Article
Chemistry, Medicinal
Shiou-Shiow Farn, Kang-Wei Chang, Wan-Chi Lin, Hung-Man Yu, Kun-Liang Lin, Yu-Chin Tseng, Yu Chang, Chung-Shan Yu, Wuu-Jyh Lin
Summary: Novel PET tracer IPCAT-NOTA 24 was successfully synthesized with high radiochemical yield and specific activity, showing promising stability and binding affinity in biological studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Waijiao Cai, Kazumasa Wakamatsu, Fabio A. Zucca, Qing Wang, Kai Yang, Niyaz Mohamadzadehonarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella, Shosuke Ito, Luigi Zecca, Xiqun Chen
Summary: By studying samples of substantia nigra from patients with Parkinson's disease, we found increased ratios of pheomelanin to dopamine in the melanin content, as well as reduced levels of eumelanins derived from both DOPA and dopamine. Additionally, an increase in pheomelanin relative to dopamine pheomelanin was observed in Parkinson's disease. These findings provide insights into the roles of pheomelanin and eumelanin in the pathophysiology of Parkinson's disease.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Rehabilitation
Juliana M. P. Toldo, Michelly Arjona, Guilherme C. Campos Neto, Taise Vitor, Solange Amorim Nogueira, Edson Amaro, Roberta A. Saba, Sonia M. C. A. Silva, Henrique B. Ferraz, Andre C. Felicio
Summary: The study demonstrated that a virtual rehabilitation protocol for patients with Parkinson's disease led to an increase in dopamine transporters in the putamen contralateral to the clinically most affected body side, as well as significant improvement in motor symptoms and quality of life.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Neurosciences
Thea P. Lillethorup, Ove Noer, Aage Kristian Olsen Alstrup, Caroline C. Real, Kathrine Stokholm, Majken Borup Thomsen, Hamed Zaer, Dariusz Orlowski, Trine Werenberg Mikkelsen, Andreas N. Glud, Erik Holm Toustrup Nielsen, Anna C. Schacht, Michael Winterdahl, David J. Brooks, Jens Christian H. Sorensen, Anne M. Landau
Summary: This study investigates the temporal evolution of presynaptic dopaminergic function in the Gottingen minipig after injections of MPTP. The results show mild bradykinesia and impaired coordination in the minipigs at early timepoints after MPTP injection, as well as decreases in dopamine uptake with partial spontaneous recovery after 10 months.
Article
Clinical Neurology
Seong Ho Jeong, Hye Sun Lee, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigates the influence of nigrostriatal dopaminergic degeneration on longitudinal outcomes in Parkinson's disease (PD) according to sex. It reveals that there are differences in the severity of dopamine transporter (DAT) availability and the risk of developing levodopa-induced dyskinesia (LID) and PD dementia (PDD) between male and female PD patients.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Summary: This study aimed to understand the development of dysphagia in patients with Parkinson's disease (PD) and identify potential target regions for neuromodulation by analyzing the distribution of dopamine transporter availability in the striatum. The results showed that decreased dopamine transporter availability in specific subregions of the striatum may explain the dysphagia in PD, particularly in the pharyngeal phase.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Zhaoying Dong, Rui Zuo, Xiaoni Zhong, Changhong Zhang, Xiaoya Zou, Yuan Tian, Hongzhou Zuo, Xinyi Du, Qian Yu, Oumei Cheng
Summary: There is no evidence that antihypertensive drugs can delay the progression of Parkinson's disease within 2 years.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elon D. Wallert, Elsmarieke van de Giessen, Remco J. J. Knol, Martijn Beudel, Rob M. A. de Bie, Jan Booij
Summary: Imaging of dopaminergic transmission plays a crucial role in the diagnosis and research of neurodegenerative disorders. It provides high diagnostic accuracy in detecting nigrostriatal degeneration in diseases such as Parkinson's disease and dementia with Lewy bodies. Additionally, it helps in studying the preclinical and premotor phases of these disorders and examining different subtypes of Parkinson's disease. Imaging also aids in understanding the neuronal substrates of impulse control disorders and measuring endogenous dopamine release in the treatment of Parkinson's disease.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Eve Privman Champaloux, Nathan Donelson, Poojan Pyakurel, Danielle Wolin, Leah Ostendorf, Madelaine Denno, Ryan Borman, Chris Burke, Jonah C. Short-Miller, Maria R. Yoder, Jeffrey M. Copeland, Subhabrata Sanyal, B. Jill Venton
Summary: Recent research shows that RNF11 plays a critical role in dopamine neurotransmission, with RNF11 knockdown significantly increasing dopamine release and overexpression having no effect on dopamine levels. This study demonstrates for the first time that RNF11 affects both dopamine release and uptake.
Article
Radiology, Nuclear Medicine & Medical Imaging
Carlos Juri, Vasko Kramer, Patrick J. Riss, Cristian Soza-Ried, Arlette Haeger, Rossana Pruzzo, Frank Rosch, Horacio Amaral, Pedro Chana-Cuevas
Summary: The study utilized [F-18]PR04.MZ PET/CT scans in healthy controls, early PD patients, and moderate-advanced PD patients, revealing a reduction in specific binding of dopamine transporter in PD patients with patterns of involvement in striatum and substantia nigra, correlating with motor symptoms.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Neurosciences
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin
Summary: In this study, a mouse maternal infection model was used to investigate the impact of maternal herpesvirus infection on the development and physiology of midbrain dopaminergic neurons in adult offspring. The results suggested that maternal infection with Herpesviridae, specifically MHV68, can trigger changes in midbrain development that affect dopamine neuron physiology in adulthood. This study is important for understanding the neuronal susceptibility underlying neurodegenerative diseases, particularly Parkinson's disease.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Da Hyun Lee, Chong Hyun Suh, Minjae Kim, Woo Hyun Shim, Sang Joon Kim
Summary: Loss of nigral hyperintensity on SWI can accurately differentiate idiopathic Parkinson's disease or primary parkinsonism from a healthy/disease control group. However, the proportion of non-diagnostic scans is not negligible and must be considered.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Mali Gamez Tansey, Habibeh Khoshbouei
Summary: Our understanding of the role of immune cell function in brain health and neurodegenerative diseases is still limited. Inflammation and immune dysfunction play a significant part in Parkinson's disease, affecting both motor and non-motor symptoms. The outdated notion of the central nervous system being an immune-privileged organ has been debunked, as the immune system in the brain can influence peripheral systems and vice versa. Identifying immune and inflammatory pathways that compromise neuronal health is crucial for designing effective strategies to mitigate their detrimental effects.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Jamie van Son, Katy A. van Galen, Anne Marijn Bruijn, Karin E. Koopman, Ruth I. Versteeg, Susanne E. la Fleur, Mireille J. Serlie, Jan Booij
Summary: Food craving is increased in obesity, but the scores for food craving are not significantly related to changes in striatal DAT availability.
Article
Neurosciences
Rui-Fang Wang, Yan-Peng Li, Han-Yue Zhang, Sha-Sha Xu, Zhuo Wang, Xing-Min Han, Bao-Ping Liu
Summary: The purpose of this study was to evaluate the association between sleep benefit (SB) phenomenon in Parkinson's disease (PD) patients and dopamine transporter (DAT) expression levels in the striatum. The results showed significant differences in clinical variables, sleep scores, and striatum DAT expression levels between SB and nSB groups. The DAT expression level in the putamen could predict the occurrence of SB phenomenon in PD patients.
Article
Psychology, Clinical
Nikolina Skandali, Joonas Majuri, Juho Joutsa, Kwangyeol Baek, Eveliina Arponen, Sarita Forsback, Valtteri Kaasinen, Valerie Voon
Summary: This study adopted a transdiagnostic approach to delineate the neurochemical substrates of decision making under risk. The findings show distinct neurochemical substrates underlying risk-taking behavior, with dorsal cingulate cortex mu-opioid receptor binding associated with rewards and dorsal striatal serotonin transporter binding associated with losses. Risk-taking and goal-directed control appear to dissociate between dorsal and ventral fronto-striatal systems.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Ning Wang, Vladislav Lysenkov, Katri Orte, Veli Kairisto, Juhani Aakko, Sofia Khan, Laura L. Elo
Summary: This article presents a comparative study of variant calling tools for indel calling and highlights the importance of choosing the right tool for accurate and reliable detection of indels. It also emphasizes the need for NGS technologies with long read length and high coverage in combination with specific variant calling tools to effectively detect indels.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Oncology
Eva-Maria Talvitie, Lassi Liljeroos, Heikki Vilhonen, Katri Orte, Ilmo Leivo, Markku Kallajoki, Pekka Taimen
Summary: This study aimed to assess the frequency of gene alterations in Finnish patients with lung adenocarcinoma and investigate their association with patient outcomes. The results showed that over two thirds of the patients in the overall cohort had actionable genomic alterations or signatures, with a higher percentage in never-smokers. Any alteration in SMARCA4 was found to be associated with shortened survival, regardless of the alteration type.
Article
Biochemistry & Molecular Biology
Valtteri Kaasinen, Emma A. Honkanen, Kari Lindholm, Elina Jaakkola, Joonas Majuri, Riitta Parkkola, Tommi Noponen, Tero Vahlberg, Valerie Voon, Luke Clark, Juho Joutsa, Marko Seppanen
Summary: Gambling disorder is a major public health issue, and it shares similarities with substance use disorders in terms of the role of brain monoamines in addiction susceptibility and outcome. The study used [I-123]FP-CIT SPECT imaging to assess the roles of striatal dopamine transporter binding and extrastriatal serotonin transporter binding in gambling disorder, and found that patients with gambling disorder had higher impulsivity scores and higher binding in the ventromedial prefrontal cortex, likely reflecting serotonin transporter activity.
Article
Clinical Neurology
Valtteri Kaasinen, Sheng Luo, Pablo Martinez-Martin, Christopher G. G. Goetz, Glenn T. T. Stebbins
Summary: This study compared patient and clinician evaluations of levodopa-induced dyskinesia (LID) severity across multiple cultures in patients with Parkinson's disease (PD). The results showed that language and cultural differences influence the subjective perception of LID, which is important to consider in multinational clinical trials on dyskinesia assessment.
MOVEMENT DISORDERS
(2023)
Article
Computer Science, Information Systems
Ilkka Suuronen, Antti Airola, Tapio Pahikkala, Mika Murtojarvi, Valtteri Kaasinen, Henry Railo
Summary: Early detection plays a crucial role in future neuroprotective treatments for Parkinson's disease (PD). Resting state electroencephalographic (EEG) recording has the potential to be a cost-effective method for detecting neurological disorders such as PD. This study explored the impact of the number and placement of electrodes on classifying PD patients and healthy controls using machine learning based on EEG sample entropy. The results indicate that a small subset of electrodes placed in different areas of the brain can achieve classification performance comparable to using a full set of electrodes.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Letter
Environmental Sciences
Isabell Katharina Rumrich, Valtteri Kaasinen, Otto Hanninen Kuopio, Sirpa Hartikainen, Anna-Maija Tolppanen
ENVIRONMENT INTERNATIONAL
(2023)
Article
Clinical Neurology
Jussi O. T. Sipila, Laura Kytovuori, Valtteri Kaasinen
Summary: Genotype-phenotype correlation data on Wilson's disease in Caucasian patients of all ages are limited. A retrospective cohort study was conducted in Finnish patients and found that there were no differences in symptoms at diagnosis between homozygous and compound heterozygous patients. However, homozygous patients were diagnosed at an earlier age. Severe liver affliction was mostly associated with a specific genetic variant.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Behavioral Sciences
Kirsi Murtomaki, Juho Joutsa, Tuomas Mertsalmi, Elina Jaakkola, Elina Makinen, Reeta Levo, Mikael Eklund, Simo Nuuttila, Eero Pekkonen, Tommi Noponen, Toni Ihalainen, Valtteri Kaasinen, Filip Scheperjans
Summary: In this study, it was found that Parkinson's disease patients with irritable bowel syndrome (IBS) had higher I-1(2)3-FP-CIT binding in the right posterior putamen and adjacent areas. No other significant associations were found between gastrointestinal symptoms and DAT or SERT binding.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Jussi O. T. Sipila, Laura Kytovuori, Tuomas Rauramaa, Hugo Rauhamaa, Valtteri Kaasinen, Kari Majamaa
Summary: Several heterozygous variants of the GBA1 gene have been linked to increased risk of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1-associated PD is more severe than idiopathic PD, and more severe variants are associated with worse clinical phenotypes. A family with a heterozygous p.Pro454Leu variant in GBA1 is reported, which is associated with a diverse range of severe and rapidly progressive neurodegenerative diseases with Lewy bodies. Pathogenicity prediction algorithms and evolutionary analyses suggest that p.Pro454Leu is deleterious.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Dani Flinkman, Ye Hong, Jelena Gnjatovic, Prasannakumar Deshpande, Zsuzsanna Ortutay, Sirkku Peltonen, Valtteri Kaasinen, Peter James, Eleanor Coffey
Summary: Deficits in protein synthesis are associated with Parkinson's disease (PD). We conducted a study to identify the specific proteins affected and differences in synthesis between sporadic and LRRK2-G2019S PD patients. Through proteomic analysis, we found that regulators of endo-lysosomal sorting, mRNA processing, and components of the translation machinery were consistently low in both sporadic and LRRK2-G2019S PD patients. This study provides valuable insights into the dysregulation of proteostasis in PD.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Emma A. Honkanen, Jaana Roenkae, Eero Pekkonen, Juho Aaltonen, Maija Koivu, Olli Eskola, Hazem Eldebakey, Jens Volkmann, Valtteri Kaasinen, Martin M. Reich, Juho Joutsa
Summary: Deep brain stimulation (DBS) of the globus pallidus interna (GPi) can significantly improve symptoms of cervical dystonia. This study used brain metabolic imaging to investigate the effects of GPi-DBS on brain metabolism in cervical dystonia. The results showed that GPi-DBS increases metabolic activity at the stimulation site and is related to modulation of specific networks. The study also found a strong correlation between stimulation amplitude and metabolic activity.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Eva-Juliane Vollstedt, Harutyun Madoev, Anna Aasly, Azlina Ahmad-Annuar, Bashayer Al-Mubarak, Roy N. Alcalay, Victoria Alvarez, Ignacio Amorin, Grazia Annesi, David Arkadir, Soraya Bardien, Roger A. Barker, Melinda Barkhuizen, A. Nazli Basak, Vincenzo Bonifati, Agnita Boon, Laura Brighina, Kathrin Brockmann, Andrea Carmine Belin, Jonathan Carr, Jordi Clarimon, Mario Cornejo-Olivas, Leonor Correia Guedes, Jean-Christophe Corvol, David Crosiers, Joana Damasio, Parimal Das, Patricia de Carvalho Aguiar, Anna De Rosa, Jolanta Dorszewska, Sibel Ertan, Rosangela Ferese, Joaquim Ferreira, Emilia Gatto, Gencer Genc, Nir Giladi, Pilar Gomez-Garre, Hasmet Hanagasi, Nobutaka Hattori, Faycal Hentati, Dorota Hoffman-Zacharska, Sergey N. Illarioshkin, Joseph Jankovic, Silvia Jesus, Valtteri Kaasinen, Anneke Kievit, Peter Klivenyi, Vladimir Kostic, Dariusz Koziorowski, Andrea A. Kuehn, Anthony E. Lang, Shen-Yang Lim, Chin-Hsien Lin, Katja Lohmann, Vladana Markovic, Mika Henrik Martikainen, George Mellick, Marcelo Merello, Lukasz Milanowski, Pablo Mir, Oezguer oeztop-cakmak, Marcia Mattos Goncalves Pimentel, Teeratorn Pulkes, Andreas Puschmann, Ekaterina Rogaeva, Esther M. Sammler, Maria Skaalum Petersen, Matej Skorvanek, Mariana Spitz, Oksana Suchowersky, Ai Huey Tan, Pichet Termsarasab, Avner Thaler, Vitor Tumas, Enza Maria Valente, Bart van de Warrenburg, Caroline H. Williams-Gray, Ruey-Mei Wu, Baorong Zhang, Alexander Zimprich, Justin Solle, Shalini Padmanabhan, Christine Klein
Summary: Parkinson's disease is a rapidly growing neurodegenerative disorder that affects approximately 7 million people worldwide. The majority of research on monogenic Parkinson's disease is focused on patients of European White ancestry, leaving a significant knowledge gap in underrepresented populations. To address this, a global network of centers working on monogenic Parkinson's disease has been established to facilitate collaborative research and the development of new therapies. An interactive map and online tool have also been developed to enable quick access to available resources and promote collaboration. This initiative aims to fill the knowledge gap and impact the treatment of monogenic and potentially idiopathic Parkinson's disease patients.
Article
Psychiatry
Albert Bellmunt-Gil, Joonas Majuri, Eveliina Arponen, Valtteri Kaasinen, Juho Joutsa
Summary: Gambling disorder is associated with abnormal frontostriatal connectivity in the right hemisphere and serotonergic function.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Article
Clinical Neurology
Jussi O. T. Sipila, Valtteri Kaasinen, Paeivi Rautava, Ville Kyto
Summary: Currently, there is a lack of robust estimates regarding the risk of mortality among patients with Parkinson's disease (PD). However, this study found that the case-fatality rate in PD patients was higher compared to matched controls, and this increased risk was evident from early on, especially among young-onset patients.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)