Article
Pharmacology & Pharmacy
Tabea Klasfauseweh, Mathilde R. Israel, Lotten Ragnarsson, James J. Cox, Thomas Durek, David A. Carter, Andreas Leffler, Irina Vetter, Jennifer R. Deuis
Summary: QX-314, a quaternary permanently charged lidocaine derivative, inhibits voltage-gated sodium channels (Na-V). Research showed that externally applied high concentrations of QX-314 can inhibit Na(V)1.7 current and modulate voltage dependence in a different manner compared to lidocaine. Additionally, QX-314 may have an externally accessible site of action other than the local anesthetic binding site.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Aerziguli Aierken, Ya-Kai Xie, Wenqi Dong, Abuliken Apaer, Jia-Jia Lin, Zihan Zhao, Shilong Yang, Zhen-Zhong Xu, Fan Yang
Summary: DeC-1.2, a novel cyclic peptide designed with a hot-spot centric approach, selectively inhibits the ligand activation of TRPM8 channels, effectively abolishing cold allodynia in oxaliplatin treated mice without altering body temperature. This indicates its potential as a novel analgesic against oxaliplatin-induced neuropathic pain.
Article
Biochemistry & Molecular Biology
Mariana A. Freitas, Amanda Vasconcelos, Elaine C. D. Goncalves, Eduarda G. Ferrarini, Gabriela B. Vieira, Donatella Cicia, Maira Cola, Raffaele Capasso, Rafael C. Dutra
Summary: Spirulina platensis is a super-food with anti-inflammatory, antioxidant, and analgesic properties, showing significant analgesic effects in rodent models of inflammatory pain by potentially modulating TRMP8 and TRPA1.
Editorial Material
Cell Biology
Brie Trusiano, Juselyn D. Tupik, Irving C. Allen
Summary: Understanding the role of membrane bound transient receptor potential (TRP) ion channels, specifically TRPM8, is crucial for the management and treatment of hyperinflammatory conditions, including inflammatory bowel disease. TRPM8 plays a significant role in prostate cancer and cold sensing neurons, as well as the release of calcitonin gene-related peptide (CGRP) by sensory neurons.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Genetics & Heredity
Roberta Gualdani, Jun-Hui Yuan, Philip R. Effraim, Giulia Di Stefano, Andrea Truini, Giorgio Cruccu, Sulayman D. Dib-Hajj, Philippe Gailly, Stephen G. Waxman
Summary: The TRPM8 mutation enhances channel activation, increases basal current amplitude and intracellular [Ca2+] in cells carrying the mutant channel, and enhances the response to menthol, suggesting gain-of-function attributes on TRPM8 contribute to trigeminal neuralgia pathogenesis in patients carrying this mutation.
NEUROLOGY-GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Vittoria Rimola, Tabea Osthues, Vanessa Koenigs, Gerd Geisslinger, Marco Sisignano
Summary: Oxaliplatin treatment leads to transient changes in TRPM8 channel activity, causing acute peripheral pain and neuropathic pain, which may be associated with activation of the PLC pathway and depletion of PIP2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xiancui Lu, Zhihao Yao, Yunfei Wang, Chuanlin Yin, Jiameng Li, Longhui Chai, Wenqi Dong, Licheng Yuan, Ren Lai, Shilong Yang
Summary: Molecular thermosensors in animals, specifically the TRPM8 gene, play a critical role in accurately sensing and responding to ambient temperature fluctuations. Through the process of evolution, the TRPM8 gene has evolved to form and regulate different domains, allowing for distinct cold-sensitive properties among vertebrate TRPM8 orthologs. The acquisition of cold sensitivity in TRPM8 facilitated terrestrial adaptation during the water-to-land transition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Cheng Zhao, Yuan Xie, Lizhen Xu, Fan Ye, Ximing Xu, Wei Yang, Fan Yang, Jiangtao Guo
Summary: The TRPM8 channel acts as the primary cold sensor in humans and can be activated by ligands such as menthol, icilin, and PIP2. This study determined the structures of mouse TRPM8 in different states, revealing its overall architecture and the basis for ligand recognition.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
David Alarcon-Alarcon, David Cabanero, Jorge De Andres-Lopez, Magdalena Nikolaeva-Koleva, Simona Giorgi, Gregorio Fernandez-Ballester, Asia Fernandez-Carvajal, Antonio Ferrer-Montiel
Summary: TRPA1 and TRPM8 are channels expressed in trigeminal neurons that play important roles in migraine models. A mouse model of chronic migraine was used in this study and showed a sexually dimorphic phenotype, with female mice displaying mechanical hypersensitivity persisting until day 20, while male mice recovered by day 18. TRPA1 was found to be necessary for the development of hypersensitivity in both males and females, while TRPM8 contributed to faster recovery in males. The antinociceptive effects mediated by TRPM8 required the presence of endogenous testosterone in males. Administration of exogenous testosterone led to recovery from hypersensitivity in females and orchidectomized males. Calcium imaging and electrophysiological recordings confirmed testosterone's activity on murine and human TRPM8, independent of androgen receptor expression. These findings suggest a protective role of TRPM8 in shortening the duration of hypersensitivity in a mouse model of migraine.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Chenyu Yang, Shanni Yamaki, Tyler Jung, Brian Kim, Ryan Huyhn, David D. McKemy
Summary: The detection of environmental temperatures is crucial for survival and inappropriate responses to thermal stimuli can negatively affect overall health. The physiological effect of cold is distinct and can be soothing and analgesic, but also agonizing in the context of tissue damage. Inflammatory mediators induce neurogenic inflammation that alters cold sensitivity through the activation of TRPV1 and TRPA1 ion channels.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Moe Soeda, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Tatsuya Ichinohe, Ken-ichi Fukuda, Kazutaka Ikeda
Summary: The study identified associations between genetic polymorphisms of PAR2 and TRPM8 genes and cold pain sensitivity, with carriers of specific alleles showing decreased sensitivity in cold-induced pain test. This suggests that genetic factors play a role in individual differences in cold pain sensitivity.
Article
Biology
Dibesh Thapa, Joao de Sousa Valente, Brentton Barrett, Matthew John Smith, Fulye Argunhan, Sheng Y. Lee, Sofya Nikitochkina, Xenia Kodji, Susan D. Brain
Summary: Ageing is associated with increased vulnerability to environmental cold exposure, leading to impaired behavioural and vascular responses to skin local environmental cooling in aged mice. The decline in TRPM8 gene/protein expression in ageing mice suggests a reliance on remaining TRP receptor activity for cold-induced vascular response. Sympathetic-induced vasoconstriction is also reduced with aging, indicating a decline in the cold-induced vascular response necessary for maintaining body heat and health.
Article
Neurosciences
Somayeh Ezzatpanah, Mina Baarnes Eriksen, Anne-Mari Gjestvang Moe, Fred Haugen
Summary: Chronic exposure to cold temperatures can alter thermosensory behaviors in mice, making them appear less sensitive to cold, potentially involving the TRPM8 molecular cold sensor in the process.
Article
Multidisciplinary Sciences
Ying Yin, Feng Zhang, Shasha Feng, Kevin John Butay, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee
Summary: This study reveals the structural basis of TRPM8 activation dependent on ligand and PIP2, shedding light on the chemically induced cool sensation in mammals.
Review
Biochemistry & Molecular Biology
Carolina Izquierdo, Mercedes Martin-Martinez, Isabel Gomez-Monterrey, Rosario Gonzalez-Muniz
Summary: TRPM8 is a cold sensor in humans, playing a role in cold thermal transduction, pain detection, and various diseases. Research on TRPM8 channel structure and modulators provides potential directions for future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)