vessel diameter; P =. 01) were predictors of aneurysm rupture on univariate analysis. Aspect ratio, daughter sacs, multiple lobes, aneurysm angle, neck diameter, parent vessel diameter, and calculated aneurysm volume were not statistically significant predictors of rupture. On multivariate analysis, perpendicular height was the only significant predictor of rupture (Chi-square 7.1, P-value .008). CONCLUSION: This study underscores the importance of other morphological factors, such as perpendicular height and size ratio, that may influence unruptured intracranial aneurysm rupture risk in addition to greatest diameter and anterior vs posterior location.
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