Review
Biochemistry & Molecular Biology
Kevin Nay, William J. Smiles, Jacqueline Kaiser, Luke M. McAloon, Kim Loh, Sandra Galic, Jonathan S. Oakhill, Andrew L. Gundlach, John W. Scott
Summary: This review highlights the increasing prevalence of age-related neurological diseases and mental health disorders as life expectancy rises in developed countries, and the innovative strategy of prescribing exercise to prevent or delay these pathologies. It also discusses the therapeutic benefits of exercise and the underlying mechanisms related to brain function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Lorenzo Pini, Alessandro Salvalaggio, Alexandra M. Wennberg, Anastasia Dimakou, Michela Matteoli, Maurizio Corbetta
Summary: The study of pollutant effects is crucial due to the increasing urbanization and its exacerbating effects on pollution. Epidemiological studies have reported the risk of neurological diseases and neurodegenerative disorders due to pollution, mainly caused by air pollution and water pollutants. However, the biological mechanisms behind this association are still unknown. This review focuses on the link between pollution and brain network connectivity, providing an updated overview of epidemiological findings and discussing the mechanistic insights of pollution-induced brain changes.
AGEING RESEARCH REVIEWS
(2023)
Review
Rehabilitation
Alessandro Picelli, Marianna Capecci, Mirko Filippetti, Valentina Varalta, Cristina Fonte, Rita Di Censo, Alessandro Zadra, Irene Chignola, Stefano Scarpa, Angelo P. Amico, Roberto Antenucci, Alessio Baricich, Paolo Benanti, Luciano Bissolotti, Paolo Boldrini, Donatella Bonaiuti, Enrico Castelli, Loredana Cavalli, Giuseppina Di Stefano, Francesco Draicchio, Vincenzo Falabella, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Johanna Jonsdodttir, Carmelo Lentino, Perla Massai, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Sandra Morelli, Giovanni Morone, Daniele Panzeri, Maurizio Petrarca, Federico Posteraro, Michele Senatore, Elisa Taglione, Giuseppe Turchetti, Thomas Bowman, Antonio Nardone
Summary: Robot-assisted gait training shows therapeutic effects on postural instability in patients with Parkinson's disease, especially in terms of balance and freezing of gait. The research results indicate a high level of evidence that robot-assisted gait training can improve patients' quality of life.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Review
Cell Biology
Delsuz Rezaee, Fatemeh Saadatpour, Nayyereh Akbari, Anahita Zoghi, Sajad Najafi, Parisa Beyranvand, Fahimeh Zamani-Rarani, Mohammad Amin Rashidi, Saeid Bagheri-Mohammadi, Mohammad Bakhtiari
Summary: MicroRNAs (miRNAs) have been found to play significant roles in regulating the development and functions of the central nervous system (CNS). Dysregulation of miRNAs has been associated with various neurodegenerative diseases and CNS tumors. They affect the expression of key genes and proteins involved in the pathogenesis of these diseases.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Eva Schaeffer, Thomas Vaterrodt, Laura Zaunbrecher, Inga Liepelt-Scarfone, Kirsten Emmert, Benjamin Roeben, Morad Elshehabi, Clint Hansen, Sara Becker, Susanne Nussbaum, Jan-Hinrich Busch, Matthis Synofzik, Daniela Berg, Walter Maetzler
Summary: Our independent analysis of three PD cohorts consisting of a total of 1124 PD patients found that patients taking Levodopa CR reported a significantly higher burden of nocturnal akinesia. Higher Levodopa intake and MDS-UPDRS part IV scores predicted worse quality of sleep and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marisa DiMarzio, Radhika Madhavan, Ileana Hancu, Eric Fiveland, Julia Prusik, Suresh Joel, Michael Gillogly, Ilknur Telkes, Michael D. Staudt, Jennifer Durphy, Damian Shin, Julie G. Pilitsis
Summary: This study aimed to investigate the impact of altered frequencies on brain activation in PD patients. It was found that changing the frequency significantly affected the activation levels in regions such as the thalamus, globus pallidum externa, and cerebellum. Additionally, using fMRI signatures may be helpful in determining the optimal frequency for DBS programming.
Article
Geriatrics & Gerontology
Fatih Soke, Bilge Kocer, Isil Fidan, Pembe Keskinoglu, Arzu Guclu-Gunduz
Summary: The study aimed to investigate the effects of TOT combined with AT on PD patients, showing that TOT-AT did not significantly alter the levels of BDNF, GDNF, IGF-1, VEGF, TNF-alpha, and IL-1 beta.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Clinical Neurology
Ryul Kim, Seohee Choi, Nyeonju Kang, Kiwon Park, Heehyun Shin, Hanall Lee, Hyungwoo Lee, Jin-Sun Jun, Beomseok Jeon, Kyeongho Byun
Summary: This study found that high-intensity interval training (HIIT) may be more effective than moderate-intensity continuous training (MICT) in improving sarcopenia in patients with Parkinson's disease (PD). However, further large-scale investigations are needed to confirm these findings.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Rehabilitation
Pei-Ling Wong, Shih-Jung Cheng, Yea-Ru Yang, Ray-Yau Wang
Summary: This study aimed to explore the effects of dual task training on gait performance and cognitive function in individuals with Parkinson's disease. The meta-analysis of ten randomized controlled trials showed that dual task training had positive effects on dual task gait speed, step and stride length, attention, and executive function. Moreover, participants with slower initial single task gait speed showed greater improvement in dual task step and stride length after dual task training.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Clinical Neurology
Jiazhen Wang, Ru Pan, Ying Cui, Zhigang Wang, Qinghua Li
Summary: Compared to drug treatment, the verbal fluency of patients in the experimental group decreased significantly, especially phonemic fluency. Learning and memory abilities also showed a slight decline. Other neurocognitive functions were not significantly affected.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Siobhan Reilly, Simran Dhaliwal, Usman Arshad, Antonella Macerollo, Nusrat Husain, Antonio Da Costa
Summary: There is evidence that rivastigmine is beneficial for rapid eye movement sleep behavior disorder (RBD) and apathy in Parkinson's disease patients without dementia. There is also high level evidence that rivastigmine reduces the risk of falls.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Engineering, Biomedical
Kate McMaster, Michael H. Cole, Daniel Chalkley, Mark W. Creaby
Summary: This study suggests that real-time visual biofeedback can effectively modify specific gait characteristics associated with falls in PD patients, such as reducing mediolateral trunk lean, step length and gait velocity.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Clinical Neurology
Hai-Yang Wang, Xinqing Hao, Ren Lu, Tao Li, Lanlan Pu, Wei Liu, Zhanhua Liang
Summary: This study investigated the effects of THP on prefrontal executive function and spontaneous neural activity in patients with tdPD, suggesting that THP treatment may lead to prefrontal dysfunction in tdPD patients, attenuating brain activation in executive function and cognition-related spontaneous neural activity.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Medicine, General & Internal
Seo Jung Yun, Hyun Haeng Lee, Woo Hyung Lee, Seung Hak Lee, Byung-Mo Oh, Han Gil Seo
Summary: This study investigated the effect of robot-assisted gait training (RAGT) on gait automaticity, speed, and balance in patients with Parkinson's disease (PD). While improvements were seen in walking speed and balance, gait automaticity did not improve with RAGT using an exoskeleton-type robot. Additional therapeutic components may be needed to enhance gait automaticity in PD patients.
Article
Multidisciplinary Sciences
Bilel Tounsi, Amal Acheche, Thierry Lelard, Zouhair Tabka, Yassine Trabelsi, Said Ahmaidi
Summary: This study demonstrated that inspiratory muscle training (IMT) combined with endurance training (ET) can effectively enhance inspiratory muscle function and functional balance in patients with chronic obstructive pulmonary disease (COPD).
Article
Clinical Neurology
Tanya Simuni, Liz Uribe, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Christopher S. Coffey, Andrew Siderowf, John Q. Trojanowski, Leslie M. Shaw, John Seibyl, Andrew Singleton, Arthur W. Toga, Doug Galasko, Tatiana Foroud, Duygu Tosun, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M. Tanner, Karl Kieburtz, Lana M. Chahine, Alyssa Reimer, Samantha J. Hutten, Susan Bressman, Kenneth Marek, Vanessa Arnedo, Adrienne Clark, Mark Fraiser, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Christina Salerno, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali GaniWeisz, Avi Orr-Urtreger, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Karen Williams, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
Article
Clinical Neurology
Anat Mirelman, Inbar Hillel, Lynn Rochester, Silvia Del Din, Bastiaan R. Bloem, Laura Avanzino, Alice Nieuwboer, Inbal Maidan, Talia Herman, Avner Thaler, Tanya Gurevich, Meir Kestenbaum, Avi Orr-Urtreger, Mirek Brys, Jesse M. Cederbaum, Nir Giladi, Jeffrey M. Hausdorff
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Talia Herman, Moria Dagan, Shirley Shema-Shiratzky, Tal Reches, Marina Brozgol, Nir Giladi, Brad Manor, Jeffrey M. Hausdorff
JOURNAL OF NEUROLOGY
(2020)
Article
Clinical Neurology
Nurit Omer, Nir Giladi, Tanya Gurevich, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Meir Kestenbaum, Jesse M. Cedarbaum, Avi Orr-Urtreger, Anat Mirelman, Avner Thaler
MOVEMENT DISORDERS
(2020)
Article
Multidisciplinary Sciences
Avner Thaler, Shani Shenhar-Tsarfaty, Yanay Shaked, Tanya Gurevich, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Meir Kestenbaum, Jesse M. Cedarbaum, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Biomedical
Nofar Schneider, Moria Dagan, Racheli Katz, Pablo Cornejo Thumm, Marina Brozgol, Nir Giladi, Brad Manor, Anat Mirelman, Jeffery M. Hausdorff
Summary: The study found that tDCS during challenging walking decreased the dual-task cost to walking in older adults. These results support the presence of a state-dependent impact of neuro-modulation.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Clinical Neurology
Anat Mirelman, Mor Ben Or Frank, Michal Melamed, Lena Granovsky, Alice Nieuwboer, Lynn Rochester, Silvia Del Din, Laura Avanzino, Elisa Pelosin, Bastiaan R. Bloem, Ugo Della Croce, Andrea Cereatti, Paolo Bonato, Richard Camicioli, Theresa Ellis, Jamie L. Hamilton, Chris J. Hass, Quincy J. Almeida, Maidan Inbal, Avner Thaler, Julia Shirvan, Jesse M. Cedarbaum, Nir Giladi, Jeffrey M. Hausdorff
Summary: This study utilized wearable sensors to record gait and mobility measures in PD patients and healthy controls, and applied machine-learning algorithms to distinguish between different stages of PD severity. The findings suggest that gait and mobility measures can reflect distinct PD stages with high discriminatory values.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Brad Manor, Moria Dagan, Talia Herman, Natalia A. Gouskova, Veronique G. Vanderhorst, Nir Giladi, Thomas G. Travison, Alvaro Pascual-Leone, Lewis A. Lipsitz, Jeffrey M. Hausdorff
Summary: This study found that multi-session transcranial direct current stimulation targeting the left dorsolateral prefrontal cortex and primary motor cortex did not significantly improve laboratory-based FOG-provoking test performance, but showed some improvement in patients with mild-to-moderate FOG severity.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Tamir Eisenstein, Nir Giladi, Talma Hendler, Ofer Havakuk, Yulia Lerner
Summary: The study found that aerobic activity and cardiorespiratory fitness in older adults are associated with neurocognitive abilities and identified potential neural pathways mediating this relationship. The results support a neuroprotective role of aerobic exercise on the aging brain.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Inbal Maidan, Noa Zifman, Jeffrey M. Hausdorff, Nir Giladi, Ofri Levy-Lamdan, Anat Mirelman
Summary: The study investigated specific changes in electrical brain activity in response to stimulation of four brain areas in patients with Parkinson's disease (PD) using a combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) assessment. Patients with PD showed lower waveform adherence, lower early phase deflection, lower inter-trial adherence, and lower connectivity between homologous brain areas compared to healthy controls. The findings suggest various alterations in neurophysiological measures in PD patients, indicating different aspects related to the pathophysiology of the disease.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Nir Giladi, Tanya Gurevich, Ruth Djaldetti, Liat Adar, Ryan Case, Shelly Leibman-Barak, Nissim Sasson, Yoseph Caraco
Summary: ND0612, a continuous subcutaneous levodopa/carbidopa delivery system, was well-tolerated and resulted in reduced OFF time and decreased plasma levodopa fluctuations when used adjunctively in PD patients. Although most patients experienced infusion site nodules, they all resolved without sequelae.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Mor Yam, Sigal Glatt, Shai Nosatzki, Anat Mirelman, Jeffrey M. Hausdorff, Lilach Goldstein, Nir Giladi, Firas Fahoum, Inbal Maidan
Summary: Juvenile myoclonic epilepsy (JME) is a common epileptic syndrome, and drug resistance is a significant issue. This study found that drug-resistant JME patients have altered brain activity during highly demanding tasks that combine cognitive and motor functions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Analytical
Dan Z. Milikovsky, Yotam Sharabi, Nir Giladi, Anat Mirelman, Ronen Sosnik, Firas Fahoum, Inbal Maidan
Summary: This study aimed to examine the presence of paroxysmal slow-wave events (PSWE) as a biomarker for cortical involvement in Parkinson's disease (PD). The results showed no significant differences in the number of PSWEs between PD patients and controls in all brain regions. However, the correlation between PSWEs and disease duration suggests early signs of cortical involvement in PD.
Article
Clinical Neurology
Shachar Shani, Orly Goldstein, Mali Gana-Weisz, Anat Bar-Shira, Avner Thaler, Tanya Gurevich, Anat Mirelman, Nir Giladi, Roy N. Alcalay, Avi Orr-Urtreger
Summary: Recent studies have found a link between Parkinson's disease (PD) and changes in the innate immune system. This study aimed to determine if genetic variations in innate immune genes are differentially associated with PD in different subgroups, including GBA-PD, LRRK2-PD, and non-carrier PD (NC-PD).
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Chemistry, Analytical
Eden Shkury, Shani Danziger-Schragenheim, Zoya Katzir, Yael Ezra, Nir Giladi, Anat Mirelman, Inbal Maidan
Summary: This study investigated the neurophysiological changes in Parkinson's disease patients with and without the G2019S-LRRK2 gene mutation. The results showed that patients with the mutation performed better in cognitive tasks and exhibited more efficient early cognitive processes, which may contribute to their better cognitive performance.