Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 117, Issue -, Pages 297-316Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2017.08.002
Keywords
Transgenerational inheritance; Perinatal programming; Intergenerational stress; Multigenerational stress; Aging; Maternal lineage transmission; Paternal lineage transmission; Chronic disease; Environmental enrichment; Epigenetic regulation; Reactive oxygen species; Cellular repair; Inflammaging; Brain development; Animal studies; Clinical studies; Sex differences
Categories
Funding
- Canadian Institutes of Health Research Grant [102652]
- NSERC CREATE [371155]
- NSERC Postgraduate Scholarship
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Adverse early life experiences are major influences on developmental trajectories with potentially life-long consequences. Prenatal or early postnatal exposure to stress, undernutrition or environmental toxicants may reprogram brain development and increase risk of behavioural and neurological disorders later in life. Not only experience within a single lifetime, but also ancestral experience affects health trajectories and chances of successful aging. The central mechanism in transgenerational programming of a disease may be the formation of epigenetic memory. This review explores transgenerational effects of early adverse experience on health and disease incidence in older age. First, we address mechanisms of developmental and transgenerational programming of disease and inheritance. Second, we discuss experimental and clinical findings linking early environmental determinants to adverse aging trajectories in association with possible parental contributions and sex-specific effects. Third, we outline the main mechanisms of age-related functional decline and suggest potential interventions to reverse negative effects of transgenerational programming. Thus, strategies that support healthy development and successful aging should take into account the potential influences of transgenerational inheritance.
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