Article
Anesthesiology
Lisa Goudman, Ann De Smedt, Sam Eldabe, Philippe Rigoard, Bengt Linderoth, Mats De Jaeger, Maarten Moens
Summary: High-dose spinal cord stimulation (HD-SCS) has shown significant and sustained pain relief over a period of 12 months in patients with failed back surgery syndrome (FBSS). Additionally, HD-SCS resulted in improvement in sleep quality, functionality, and a decrease in pain medication usage.
Review
Clinical Neurology
Marco Echeverria-Villalobos, Justin Mitchell, Juan Fiorda-Diaz, Tristan Weaver
Summary: This narrative review discusses the molecular mechanisms of neuroinflammation in chronic neuropathic lumbar and leg pain in patients with persistent spinal pain syndrome, and the impact of spinal cord stimulation (SCS) on neuroinflammation. Novel SCS techniques like burst-SCS, high frequency SCS, and differential targeted multiplexed SCS have shown promising results in improving clinical outcomes for patients with refractory chronic lumbar pain and persistent spinal pain syndrome. Further clinical trials are needed to understand the long-term benefits and mechanisms of different types of SCS.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Clinical Neurology
Mette Nissen, Tiina-Mari Ikaheimo, Jukka Huttunen, Ville Leinonen, Henna-Kaisa Jyrkkanen, Mikael von Und Zu Fraunberg
Summary: The study showed that patients using gabapentinoids had lower rates of spinal cord stimulator explantation and were more likely to discontinue or reduce opioid use, indicating potential benefits of concomitant use of gabapentinoids in SCS patients.
Review
Health Care Sciences & Services
Giusy Guzzi, Attilio Della Torre, Domenico La Torre, Giorgio Volpentesta, Carmelino Angelo Stroscio, Angelo Lavano, Federico Longhini
Summary: Chronic low-back pain is a common disease with negative impacts on patients' quality of life and healthcare costs. When conventional treatments fail, patients may consider Spinal Cord Stimulation (SCS), which can effectively reduce symptoms in well-selected patients for up to eight years.
Article
Rehabilitation
Mats De Jaeger, Lisa Goudman, Sam Eldabe, Robert Van Dongen, Ann De Smedt, Maarten Moens
Summary: This study aimed to investigate the relationship between pain intensity pre-treatment and disability, finding that pain reduction can help alleviate disability levels, but a low degree of disability does not always reflect low pain intensity.
DISABILITY AND REHABILITATION
(2021)
Article
Anesthesiology
Concepcion Perez, Elena Rojo, Cesar Margarit, Noelia Sanchez, Tania Blanco, Manuel Munoz, Carlos Crespo, Dolores Ochoa
Summary: This study compared the effectiveness of CMM and SCS for managing FBSS, finding that SCS may improve HRQoL and functionality in the long term. However, there were also limitations in the study design and sample size.
Article
Clinical Neurology
Richard L. Witkam, Elisabeth A. M. Kragt, Inge J. J. Arnts, Ewald M. Bronkhorst, Robert van Dongen, Erkan Kurt, Monique A. H. Steegers, Frank G. A. M. van Haren, Natasja J. G. Maandag, Cees Gort, Dylan J. H. A. Henssen, Jessica T. Wegener, Kris C. P. Vissers
Summary: Spinal cord stimulation (SCS) is recommended for treating failed back surgery syndrome (FBSS). The study compared the long-term clinical outcomes and safety of trialed and nontrialed implantation strategies, finding a statistically significant but not clinically significant difference in pain intensity between the two groups.
Article
Clinical Neurology
Sally El Sammak, William Mualem, Giorgos D. Michalopoulos, Joshua M. Romero, Christopher T. Ha, Christine L. Hunt, Mohamad Bydon
Summary: This study systematically reviewed and evaluated the current literature on the use of novel waveform spinal cord stimulation for the management of failed back surgery syndrome refractory to conventional SCSs. The results showed that conversion to novel stimulation can significantly reduce back pain.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Anesthesiology
Martijn R. Mons, Kenneth B. Chapman, Chris Terwiel, Elbert A. Joosten, Jan-Willem Kallewaard
Summary: BurstDR (TM) spinal cord stimulation is an effective treatment for chronic discogenic low back pain, resulting in significant reduction of pain, improvement in quality of life, and positive patient satisfaction.
Review
Clinical Neurology
Sally El Sammak, William Mualem, Giorgos D. Michalopoulos, Joshua M. Romero, Christopher T. Ha, Christine L. Hunt, Mohamad Bydon
Summary: This study systematically reviewed and evaluated the use of novel waveform spinal cord stimulation for patients with failed back surgery syndrome refractory to conventional SCSs. The results suggest that novel waveform spinal cord stimulation may be a potential option for pain reduction.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Clinical Neurology
Christian Saleh, Tatiani Soultana Ilia, Phillip Jaszczuk, Margret Hund-Georgiadis, Anna Walter
Summary: This systematic review suggests that high-frequency rTMS applied to the primary motor cortex and left dorsolateral prefrontal cortex may be promising stimulation targets for neuropathic pain in individuals with spinal cord injury (SCI).
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Guiomar Niso, Marleen C. Tjepkema-Cloostermans, Mathieu W. P. M. Lenders, Cecile C. de Vos
Summary: This explorative study assessed the influence of attention on somatosensory evoked brain responses under conventional tonic SCS and burst SCS. Results indicated that burst SCS may reduce cortical attention to somatosensory stimuli to a larger extent than conventional SCS, which helps understand why burst SCS is more effective for certain chronic pain patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Anesthesiology
Valerie Dauriac-Le Masson, Marie-Therese Gatt, Corinne Chekroun, Baris Turak, Marie Christine Djian
Summary: The study found that spinal cord stimulation (SCS) is an effective treatment for patients with failed back surgery syndrome (FBSS), resulting in a high return to work (RTW) rate. Factors positively associated with RTW include functional improvement and shorter unemployment duration, while longer unemployment duration has a negative impact on RTW.
Article
Clinical Neurology
Sven Vanneste, Dirk De Ridder
Summary: Chronic pain is an imbalance between pain pathways in the brain. Burst spinal cord stimulation can normalize this imbalance.
Article
Medicine, General & Internal
Colin Mychak, Shravan Gupta, Joseph E. Mouhanna
Summary: Chronic axial low back pain is a common ailment in the United States that significantly impacts quality of life and function. Spinal cord stimulation is currently used for various chronic neuropathic conditions, but there is no specific indication for its use in axial low back pain. However, it can be considered in patients with significant or predominant complaints of axial low back pain.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Bjoern B. Hofmann, Christian Rubbert, Bernd Turowski, Daniel Haenggi, Sajjad Muhammad
Summary: For extremely rare bilateral distal fusiform superior cerebellar artery (SCA) aneurysms, surgical therapy reaches its limit, but mini-flow diverter devices (FDDs) offer an effective and successful alternative treatment option.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Review
Immunology
Martin Regensburger, Shafqat Rasul Chaudhry, Hammad Yasin, Yining Zhao, Andreas Stadlbauer, Michael Buchfelder, Thomas Kinfe
Summary: An increasing body of experimental evidence suggests a link between immunometabolic deterioration and the progression of Parkinson's disease. In particular, the dysregulation of central and peripheral neuroinflammatory networks mediated by circulating adipokines, such as leptin, may play a role. This article summarizes the existing evidence on the role of adipokines in Parkinson's disease and discusses their potential as therapeutic targets.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Health Care Sciences & Services
Lara Schorn, Max Wilkat, Julian Lommen, Maria Borelli, Sajjad Muhammad, Majeed Rana
Summary: This technical note explains the application of plasma electrolytic polishing on orbital patient-specific implants and demonstrates its clinical handling and use through the insertion of a plasma electrolytic polished orbital implant into a patient.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Dilaware Khan, Peter Bedner, Julia Mueller, Fabienne Luelsberg, Lukas Henning, Marco Prinz, Christian Steinhaeuser, Sajjad Muhammad
Summary: Inflammation promotes epileptogenesis, and TAK1 plays a central role in neuroinflammation. The activation of TAK1 in microglia contributes to the pathogenesis of chronic epilepsy, and its deletion in microglia reduces reactive microgliosis and epileptic activity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Critical Care Medicine
Bjoern B. Hofmann, Daniel M. Donaldson, Igor Fischer, Cihat Karadag, Milad Neyazi, Guilherme S. Piedade, Yousef Abusabha, Sajjad Muhammad, Christian Rubbert, Daniel Haenggi, Kerim Beseoglu
Summary: This study aimed to investigate the influence of blood pressure on early computed tomography perfusion (CTP) imaging in patients with aneurysmatic subarachnoid hemorrhage (aSAH). The results showed an inverse correlation between mean arterial pressure (MAP) and mean transit time (MTT) in early CTP imaging. Lower blood pressure was associated with longer MTT, and this correlation became stronger with the severity of aSAH. Therefore, maintaining physiological blood pressure values in the early phase of aSAH is crucial.
NEUROCRITICAL CARE
(2023)
Article
Oncology
Anke Meyer-Baese, Kerstin Juetten, Uwe Meyer-Baese, Ali Moradi Amani, Hagen Malberg, Andreas Stadlbauer, Thomas Kinfe, Chuh-Hyoun Na
Summary: This study investigates the impact of gliomas on the controllability and robustness of neural networks. The findings suggest that glioma patients exhibit changes in network controllability and robustness, which are associated with tumor type and prognosis. This novel approach provides insights into disease evolution and potential treatment targets in brain cancer.
Article
Biochemistry & Molecular Biology
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Summary: Inflammaging is a potential risk factor for cardiovascular diseases, leading to the development of thrombosis and atherosclerosis. Ethanol can induce inflammation and senescence, which are both implicated in cardiovascular diseases. In this study, colchicine was used to mitigate the damaging effects of ethanol on endothelial cells. It prevented senescence, reduced oxidative stress, and inhibited the activation of NF-κB and MAPKs in ethanol-treated endothelial cells. Colchicine ameliorated the ethanol-induced molecular events, resulting in attenuated senescence and senescence-associated secretory phenotype in endothelial cells.
Review
Neurosciences
Hebatallah Qassim, Yining Zhao, Armin Stroebel, Martin Regensburger, Michael Buchfelder, Daniela Souza de Oliveira, Alessandro Del Vecchio, Thomas Kinfe
Summary: Despite available therapies, chronic facial pain remains challenging to treat. Deep brain stimulation (DBS) is considered an effective treatment option for refractory cases. A meta-analysis of seven trials showed that DBS significantly reduced pain levels after 3 months, regardless of the specific target or patient characteristics. However, the evidence is of low quality and reporting bias and placebo effects should be considered in future trials.
Article
Neurosciences
Bjoern B. Hofmann, Igor Fischer, Daniel M. Donaldson, Yousef Abusabha, Cihat Karadag, Sajjad Muhammad, Kerim Beseoglu, Daniel Haenggi, Bernd Turowski, Christian Rubbert, Jan F. Cornelius, Marcel A. Kamp
Summary: The concept of early brain injury (EBI) assumes a decrease in brain perfusion after aneurysmal subarachnoid hemorrhage (aSAH). This study investigated whether the heterogeneity of computed tomography perfusion (CTP) imaging in the EBI phase is an independent predictor of the neurological outcome after aSAH. The analysis found that microvascular perfusion heterogeneity, assessed by the heterogeneity of mean transit time (MTT) in early CTP imaging, does not appear to be an independent predictor of the neurological outcome 6 months after aSAH.
Article
Chemistry, Medicinal
Rukhsana Batool, Jahanzeb Mudassir, Mahtab Ahmad Khan, Saman Zafar, Sadia Jafar Rana, Nasir Abbas, Amjad Hussain, Muhammad Sohail Arshad, Sajjad Muhammad
Summary: The aim of this study was to prepare celecoxib-loaded chitosan/guar gum (CS/GG) hydrogel beads and evaluate their performance. The beads showed sustained drug release and exhibited potential for managing inflammatory conditions. The SC formulation demonstrated better therapeutic efficiency compared to the DC counterpart.
Review
Biochemistry & Molecular Biology
Dilaware Khan, Jan Frederick Cornelius, Sajjad Muhammad
Summary: This systematic review examines the role of NF-kappa B in the pathogenesis of intracranial aneurysms (IAs), finding that its activation is closely associated with the formation, progression, and rupture of IAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Maria Kipele, Michael Buchfelder, R. Verena Taudte, Andreas Stadlbauer, Thomas Kinfe, Yavor Bozhkov
Summary: This study utilized mass spectrometry untargeted metabolic analysis to examine hematoma samples from patients with chronic subdural hematoma (cSDH). The results showed a decrease in acylcarnitine concentrations and reduced levels of Acyl-CoA-dehydrogenases in the recurrence group. These findings suggest impaired fatty acid oxidation may play a role in cSDH recurrence.
Article
Clinical Neurology
Matthias C. Borutta, Julia Koehn, Daniela Souza de Oliveira, Alessandro Del Vecchio, Tobias Engelhorn, Stefan Schwab, Michael Buchfelder, Thomas M. Kinfe
Summary: A study found that after 4 months of adjunctive motor cortex stimulation, the pain intensity and autonomic cardiovascular parameters of chronic pain patients improved. This suggests that motor cortex stimulation can not only reduce subjective pain perception, but also improve objective measures of autonomic cardiovascular modulation.
Article
Clinical Neurology
Igor Fischer, Shafqat Rasul Chaudhry, Daniel Haenggi, Sajjad Muhammad
Summary: This study aimed to identify clusters of serum biomarkers associated with cerebral vasospasm (CVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH). By analyzing serum concentrations and clinical parameters of 66 aSAH patients, clusters of biomarkers related to CVS were identified. These biomarkers may serve as early predictors of CVS.
NEUROSURGICAL REVIEW
(2023)
Article
Critical Care Medicine
Bjoern B. Hofmann, Daniel M. Donaldson, Milad Neyazi, Yousef Abusabha, Kerim Beseoglu, Daniel Haenggi, Jan F. Cornelius, Igor Fischer, Sajjad Muhammad
Summary: This study aimed to develop a predictive scoring system for early brain injury (EBI) in aneurysmal subarachnoid hemorrhage (aSAH) to improve patient management and decision-making. The study identified seven clinical and radiological features and constructed the SHELTER scoring system, which demonstrated strong predictive performance.
NEUROCRITICAL CARE
(2023)