Article
Urology & Nephrology
Jacqueline Zillioux, Kevin C. Lewis, Daniel Hettel, Howard B. Goldman, Sandip P. Vasavada, Bradley C. Gill
Summary: This study aimed to evaluate the impact of cognitive impairment (CI) diagnoses on sacral neuromodulation (SNM) outcomes in older patients with overactive bladder (OAB). The study found that a diagnosis of CI does not affect the implantation rates of SNM therapy for refractory OAB. Therefore, patients with OAB and CI diagnoses should not be excluded from SNM therapy.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Engineering, Biomedical
A. Giannotti, S. Lo Vecchio, S. Musco, L. Pollina, F. Vallone, I. Strauss, V. Paggi, F. Bernini, K. Gabisonia, L. Carlucci, C. Lenzi, A. Pirone, E. Giannessi, V. Miragliotta, S. Lacour, G. Del Popolo, S. Moccia, S. Micera
Summary: In this study, a conditional closed-loop stimulation paradigm was used to improve bladder capacity and voiding efficacy, addressing the current limitations of lacking robust and real-time decoding strategies for bladder fullness state.
APL BIOENGINEERING
(2023)
Article
Neurosciences
Nastaran Majdinasab, Neda Orakifar, Leila Kouti, Gholamreza Shamsaei, Maryam Seyedtabib, Mohammad Jafari
Summary: This study compared the effects of solifenacin (SS) and posterior tibial nerve stimulation (PTNS) treatments in multiple sclerosis (MS) patients with overactive bladder (OAB). The results showed that the SS group had better improvement in urinary incontinence after 12 weeks, higher treatment satisfaction, and decreased daytime frequency compared to the PTNS group. In conclusion, SS was more effective in improving OAB symptoms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Urology & Nephrology
Mathieu Fourel, Samy Hafez, Nassima Ramdane, Marie-Aimee Perrouin-Verbe, Stefan De Wachter, Patrick Vermersch, Xavier Biardeau
Summary: This study assessed the correlation between the response to TTNS and subsequent response to SNM in the treatment of overactive bladder. The results showed that the response to TTNS does not predict the response to SNM. Therefore, TTNS and SNM should be considered as separate therapies in the treatment of overactive bladder.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Multidisciplinary Sciences
Robert F. Hoey, Daniel Medina-Aguinaga, Fahmi Khalifa, Beatrice Ugiliweneza, Sharon Zdunowski, Jason Fell, Ahmed Naglah, Ayman S. El-Baz, April N. Herrity, Susan J. Harkema, Charles H. Hubscher
Summary: Spinal cord epidural stimulation (scES) was used to identify parameters for bladder and bowel activity in rats, showing frequency-dependent effects with differences based on neurological intactness and sex. A custom-designed electrode array exhibited similar urinary effects over a smaller surface area.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Robert F. Hoey, Daniel Medina-Aguinaga, Fahmi Khalifa, Beatrice Ugiliweneza, Dengzhi Wang, Sharon Zdunowski, Jason Fell, Ahmed Naglah, Ayman S. El-Baz, April N. Herrity, Susan J. Harkema, Charles H. Hubscher
Summary: Pre-clinical studies have shown that spinal cord epidural stimulation (scES) at different levels of nerve inputs/outputs can alter bladder and bowel functions. This study found that T13-L2 scES can increase inter-contraction interval (ICI) in non-injured female rats and induce short-latency voiding in chronic T9 transected rats. It also increased bladder activity while inhibiting the external urethral sphincter, but did not elevate detrusor pressure. Optimization of scES for bladder and bowel will likely require targeting different locations and circuitries.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Lingfeng Meng, Zijian Tian, Yaoguang Zhang, Jianye Wang, Limin Liao, Guoqing Chen, Xiaojun Tian, Lulin Ma, Yan Li, Benkang Shi, Yong Zhang, Qing Ling, Peng Zhang, Zhongqing Wei, Tie Zhong, Zhihui Xu, Jiayi Li, Deyi Luo
Summary: This study evaluated the clinical outcomes of different sacral neuromodulation systems (InterStim and BetterStim) in the treatment of overactive bladder. The results showed that both systems were effective in improving voiding frequency, urinary leakage, and quality of life. However, the InterStim system may be more beneficial for patients with dry overactive bladder, while the BetterStim system may be more suitable for patients with wet overactive bladder.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Ding-Yuan Yang, Liu-Ni Zhao, Ming-Xing Qiu
Summary: Transcutaneous tibial nerve stimulation (TTNS) and percutaneous tibial nerve stimulation (PTNS) showed similar efficacy in treating overactive bladder, with no significant differences in voiding frequency, urgency episodes, incontinence episodes, nocturia frequency, HRQL scores, and incontinence quality of life scores between the two groups. The total complication rate was low, and no adverse events were reported in the TTNS group.
Article
Anesthesiology
Kai-kai Guo, Long Wang, Fang Liu, Jie-jie Niu, Chao Wang, Shao-hua You, Ze-guo Feng, Gui-jun Lu
Summary: SNS can effectively alleviate pain severity, improve quality of life, and prolong sleep duration in patients with refractory PN.
Article
Neurosciences
Xue Jin, Payam Gharibani, Jieyun Yin, Jiande D. Z. Chen
Summary: Sacral nerve stimulation can improve visceral hypersensitivity in rats by reducing mast cell overactivation, thus alleviating pain symptoms in the rodents.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Rafael Moreta-Martinez, Ines Rubio-Perez, Monica Garcia-Sevilla, Laura Garcia-Elcano, Javier Pascau
Summary: This study proposes and evaluates two navigation systems for guiding electrode placement in sacral nerve stimulation (SNS) surgeries. Both navigation methods demonstrate better results than the standard clinical method in terms of reducing surgical time, minimizing patient discomfort, and improving surgical outcomes.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Medicine, General & Internal
Ximeng Wang, Jiande D. Z. Chen
Summary: The systematic review aims to introduce the clinical applications and potential mechanisms of sacral nerve stimulation (SNS) for various gastrointestinal diseases. The results showed that SNS is highly effective in treating fecal incontinence, but it is ineffective for constipation. Further research is needed to explore the potential applications of SNS for irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2023)
Review
Urology & Nephrology
Luis Lopez-Fando, Paulina Bueno, David Carracedo, Marcio Averbeck, David M. Castro-Diaz, Emmanuel Chartier-Kastler, Francisco Cruz, Roger Dmochowski, Enrico Finazzi-Agro, Sakineh Hajebrahimi, John Heesakkers, George Kasyan, Tufan Tarcan, Benoit Peyronnet, Mauricio Plata, Barbara Padilla-Fernandez, Frank Van Der Aa, Salvador Arlandis, Hashim Hashim
EUROPEAN UROLOGY FOCUS
(2020)
Article
Urology & Nephrology
Emmanuel Chartier-Kastler, Loic Le Normand, Alain Ruffion, Francois Dargent, Raissa Braguet, Christian Saussine, Yves Tanneau, Jean Pierre Graziana, Evelyne Ragni, Bertrand Rabut, Thierry Rousseau, Xavier Biardeau, Xavier Game, Jean Pierrevelcin, Elena Brassart, Marc Fourmarier, Gabriel Stoica, Nathalie Berrogain, Najdat Yaghi, Francois Pecoux, Gregoire Capon, Jerome Ferchaud, Laurence Peyrat, Pierre Emmanuel Bryckaert, Gilles Karsenty, Alice Melotti, Abdallah Abouihia, David Urs Josef Keller, Jean-Nicolas Cornu
Summary: This study evaluated the real-life effectiveness, quality of life, and safety of SNM with the InterStim system in patients with lower urinary tract dysfunctions. The results showed significant improvements in symptoms and quality of life for OAB patients, but also highlighted the risk of revisions.
EUROPEAN UROLOGY FOCUS
(2021)
Editorial Material
Urology & Nephrology
E. Chartier-Kastler, C. Guillot-Tantay, V. Phe
PROGRES EN UROLOGIE
(2021)
Letter
Urology & Nephrology
A. Tsilanizara, L. Karila, C. Sallee, P. Denys, A. Fechner, K. Benistan, V. Cardot, X. Deffieux
PROGRES EN UROLOGIE
(2021)
Review
Clinical Neurology
P. Denys, E. Chartier-Kastler, A. Even, C. Joussain
Summary: Neurogenic bladder and sexual dysfunction are common after spinal cord lesions, with treatment goals focusing on preventing complications and improving quality of life. Patients often prioritize addressing sexual dysfunction within the first year post-injury.
REVUE NEUROLOGIQUE
(2021)
Article
Health Care Sciences & Services
Stephane Sanchez, Isabelle Adamowicz, Jan Chrusciel, Philippe Denormandie, Pierre Denys, Laurent Degos
Summary: The study described the profile of patients seeking a second medical opinion in France, finding that gynecological, urological, and respiratory diseases had higher probabilities of divergent opinions. Complex cases were also associated with a higher risk of divergent opinions, while factors such as age and sex were not predictive of divergent opinions.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Urology & Nephrology
Claire Hentzen, Xavier Biardeau, Nicolas Turmel, Rebecca Haddad, Elsa Bey, Gerard Amarenco, Pierre Denys, Veronique Phe, Marie Aimee Perrouin-Verbe, Benoit Peyronnet, Charles Joussain
Summary: This study established guidelines for the management of neurogenic lower urinary tract dysfunction, prioritizing clinical situations based on risk assessment and expert opinions. The recommendations complement existing guidelines and assist clinicians in reorganizing patient lists in the long term with a personalized medicine approach.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Andrology
Celine Chalas, Lea Jilet, Jean-Philippe Wolf, Veronique Drouineaud, Hendy Abdoul, Catherine Patrat, Pierre Denys, Francois Giuliano
Summary: The study found that in spinal cord injury patients, although there were some abnormalities in semen quality, there was no significant decline observed over time. Additionally, chronic genital inflammatory status did not impact semen quality.
Article
Food Science & Technology
Jacquie Maignel, Vincent Martin, Rana Assaly, Mathieu L. Vogt, Kevin Retailleau, Fraser Hornby, Alexandra Laugerotte, Stephane Lezmi, Pierre Denys, Johannes Krupp, Charles Joussain
Summary: This study reveals the mechanisms of secondary failure of BoNT/A1 in NDO through functional and structural analysis, showing a lower sensitivity to the toxin ex vivo and the presence of residual c-SNAP25 in detrusor from toxin-secondary failure patients. The study suggests that the escape from BoNT/A1 efficacy in NDO occurs at least at the parasympathetic level and could involve compensatory mechanisms for detrusor contraction.
Article
Urology & Nephrology
Michael Kennelly, Francisco Cruz, Sender Herschorn, Paul Abrams, Kadir Onem, Viktor Kibanov Solomonov, Elena del Rosario Figueroa Coz, Andrei Manu-Marin, Antonella Giannantoni, Catherine Thompson, Claire Vilain, Magali Volteau, Pierre Denys
Summary: This study assessed the efficacy and safety of abobotulinumtoxinA (aboBoNT-A) for patients with neurogenic detrusor overactivity incontinence (NDOI). The results showed that aboBoNT-A can effectively reduce the episodes of NDOI and improve patients' quality of life.
Article
Food Science & Technology
Francois Giuliano, Pierre Denys, Charles Joussain
Summary: This study aimed to evaluate the safety and effectiveness of incobotulinumtoxinA intracavernosal injection (ICI) as an add-on therapy for erectile dysfunction (ED). The results showed that incobotulinumtoxinA ICI has a certain efficacy and safety in ED patients who did not respond sufficiently to standard treatment.
Article
Oncology
Elliott Diamant, Mathieu Roumiguie, Alexandre Ingels, Jerome Parra, Dimitri Vordos, Anne-Sophie Bajeot, Emmanuel Chartier-Kastler, Michel Soulie, Alexandre de la Taille, Morgan Roupret, Thomas Seisen
Summary: There is conflicting evidence regarding the use of early radical cystectomy (eRC) for high-risk non-muscle-invasive bladder cancer. This study compared the perioperative and oncological outcomes between upfront and delayed eRC. The results showed similar perioperative outcomes between the two groups, but an increased risk of upstaging after upfront eRC, which did not impact survival. Further research is needed to determine which patients might benefit from upfront eRC.
Article
Urology & Nephrology
Pierre Denys, Juan Carlos Castano Botero, Ricardo Luis Vita Nunes, Barton Wachs, Cristiano Mendes Gomes, Grigory Krivoborodov, Le Mai Tu, Giulio Del-Popolo, Catherine Thompson, Claire Vilain, Magali Volteau, Michael Kennelly
Summary: This study aimed to evaluate the efficacy and safety of AboBoNT-A in patients with neurogenic detrusor overactivity incontinence. The results showed that AboBoNT-A significantly reduced the episodes of incontinence, improved bladder function and quality of life.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Food Science & Technology
Francois Giuliano, Pierre Denys, Charles Joussain
Summary: Intracavernosal injections of botulinum toxin A (BTX/A ic) may be effective for difficult-to-treat erectile dysfunction (ED). This retrospective case series study evaluated the effectiveness of repeated off-label BTX/A ic in men with ED and insufficient response to PDE5-Is or PGE1 ICIs. Out of 216 men treated, 92 requested at least a second injection. The overall response rate was 77.5%, with higher rates observed in men with mild ED and with repeated injections.
Article
Urology & Nephrology
Emmanuel Chartier-Kastler, Loic Le Normand, Alain Ruffion, Christian Saussine, Raissa Braguet, Bertrand Rabut, Evelyne Ragni, Marie-Aimee Perrouin-Verbe, Jean Pierrevelcin, Thierry Rousseau, Xavier Game, Yves Tanneau, Francois Dargent, Xavier Biardeau, Jean Pierre Graziana, Gabriel Stoica, Elena Brassart, Marc Fourmarier, Najdat Yaghi, Gregoire Capon, Jerome Ferchaud, Nathalie Berrogain, Laurence Peyrat, Francois Pecoux, Pierre-Emmanuel Bryckaert, Alice Melotti, Abdallah Abouihia, David Urs Josef Keller, Jean-Nicolas Cornu
Summary: This study confirms the safety and effectiveness of sacral neuromodulation (SNM) for overactive bladder (OAB) through real-world data. The study showed that SNM with the InterStim system significantly reduced voids and leaks, improved quality of life (QoL), and decreased symptom bother for up to 3 years after implantation.
EUROPEAN UROLOGY FOCUS
(2022)
