Article
Neurosciences
Gloria Brunori, Oliver B. Pelletier, Anna M. Stauffer, Janet D. Robishaw
Summary: The study reveals the importance of Gaolfb2c7/cAMP signaling in specific populations of MSNs in regulating motor behaviors, acting through D1R and A2AR to coordinate behavior. Additionally, the loss of Gaolfb2c7 in A2AR/D2R-MSNs leads to a hyperlocomotor phenotype and enhanced locomotor response to amphetamine.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maximiliano Elgueta-Reyes, Victoria B. Velasquez, Pedro Espinosa, Raul Riquelme, Tatiana Dib, Nicole K. Sanguinetti, Angelica P. Escobar, Jonathan Martinez-Pinto, Georgina M. Renard, Ramon Sotomayor-Zarate
Summary: Early life exposure to sex hormones has long-lasting effects on brain areas involved in regulating locomotor and motivation behaviors. This study demonstrates that neonatal exposure to sex hormones alters the brain dopamine system and affects behavioral and neurochemical responses to amphetamine and methylphenidate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aske L. Ejdrup, Joel Wellbourne-Wood, Jakob K. Dreyer, Nina Guldhammer, Matthew D. Lycas, Ulrik Gether, Benjamin J. Hall, Gunnar Sorensen
Summary: A fundamental concept in neuroscience is the transmission of information between neurons via neurotransmitters, modulators, and peptides. The gold standard for measuring neurochemicals in awake animals has been microdialysis (MD), but genetically encoded fluorescence-based biosensors and in vivo optical techniques have introduced technologically distinct means of measuring neurotransmission. Comparing MD and fiber photometry (FP), the study found that although there were temporal differences, the readouts of extracellular dopamine (DA) correlated well within mice. Down-sampling of FP data showed temporal correlation to MD, with less variance observed using FP. The study also discovered periodic low levels of DA fluctuations and rapid predrug DA dynamics measured with FP that correlated to the subsequent pharmacodynamics of amphetamine as measured with MD and FP.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Klara Danielsson, Oona Lagstrom, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: The study suggests that repeated amphetamine exposure leads to selective effects on dopamine signaling in striatal subregions, explaining why tolerance develops towards the drug's rewarding effects but not its psychosis inducing properties.
Article
Neurosciences
Angelica P. Escobar, Jonathan Martinez-Pinto, Francisco Silva-Olivares, Ramon Sotomayor-Zarate, Pablo R. Moya
Summary: EAAT3 overexpression impacts dopamine transmission, making dopamine neurons more sensitive to the effects of amphetamine and leading to an imbalance between the direct and indirect striatal pathways that favors the performance of repetitive behaviors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ornela Kljakic, Helena Janickova, Miguel Skirzewski, Amy Reichelt, Sara Memar, Salah El Mestikawy, Yulong Li, Lisa M. Saksida, Timothy J. Bussey, Vania F. Prado, Marco A. M. Prado
Summary: In the striatum, cholinergic interneurons can release both acetylcholine and glutamate, and their individual and combined contributions to behavior regulation were assessed in mice using reward-based touchscreen tests. Changes in VAChT and VGLUT3 levels have different effects on reward responses, and the simultaneous loss of both vesicular transporters affects dopamine signaling and behavior in a more severe way than the loss of VAChT alone. This shows that the ability of CINs to secrete two different neurotransmitters allows for complex modulation of various behaviors.
Review
Chemistry, Medicinal
Kazumoto Shibuya, Ryo Otani, Yo-ichi Suzuki, Satoshi Kuwabara, Matthew C. Kiernan
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating disease involving degeneration of upper and lower motor neurons. Riluzole and edaravone have been shown to slow disease progression in ALS by inhibiting glutamate and eliminating free radicals, respectively. Excessive activation of glutamate receptors generates free radicals, leading to excitotoxicity and neurodegeneration, which are key mechanisms in ALS.
Article
Biology
Ali Mohebi, Val L. Collins, Joshua D. Berke
Summary: This study investigates the role of cholinergic interneurons (CINs) in the regulation of dopamine (DA) release and its impact on motivated behavior. The findings highlight the crucial influence of CINs on DA dynamics and provide insights into the underlying mechanisms of motivation.
Article
Clinical Neurology
Fernando Caravaggio, Alexander J. Barnett, Shinichiro Nakajima, Yusuke Iwata, Julia Kim, Carol Borlido, Wanna Mar, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrero
Summary: This study investigated the effects of AMPT-induced dopamine depletion on resting-state functional connectivity of the basal ganglia and canonical resting-state networks in healthy individuals. The results showed reduced connectivity between the caudate and the medial prefrontal cortex, as well as decreased connectivity between several brain regions and the occipital cortex, while increased connectivity was observed between the dorsal caudate and the sensorimotor network. AMPT also significantly decreased self-reported motivation and increased fatigue. Moreover, greater fatigue was associated with reduced connectivity between the substantia nigra and the medial prefrontal cortex, and decreased motivation was correlated with decreased connectivity between the ventral tegmental area and the left sensorimotor cortex.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Jie Jiang, Yuchen Cao, Jilin Liu, Hong Zhang, Guangfeng Kan, Kai Yu
Summary: The newly developed EC-NR-MS technique successfully allowed for online investigation of the electrooxidation process of dopamine, confirming the formation of various reaction products and demonstrating their presence in the mass spectrum.
ANALYTICA CHIMICA ACTA
(2022)
Article
Multidisciplinary Sciences
Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R. Gainetdinov, Stefano Espinoza
Summary: Trace amine-associated receptor 5 (TAAR5) modulates cognitive processes, potentially affecting the number of errors and the rate of task improvement.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jerome, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis
Summary: Food odour coding is crucial for food intake, and dopamine plays a regulatory role in food odour information processing in the ventral striatum.
Article
Pharmacology & Pharmacy
Jose A. Pino, Gabriel Nunez-Vivanco, Gabriela Hidalgo, Miguel Reyes Parada, Habibeh Khoshbouei, Gonzalo E. Torres
Summary: This study reveals that G protein beta gamma subunits can bind to the dopamine transporter (DAT) and activate DAT-mediated dopamine efflux, similar to the mechanism of action of psychostimulants like amphetamine (AMPH). Through a combination of computational biology, mutagenesis, biochemical, and functional assays, the amino acid residues within the 582-596 sequence of the DAT carboxy terminus involved in the DAT-G beta gamma interaction and G beta gamma-induced dopamine efflux were identified. Residues like R588 and F587 within the carboxy terminus of DAT play critical roles in the physical interaction between DAT and G beta gamma, influencing dopamine efflux.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Jiantao Chen, Xiaoli Liu, Michelle M. T. Jansman, Peter W. Thulstrup, Leticia Hosta-Rigau
Summary: The timely administration of donor red blood cells (RBCs) is crucial, but there are limitations such as limited availability and specific storage requirements. A promising strategy to overcome these limitations is the engineering of hemoglobin nanoparticles (Hb-NPs) as RBC substitutes. However, challenges remain in creating Hb-NPs with high Hb content and preventing autoxidation. In this study, small, solid Hb-NPs with an antioxidant coating were fabricated, which showed excellent antioxidant properties and biocompatibility.
CHEMISTRY OF MATERIALS
(2022)
Article
Endocrinology & Metabolism
Jarkko Johansson, Madelene Ericsson, Jan Axelsson, Sara af Bjerken, Ana Virel, Nina Karalija
Summary: Mapping the effects of drugs on the entire brain is crucial for understanding the neural mechanisms behind drug-related behaviors. Using PET, this study investigated the regional and temporal characteristics of amphetamine-induced dopamine release in the brain, revealing distinct responses in different brain regions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)