Article
Medicine, Research & Experimental
Giuliano De Carolis, Mery Paroli, Alessandro Dario, Emil Isagulyan, Elizaveta Makashova
Summary: The aim of this case series was to assess the safety and effectiveness of peripheral nerve stimulation (PNS) of the brachial plexus performed using a low invasive percutaneous approach with ultrasound guide. Results from an observational study showed that PNS systems of the brachial plexus implanted with percutaneous approach appear to be safe and effective in a follow-up period of 18 months.
Review
Biochemistry & Molecular Biology
Steven Char, Max Y. Jin, Vinicius Tieppo Francio, Nasir Hussain, Eric J. Wang, Mahmoud Morsi, Vwaire Orhurhu, Larry J. Prokop, Adam Fink, Ryan S. D'Souza
Summary: This review synthesized data from prospective studies on the efficacy of peripheral nerve stimulation (PNS) for neuropathic pain. The results showed that there is limited and low-quality evidence supporting the effectiveness of PNS for peripheral neuropathic pain, with modest improvement in pain and neurological function. Only PNS for phantom limb pain had moderate level evidence.
Review
Biochemistry & Molecular Biology
Vincent Yaccarino, Max Y. Jin, Alaa Abd-Elsayed, Jacob M. Kraemer, Nalini Sehgal
Summary: This article briefly introduces the evolution, mechanisms, applications, and complications of peripheral nerve stimulation. The latest technology provides new treatment options for chronic neuropathic pain of the upper extremity.
Article
Clinical Neurology
Junchi Li, Yongjie Li, Wei Shu
Summary: This study presents a case report of a 57-year-old male patient who developed post-traumatic trigeminal neuropathic pain (PTNP) and secondary hemifacial dystonia after orbital trauma. Peripheral nerve stimulation (PNS) was performed to relieve the patient's neuropathic pain and dystonia, with successful results. The findings highlight the potential benefits of PNS in treating PTNP and dystonia and discuss the underlying therapeutic mechanism.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Clayton Busch, Olivia Smith, Tristan Weaver, Jayesh Vallabh, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) is a widely used interventional pain treatment modality for chronic lower extremity pain. Despite the lack of large prospective evidence, PNS has shown potential for improving pain scores, functionality, and opioid consumption, making it a viable option for patients with chronic lower extremity pain.
Review
Anesthesiology
Jijun Xu, Zhuo Sun, Jiang Wu, Maunak Rana, Joshua Garza, Alyssa C. Zhu, Krishnan Chakravarthy, Alaa Abd-Elsayed, Ellen Rosenquist, Hersimren Basi, Paul Christo, Jianguo Cheng
Summary: PNS may be effective in managing chronic headaches, postamputation pain, chronic pelvic pain, and chronic low back and lower extremity pain.
Review
Biochemistry & Molecular Biology
Lady Christine Ong Sio, Brian Hom, Shuchita Garg, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) has been widely used for treating chronic pain, although its mechanism of action remains largely unknown. The gate control theory proposed by Melzack and Wall in the 1960s has been the mainstay for understanding its mechanism. This review article discusses the mechanism of action, safety, and effectiveness of PNS in treating chronic pain, as well as current PNS devices available in the market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Anesthesiology
Eric J. Wang, Lauren E. Berninger, Olga Komargodski, Thomas J. Smith
Summary: The evidence for neuromodulation devices for the treatment of painful diabetic neuropathy (PDN) mainly consists of open-label prospective trials or case reports. Spinal cord stimulators (SCS) have the most evidence for efficacy, while studies on transcutaneous electrical nerve stimulators (TENS) show mixed results. Peripheral nerve stimulators (PNS) and scrambler therapy devices (ST) may hold promise but require further prospective controlled trials.
Article
Medicine, Research & Experimental
Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel
Summary: Two interlinked studies examined the therapeutic LTD for chronic peripheral nerve injury pain, with the clinical trial showing non-significant results and the mechanistic study indicating improvement in mechanical hyperalgesia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Gurgen Soghoyan, Artur Biktimirov, Yury Matvienko, Ilya Chekh, Mikhail Sintsov, Mikhail A. Lebedev
Summary: By implanting stimulating electrodes near the medial, ulnar, and radial nerves in two bilateral transradial amputees, tactile and proprioceptive sensations in the phantom hand could be evoked using peripheral nerve stimulation (PNS). Both patients were able to determine the shape of invisible objects by scanning a computer tablet with a stylus while receiving feedback based on PNS or transcutaneous electrical nerve stimulation (TENS). PNS completely abolished phantom limb pain (PLP) in one patient and reduced it by 40-70% in the other. Incorporating PNS and/or TENS in active tasks is suggested to reduce PLP and restore sensations in amputees.
Review
Clinical Neurology
Haijun Li, Jinxiu Chen, Juehan Wang, Tianfang Zhang, Zuobing Chen
Summary: Brachial plexus injury (BPI) is a serious peripheral nerve injury that leads to severe and persistent impairments of the upper limb. The demand for rehabilitation treatment after BPI is increasing due to the relatively mature early diagnosis and surgical technique. Rehabilitation intervention can benefit different stages of recovery, but the treatment methods vary due to the complexity of the brachial plexus. This article explores the potential contributions of various methods to BPI rehabilitation and provides a concise overview of beneficial interventions, forming clear rehabilitation processes based on different periods and populations.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Josianna Henson, Narayana C. Varhabhatla, Zvonimir Bebic, Alan D. Kaye, R. Jason Yong, Richard D. Urman, Justin S. Merkow
Summary: Painful diabetic neuropathy is a common disease causing significant pain and disability. Spinal cord stimulation has shown moderate-quality evidence for safety and efficacy in treating this condition. Further high-quality research, including large-scale randomized controlled trials, is needed to confirm its effectiveness.
Article
Neurosciences
Hang Xian, Huan Guo, Yuan-Ying Liu, Jian-Lei Zhang, Wen-Chao Hu, Ming-Jun Yu, Rui Zhao, Rou-Gang Xie, Hang Zhang, Rui Cong
Summary: Brachial plexus avulsion (BPA) is a complex injury involving the central and peripheral nervous systems, which often leads to severe neuropathic pain (NP) in the affected limb. The existing treatments for NP are not effective, and the role of somatosensory-sympathetic coupling in BPA-induced NP remains unclear. This study discovered that peripheral BDNF plays a key role in regulating somatosensory-sympathetic coupling in BPA-induced NP, and it also identified BDNF as a potential analgesic target for the treatment of this pain.
NEUROSCIENCE BULLETIN
(2023)
Review
Medicine, Research & Experimental
Yuncheng Ni, Liuqing Yang, Rui Han, Gangwen Guo, Shitong Huang, Lili Weng, Xun Wang, Zhenxing Li, Dong Huang, Rong Hu, Haocheng Zhou
Summary: Implantable peripheral nerve stimulation shows promise in managing trigeminal neuropathic pain, with better clinical outcomes associated with stimulation of the trigeminal peripheral branch.
Article
Clinical Neurology
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Michelle Paff, Samuelle-Arianne Villeneuve, Artur Vetkas, Kazuaki Yamamoto, Nardin Samuel, Vanessa Milano, Aaron Loh, Brendan Santyr, Ajmal Zemmar, Andres M. Lozano, Mojgan Hodaie
Summary: This study systematically reviewed the literature on peripheral nerve field stimulation (PNFS) for trigeminal pain and found that PNFS can provide effective long-term pain control for patients with trigeminal pain.
JOURNAL OF NEUROSURGERY
(2022)
Article
Medicine, Research & Experimental
Lisa Goudman, Ann De Smedt, Frederic Louis, Virginie Stalmans, Bengt Linderoth, Philippe Rigoard, Maarten Moens
Summary: This study showed that spinal cord stimulation (SCS) significantly reduced back and leg pain intensity in patients with Failed Back Surgery Syndrome (FBSS), and also significantly decreased heart rate and respiration rate. However, skin conductance level and blood volume pulse did not change between SCS on and off states.
Article
Nursing
Marion Dumain, Pauline Jaglin, Chantal Wood, Pierre Rainville, Benjamin Pageaux, Anaick Perrochon, Martin Lavalliere, Tanguy Vendeuvre, Romain David, Pascaline Langlois, Noelle Cardinaud, Achille Tchalla, Philippe Rigoard, Maxime Billot
Summary: This study aimed to evaluate the effectiveness of home-care hypnosis in elderly participants with chronic pain over a 12-month period. The results showed that seven sessions of 15-minute hypnosis significantly decreased pain perception and pain interference. Hypnosis could be considered as an effective additional method for health practitioners to manage chronic pain in the elderly population.
PAIN MANAGEMENT NURSING
(2022)
Article
Medicine, Research & Experimental
Lisa Goudman, Maxime Billot, Rui Duarte, Sam Eldabe, Philippe Rigoard, Maarten Moens
Summary: The aim of this study is to evaluate which measures should be included in a composite outcome and develop a new composite outcome to evaluate the degree of being a clinical holistic responder. Data from patients with persistent spinal pain syndrome type 2 were used, and various measures including pain intensity, disability, health-related quality of life, medication use, and patient satisfaction were evaluated. A new composite outcome was developed and the minimal clinical important difference (MCID) was determined.
Article
Medicine, Research & Experimental
Lisa Goudman, Philippe Rigoard, Maxime Billot, Ann De Smedt, Manuel Roulaud, Maarten Moens
Summary: This study found that it is not possible to distinguish between SCS-naive patients and patients with previous SCS experience based on routine clinical parameters, which has significant implications for research and clinical settings.
Article
Rehabilitation
Marjorie Salga, Laure Gatin, Thierry Deltombe, Thierry Gustin, Stefano Carda, Philippe Marque, Paul Winston, Rajiv Reebye, Theodore Wein, Alberto Esquenazi, Mary-Ann Keenan, Franco Molteni, Paolo Zerbinati, Alessandro Picelli, Flavia Coroian, Bertrand Coulet, Nadine Sturbois-Nachef, Christian Fontaine, Alain Yelnik, Bernard Parratte, Prakash Henry, Srikant Venkatakrishnan, Philippe Rigoard, Romain David, Philippe Denormandie, Alexis Schnitzler, Etienne Allart, Francois Genet
Summary: International recommendations for the management of spastic equinovarus foot deformity were established through the Delphi method. It is recommended to assess the impact of the deformity on functional activities and differentiate between muscle overactivity and soft tissue contractures. The treatment approach depends on the correctability of the deformity and the patient's ability to stand or walk. Preoperative assessment should involve interdisciplinary consultations to define personalized goals before surgery.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Philippe Rigoard, Amine Ounajim, Lisa Goudman, Chantal Wood, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Emmanuel Cuny, Jimmy Voirin, Denys Fontaine, Sylvie Raoul, Patrick Mertens, Philippe Peruzzi, Francois Caire, Nadia Buisset, Romain David, Maarten Moens, Maxime Billot
Summary: This study evaluates the performance of spinal cord stimulation (SCS) during surgery and finds that awake anesthesia (AA) has better outcomes in terms of pain coverage, pain surface area, and pain intensity compared to general anesthesia. Additionally, AA leads to improved secondary outcomes such as quality of life, functional disability, and depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Aurelie Leplus, Michel Lanteri-Minet, Anne Donnet, Nelly Darmon, Jean Regis, Denys Fontaine
Summary: This study aims to evaluate the feasibility and safety of combining ACC-DBS and thalamic DBS for the treatment of refractory chronic unilateral neuropathic pain. It will assess the efficacy of this combination therapy compared to thalamic DBS alone, and evaluate the safety through neurological, psychiatric, cognitive, and affective function assessments.
Article
Public, Environmental & Occupational Health
Maarten Moens, Rui V. V. Duarte, Ann De Smedt, Koen Putman, Jonas Callens, Maxime Billot, Manuel Roulaud, Philippe Rigoard, Lisa Goudman
Summary: The quality of life of post-COVID-19 infected persons is severely impacted, with symptoms of pain, fatigue, and limitations in daily activities. Their quality of life is lower compared to the general population and patients with chronic pain, but better compared to patients with chronic pain after spinal surgery.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Maarten Moens, William Alliet, Maxime Billot, Ann De Smedt, Panagiotis Flamee, Domien Vanhonacker, Manuel Roulaud, Philippe Rigoard, Lisa Goudman
Summary: The goals of representatives of neuromodulation device manufacturers focus on building good relationships with physicians and providing excellent service for patients. Pain control, quality of life, and patient satisfaction are important factors for company representatives.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Medicine, Research & Experimental
Philippe Rigoard, Konstantin Slavin
Article
Multidisciplinary Sciences
Maxime Billot, Julien Duclay, Philippe Rigoard, Romain David, Alain Martin
Summary: This study compares the mechanical impact of antagonist torque in eccentric, isometric, and concentric contractions in PF and DF MVCs. The results show that the antagonist torque underestimates the agonist torque, and the antagonist torque varies with muscle contraction type. Estimating the antagonist torque in isometric or anisometric conditions provides insights to improve neuromuscular performance assessment and design strength training and rehabilitation programs.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
L. Goudman, J. G. Pilitsis, B. Billet, R. De Vos, K. Hanssens, M. Billot, M. Roulaud, P. Rigoard, M. Moens
Summary: This study examines the interchangeability of numerical rating scale and visual analogue scale in adults with chronic pain, and finds differences and lack of sufficient agreement between the two scales in measuring pain intensity.
Article
Medicine, General & Internal
Philippe Rigoard, Manuel Roulaud, Lisa Goudman, Nihel Adjali, Amine Ounajim, Jimmy Voirin, Christophe Perruchoud, Benedicte Bouche, Philippe Page, Remy Guillevin, Mathieu Naudin, Martin Simoneau, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Iona Maitre, Raphael Rigoard, Romain David, Maarten Moens, Maxime Billot
Summary: BOOST DRG is a study comparing SCS, DRGS, and SCS+DRGS to evaluate the effects of different stimulation modalities on pain symptoms, quality of life, and functional disability in PSPS-T2 patients.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Maarten Moens, Julie Jansen, Ann De Smedt, Manuel Roulaud, Maxime Billot, Jorne Laton, Philippe Rigoard, Lisa Goudman
Summary: Chronic pain is a difficult condition to manage, and a biopsychosocial approach seems to be the most beneficial. Medication is the most common treatment for chronic pain, but often comes with side effects. Therefore, nonpharmacological therapies, such as psychological interventions, are being emphasized. Research has shown that resilience is an important aspect in coping with chronic pain.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Chantal Wood, Gaelle Martine, Gaelle Espagne-Dubreuilh, Karine Le Goff, Maarten Moens, Lisa Goudman, Sandrine Baron, Romain David, Nicolas Naiditch, Maxime Billot, Philippe Rigoard
Summary: Combining intraoperative hypnosis with awake anesthesia can improve the effectiveness of spinal cord stimulation lead implantation. It enhances patient cooperation, allows optimization of lead positioning, and leads to better pain control, positive and resourceful memory.
MEDICINA-LITHUANIA
(2022)