Article
Psychiatry
Tong Yue, Jia Zhao, Anguo Fu
Summary: Positive empathy is associated with specific brain regions' activity and functional connectivity, including the right insula, right subgenual cingulate, and right dorsomedial prefrontal cortex. The activity and connections in these regions are related to positive empathy, emotional experience, and self-referential processing.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Siyu Liu, Cun Zhang, Chun Meng, Rui Wang, Ping Jiang, Huanhuan Cai, Wenming Zhao, Yongqiang Yu, Jiajia Zhu
Summary: The expression of specific genes is correlated with the fractional amplitude of low-frequency fluctuations in certain frequency bands, and these genes are associated with ion channels, synaptic function, neuronal system, and various neuropsychiatric disorders. These genes are specifically expressed in brain tissue and neurons, and are linked to behavioral domains such as dementia, attention, and emotion.
Article
Clinical Neurology
Yun Chen, Xinbo Xing, Wei Dai, Lixia Tian, Zhao Dong, Shengyuan Yu
Summary: In cluster headache patients, abnormal brain activity in the non-painful state is observed, with some correlation to clinical characteristics. Decreased fALFF values were found in specific brain regions in both left and right CH groups, while no patients showed increased fALFF values.
Article
Clinical Neurology
Hongzhuo Wang, Yunxuan Huang, Mingrui Li, Han Yang, Jie An, Xi Leng, Danghan Xu, Shijun Qiu
Summary: This study aimed to explore the abnormal local brain function in patients with post-stroke insomnia using fMRI and investigate the possible neuropathological mechanisms of insomnia. The findings suggest that patients with post-stroke insomnia exhibit abnormal activities in multiple brain regions, including the visual processing-related cortex, sensorimotor cortex, and some default-mode network (DMN) regions. Over-arousal of the DMN and over-sensitivity to audiovisual stimuli may be the main mechanisms of insomnia in these patients, leading to cognitive decline and abnormalities in emotion regulation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Ya Wen, Xiao-Min Chen, Xin Jin, Dong-Ya Ling, Shao Chen, Qin Huang, Ning Kong, Jin-Er Chai, Qing Wang, Mao-Sheng Xu, Hong-Gen Du
Summary: This study investigated the brain alterations of lumbar disc herniation (LDH) patients with spinal manipulative therapy (SMT) and found that SMT may relieve pain by modulating dysfunctional brain regions involved in pain processing.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neuroimaging
Dongqiong Fan, Tao Liu, Jiyang Jiang, Nicole A. Kochan, Yilong Wang, Henry Brodaty, Perminder S. Sachdev, Wei Wen
Summary: Research shows that examining low-frequency oscillations in different frequency bands can help us better understand cognitive aging. The study found significant reductions and increases in low-frequency oscillations in specific brain regions of cognitively normal older adults, and these changes were correlated with changes in cognitive function.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Qing Zhang, Meng-Ying Peng, Shi-Nan Wu, Chen-Yu Yu, Si-Yi Chen, Si-Wen Tan, Yi Shao, Qiong Zhou
Summary: The study revealed dysfunction in several brain regions of NVG patients, aiding in uncovering the underlying neural mechanism associated with NVG.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Clinical Neurology
Yu Wang, Yi Lu, Meimei Du, Nimo Mohamed Hussein, Lan Li, Yu Wang, Chuanwan Mao, Tao Chen, Fangfang Chen, Xiaozheng Liu, Zhihan Yan, Yuchuan Fu
Summary: This study found that the lack of direct parental care during early childhood could affect brain function development involving cognition, behavior, and emotion in left-behind children. The findings emphasize the importance of intellectual and emotional care for left-behind children.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Qiaowen Tan, Shaoke Li, Juan Niu, Shien Liu, Yaling Li, Yujie Lu, Zhihong Wang, Wanqun Xu, Yalin Wei, Zongjun Guo
Summary: The study found that habitual brain network activity is significantly enhanced in tobacco-dependent participants in the resting state, and is associated with tobacco selection preference behavior. This suggests that increased activity of the habitual brain network may be essential in the development of tobacco-dependent behavior.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Neurosciences
Meng-Yan Hu, Yi-Cong Pan, Li-Juan Zhang, Rong-Bin Liang, Qian-Min Ge, Hui-Ye Shu, Qiu-Yu Li, Chong-Gang Pei, Yi Shao
Summary: More and more studies have shown that strabismus is not only an ocular disease but also a neuro-ophthalmology disease. This study compared the spontaneous brain activity between patients with comitant strabismus and healthy controls using resting-state functional magnetic resonance imaging. The results revealed abnormal activity in two brain regions of strabismus patients, which may indicate underlying pathologic mechanisms and have implications for diagnosis and clinical treatment.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Geriatrics & Gerontology
Xulian Zhang, Chen Xue, Xuan Cao, Qianqian Yuan, Wenzhang Qi, Wenwen Xu, Shaojun Zhang, Qingling Huang
Summary: The study found remarkable differences in the patterns of ALFF and fALFF between aMCI and vMCI patients compared to healthy controls, which may serve as a reliable tool for distinguishing between these cognitive impairments. These findings could contribute to a better understanding of the pathophysiological mechanisms underlying these diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Ying Liang, Yi-Cong Pan, Hui-Ye Shu, Xue-Mei Chou, Qian-Min Ge, Li-Juan Zhang, Qiu-Yu Li, Rong-Bing Liang, Han-Lin Li, Yi Shao
Summary: This study investigated the nature of spontaneous brain activity in ocular hypertension (OH) patients and its relationship with clinical features using rs-fMRI and fALFF method. The results revealed that the fALFF values in two specific brain areas were associated with visual impairment in OH patients.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Siwen Liu, Yesong Guo, Jie Ni, Na Yin, Chenchen Li, Xuan Pan, Rong Ma, Jianzhong Wu, Shengwei Li, Xiaoyou Li
Summary: The study found that CRC patients after chemotherapy had decreased intrinsic brain activity in the left anterior cingulate gyrus, which might be vulnerable to the neurotoxic side-effect of chemotherapeutic drugs and related to chemotherapy-induced cognitive impairment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Changqiang Feng, Wenyan Jiang, Yousheng Xiao, Yang Liu, Lulu Pang, Meilan Liang, Jingqun Tang, Yulin Lu, Jing Wei, Wenmei Li, Yiwu Lei, Wenbin Guo, Shuguang Luo
Summary: This study found widespread differences in brain function between patients with blepharospasm (BSP) and dry eye disease (DED) when compared with healthy controls. Patients with BSP exhibited abnormal low-frequency fluctuations in sensorimotor integration related-brain regions, emphasizing the primary role of sensorimotor integration in the pathophysiology of BSP. The results suggest distinctive changes in brain function in patients with BSP compared to patients with DED and healthy controls.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychiatry
Jun Zhou, Xiaoqian Ma, Chunwang Li, Aijun Liao, Zihao Yang, Honghong Ren, Jinsong Tang, Jinguang Li, Zongchang Li, Ying He, Xiaogang Chen
Summary: This study investigated the changes in fALFF in the DMN of medication-free patients with bipolar II depression after a 16-week treatment of escitalopram and lithium. Results showed increased slow 5 fALFF values in various brain regions after treatment compared to baseline, indicating a positive association between fALFF increases and decreases in depressive symptoms. This suggests that slow 5 fALFF of the DMN plays a significant role in bipolar depression and can be modified by medication.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)