Article
Physiology
Inmaculada Leon, Silvia Herrero Roldan, Maria Jose Rodrigo, Maykel Lopez Rodriguez, Jonah Fisher, Colter Mitchell, Agustin Lage-Castellanos
Summary: Studies on DNA methylation have shown the impact of life adversity on physical and mental health, but it is still unclear how maternal adverse experiences manifest in maladaptive parenting and whether these effects are passed on to the next generation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Klaudia Sojta, Dominik Strzelecki
Summary: Several factors, including temperament, unmet core emotional needs, and adverse childhood events, play a key role in the development of early maladaptive schemas. Parental care has a substantial impact on the potential development of these schemas.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Eileen M. Condon, Amanda Dettmer, Ellie Baker, Ciara McFaul, Carla Smith Stover
Summary: Fathers play a significant role in child development, but there is a lack of research on the effects of early life adversity on fathers' parenting. This review examines the impact of early life adversity on males in areas such as neurobiology, hormones, gene-environment interactions, and behavior. Based on the findings, a conceptual model is proposed to understand the biological and behavioral pathways through which early life adversity may influence fathers' parenting. Empirical studies are needed to improve understanding in this area and develop interventions to prevent intergenerational transmission of early life adversity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Nursing
Xiao Xiao, Alice Yuen Loke
Summary: Co-parenting interventions have shown positive effects in enhancing co-parenting support, reducing co-parenting undermining, improving couple communication, parent-child interactions, and decreasing depressive symptoms in mothers. However, evidence on the overall effects of co-parenting, division of labor, childrearing agreement, fathers' psychological health, parenting self-efficacy, and baby feeding practices is limited. Further studies are needed to explore the effects of interventions, especially for intergenerational families, during the postpartum period.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Multidisciplinary Sciences
Francesca R. Querdasi, Craig Enders, Neerja Karnani, Birit Broekman, Chong Yap Seng, Peter D. Gluckman, Lourdes Mary Daniel, Fabian Yap, Johan G. Eriksson, Shirong Cai, Mary Foong- Fong Chong, Jia Ying Toh, Keith Godfrey, Michael J. Meaney, Bridget L. Callaghan
Summary: Exposure to adversity in the prenatal and postnatal period can increase the risk of psychopathology, which may continue across generations. The gut microbiome is suggested to be a biological mechanism underlying such generational risks. In a sample of 450 mother-child dyads in Singapore, the associations between three different adversity exposures across two generations (maternal childhood maltreatment, maternal prenatal anxiety, and second-generation children's exposure to stressful life events) and the gut microbiome composition of second-generation children at 2 years old were examined. The study found distinct differences in the gut microbiome profiles associated with each adversity exposure, as well as some unaffected microbiome features. Interestingly, certain microbial taxa associated with socioemotional functioning in children showed similar functions as those affected by adversity, suggesting that the intergenerational transmission of adversity may have lasting effects on children's mental health through alterations in gut microbiome functions. These findings open up a new avenue of research into the underlying mechanisms of intergenerational transmission of mental health risks and the potential for targeting the gut microbiome for intervention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychology, Multidisciplinary
J. Carola Perez, Daniela Aldoney, Anastassia Vivanco-Carlevari, Soledad Coo, Eugenio J. Guzman, Jaime R. Silva
Summary: The outbreak of the pandemic in March 2020 and the subsequent sanitary regulations and restrictions have caused significant changes in society and families' organization. This study examines the impact of these changes on parental depression and perceived home organization of mothers and fathers in Chile. The findings highlight several factors that moderate the changes in home chaos and parental mental health perception, including financial strain, personality traits, parent-child interaction, stressful events, and number of children. The study provides insights into the effects of the pandemic on the family system and identifies vulnerability indicators.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pediatrics
Adam Schickedanz, Jose J. Escarce, Neal Halfon, Narayan Sastry, Paul J. Chung
Summary: This study found significant intergenerational links between parents' adverse childhood experiences (ACEs) and children's ACEs. Children of parents with higher ACE scores are more likely to have higher ACE scores themselves, with parent aggravation, disagreement, and emotional distress acting as partial mediators.
Article
Immunology
Clare McCormack, Vincenzo Lauriola, Tianshu Feng, Seonjoo Lee, Marisa Spann, Anika Mitchell, Frances Champagne, Catherine Monk
Summary: Inflammatory processes may be a mechanism through which early adversity is biologically embedded and leads to poorer health outcomes, with pregnancy being a pathway for intergenerational transmission of adversity. Research indicates that factors such as mood, diet, BMI, and social support may moderate the association between childhood trauma history and inflammation in adulthood, with limited studies examining these associations among pregnant women.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Psychology, Multidisciplinary
Maria E. Bleil, Susan J. Spieker, Cathryn Booth-LaForce
Summary: Mounting evidence suggests that early life adversity exposures are linked to increased risk of cardiometabolic disease, prompting a review exploring parenting quality as a potential intervention target. Limited family-based intervention studies have shown positive impacts of parenting on cardiometabolic health outcomes in ELA-exposed children, warranting further research and recommendations for future studies in this area.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Kathryn L. Humphreys, Lucy S. King, Katherine L. Guyon-Harris, Charles H. Zeanah
Summary: Early adversity has heterogeneous effects on children, with many showing resilience. Caregiver regulation of children's emotions is a key modifiable environmental feature that promotes resilience. Interventions targeting caregiver regulation's availability, consistency, and quality can support children's healthy development.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Public, Environmental & Occupational Health
Xin Lin, Xiaofan Ma, Xiaoting Yi, Chao Qu, Fuye Li
Summary: This study investigates the current situation of occupational burnout among coal miners, explores the relationship between NR3C2 gene polymorphism and occupational burnout, and analyzes the influence of gene-environment interaction on occupational burnout.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Substance Abuse
Jenna van Draanen, Carol S. Aneshensel
Summary: This study reveals that the association between parental substance use disorder (SUD) and children's own SUD varies depending on gender, childhood trauma, and household environment.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Psychology, Developmental
Eyal Abraham, Allison M. Letkiewicz, Priya J. Wickramaratne, Maya Bunyan, Milenna T. van Dijk, Marc J. Gameroff, Jonathan Posner, Ardesheer Talati, Myrna M. Weissman
Summary: This study examined the continuity of parenting styles, major depressive disorder (MDD), temperament, and social support in familial depression across generations. The results revealed a transmission of parenting styles between generations and highlighted the roles of MDD, temperament, and social support in breaking the cycle of poor parenting practices in interventions.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Review
Psychology, Clinical
Laura Chapman, Sam Cartwright-Hatton, Abigail Thomson, Kathryn J. Lester
Summary: Parents with eating disorders may experience higher levels of parenting stress and may exhibit more intrusive, less sensitive behavior towards their children in non-feeding interactions. They also tend to show increased concern about their children's weight and mealtime interactions with their children may be characterized by high levels of conflict.
CLINICAL PSYCHOLOGY REVIEW
(2021)
Article
Nutrition & Dietetics
Mengmeng Ji, Ruopeng An
Summary: This study found evidence that parenting styles can moderate the genetic and environmental influences on body weight status and smoking. The moderation effects of parenting on BMIz were observed only at a very young age. Parenting styles influenced adolescent smoking but not drinking.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Psychology, Developmental
Massimiliano Orri, Cedric Galera, Gustavo Turecki, Michel Boivin, Richard E. Tremblay, Marie-Claude Geoffroy, Sylvana M. Cote
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2019)
Article
Psychology, Developmental
Lea C. Perret, Massimiliano Orri, Michel Boivin, Isabelle Ouellet-Morin, Anne-Sophie Denault, Sylvana M. Cote, Richard E. Tremblay, Johanne Renaud, Gustavo Turecki, Marie-Claude Geoffroy
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2020)
Article
Anesthesiology
Marco Battaglia, Gabrielle Garon-Carrier, Lance Rappaport, Mara Brendgen, Ginette Dionne, Frank Vitaro, Richard E. Tremblay, Michel Boivin
Summary: Adolescent pain is common and continues into adulthood, and defining its construct through empirical research can help early detection of persistent pain trajectories. This study found that back pain is consistently associated with frequent adolescent pain trajectory, and it has good sensitivity in predicting the trajectory.
Article
Psychology, Developmental
Frank Vitaro, Kevin M. Beaver, Mara Brendgen, Daniel J. Dickson, Ginette Dionne, Michel Boivin
Summary: The study aimed to replicate previous findings on the influence of peers' deviance on self-reported delinquency of twins, but found no significant causal link between peer deviance and delinquent behavior.
DEVELOPMENTAL PSYCHOLOGY
(2021)
Article
Psychology, Developmental
Rene Carbonneau, Frank Vitaro, Mara Brendgen, Michel Boivin, Richard E. Tremblay
Summary: This study investigated prenatal and early postnatal risk factors associated with the development of disruptive behaviors. The findings showed that pure forms of disruptive behaviors have specific etiologies, while co-occurrent disruptive behaviors share common risk factors. Risk factors such as male sex, a higher number of siblings, maternal symptoms of depression and conduct problems, young motherhood, lack of positive parenting, family dysfunction, and lower socioeconomic status were found to affect the development of disruptive behaviors.
DEVELOPMENTAL PSYCHOLOGY
(2022)
Article
Psychology, Developmental
Sophie Aube, Catherine Mimeau, Eloi Gagnon, Alexandra Remon, Mara Brendgen, Frank Vitaro, Isabelle Ouellet-Morin, Richard E. Tremblay, Michel Boivin, Ginette Dionne
Summary: This study aimed to understand how early oral language contributes to later writing skills and to explore the extent to which genetic and environmental factors explain these potential associations. The results showed that preschool language skills were modestly associated with high school writing and that school age language fully mediated this association. Additionally, genetic factors explained a significant portion of the associations between preschool language and school age language, as well as between school age language and high school writing.
DEVELOPMENTAL PSYCHOLOGY
(2022)
Article
Substance Abuse
Nina Pocuca, Kira London-Nadeau, Marie-Claude Geoffroy, Nicholas Chadi, Jean R. Seguin, Sophie Parent, Michel Boivin, Richard E. Tremblay, Sylvana M. Cote, Natalie Castellanos-Ryan
Summary: Prospective research is needed to better understand the changes in substance use among emerging adults during the COVID-19 pandemic. The study found that changes in alcohol and cannabis use varied according to preexisting substance use, COVID-19-related factors, and preexisting factors. While some young individuals with preexisting vulnerabilities showed stable or decreased substance use, those who experienced employment loss, loneliness, and financial concerns during COVID-19 increased their substance use. This highlights the importance of providing support for vulnerable populations during the pandemic.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2022)
Article
Psychology, Developmental
Mara Brendgen, Yao Zheng, Frank Vitaro, Ginette Dionne, Michel Boivin
Summary: This study examined the role of genetic and environmental factors in explaining different trajectories of adolescents' depressive symptoms, as well as the correlation between genetic factors and peer victimization. The results showed that genetic factors explained about half of the probability of following a low or increasing trajectory, while nonshared environmental factors explained the remaining variance. Moreover, frequent peer victimization increased the influence of nonshared environmental factors.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Education & Educational Research
Rene Carbonneau, Richard E. Tremblay, Frank Vitaro, Mara Brendgen, Michel Boivin, Pascale Domond, Sylvana Cote
Summary: This study explores the patterns of relative academic achievement of children in the classroom from grade 1 to grade 6 and their associations with child, parental, and socio-familial characteristics. The findings indicate that low parental education and family income, male sex, and poor parental behaviors and attitudes towards the child are associated with a lower trajectory of relative academic achievement.
EARLY CHILDHOOD RESEARCH QUARTERLY
(2023)
Article
Clinical Neurology
Dominique Petit, Evelyne Touchette, Marie-Helene Pennestri, Jean Paquet, Sylvana Cote, Richard E. Tremblay, Michel Boivin, Jacques Y. Montplaisir
Summary: Sleep duration during early childhood is associated with long-term academic achievement. Children who slept less than 8 hours per night at 2.5 years had higher odds of having below average grades in various subjects compared to those who slept sufficiently. Sufficient sleep in early childhood is important for academic success.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Biological
Jasmin Wertz, Terrie E. Moffitt, Louise Arseneault, J. C. Barnes, Michel Boivin, David L. Corcoran, Andrea Danese, Robert J. Hancox, HonaLee Harrington, Renate M. Houts, Stephanie Langevin, Hexuan Liu, Richie Poulton, Karen Sugden, Peter T. Tanksley, Benjamin S. Williams, Avshalom Caspi
Summary: A study of 36,516 parents from six international cohorts reveals associations between parental genetics and parental investments in offspring, from behaviors during pregnancy to wealth inheritance in adulthood. The effects of parental genetics on behaviors tend to be small at any given time point, but accumulate over development. This suggests that parents pass on advantages to their children through genetic associations with investments across various stages of development.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Psychology, Clinical
Rachel Dufour, Edith Breton, Alexandre J. S. Morin, Sylvana M. Cote, Lise Dubois, Frank Vitaro, Michel Boivin, Richard E. Tremblay, Linda Booij
Summary: This study, using a longitudinal design, found that early hyperactivity, overeating, cognitive inflexibility, and working memory may precede the onset of eating-disorder symptoms in adolescence. Screening children's behavior and cognition early on may help identify those most at risk for eating disorders and guide preventive interventions.
JOURNAL OF EATING DISORDERS
(2023)
Article
Psychology, Clinical
Kira London-Nadeau, Charlie Rioux, Sophie Parent, Frank Vitaro, Sylvana M. Cote, Michel Boivin, Richard E. Tremblay, Jean R. Seguin, Natalie Castellanos-Ryan
Summary: The study found bidirectional associations between cannabis use and symptoms of depression and anxiety, especially among sexual minorities. Sexual minorities showed significantly larger associations between cannabis use and depression symptoms between the ages of 15 and 17.
JOURNAL OF ABNORMAL PSYCHOLOGY
(2021)
Article
Psychology, Developmental
Genevieve Morneau-Vaillancourt, Celia Matte-Gagne, Rosa Cheesman, Mara Brendgen, Frank Vitaro, Richard Tremblay, Ginette Dionne, Michel Boivin
Summary: The study found that preference for solitude, instead of social wariness, predicts peer difficulties. Preference for solitude was closely related to peer rejection starting at age 6 and gradually became associated with peer victimization over time. These results highlight the importance of distinguishing different dimensions of social withdrawal.
DEVELOPMENTAL PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Jeffrey Henry, Ginette Dionne, Essi Viding, Amelie Petitclerc, Bei Feng, Frank Vitaro, Mara Brendgen, Richard E. Tremblay, Michel Boivin
JOURNAL OF ABNORMAL PSYCHOLOGY
(2018)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.