☆ 4.6 Article Proceedings Paper

Translational Advances in the Management of Acute Spinal Cord Injury: What is New? What is Hot?

NEUROSURGERY (2017)

Journal

NEUROSURGERY

Volume 64, Issue -, Pages 119-128

Publisher

OXFORD UNIV PRESS INC

DOI: 10.1093/neuros/nyx217

Keywords

-

Categories

Clinical Neurology Surgery

Funding

Canadian Institutes of Health Research
AOSpine North America
Rick Hansen Institute
Halbert Chair in Neural Repair and Regeneration
Dezwirek Foundation

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Chemistry, Multidisciplinary

Advances in Biomaterial-Based Spinal Cord Injury Repair

He Shen, Caixia Fan, Zhifeng You, Zhifeng Xiao, Yannan Zhao, Jianwu Dai

Summary: Spinal cord injury (SCI) leads to the loss of motor and sensory functions and understanding the pathophysiological changes and inhibitory microenvironment is crucial for potential mechanisms of functional restoration. Implantation of functionalized biomaterials and transplantation of spinal cord tissue grafts have shown promising results for SCI repair, opening up new avenues for treatment.

ADVANCED FUNCTIONAL MATERIALS (2022)

Add to Collection

Review Clinical Neurology

Advances in monitoring for acute spinal cord injury: a narrative review of current literature

Yohannes Tsehay, Carly Weber-Levine, Timothy Kim, Alejandro Chara, Safwan Alomari, Tolulope Awosika, Ann Liu, Jeffrey Ehresman, Kurt Lehner, Brian Hwang, Andrew M. Hersh, Ian Suk, Eli Curry, Fariba Aghabaglou, Yinuo Zeng, Amir Manbachi, Nicholas Theodore

Summary: Spinal cord injury is a devastating condition that requires advanced monitoring techniques for accurate assessment. This review discusses various SCI monitoring modalities and suggests that the next-generation monitoring setup should integrate multiple modalities to improve patient outcomes.

SPINE JOURNAL (2022)

Add to Collection

Review Neurosciences

Porcine spinal cord injury model for translational research across multiple functional systems

Rakib Uddin Ahmed, Chase A. Knibbe, Felicia Wilkins, Leslie C. Sherwood, Dena R. Howland, Maxwell Boakye

Summary: Animal models are important for spinal cord injury research. Small animal models have advantages in terms of management and cost, but their neurologic and anatomical differences may limit their translation to humans. In contrast, large animal models are more similar to humans and have greater translational value in studying spinal cord injury.

EXPERIMENTAL NEUROLOGY (2023)

Add to Collection

Review Clinical Neurology

Posterior spinal decompression in adults with spinal cord injury without traumatic compromise of the spinal canal: what is the data?

Mary Solou, Anastasios A. Politis, Ioannis Ydreos, Evangelos K. Papadopoulos, Stamatios Banos, Georgios Savvanis, Maria M. Gavra, Efstathios J. Boviatsis, Lampis C. Stavrinou

Summary: Treatment of spinal cord injury depends on the type and severity of the injury. Early decompression remains a reasonable option, but there is no specific evidence supporting the use of laminectomy alone.

FRONTIERS IN NEUROLOGY (2023)

Add to Collection

Review Chemistry, Multidisciplinary

Review of advances in electrospinning-based strategies for spinal cord regeneration

Yiran Li, Ting Dong, Zhiwei Li, Shilei Ni, Fang Zhou, Olawale A. Alimi, Shaojuan Chen, Bin Duan, Mitchell Kuss, Shaohua Wu

Summary: Spinal cord injury is a devastating neurological condition, and neural tissue engineering combined with electrospinning technique shows great potential for its treatment.

MATERIALS TODAY CHEMISTRY (2022)

Add to Collection

Review Clinical Neurology

Hemodynamic Management of Acute Spinal Cord Injury: A Literature Review

Young-Seok Lee, Kyoung-Tae Kim, Brian K. Kwon

Summary: Hemodynamic management is crucial for neurological recovery in acute spinal cord injury, but further research is needed to determine the optimal approach. Current guidelines acknowledge gaps in knowledge and limitations in the literature.

NEUROSPINE (2021)

Add to Collection

Article Engineering, Biomedical

Recent advances in nanomaterials for the treatment of spinal cord injury

Weiquan Gong, Tianhui Zhang, Mingxue Che, Yongjie Wang, Chuanyu He, Lidi Liu, Zhenshan Lv, Chunsheng Xiao, Hao Wang, Shaokun Zhang

Summary: Spinal cord injuries (SCIs) are devastating, leading to permanent loss of nerve function and paralysis. Current clinical treatments have limitations, and nanomaterials offer new possibilities for SCI treatment. Nanomaterials can improve the microenvironment of traumatic injury, promote neuron regeneration, optimize drug effects, and enhance gene delivery efficiency. This review provides new perspectives for future clinical therapies.

MATERIALS TODAY BIO (2023)

Add to Collection

Review Cell Biology

MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury

Serena Silvestro, Emanuela Mazzon

Summary: Spinal cord injury is a devastating injury to the central nervous system, and current therapies have not been successful. MiRNA plays a crucial role in CNS development and pathological processes after neural injury, making it a promising candidate for SCI therapy.

CELLS (2022)

Add to Collection

Article Health Care Sciences & Services

Pressure Injuries and Management after Spinal Cord Injury

Nicole M. Vecin, David R. Gater

Summary: This manuscript reviews the risk of pressure injuries caused by spinal cord injury and discusses the multidisciplinary approach required to prevent and treat these injuries in the vulnerable population.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury

Di Lu, Jiu-Ping Wu, Qi-Wei Yang, Hua-Yi Wang, Jun-Jie Yang, Gang-Gang Zhang, Chen Wang, Yan-Lian Yang, Ling Zhu, Xin-Zhi Sun

Summary: Lipid nanovesicles are effective delivery systems for targeted treatment of spinal cord injury due to their biocompatibility and ability to penetrate the blood-spinal cord barrier. Although most studies are still in preclinical stages, these nanovesicles hold great promise for future spinal cord injury treatments due to their low immunogenicity, low toxicity, and high engineerability.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

Add to Collection

Article Emergency Medicine

The acute phase management of spinal cord injury affecting polytrauma patients: the ASAP study

Edoardo Picetti, Corrado Iaccarino, Raul Coimbra, Fikri Abu-Zidan, Giovanni D. Tebala, Zsolt J. Balogh, Walter L. Biffl, Federico Coccolini, Deepak Gupta, Ronald V. Maier, Ingo Marzi, Chiara Robba, Massimo Sartelli, Franco Servadei, Philip F. Stahel, Fabio S. Taccone, Andreas W. Unterberg, Marta Velia Antonini, Joseph M. Galante, Luca Ansaloni, Andrew W. Kirkpatrick, Sandro Rizoli, Ari Leppaniemi, Osvaldo Chiara, Belinda De Simone, Mircea Chirica, Vishal G. Shelat, Gustavo P. Fraga, Marco Ceresoli, Luca Cattani, Francesco Minardi, Edward Tan, Imtiaz Wani, Massimo Petranca, Francesco Domenichelli, Yunfeng Cui, Laura Malchiodi, Emanuele Sani, Andrey Litvin, Andreas Hecker, Vito Montanaro, Solomon Gurmu Beka, Salomone Di Saverio, Sandra Rossi, Fausto Catena

Summary: There is a great variability in clinical practices for the acute phase management of tSCI patients with polytrauma worldwide. These findings can provide insights for future research to optimize the care of tSCI patients.

WORLD JOURNAL OF EMERGENCY SURGERY (2022)

Add to Collection

Article Neurosciences

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

Alicia K. Vose, Joseph F. Welch, Jayakrishnan Nair, Erica A. Dale, Emily J. Fox, Gillian D. Muir, Randy D. Trumbower, Gordon S. Mitchell

Summary: The study reviews the progress of a strategy involving therapeutic acute intermittent hypoxia (tAIH) to improve respiratory and non-respiratory motor function in people with neuromuscular disorders. Key areas of focus include greater mechanistic understanding, optimization of treatment protocols, identification of combinatorial treatments, assessment of long-term safety, and the development of a simple, safe and effective device for administering tAIH in clinical and home settings.

EXPERIMENTAL NEUROLOGY (2022)

Add to Collection

Review Clinical Neurology

Early surgical intervention for acute spinal cord injury: time is spine

Ayesha Quddusi, Karlo M. M. Pedro, Mohammed Ali Alvi, Nader Hejrati, Michael G. G. Fehlings

Summary: Acute traumatic spinal cord injury (tSCI) is a severe event with global impact on morbidity and mortality. Early surgical intervention within 24 hours has been shown to improve prognosis and functional outcomes. This review explores the evidence, nuances, and challenges associated with timing of surgery, as well as the barriers to early surgical care for tSCI.

ACTA NEUROCHIRURGICA (2023)

Add to Collection

Review Surgery

Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature

Timothy Y. Wang, Christine Park, Hanci Zhang, Shervin Rahimpour, Kelly R. Murphy, C. Rory Goodwin, Isaac O. Karikari, Khoi D. Than, Christopher I. Shaffrey, Norah Foster, Muhammad M. Abd-El-Barr

Summary: Traumatic spinal cord injury is a debilitating disease that presents significant functional and economic burdens. Prognosis depends on the extent of injury and severity of dysfunction, with rapid treatment crucial to prevent further damage. Managing TSCI patients involves various factors, from initial assessment to long-term care for optimal recovery.

FRONTIERS IN SURGERY (2021)

Add to Collection

Review Biotechnology & Applied Microbiology

Advances in Spinal Cord Stimulation

Christopher M. Lam, Usman Latif, Andrew Sack, Susheel Govindan, Miles Sanderson, Dan T. Vu, Gabriella Smith, Dawood Sayed, Talal Khan

Summary: Neuromodulation, particularly spinal cord stimulation (SCS), has become an essential tool for managing chronic pain in various conditions. Recent advances in SCS focus on improving safety and convenience for both patients and physicians, including novel programming modalities and modifications of existing hardware. This review examines the history of SCS, different SCS waveforms, new materials for SCS electrodes, closed loop systems, and neurorestorative devices.

BIOENGINEERING-BASEL (2023)

Add to Collection

Article Clinical Neurology

Patient-Reported Outcomes After Complex Adult Spinal Deformity Surgery: 5-Year Results of the Scoli-Risk-1 Study

Scott L. Zuckerman, Meghan Cerpa, Lawrence G. Lenke, Christopher Shaffrey, Leah Y. Carreon, Kenneth M. C. Cheung, Michael P. Kelly, Michael G. Fehlings, Christopher P. Ames, Oheneba Boachie-Adjei, Mark B. Dekutoski, Khaled M. Kabeaish, Stephen J. Lewis, Yukihiro Matsuyama, Ferran Pellise, Yong Qiu, Frank J. Schwab, Justin S. Smith

Summary: After complex ASD surgery, significant improvements in patient-reported outcomes (PROs) were observed at the 5-year follow-up. However, no significant changes in PROs were seen during the 2 to 5-year postoperative period. Patients with major surgery-related complications showed similar PROs and proportion of patients achieving MCID compared to those without such complications.

GLOBAL SPINE JOURNAL (2022)

Add to Collection

Article Clinical Neurology

Prevention of Surgical Site Infections in Spine Surgery: An International Survey of Clinical Practices Among Expert Spine Surgeons

Dimitri Tkatschenko, Sonja Hansen, Julia Koch, Christopher Ames, Michael G. Fehlings, Sigurd Berven, Lali Sekhon, Christopher Shaffrey, Justin S. Smith, Robert Hart, Han Jo Kim, Jeffrey Wang, Yoon Ha, Kenny Kwan, Yong Hai, Marcelo Valacco, Asdrubal Falavigna, Nestor Taboada, Alfredo Guiroy, Juan Emmerich, Bernhard Meyer, Frank Kandziora, Claudius Thome, Markus Loibl, Wilco Peul, Alessandro Gasbarrini, Ibrahim Obeid, Martin Gehrchen, Andrej Trampuz, Peter Vajkoczy, Julia Onken

Summary: This study provides an international overview of the heterogeneity of surgical site infection prevention strategies in spine surgery. The results demonstrate a significant variation in pre-, peri-, and postoperative measures to prevent surgical site infection. There is a need for developing universal guidelines and testing areas of controversy in prospective clinical trials.

GLOBAL SPINE JOURNAL (2023)

Add to Collection

Article Clinical Neurology

A Practical Classification System for Acute Cervical Spinal Cord Injury Based on a Three-Phased Modified Delphi Process From the AOSpine Spinal Cord Injury Knowledge Forum

Laureen D. Hachem, Mary Zhu, Bizhan Aarabi, Benjamin Davies, Anthony DiGiorgio, Nathan Evaniew, Michael G. Fehlings, Mario Ganau, Daniel Graves, James Guest, Yoon Ha, James Harrop, Christopher Hofstetter, Paul Koljonen, Shekar Kurpad, Rex Marco, Allan R. Martin, Narihito Nagoshi, Aria Nouri, Vafa Rahimi-Movaghar, Ricardo Rodrigues-Pinto, Valerie Ter Wengel, Lindsay Tetreault, Brian Kwon, Jefferson R. Wilson

Summary: This study aims to assess current practice patterns in the management of cervical spinal cord injury (SCI) and develop a simplified, practical classification system. The results show that spinal stability, cord compression, and neurological status are the most important factors influencing surgeons' decisions in the surgical management of cervical SCI.

GLOBAL SPINE JOURNAL (2022)

Add to Collection

Article Clinical Neurology

Morphological Changes of Deep Extensor Neck Muscles in Relation to the Maximum Level of Cord Compression and Canal Compromise in Patients With Degenerative Cervical Myelopathy

Neda Naghdi, James M. Elliott, Michael H. Weber, Michael G. Fehlings, Maryse Fortin

Summary: The study found that greater fatty infiltration and asymmetry of the deep cervical muscles in patients with degenerative cervical myelopathy were associated with increased maximum spinal cord compression and canal compromise. Additionally, there was a negative association between muscle asymmetry and Neck Disability Index scores.

GLOBAL SPINE JOURNAL (2022)

Add to Collection

Article Oncology

Outcomes of Surgical Treatment for Extradural Benign Primary Spinal Tumors in Patients Younger than 25 Years: An Ambispective International Multicenter Study

Alexander C. Disch, Stefano Boriani, Aron Lazary, Laurence D. Rhines, Alessandro Luzzati, Ziya L. Gokaslan, Charles G. Fisher, Michael G. Fehlings, Michelle J. Clarke, Dean Chou, Nicole M. Germscheid, Klaus-Dieter Schaser, Jeremy J. Reynolds

Summary: Compared to secondary lesions, primary spinal tumors are rare. The effect of different resection strategies on local recurrence and survival in patients with benign primary spinal tumors under the age of 25 was studied. The results showed no correlation between the grade of aggressiveness in resection and local recurrence rates in this younger patient cohort. The most common tumors in young patients were osteoblastomas, osteoid osteomas, and aneurysmal bone cysts.

CANCERS (2023)

Add to Collection

Article Oncology

Extradural Primary Malignant Spinal Tumors in a Population Younger than 25 Years: An Ambispective International Multicenter Study on Onco-Surgical Outcomes

Alexander C. Disch, Stefano Boriani, Alessandro Luzzati, Laurence D. Rhines, Charles G. Fisher, Aron Lazary, Ziya L. Gokaslan, Dean Chou, Michelle J. Clarke, Michael G. Fehlings, Klaus-Dieter Schaser, Nicole M. Germscheid, Jeremy J. Reynolds

Summary: Extradural primary malignant spinal tumors in young patients are rare. This study reports the clinical outcomes of young patients who underwent surgery for these tumors. The results show that surgery, combined with adjuvant therapy, can achieve better overall survival and low local recurrence rates.

CANCERS (2023)

Add to Collection

Article Clinical Neurology

Clinical trials for neuroregenerative therapies for spinal cord injury: what have we learnt so far?

Raymond Wong, Nader Hejrati, Michael G. G. Fehlings

Summary: This article discusses several key challenges that clinical investigators evaluating novel therapeutic strategies to treat traumatic spinal cord injury (SCI) may face, and proposes potential solutions, including patient recruitment, patient follow-up, heterogeneity of patients, complex pathophysiology of SCI, capturing treatment effects, high costs, implementation of guidelines, demographic shifts, and navigating regulatory bodies.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2023)

Add to Collection

Review Cell & Tissue Engineering

Incorporating Combinatorial Approaches to Encourage Targeted Neural Stem/Progenitor Cell Integration Following Transplantation in Spinal Cord Injury

Katarzyna Pieczonka, Michael G. Fehlings

Summary: Spinal cord injury (SCI) has a significant impact on quality of life and finances. Neural stem/progenitor cell (NSPC) transplantation shows promise for spinal cord regeneration, but the integration of transplanted cells remains a challenge. This review proposes various techniques, including molecular cues and alternative methods, to guide the integration of grafted cells towards specific circuits. Future research in these areas may improve outcomes for SCI patients.

STEM CELLS TRANSLATIONAL MEDICINE (2023)

Add to Collection

Article Cell Biology

Promoting the Differentiation of Neural Progenitor Cells into Oligodendrocytes through the Induction of Olig2 Expression: A Transcriptomic Study Using RNA-seq Analysis

Katarzyna Pieczonka, Mohamad Khazaei, Michael G. G. Fehlings

Summary: In this study, the expression of Olig2 transcription factor was induced in tripotent neural progenitor cells (NPCs), leading to a significantly higher proportion of differentiated oligodendrocytes compared to NPCs. The induction of Olig2 was also associated with the upregulation of genes involved in oligodendrocyte development and function, and the downregulation of genes involved in other cell lineages. GO and GSEA analyses further confirmed the oligodendrocyte specification of the induced NPCs.

CELLS (2023)

Add to Collection

Article Cell & Tissue Engineering

Human Spinal Oligodendrogenic Neural Progenitor Cells Enhance Pathophysiological Outcomes and Functional Recovery in a Clinically Relevant Cervical Spinal Cord Injury Rat Model

Katarzyna Pieczonka, Hiroaki Nakashima, Narihito Nagoshi, Kazuya Yokota, James Hong, Anna Badner, Jonathon C. T. Chio, Shinsuke Shibata, Mohamad Khazaei, Michael G. Fehlings

Summary: Traumatic spinal cord injury (SCI) causes the loss of neurons and glial cells. Current interventions for SCI lack regenerative solutions. Neural stem/progenitor cell (NPC) transplantation is a promising strategy for regeneration but inconsistent differentiation hinders functional recovery. This study generated oligodendrogenically biased NPCs (oNPCs) from human induced pluripotent stem cells (hiPSCs) and demonstrated their effectiveness in a rodent model of cervical SCI, showing enhanced tissue preservation, remyelination, and functional recovery without adverse effects. These findings highlight the therapeutic potential of oNPCs in cervical SCI and call for further investigation to optimize this approach.

STEM CELLS TRANSLATIONAL MEDICINE (2023)

Add to Collection

Article Orthopedics

Current insights into the management of spinal cord injury

Nisaharan Srikandarajah, Mohammed Ali Alvi, Michael G. Fehlings

Summary: Traumatic spinal cord injury (SCI) is a serious disorder that leads to neurological impairment and disability, affecting the quality of life for patients. The pathophysiology involves primary and secondary phases, causing neurological damage. Current clinical management focuses on early decompressive surgery, optimizing arterial pressure, steroid therapy, and rehabilitation. Emerging therapies aim to repair the spinal cord through cell-based, gene, pharmacological, and neuromodulation approaches. Addressing both primary and secondary phases of SCI can enhance outcomes for patients.

JOURNAL OF ORTHOPAEDICS (2023)

Add to Collection

Review Clinical Neurology

Early surgical intervention for acute spinal cord injury: time is spine

Ayesha Quddusi, Karlo M. M. Pedro, Mohammed Ali Alvi, Nader Hejrati, Michael G. G. Fehlings

Summary: Acute traumatic spinal cord injury (tSCI) is a severe event with global impact on morbidity and mortality. Early surgical intervention within 24 hours has been shown to improve prognosis and functional outcomes. This review explores the evidence, nuances, and challenges associated with timing of surgery, as well as the barriers to early surgical care for tSCI.

ACTA NEUROCHIRURGICA (2023)

Add to Collection

Review Clinical Neurology

Degenerative cervical myelopathy: Where have we been? Where are we now? Where are we going?

Nader Hejrati, Karlo Pedro, Mohammed Ali Alvi, Ayesha Quddusi, Michael G. Fehlings

Summary: Degenerative cervical myelopathy (DCM) includes age-related and genetically associated pathologies affecting the cervical spine. The RECODE-DCM consensus group has identified ten priority areas for translational research to improve the management and treatment of DCM. This article summarizes recent advancements in the field, including a refined definition, understanding of pathophysiology, assessment and diagnosis methods, treatment modalities, and genetic research opportunities.

ACTA NEUROCHIRURGICA (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Racial and ethnic disparities in COVID-19 diagnosis and adherence to mitigation behaviours in a national United States older adult sample

Roger Wong, Margaret Anne Lovier

Summary: Older adults and people of colour are more vulnerable to COVID-19, and despite higher adherence to mitigation behaviours, minority older adults still have elevated odds of COVID-19. Research is needed to explore potential mechanisms for this disparity.

EPIDEMIOLOGY AND INFECTION (2023)

Add to Collection

Review Oncology

The biology of ependymomas and emerging novel therapies

Amr H. Saleh, Nardin Samuel, Kyle Juraschka, Mohammad H. Saleh, Michael D. Taylor, Michael G. Fehlings

Summary: This review discusses important biological features of ependymomas, including subgroup categorization and clinical implications, oncogenic and tumor suppressor signaling pathways, epigenetic dysregulation, as well as the limitations of current therapies and potential next-generation treatments.

NATURE REVIEWS CANCER (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.