Article
Multidisciplinary Sciences
Joseph T. Marmerstein, Grant A. McCallum, Dominique M. Durand
Summary: This study successfully recorded neural activity of the cervical vagus nerve in rats using custom carbon nanotube yarn electrodes, finding no correlation between baseline vagal activity and common HRV metrics. The study also discovered that average vagal activity is higher during inspiration and lower during expiration, but is not correlated with HRV.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Bhagwati Joshi, Jagdish Chandra Joshi, Dolly Mehta
Summary: This review summarizes the regulatory mechanisms of cGAS activity, including structure, sub-cellular localization, post-translational modifications, and Ca2+ signaling. The role of cGAS activation in different diseases and clinical outcomes is also discussed.
Article
Clinical Neurology
Lei Liu, Kathryn N. Kearns, Ilyas Eli, Khadijeh A. Sharifi, Sauson Soldozy, Elizabeth W. Carlson, Kyle W. Scott, M. Filip Sluzewski, Scott T. Acton, Kenneth A. Stauderman, M. Yashar S. Kalani, Min Park, Petr Tvrdik
Summary: The study revealed that microglia participate in ischemic brain injury through previously undetected mechanisms, which may provide new avenues for therapeutic interventions.
Article
Cell Biology
Sen Li, Zhaoqi Jia, Zhang Zhang, Yuxin Li, Meihui Yan, Tingting Yu
Summary: Novel associations between cardiovascular diseases and key genetic variants were identified in the study, highlighting the importance of genetic testing in the diagnosis and prevention of CVDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yen-Lin Chen, Zdravka Daneva, Maniselvan Kuppusamy, Matteo Ottolini, Thomas M. Baker, Eliska Klimentova, Soham A. Shah, Jennifer D. Sokolowski, Min S. Park, Swapnil K. Sonkusare
Summary: This study demonstrates the role of TRPV4(SMC) channels in blood pressure regulation, showing that their activity increases resting blood pressure in normal mice. The study also reveals the opposite effects of α1AR-TRPV4(SMC) signaling and intraluminal pressure-TRPV4(SMC)-BK channel signaling on blood pressure. In hypertension, constrictor α1AR-PKCα-TRPV4 signaling is upregulated, while dilator pressure-TRPV4-BK channel signaling is disrupted, leading to increased vasoconstriction and elevated blood pressure.
Article
Plant Sciences
Tiantian Xiong, Qinqin Tan, Shaoshan Li, Chiristian Mazars, Jean-Philippe Galaud, Xiaoyang Zhu
Summary: This article reviews the roles of calcium and ABA in stress responses and fruit ripening, and proposes an interaction model between calcium sensors and ABA signaling components in the control of fruit ripening.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Alina Scridon, Vasile Bogdan Halatiu, Alkora Ioana Balan, Dan Alexandru Cozac, Valeriu Moldovan, Claudia Banescu, Marcel Perian, Razvan Constantin Serban
Summary: Chronic administration of ivabradine enhances vagal modulation and shifts the sympatho-vagal balance towards vagal dominance in healthy rats. Ivabradine reduces the heart rate response to direct muscarinic receptors stimulation, cancels the cardioinhibitory response, and blunts the hemodynamic response to in situ vagal stimulation. These findings provide new insights into the mechanisms of ivabradine-related atrial proarrhythmia and suggest potential protective effects of long-term I(f) blockade against excessive bradycardia induced by acute vagal activation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Samar Sayedyahossein, Louise Thines, David B. Sacks
Summary: The Hippo signaling pathway regulates various cellular processes, including cell proliferation, differentiation, migration, and mechanosensation. Calcium ion (Ca2+) has been found to influence core components of the Hippo pathway. However, the crosstalk between Ca2+ signaling and the Hippo pathway is not fully understood.
CELLULAR SIGNALLING
(2023)
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Psychology, Multidisciplinary
Ethan G. Harrod, Ilan Shrira, Jared D. Martin, Paula M. Niedenthal
Summary: Despite the historically negative reactions towards strangers, contemporary migration patterns have increased interaction between different groups. This study suggests that cultural practices in ancestrally diverse societies promote emotion regulation and higher vagal tone, enabling individuals to effectively manage arousal and engage with outgroup members. The analysis of data from the MIDUS 2 Biomarker Project shows that the ancestral diversity of states in the United States significantly predicts the average vagal tone of its citizens, highlighting the impact of social context on human physiology.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Lei Yang, Rong-Chang Li, Bin Xiang, Yi-Chen Li, Li-Peng Wang, Yun-Bo Guo, Jing-Hui Liang, Xiao-Ting Wang, Tingting Hou, Xin Xing, Zeng-Quan Zhou, Haihong Ye, Ren-Qing Feng, Edward G. Lakatta, Zhen Chai, Shi-Qiang Wang
Summary: The contraction of heart cells is regulated by the signaling interaction between LCCs and RyRs, which is influenced by the nanodistance between JPH2 in the SR and CAV3 in the TT. Our study revealed that SRF and myocardin concurrently regulate the expression of JPH2 and CAV3, leading to enhanced efficiency of LCC-RyR signaling and compensation for LCC down-regulation during hibernation, maintaining heart power and avoiding calcium overload.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Vanessa J. Li, Anne Schohl, Edward S. Ruthazer
Summary: The development of functional topography in the developing brain involves a progression from coarse to more precisely organized maps. NMDA receptor conductance is not necessary for the coarse topographic ordering of retinotectal inputs but does contribute to the fine-scale organization of the projection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Anatomy & Morphology
Divya Adiga, Raghu Radhakrishnan, Sanjiban Chakrabarty, Prashant Kumar, Shama Prasada Kabekkodu
Summary: Metastasis remains a challenge for successful cancer treatment. Ca2+ signaling plays a crucial role in regulating the activity of metastatic cells through modulating EMT.
CELLS TISSUES ORGANS
(2022)
Article
Pharmacology & Pharmacy
Fenglan Chu, Hanxing Wan, Weidong Xiao, Hui Dong, Muhan Lue
Summary: Calcium signaling is crucial for intestinal glutamine (Gln) transport, and multiple plasma membrane Ca2+-permeable channels and transporters are involved in this process.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.