Article
Cell Biology
Jie Ren, Yu Sang, Alejandro Aballay
Summary: This study reveals the important role of the gut-brain-microbial axis in controlling immune activation caused by alterations in intestinal homeostasis, through neural cholinergic signaling and the Wnt pathway.
Article
Multidisciplinary Sciences
Sanaya N. Shroff, Eric Lowet, Sudiksha Sridhar, Howard J. Gritton, Mohammed Abumuaileq, Hua-An Tseng, Cyrus Cheung, Samuel L. Zhou, Krishnakanth Kondabolu, Xue Han
Summary: This study demonstrates that the membrane potentials of striatal cholinergic neurons exhibit sustained delta-frequency oscillations, which are coupled to animals' stepping cycles and regulate network rhythmicity and movement patterning.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Manuela Sauter, Reinhard J. Sauter, Marcus Olbrich, Martin Thunemann, Susanne Feil, Robert Feil, Harald F. Langer
Summary: In this article, an in vivo approach to visualize CD11c+ cells in atherosclerosis is described. The authors use X-Gal staining to analyze plaque composition and cell-specific molecules as an alternative method. By breeding mice with LacZ knockin and CD11ccre recombinase onto an ApoE-/- background, the interested cell type in the plaques can be visualized by X-Gal staining. This approach allows for the examination of various immune cells in atherogenesis.
Article
Multidisciplinary Sciences
Li Cheng, Cenglin Xu, Lu Wang, Dadao An, Lei Jiang, Yanrong Zheng, Yixin Xu, Yi Wang, Yujing Wang, Kuo Zhang, Xiaodong Wang, Xiangnan Zhang, Aimin Bao, Yudong Zhou, Jingyu Yang, Shumin Duan, Dick F. Swaab, Weiwei Hu, Zhong Chen
Summary: This study indicates that the deficiency of histamine H-1 receptor in cholinergic neurons in the basal forebrain is critical for sensorimotor gating deficit, social impairments, and anhedonia-like behavior in patients with schizophrenia. Deletion of the H1R gene in cholinergic neurons in mice resulted in functional deficiency of cholinergic projections and led to behavioral deficits, which could be rescued by re-expressing H1R or by chemogenetic activation of cholinergic neurons in the BF.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukawa
Summary: Cholinergic activation and glutamatergic dysfunction in the hippocampus are closely related. The study shows the importance of hippocampal cholinergic neurostimulating peptide (HCNP) in acetylcholine synthesis and suggests that HCNP-pp KO mice can serve as genetic models for cholinergic functional impairment. The findings support the cholinergic hypothesis and suggest that the model mice may be potential partial pathological animal models for Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Ye Liu, Fang-Fang Zhang, Ying Song, Ran Wang, Qi Zhang, Zhong-Shan Shen, Fei-Fei Zhang, Dan-Ya Zhong, Xiao-Hui Wang, Qing Guo, Qiong-Yao Tang, Zhe Zhang
Summary: The Slack channel plays an important role in regulating mechanical pain-sensing, with high expression in specific neurons in the dorsal root ganglion and spinal cord.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. L. Wokosin, Patricia Gonzalez-Rodriguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier
Summary: Using a mouse model of Huntington's disease, the authors found increased connectivity in the corticostriatal pathway due to deficient cholinergic transmission. Lowering mutant huntingtin specifically in striatal cholinergic interneurons normalized the connectivity, providing evidence for a key node in the network underlying corticostriatal pathophysiology in Huntington's disease.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Felicia Reed, Alex Reichenbach, Harry Dempsey, Rachel E. Clarke, Mathieu Mequinion, Romana Stark, Sasha Rawlinson, Claire J. Foldi, Sarah H. Lockie, Zane B. Andrews
Summary: This study reveals that hunger and the environmental context can increase food-seeking behavior, and the activity of AgRP neurons plays a crucial role in this process. Precise temporal control of AgRP neuron activity is necessary for the development of the context-induced feeding response.
MOLECULAR METABOLISM
(2023)
Article
Cell Biology
Weston Fleming, Junuk Lee, Brandy A. Briones, Scott S. Bolkan, Ilana B. Witten
Summary: The study revealed that high endogenous acetylcholine event frequency is correlated with greater extinction of cocaine-context associations in male mice, and extinction is related to a weakening of glutamatergic synapses across different MSN subtypes. Manipulating ChIN activity bidirectionally influences the rate of extinction and associated plasticity at MSNs.
Article
Multidisciplinary Sciences
Rose Z. Hill, Meaghan C. Loud, Adrienne E. Dubin, Brooke Peet, Ardem Patapoutian
Summary: This study reveals that the transduction of mechanical itch is mainly mediated by the ion channel PIEZO1. Loss of PIEZO1 function greatly reduces mechanically evoked scratching behaviors and acute/chronic itch sensitization. In addition, mice expressing a gain-of-function Piezo1 allele exhibit enhanced mechanical itch behaviors.
Article
Biochemical Research Methods
Jocelyn Y. Kishi, Ninning Liu, Emma R. West, Kuanwei Sheng, Jack J. Jordanides, Matthew Serrata, Constance L. Cepko, Sinem K. Saka, Peng Yin
Summary: Light-Seq is an approach that utilizes light-directed DNA barcoding for multiplexed spatial indexing in fixed cells and tissues. It enables in situ selection of multiple cell populations for sequencing, allowing analysis of rare cell types without dissociation. This method combines spatial and omics information, providing a workflow for in situ imaging, protein staining, and next generation sequencing of the same cells.
Article
Neurosciences
Pankaj Patyal, Daniel Fil, Hamdan Hamdan, Patricia A. Wight
Summary: By using transgenic animal models, researchers have gained insights into the mechanisms that control the developmental expression of the PLP1 gene. They analyzed the expression of transgenes containing PLP1 genomic DNA from humans or mice, and observed differences in their expression patterns. The findings suggest that the differences between human and mouse PLP1 sequences play a critical role in gene expression.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Ines Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen
Summary: Coupling the release of pituitary hormones to the developmental stage of the oocyte is crucial for female fertility. In this study, the researchers found that estrogen plays a role in restraining and activating different regions of the hypothalamus to control the activity of KISS1-neuron and the expression of Kiss1 gene. These findings provide mechanistic insights into how estrogen regulates fertility in females.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jonathan Madar, Namrata Tiwari, Cristina Smith, Divya Sharma, Shanwei Shen, Alsiddig Elmahdi, Liya Y. Qiao
Summary: Piezo2 in mucosa and primary afferents mediates colonic mechanical sensation. Activation of Piezo2 regulates colonic mechanical sensitivity in a sex-dependent manner. Clozapine N-oxide induced activation of Piezo2 causes colonic hypersensitivity in male mice and dyspnea in female mice.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Wenlong Zou, Yankun Peng, Deyong Yang, Jiewen Zuo, Yang Li, Qinghui Guo
Summary: A miniaturized detector was developed for rapid and cost-effective testing of fresh pork freshness, utilizing a multi-channel spectral sensor and partial least squares discriminant analysis (PLS-DA) model to distinguish between fresh and deteriorated meat.
Article
Cardiac & Cardiovascular Systems
Atsuko Kato, Mauro Lo Rito, Kyong-Jin Lee, Christoph Haller, Anne Marie Guerguerian, Venkatesan Ben Sivarajan, Osami Honjo
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2017)
Article
Cardiac & Cardiovascular Systems
Jiaquan Zhu, James Meza, Atsuko Kato, Arezou Saedi, Devin Chetan, Rachel Parker, Christopher A. Caldarone, Brian W. McCrindle, Glen S. Van Arsdell, Osami Honjo
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2016)
Article
Cardiac & Cardiovascular Systems
Atsuko Kato, Eugenie Riesenkampff, Deane Yim, Shi-Joon Yoo, Mike Seed, Lars Grosse-Wortmann
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Atsuko Kato, Juan Pablo Sandoval, Dariusz Mroczek, Rajiv Chaturvedi, Helene Houle, Bogdan Georgescu, Shi-Joon Yoo, Lee N. Benson, Kyong-Jin Lee
CANADIAN JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Jun Sato, Atsuko Kato, Sho Takeda, Hiroshi Nishikawa
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2019)
Article
Cardiac & Cardiovascular Systems
Jun Sato, Atsuko Kato, Naoki Ohashi
CARDIOLOGY IN THE YOUNG
(2019)
Article
Cardiac & Cardiovascular Systems
Atsuko Kato, Naoki Ohashi, Hiroshi Nishikawa
EUROPEAN HEART JOURNAL-CASE REPORTS
(2019)
Article
Cardiac & Cardiovascular Systems
Atsuko Kato, Christian Drolet, Shi-Joon Yoo, Andrew N. Redington, Lars Grosse-Wortmann
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2016)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)