Article
Clinical Neurology
Andrew I. Yang, Ashley L. B. Raghu, Faical Isbaine, Abdulrahman Alwaki, Robert E. Gross
Summary: This study aims to determine the LFP features that can distinguish ictal from inter-ictal states, which may help track seizure outcomes with thalamic DBS. The analysis of power spectra recorded during patient-marked seizure events revealed oscillatory activity in multiple frequency bands, with delta oscillations present in all patients, followed by theta and beta. Although there were no differences in oscillatory LFP features between the ictal and inter-ictal states, there was a steeper decline in the 1/f slope of the aperiodic component of the LFP during seizures.
Article
Psychology, Biological
Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-ih, Ekkasit Kumarnsit
Summary: This study aimed to investigate the neural adaptive mechanisms associated with the formation of morphine conditioned place preference. The findings suggested that NAc LFP signaling and neural connectivities between the NAc and HC may play a role in morphine CPP.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Clinical Neurology
Jiali Liu, Tao Yu, Jinfeng Wu, Yali Pan, Zheng Tan, Ruobing Liu, Xueyuan Wang, Liankun Ren, Liang Wang
Summary: Electrical stimulation of the anterior nucleus of thalamus (ANT) can improve working memory precision by modulating hippocampal gamma activity.Increased gamma power in the pre-stimulus and retrieval period predicts the improvement of working memory precision judgements.
Article
Behavioral Sciences
Maximilian Schlecht, Maanasa Jayachandran, Gabriela E. Rasch, Timothy A. Allen
Summary: The interactions between the medial prefrontal cortex (mPFC) and the hippocampus (HC) are crucial for memory and decision making, with newly identified dual projecting cell populations in the septum, Sub, and EC of the rat brain potentially modifying information flow within the mPFC-HC circuit through synchronous activity, offering new cell-specific circuit targets for memory studies.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2022)
Article
Neurosciences
Annie Y. Luma, Claudia I. Perez, Ana K. Pimentel-Farfan, Ana S. Baez-Cordero, Perla Gonzalez-Pereyra, Diana I. Ortega-Romero, Mario G. Martinez-Montalvo, Teresa M. Pena-Rangel, Pavel E. Rueda-Orozco
Summary: This study investigated the contribution of intralaminar thalamic nuclei, specifically the central medial nucleus (CMT), to motor control and coordination. The findings suggest that optogenetic stimulation of the CMT can induce bilateral recruitment of neural activity in the sensorimotor cortex and striatum, leading to enhanced bilateral movement coordination.
Article
Anatomy & Morphology
Tatiana D. Viena, Gabriela E. Rasch, Timothy A. Allen
Summary: The paraventricular nucleus (PVT) of the midline thalamus is a crucial integration site for cortico-thalamo-cortical pathways and plays a critical role in various behaviors. This study characterized the projection populations of PVT neurons that send collaterals to the medial prefrontal cortex (mPFC) and/or ventral hippocampus (vHC) in rats. The study also examined the distribution of calcium binding proteins calretinin (CR) and calbindin (CB) in relation to these projection populations. The results revealed separate populations of PVT cells that project to mPFC, vHC, and both regions, with dual projecting cells lacking expression of CR and CB. The study suggests the presence of a functional mPFC-PVT-vHC system that may support interactions between the mPFC and vHC in PVT-dependent behaviors.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Guang-Wei Zhang, Li Shen, Can Tao, A-Hyun Jung, Bo Peng, Zhong Li, Li Zhang, Huizhong Whit Tao
Summary: Research has found that anxiogenic stressors can elicit acute and prolonged responses in glutamatergic neurons of the mouse medial preoptic area, affecting the induction and expression of anxiety-like behaviors and the production of anxiolytic effects. These neurons interact to play important roles in coordinating emotional state and social behavior.
NATURE NEUROSCIENCE
(2021)
Article
Cell Biology
Farah Chamaa, Batoul Darwish, Rami Arnaout, Ziad Nahas, Elie D. Al-Chaer, Nayef E. Saade, Wassim Abou-Kheir
Summary: The study demonstrates that stimulating the anterior nucleus of the thalamus can enhance adult hippocampal neurogenesis and improve spatial memory in rats. However, administering dexamethasone prior to and simultaneously with the stimulation can diminish these effects.
Article
Neurosciences
Nora A. Herweg, Lukas Kunz, Daniel Schonhaut, Armin Brandt, Paul A. Wanda, Ashwini D. Sharan, Michael R. Sperling, Andreas Schulze-Bonhage, Michael J. Kahana
Summary: Distinct lines of research in both humans and animals have found that the hippocampus plays a specific role in spatial and episodic memory function. Concept cells in the hippocampus and surrounding areas suggest that the medial temporal lobe maps physical and semantic spaces using a similar neural architecture. This study examines the emergence of such maps using recordings from the medial temporal lobe of patients navigating a virtual environment with meaningful landmarks, and finds that the field potentials in the medial temporal lobe contain information to decode the subjects' locations and temporal sequences.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Qi-Jun Zhou, Xingyan Liu, Longlong Zhang, Rong Wang, Tingting Yin, Xiaolu Li, Guimei Li, Yuqi He, Zhaoli Ding, Pengcheng Ma, Shi-Zhi Wang, Bingyu Mao, Shihua Zhang, Guo-Dong Wang
Summary: This study constructed a transcriptomic atlas of the dog hippocampus, revealing cell types and features, and identified genes related to the regulation of nervous system development. The findings contribute to understanding the cellular mechanism of dog domestication.
NATIONAL SCIENCE REVIEW
(2022)
Article
Multidisciplinary Sciences
Jia-Ni Li, Xue-Mei Wu, Liu-Jie Zhao, Han-Xue Sun, Jie Hong, Feng-Ling Wu, Si-Hai Chen, Tao Chen, Hui Li, Yu-Lin Dong, Yun-Qing Li
Summary: This study reveals that the pathway involving the parabrachial nucleus, central medial thalamic nucleus, and medial prefrontal cortex is crucial for the transmission of itch signals and the affective dimension of itch in male mice. Chemical inhibition of this pathway attenuates scratching behavior and chronic itch-related affective responses. The study also found that chronic itch stimuli alter the excitatory/inhibitory balance in the medial prefrontal cortex.
NATURE COMMUNICATIONS
(2023)
Review
Clinical Neurology
Carla Fernandez-Garcia, Mariana H. G. Monje, Victor Gomez-Mayordomo, Guglielmo Foffani, Rafael Herranz, Maria Jose Catalan, Mercedes Gonzalez-Hidalgo, Jorge Matias-Guiu, Fernando Alonso-Frech
Summary: This study evaluated the effectiveness of directional subthalamic stimulation in Parkinson's disease based on intraoperatively recorded beta oscillations. The results showed a strong correlation between clinical efficacy and beta activity, and selecting the contacts with the highest beta peaks improved the therapeutic window. Long-term follow-up showed similar improvements in both groups, validating the efficacy of directional stimulation guided by intraoperative beta oscillations.
Article
Multidisciplinary Sciences
Huiling Yu, Liping Chen, Huiyang Lei, Guilin Pi, Rui Xiong, Tao Jiang, Dongqin Wu, Fei Sun, Yang Gao, Yuanhao Li, Wenju Peng, Bingyu Huang, Guoda Song, Xin Wang, Jingru Lv, Zetao Jin, Dan Ke, Ying Yang, Jian-Zhi Wang
Summary: The study found that activating Calb1 neurons in the posterior basolateral amygdala, along with the IL-pBLA pathway, strengthens reward generalization to ambiguous cues in mice and reduces anxiety and depression-like behaviors induced by chronic unpredictable mild stress. This suggests that targeting the IL-pBLA circuit could promote stress resilience through reward generalization and improve anxiety and depression-like behaviors.
NATURE COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Maeva Ferraris, Jean-Christophe Cassel, Anne Pereira de Vasconcelos, Aline Stephan, Pascale P. Quilichini
Summary: The consolidation of declarative memories mainly occurs during sleep through a dialogue between the hippocampus and the medial prefrontal cortex. Synchronization of cortico-hippocampal networks by different oscillations and the involvement of the nucleus reuniens are crucial for the transfer of information from the hippocampus to the medial prefrontal cortex. Recent studies highlight the significant role of the nucleus reuniens in memory consolidation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Christoph Wiest, Francesca Morgante, Flavie Torrecillos, Alek Pogosyan, Shenghong He, Fahd Baig, Ilaria Bertaina, Michael G. Hart, Mark J. Edwards, Erlick A. Pereira, Huiling Tan
Summary: This study explores the effects of subthalamic nucleus (STN) stimulation on Parkinson's disease and dystonia, and finds that stimulation-induced spectral changes are present in both conditions. These findings suggest that STN stimulation can be used for other disorders with excessive oscillatory peaks.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.