Article
Ophthalmology
Yifang Yang, Junshu Wu, Defu Wu, Qi Wei, Tan Zhong, Jun Yang, Xiaowei Yang, Meizhen Zeng, Xingwu Zhong
Summary: Among the 3 different administration methods, intravitreal injection of brimonidine was the most effective in slowing myopia progression in the FD guinea pig model. Intravitreal brimonidine at 4 mu g/mu L significantly reduced the development of FD myopia in guinea pigs. Expression levels of the Col1a1 and Mmp2 genes were significantly increased in the retinal tissues of the FD-Inj-Br group.
Article
Cell Biology
Yajun Wu, Yuliang Feng, Jiasong Yang, Hua Fan, Zitong Yu, Xiaolin Xie, Yumeng Dai, Xin Huang, Wensheng Li
Summary: The aim of this study was to investigate the effects of exogenous retinoic acid (RA) on intraocular parameters, especially choroidal thickness (CT) and retinal thickness (RT), in guinea pigs with form deprivation myopia (FDM). After 4 weeks, it was found that RA can increase the refractive error, axial length, and intraocular pressure of FDM guinea pigs, and might aggravate the retinal thinning. Citral, on the other hand, can inhibit these changes, but may not affect the thickness of the choroid.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Kang-Wei Qian, Yun-Yun Li, Xiao-Hua Wu, Xue Gong, Ai-Lin Liu, Wen-Hao Chen, Zhe Yang, Ling-Jie Cui, Yun-Feng Liu, Yuan-Yuan Ma, Chen-Xi Yu, Furong Huang, Qiongsi Wang, Xiangtian Zhou, Jia Qu, Yong-Mei Zhong, Xiong-Li Yang, Shi-Jun Weng
Summary: This study found that form-deprivation myopia in CBA/CaJ mice is related to changes in retinal dopamine levels. Blocking melatonin receptors reduced the magnitude of form-deprivation myopia and prevented alterations in retinal dopamine levels, suggesting that melatonin-related changes in retinal dopamine contribute to the development of myopia.
NEUROSCIENCE BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Zedu Cui, Yuke Huang, Xi Chen, Taiwei Chen, Xiangtao Hou, Na Yu, Yan Li, Jin Qiu, Pei Chen, Keming Yu, Jing Zhuang
Summary: By comparing two miRNA datasets, miR-671-5p was identified as a commonly downregulated miRNA in the retina. It is highly conserved and related to 40.78% of all downregulated miRNAs' target genes. Furthermore, 584 target genes of miR-671-5p were found to be associated with myopia, and 8 hub genes were identified. The study also revealed the important role of miR-671-5p in myopia development and identified Tead1 as a possible upstream regulator of miR-671-5p.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemical Research Methods
Pinghui Wei, Guoge Han, Yan Wang
Summary: In this study, the changes in metabolism of the retinal pigment epithelial/choroid complex were investigated, and it was found that dopamine D2 receptor antagonists can modulate eye development and are associated with the dopamine D2 receptor signaling pathway. These findings are important for understanding the pathogenesis of myopia and developing potential therapeutic approaches.
Article
Ophthalmology
Lei Guo, Rui Hua, Xinxin Zhang, Ting Yu Yan, Yang Tong, Xin Zhao, Shi Chao Chen, Moying Wang, Neil M. Bressler, Jun Kong
Summary: The study finds that scleral cross-linking may cause glaucomatous changes in guinea pig eyes and raises safety concerns for controlling myopia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Oncology
Lu Tian, Ya-Tu Guo, Ming Ying, Yang-Chen Liu, Xuan Li, Yan Wang
Summary: In this study, it was found that long periods of monocular form deprivation in guinea pigs resulted in significant refractive errors and increased axial lengths in the deprived eyes. Myopia was established at 4 weeks, while amblyopia may have occurred as early as 1 week of deprivation. This suggests that amblyopia likely precedes myopia and both conditions coexist after prolonged form deprivation in guinea pigs.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Ophthalmology
Hong Liu, Donglong Chen, Zhikuan Yang, Xiaoning Li
Summary: The study aimed to investigate the morphological and functional changes caused by atropine during myopia inhibition. It was found that there were significant differences between the atropine group and the saline group in terms of refraction error, axial length, and retinal and choroidal thickness. Atropine may mainly affect the outer retina in guinea pigs during the process of inhibiting form-deprived myopia.
CURRENT EYE RESEARCH
(2022)
Article
Ophthalmology
Man She, Bing Li, Tao Li, Xiaodong Zhou
Summary: The expression levels of AREG in the sclera of guinea pigs increased during the development of FDM and downregulated after recovery of FDM. Therefore, AREG may play a role in regulating scleral remodeling in myopia.
CURRENT EYE RESEARCH
(2022)
Article
Neurosciences
Ming-Ming Duan, Hui Liu, Yu-Lin Zhong
Summary: The purpose of this study was to investigate changes in retina thickness in myopic mice using optical coherence tomography (OCT). The results showed that the refractive power of the right eye in the form-deprivation myopia (FDM) group was significantly higher than that of the left eye after 4 weeks of form deprivation. The retina, nerve fiber layer (NFL), inner nuclear layer (INL), and outer nuclear layer (ONL) in the right eye of the FDM group were significantly thinner.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Xueqing Ding, Jinzhen Tan, Jing Meng, Yilei Shao, Meixiao Shen, Cuixia Dai
Summary: This study analyzed the biological structure parameters and optical performance of mice eyes to investigate the development and treatment of myopia. The results showed a close correlation between the eye's biological structure parameters and myopia development, as well as the significant impact of peripheral retinal defocus on inducing myopia.
Article
Multidisciplinary Sciences
Ai-Lin Liu, Yun-Feng Liu, Ge Wang, Yu-Qi Shao, Chen-Xi Yu, Zhe Yang, Zi-Rui Zhou, Xu Han, Xue Gong, Kang-Wei Qian, Li-Qin Wang, Yuan-Yuan Ma, Yong-Mei Zhong, Shi-Jun Weng, Xiong-Li Yang
Summary: Recent research has found that selectively ablating and activating intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice can induce myopic and hyperopic refractive shifts by modulating the corneal radius of curvature and axial length. The melanopsin and rod/cone-driven signals in these cells influence the axial length and corneal radius of curvature, respectively. Ablating ipRGCs or deficient melanopsin results in reduced form-deprivation myopia and enhanced melanopsin expression/photoresponses in form-deprived eyes.
Article
Ophthalmology
Furong Huang, Ziheng Shu, Qin Huang, Kaijie Chen, Wenjun Yan, Wenjing Wu, Jinglei Yang, Qiongsi Wang, Fengjiao Wang, Chunlan Zhang, Jia Qu, Xiangtian Zhou
Summary: This study investigates the locations of dopamine D2 receptors (D2Rs) that regulate form-deprivation myopia (FDM) using different transgenic mouse models. The findings suggest that D2Rs located in the retina play a role in the dopaminergic regulation of FDM in mice.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Kate Thomson, Tamsin Kelly, Cindy Karouta, Ian Morgan, Regan Ashby
Summary: In chicks, cholinergic agonists inhibit form-deprivation myopia development but have no effect on normal eye growth; atropine only affects dopamine and DOPAC levels at its highest dose; dopamine antagonists do not alter the antimyopia effects of atropine.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhengyu Chen, Kang Xiao, Qin Long
Summary: Myopia, one of the most prevalent ocular diseases worldwide, is primarily caused by elongation of the eyeball. The inflammatory mediator NLRP3 plays a critical role in regulating collagen remodeling in the sclera, and the NLRP3 inhibitor MCC950 can inhibit the progression of myopia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)