Article
Biochemistry & Molecular Biology
Shi-min Wang, Qin Wang, Li-yan Ye, Shao-xia Chen, Liang Tao, Zhao-shou Yang
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. This study investigates the potential of luteinizing hormone (LH) in PD treatment. LH acts through the luteinizing hormone/choriogonadotropin receptor (LHCGR) to regulate dopaminergic (DA) neuronal death. Additionally, LH inhibits glycogen synthase kinase 3 beta (GSK3b) activation, providing neuroprotective effects in PD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Seo
Summary: The anti-diabetic drug vildagliptin has been found to have protective effects against motor dysfunction caused by Parkinson's disease (PD), potentially through the regulation of PI3k/Akt, ERK, and JNK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Zijie Wang, Dingting Yang, Yiru Jiang, Yong Wang, Mengxi Niu, Chong Wang, Hong Luo, Huaxi Xu, Jingwen Li, Yun-wu Zhang, Xian Zhang
Summary: Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by the degeneration of dopaminergic neurons. Loss-of-function mutations in the RAB39B gene have been linked to early-onset PD. In this study, Rab39b KO mice were treated with MPTP to investigate the role of RAB39B in PD pathogenesis. Surprisingly, RAB39B deficiency did not affect MPTP-induced impairments, suggesting that its involvement in PD requires further investigation.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sandra Duperrier, Analia Bortolozzi, Veronique Sgambato
Summary: Parkinson's disease (PD) is characterized by cell loss in the substantia nigra and the presence of alpha-synuclein-containing neuronal Lewy bodies. This study investigated the expression levels of alpha-, beta-, and gamma-synucleins in brainstem regions involved in PD physiopathology. The results showed increased expression of these synucleins in the PD model macaques, which correlated with cell loss and motor score.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Manuj Ahuja, Navneet Ammal Kaidery, Otis C. Attucks, Erin McDade, Dmitry M. Hushpulian, Arsen Gaisin, Irina Gaisina, Young Hoon Ahn, Sergey Nikulin, Andrey Poloznikov, Irina Gazaryan, Masayuki Yamamoto, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Research suggests that genetic deletion or pharmacologic inhibition of Bach1 could be a promising therapeutic approach for Parkinson's disease, offering neuroprotection and reducing oxidative damage and neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen
Summary: In this study, a natural compound called morin was found to promote mitophagy and have therapeutic effects on a Parkinson's disease mouse model. Morin acts by activating the AMPK-ULK1 pathway and promoting nuclear translocation of the mitophagy regulator TFEB. This research lays the foundation for the potential use of morin as a clinical drug for Parkinson's disease treatment.
Article
Cell Biology
Tongyu Liu, Peihan Wang, Huan Yin, Xiangfei Wang, Jing Lv, Jiang Yuan, Jing Zhu, Yunfu Wang
Summary: This study found that rapamycin, an autophagy inducer, has neuroprotective effects in Parkinson's disease by inhibiting ferroptosis. Giving rapamycin in a Parkinson's disease mouse model and cell model improved behavioral symptoms, reduced dopamine neuron loss, and decreased the expression of ferroptosis-related indicators. Inhibiting ferroptosis by activating autophagy may be an important mechanism for the neuroprotective effects of rapamycin.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ellen Niederberger, Annett Wilken-Schmitz, Christine Manderscheid, Yannick Schreiber, Robert Gurke, Irmgard Tegeder
Summary: Oral administration of rotenone in mice as a model for Parkinson's disease did not show significant behavioral or biological effects within 8 weeks. Although it caused local gastrointestinal toxicity and weight gain suppression, it failed to replicate the characteristics of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
P. A. Dionisio, J. D. Amaral, C. M. P. Rodrigues
Summary: Parkinson's disease is the second most common neurodegenerative disease globally, typically associated with dopaminergic damage. The main physiological characteristics that make the nigrostriatal circuit more susceptible to mitochondrial dysfunction and oxidative stress are related to several cell death mechanisms, including apoptosis, necrosis, and ferroptosis.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Yujeong Lee, Seonguk Yang, Dong Geun Hong, Dinakaran Thirumalai, Seung-Cheol Chang, Ki Wung Chung, Young-Suk Jung, Hyung Ryong Moon, Hae Young Chung, Jaewon Lee
Summary: This study investigated the neuroprotective effects of the barbiturate derivative, MHY2699, in a mouse model of Parkinson's disease. The results showed that MHY2699 ameliorated neuroinflammation, inhibited motor dysfunction, and prevented dopaminergic neuronal death in the MPTP-induced mouse model, suggesting its potential as a treatment for PD.
Article
Biochemistry & Molecular Biology
Min Hyung Seo, Sujung Yeo
Summary: Our study investigated the effects of knocking down serping1, a protein associated with smooth muscle contraction, relaxation, and inflammation responses, using serping1 siRNA in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced Parkinson's disease (PD) mice. The results showed that serping1 siRNA decreased serping1 expression and reduced a-syn accumulation in the colon. In addition, the treatment also alleviated a-syn aggregation in the brain, suggesting that serping1 siRNA could potentially alleviate synucleinopathy in the gastrointestinal system and brain regions affected by PD.
Review
Behavioral Sciences
Abdolvahed Narmashiri, Mojtaba Abbaszadeh, Ali Ghazizadeh
Summary: This article provides a comprehensive review and meta-analysis on the effects of MPTP on memory and motor functions in Parkinson's disease. The results show that MPTP not only significantly affects motor functions, but also various mnemonic processes. However, no systematic relationship between the MPTP injection protocol parameters and the extent of induced PD symptoms was found.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Immunology
Na Liu, Liping Bai, Zhipeng Lu, Rou Gu, Dongdong Zhao, Fang Yan, Jie Bai
Summary: TRPV4 is involved in the loss of DA neurons and movement deficits in the substantia nigra of PD mice. This study provides new molecular targets and gene therapy approaches for the treatment of PD in the future.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Min Hyung Seo, Sujung Yeo
Summary: This study explored the link between srpk3 and alpha-syn in muscles in PD, revealing that MPTP intoxication could alter srpk3 expression in muscles, which may be related to changes in alpha-syn expression. These findings could contribute to further understanding of the role of srpk3 in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Nicole M. Kurnik, Lacey R. Pflibsen, Annie Do, Ruth Bristol, Davinder J. Singh
JOURNAL OF CRANIOFACIAL SURGERY
(2018)
Article
Surgery
Nicole M. Kurnik, Lacey R. Pflibsen, Ruth E. Bristol, Davinder J. Singh
JOURNAL OF CRANIOFACIAL SURGERY
(2017)
Article
Public, Environmental & Occupational Health
Jamie Bering, Lacey Pflibsen, Cassie Eno, Priya Radhakrishnan
JOURNAL OF WOMENS HEALTH
(2018)
Article
Surgery
Alanna M. Rebecca, Raman C. Mahabir, Lacey Pflibsen, Nadine Hillberg, Claire Jensen, William J. Casey
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2019)
Editorial Material
Public, Environmental & Occupational Health
Lacey R. Pflibsen, Brittney A. McCormick, Shelley S. Noland, Pelagia E. Kouloumberis
JOURNAL OF WOMENS HEALTH
(2020)
Article
Surgery
Lacey R. Pflibsen, Brittany M. Foley, Robert W. Bernard, Gordon K. Lee, Matthew R. Neville, Diana Almader-Douglas, Shelley S. Noland
Summary: Over the past decade, the representation of female plastic surgeons on editorial boards of high-impact plastic surgery journals has significantly increased. At the beginning of the study, there were fewer female editors than expected, but by the end of the study, women were adequately represented on all 3 editorial boards compared with their population data.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Sarah A. Layon, Lacey R. Pflibsen, Samantha Maasarani, Shelley S. Noland
JOURNAL OF WOMENS HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Lacey R. R. Pflibsen, Ashley A. A. Howarth, Sarah A. A. Layon, Shelley S. S. Noland
JOURNAL OF WOMENS HEALTH
(2023)
Article
Medicine, General & Internal
Jacob B. Hammond, Lacey R. Pflibsen, Erwin A. Kruger, William J. Casey, Shelley S. Noland, Salvatore C. Lettieri, Alanna M. Rebecca, Sara L. Struve, Chad M. Teven
Summary: This report presented two atypical manifestations of Pyoderma gangrenosum in the reconstructed breast, where the disease was confined to the irradiated chest wall tissue bed, sparing the abdominal donor sites and the contralateral reconstructed breast.
CLINICAL CASE REPORTS
(2021)
Editorial Material
Surgery
Lacey R. Pflibsen, Salvatore C. Lettieri, Erwin A. Kruger, Alanna M. Rebecca, Chad M. Teven
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Editorial Material
Surgery
Chad M. Teven, Lacey R. Pflibsen, Alanna M. Rebecca, Salvatore C. Lettieri
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Article
Surgery
Lacey R. Pflibsen, Ashley L. Howarth, Ana Meza Rochin, Tim Decapite, William J. Casey, Lisa A. Mansueto
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Article
Neurosciences
Eduard Bentea, Cynthia Moore, Lauren Deneyer, Lise Verbruggen, Madeline J. Churchill, Rebecca L. Hood, Charles K. Meshul, Ann Massie
BRAIN RESEARCH BULLETIN
(2017)
Article
Surgery
Lacey R. Pflibsen, Cristine S. Velazco, Daniel H. Rhee, Lyndsey A. Bryant, Alyssa B. Chapital, Alanna M. Rebecca
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.