Article
Clinical Neurology
Yvonn Kraemer, Kaisa Maki, Ivan Marinkovic, Taina Nybo, Harri Isokuortti, Antti Huovinen, Antti Korvenoja, Susanna Melkas, Hanna Harno
Summary: Post-traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI), with some patients developing persistent PTH (pPTH). This study found that risk factors for acute PTH (aPTH) include headache at the emergency department (ED), other pain, insomnia, and vertigo, while risk factors for pPTH include older age and current insomnia. Patients with pPTH had lower return to work rates.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Torgeir Hellstrom, Nada Andelic, Ann-Marie G. de Lange, Eirik Helseth, Kristin Eiklid, Lars T. Westlye
Summary: The study found that compared to non-carriers, APOE e4 carriers showed lower fractional anisotropy (FA) in the hippocampal part of the cingulum bundle, but this difference did not remain significant after multiple comparison correction. No significant differences were found in brain age prediction, brain morphometry, and volumes between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ingerid Kleffelgard, Nada Andelic, Kari Anette Bruusgaard, Birgitta Langhammer, Anne-Lise Tamber, Helene Lundgaard Soberg
Summary: Persistent dizziness and balance problems after mmTBI can lead to significant disability. This study aimed to identify factors associated with dizziness-related disability one year after injury. The findings showed that pre-injury comorbidity, neck pain, increased post-concussion symptom burden, increased dizziness symptom severity, and reduced balance and mobility were all associated with dizziness-related disability at one year.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Sophie-emilie Poulin-Lapierre, Simon Beaulieu-Bonneau, Claude Goulet, Kathleen Cairns, David Predovan, Marie-Christine Ouellet
Summary: This study aimed to investigate access and adherence to the Berlin (2016) recommendations for resuming physical and intellectual activities after mild traumatic brain injury (mTBI) (including an exploration of barriers and facilitators). The study found that almost all participants received recommendations from a health professional after their mTBI, but the adherence to these recommendations was low, with only 15.7% of participants reporting complete adherence. Adherence to recommendations was significantly related to the severity and number of unresolved post-mTBI symptoms.
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Bryce Geeraert, Xiangyu Long, Miriam H. Beauchamp, William Craig, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Roger Zemek, Catherine Lebel
Summary: Sophisticated network-based approaches such as structural connectomics may help detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children, finding that both mTBI and OI groups demonstrated reduced global and regional network efficiency and segregation compared to TD children. This suggests a general effect of childhood injury on brain structure that could reflect pre- and postinjury factors.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Zachary M. Weil, Kate Karelina, Bailey Whitehead, Ruth Velazquez-Cruz, Robin Oliverio, Mark Pinti, Divine C. Nwafor, Samuel Nicholson, Julie A. Fitzgerald, John Hollander, Candice M. Brown, Ning Zhang, A. Courtney DeVries
Summary: Recent studies have shown that traumatic brain injury (TBI) can worsen outcomes after stroke by affecting neuroimmune and neurometabolic functions. In a mouse model, TBI led to larger stroke infarcts, more severe functional deficits, and increased neuroinflammation. Treatment with the insulin sensitizing drug pioglitazone was able to prevent the exacerbation of ischemic outcomes caused by TBI, suggesting that metabolic dysfunction plays a role in these processes.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Summary: This study demonstrates altered cytokine profiles and endotoxin responses in children with traumatic brain injury (TBI), including mild TBI. Children with mild TBI showed decreased levels of IL-8, IL-10, IL-17A, and TNF-alpha compared to controls, along with increased levels of IFN-gamma. In severe TBI, there was no significant IL-6 response to endotoxin, but an increase in IL-17A. These findings suggest immune dysfunction following TBI, especially in mild cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Multidisciplinary Sciences
Yana Naumenko, Irada Yuryshinetz, Yelyzaveta Zabenko, Tetyana Pivneva
Summary: Traumatic brain injury (TBI) refers to brain dysfunction or evidence of brain pathology caused by external physical force. Over 69 million new cases of TBI are registered worldwide each year, with 80% of them being mild TBI. Mechanically induced brain injury initiates various changes in the CNS, leading to acute, subacute, and chronic neurological consequences. The heterogeneity, lack of a unified classification system, and variability of long-term consequences pose challenges for research and therapeutic strategies.
Article
Neurosciences
Daniel A. Lopez, Zachary P. Christensen, John J. Foxe, Laura R. Ziemer, Paige R. Nicklas, Edward G. Freedman
Summary: The study found that children who experienced possible mTBI or mTBI are at a higher risk of emotional or behavioral problems. However, brain metrics did not clearly mediate the relationship between mTBI and mental health outcomes.
Article
Clinical Neurology
Lichao Wei, Bowen Chang, Zhi Geng, Ming Chen, Yongsheng Cao, Liang Yao, Chao Ma
Summary: This study aimed to identify the risk factors and develop a nomogram model for predicting subdural effusion in patients with mild traumatic brain injury. The results showed that gender, age, history of hypertension, and basilar skull fracture were independent risk factors for subdural effusion.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Matias Lira, Pedro Zamorano, Waldo Cerpa
Summary: Exo70, a subunit of the exocyst complex, is involved in cellular membrane addition and polarized exocytosis. After traumatic brain injury, Exo70 is redistributed from microsomes to the synaptic compartment, where it interacts with GluN2B. This redistribution may play a compensatory role in maintaining GluN2B on synapses, potentially reducing the detrimental effects associated with TBI.
BIOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Annemarie P. M. Stiekema, Britta Nijsse, Paul L. M. de Kort, Jacoba M. Spikman, Johanna M. A. Visser-Meily, Caroline M. van Heugten
Summary: This study explored the relationship between social cognitive impairments and participation restrictions in stroke survivors. While behavior regulation was found to be related to participation restrictions in the short term, other social cognitive domains did not predict participation restrictions in the long term. Further research is needed to determine if this relationship exists in patients with more severe stroke, and to identify treatment targets for improving participation by measuring social aspects.
NEUROPSYCHOLOGICAL REHABILITATION
(2021)
Article
Rehabilitation
Noah D. Silverberg, Grant L. Iverson
Summary: The survey revealed areas of expert agreement and disagreement regarding the diagnosis of mild traumatic brain injury (TBI), suggesting that observable signs are more diagnostically important than subjective symptoms, with certain symptoms and test findings consistently rated as highly important for increasing the likelihood of a mild TBI diagnosis.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Correction
Clinical Neurology
Nada Andelic, Cecilie Roe, Cathrine Brunborg Bullet, Marina Zeldovich Bullet, Marianne Lovstad, Daniel Loke, Ida M. Borgen, Daphne C. Voormolen Bullet, Emilie I. Howe, Marit V. Forslund Bullet, Hilde M. Dahl, Nicole von Steinbuechel
Summary: The original version of this article contains a mistake.
JOURNAL OF NEUROLOGY
(2021)
Article
Critical Care Medicine
Ana Mikolic, Suzanne Polinder, Ewout W. Steyerberg, Isabel R. A. Retel Helmrich, Joseph T. Giacino, Andrew I. R. Maas, Joukje van der Naalt, Daphne C. Voormolen, Nicole von Steinbuechel, Lindsay Wilson, Hester F. Lingsma, David van Klaveren
Summary: Prognostic models for early prediction of outcomes after mild TBI lack both good calibration and discrimination, and future studies should focus on tailoring these models to the specific population with mild TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Critical Care Medicine
Jurre Blaauw, Anke G. Boxum, Bram Jacobs, Rob J. M. Groen, Wilco C. Peul, Korne Jellema, Ruben Dammers, Niels A. van der Gaag, Hester F. Lingsma, Heleen M. den Hertog, Joukje van der Naalt
Summary: Chronic subdural hematoma (CSDH) is a neurological disease commonly seen in older individuals and those taking anticoagulants. Cognitive deficits, both subjective and objective, are prevalent in CSDH patients with a tendency to improve after surgical treatment. This highlights the importance of monitoring cognitive status in these patients with appropriate methods and intervals.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Nils S. van den Berg, Fransje E. Reesink, Edward H. F. de Haan, Hubertus P. H. Kremer, Jacoba M. Spikman, Rients B. Huitema
Summary: The study found that patients with neurodegenerative diseases perform worse in emotion recognition, particularly in identifying anger, disgust, fear, and sadness. Additionally, these patients exhibit more risk-taking behavior in driving simulator scenarios and the Action Selection Test. Poor recognition of fear is specifically related to making more risky decisions in situations involving direct danger.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2021)
Article
Clinical Neurology
Jurre Blaauw, Ghislaine A. Meelis, Bram Jacobs, Niels A. van Der Gaag, Korne Jellema, Kuan H. Kho, Rob J. M. Groen, Joukje van Der Naalt, Hester F. Lingsma, Heleen M. den Hertog
Summary: In patients with chronic subdural hematoma, cognitive complaints are associated with worse functional outcomes, while headache and higher Glasgow Coma Scale scores are associated with better outcomes.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Rehabilitation
Sandra E. Rakers, Marieke E. Timmerman, Myrthe E. Scheenen, Myrthe E. de Koning, Harm J. van der Horn, Joukje van der Naalt, Jacoba M. Spikman
Summary: The study analyzed fatigue after mild traumatic brain injury (TBI) using latent class growth analysis (LCGA) to identify distinct recovery trajectories and investigate influencing factors. Results showed four patient clusters with different patterns of fatigue, emotional distress, and coping styles. Favorable recovery from posttraumatic fatigue was observed in 55% of mild TBI patients.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Neurosciences
Jacoba M. Spikman, Harm J. van der Horn, Myrthe E. Scheenen, Myrthe E. de Koning, Mesut Savas, Thomas Langerak, Elisabeth F. C. van Rossum, Joukje van der Naalt
Summary: The study found no separate impact of mild traumatic brain injury on chronic long-term cortisol levels, suggesting that the variability in cortisol levels reflects individuals' premorbid characteristics determining coping with stress in general. Additionally, the cortisol levels of patients were negatively correlated with both passive and avoidant coping styles.
Article
Critical Care Medicine
Giuseppe Citerio, Chiara Robba, Paola Rebora, Matteo Petrosino, Eleonora Rossi, Letterio Malgeri, Nino Stocchetti, Stefania Galimberti, David K. Menon
Summary: Management of PaCO2 varies between different medical centers and in response to intracranial dynamics. PaCO2 tends to be lower in patients with ICP monitoring, especially when ICP is increased. Being in a center that more frequently uses profound hyperventilation does not have an impact on patient outcomes.
INTENSIVE CARE MEDICINE
(2021)
Article
Health Care Sciences & Services
Isabel R. A. Retel Helmrich, David van Klaveren, Simone A. Dijkland, Hester F. Lingsma, Suzanne Polinder, Lindsay Wilson, Nicole von Steinbuechel, Joukje van der Naalt, Andrew I. R. Maas, Ewout W. Steyerberg
Summary: Predictors of Health-Related Quality of Life (HRQoL) following traumatic brain injury (TBI) are related to physical and mental health, as well as pre-injury quality of life. Medical and injury-related characteristics play a significant role in predicting physical health, while patient-related characteristics are more important for predicting mental health and overall quality of life after TBI.
QUALITY OF LIFE RESEARCH
(2022)
Review
Behavioral Sciences
Koen Visser, Milou Koggel, Jurre Blaauw, Harm Jan van der Horn, Bram Jacobs, Joukje van der Naalt
Summary: This systematic review summarizes clinical studies on blood-based inflammatory markers after mild traumatic brain injury (mTBI) and identifies the value of inflammatory markers as biomarkers. The review suggests a distinct systemic inflammatory response following mTBI, quantifiable within 6 hours up to 12 months post-injury.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Critical Care Medicine
Crispijn L. van den Brand, Kelly A. Foks, Hester F. Lingsma, Joukje van der Naalt, Bram Jacobs, Eline de Jong, Hugo F. den Boogert, Ozcan Sir, Peter Patka, Suzanne Polinder, Menno Gaakeer, Charlotte E. Schutte, Kim E. Jie, Huib F. Visee, Myriam G. M. Hunink, Eef Reijners, Meriam Braaksma, Guus G. Schoonman, Ewout W. Steyerberg, Diederik W. J. Dippel, Korne Jellema
Summary: The objective of this study was to update the CHIP decision rule for detecting (intra)cranial findings in adult patients with minor head injury. The updated model showed similar performance to the original model in detecting traumatic (intra)cranial findings and had a higher sensitivity for (potential) neurosurgical lesions or death as a result of traumatic brain injury. The updated CHIP decision rule is a good alternative for patients with minor head injury.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, General & Internal
Sophie M. M. Coffeng, Kelly A. A. Foks, Crispijn L. L. van den Brand, Korne Jellema, Diederik W. J. Dippel, Bram Jacobs, Joukje van der Naalt
Summary: Currently, there is no specific CT decision rule for elderly patients with minor head injury (MHI). This study aimed to evaluate the performance of existing CT decision rules for elderly MHI patients and compare their characteristics with younger MHI patients. The 30-day mortality, clinical, and CT characteristics were assessed using four CT decision rules. Elderly patients had higher 30-day mortality (2.0% vs 0.1%) and intracranial lesions (13% vs 10%) compared to younger patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychology, Clinical
Sebastian A. Balart-Sanchez, Mayra Bittencourt-Villalpando, Joukje van der Naalt, Natasha M. Maurits
Summary: This systematic review examines the neural correlates of cognitive reserve estimates using ECOG, EEG, and MEG. The findings show that (M)EEG measures are related to CR estimates, particularly in healthy individuals. The nature of this relationship depends on the population and task studied, suggesting a need for further research.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)