Article
Clinical Neurology
Brit Ellen Rod, Oivind Torkildsen, Kjell-Morten Myhr, Lars Bo, Stig Wergeland
Summary: Our study found minimal transfer of rituximab into breast milk in nursing mothers, and the levels of rituximab in infant serum were difficult to detect. The B cell counts in infants were unaffected.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Obstetrics & Gynecology
Amir Aviram, Jon F. R. Barrett, Nir Melamed, Elad Mei-Dan
Summary: The mode of delivery in multiple pregnancies has been a topic of debate, with some questions answered by the Twin Birth Study but others remaining outside its scope. Current evidence supports trial of labor in specific cases, but caesarean delivery also has benefits.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Xiaohui Zhang, Haifeng Lou, Xuejuan Tang, Xiaoli Chen
Summary: After China ended its one-child policy, some pregnancy outcomes increased as key characteristics of childbearing women changed. Policy providers and medical staff need to strengthen healthcare in response to changes in birth policy.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Medicine, General & Internal
Ishag Adam, Yasir Salih, Hamdan Z. Z. Hamdan
Summary: Anaemia during pregnancy is associated with an increased risk of caesarean delivery. This study aimed to investigate the relationship between caesarean delivery and maternal anaemia. Relevant studies on this topic were searched in several databases. The assessment and review were conducted using a specific tool. The results demonstrated that women with anaemia had a higher risk of caesarean delivery compared to non-anaemic women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Misgav Rottenstreich, Itamar Glick, Naama Srebnik, Avi Tsafrir, Sorina Grisaru-Granovsky, Hen Y. Sela
Summary: The study found that among women without a history of infertility, primary cesarean delivery does not independently influence the use of fertility treatments in subsequent deliveries.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Xiaoxiao Jin, Manman Liu, Panxi Zhang, Lingzhi Zheng, Feng Qi
Summary: This study investigated the effects of cesarean scar pregnancy (CSP) treatment on subsequent fertility and pregnancy outcomes. Among the women who desired a subsequent pregnancy, a certain proportion experienced secondary infertility. The use of uterine artery embolization or ultrasound-guided local lauromacrogol injection techniques can improve post-treatment fertility and successful pregnancy rates.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Oncology
Chloe Leproux, Valerie Seegers, Anne Patsouris, Baptiste Sauterey
Summary: This study aimed to assess the rate of live births achieved through natural or assisted reproductive technology in breast cancer patients with pregnancy desire, with a live birth rate of 19.7% observed in the cohort.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Philip D. Poorvu, Shari I. Gelber, Yue Zheng, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Matteo Lambertini, Shoshana M. Rosenberg, Ann H. Partridge
Summary: Many young women with newly diagnosed breast cancer express interest in future pregnancies. Within 5 years of diagnosis, 36% reported interest in having children, with the majority successfully conceiving if they attempted to do so. Factors such as age at diagnosis and parity status were associated with likelihood of pregnancy, while endocrine therapy was inversely linked to pregnancy outcomes. Longitudinal fertility discussions are important for this population.
Review
Clinical Neurology
Isabella Laura Simone, Carla Tortorella, Alma Ghirelli
Summary: Multiple sclerosis predominantly affects young women, impacting fertility, pregnancy, fetal outcome, and breastfeeding. The use of disease-modifying therapies has changed the natural history of the disease and perspectives on pregnancy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Tong Wu, Qingxuan Wang, Wei Liu, Jing Zhang, Wenhui Wang, Jun Wang, Cuihong Ji, Honghui Liu, Chunyan Tang, Xin Mi
Summary: This retrospective study compared the clinical efficacy and risk factors of suction curettage (SC) and hysteroscopy in treating type I and II cesarean scar pregnancy (CSP). The success rate of the surgery group was higher than the SC group. Hysteroscopy had shorter operation time and lower hospitalization cost and duration compared to SC. Patients with a gestation age greater than 8 weeks were not recommended to undergo SC for treatment.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Inge P. M. Jordans, Jolijn Vissers, Robert A. de Leeuw, Wouter J. K. Hehenkamp, Jos W. R. Twisk, Christianne J. M. de Groot, Judith A. F. Huirne
Summary: This study evaluated the impact of laparoscopic niche resection on residual myometrial thickness in pregnant women and compared niche size, obstetrical outcomes, etc. between the resection group and the expectant group. The results showed that laparoscopic niche resection increased residual myometrial thickness during subsequent pregnancies and reduced the risk of uterine dehiscence.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Microbiology
Jingran Ma, Zhenghong Li, Wenjuan Zhang, Chunli Zhang, Yuheng Zhang, Hua Mei, Na Zhuo, Hongyun Wang, Dan Wu
Summary: The specific interaction of delivery modes and feeding types has a significant impact on the infants' gut microbiota. Breastfeeding and vaginal delivery can reduce the potential adverse effects of formula feeding or cesarean section delivery on gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Matteo Bronzini, Alessandro Maglione, Rachele Rosso, Manuela Matta, Federica Masuzzo, Simona Rolla, Marinella Clerico
Summary: Multiple sclerosis (MS) is a neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system. Changes in gut microbiome driven by dietary habits may contribute to the increase in MS cases. This review explores the impact of diet on the development and course of MS by feeding the gut microbiome, discussing the role of nutrition, gut microbiota, and potential microbiome-targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Kimia Sorouri, Tal Sella, Shoshana M. Rosenberg, Maggie Loucks, Gregory Kirkner, Craig Snow, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Ann H. Partridge
Summary: This study investigated the postcancer conception and pregnancy experience of young BC survivors and found that most of them conceived naturally without negative impact from the history of BC. However, a higher rate of hypertensive disorders of pregnancy was observed, requiring further investigation.
Article
Obstetrics & Gynecology
Tomas Fait, Anna Stastna, Jirina Kocourkova, Eva Waldaufova, Ludek Sidlo, Michal Knize
Summary: Although health factors and sociodemographic characteristics both significantly affect the rate of cesarean sections, health factors represent a higher risk. Previous cesarean sections, breech position, multiple pregnancies, ART usage, diabetes, gestational diabetes, and hypertension all increase the odds of a cesarean section. Delayed childbearing is thought to be associated with the increase in cesarean section rates in Czechia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Clinical Neurology
Emilio Portaccio, Laura Tudisco, Luisa Pasto, Lorenzo Razzolini, Mattia Fonderico, Angelo Bellinvia, Angelo Ghezzi, Pietro Annovazzi, Mauro Zaffaroni, Lucia Moiola, Vittorio Martinelli, Clara Grazia Chisari, Francesco Patti, Gianluigi Mancardi, Carlo Pozzilli, Laura De Giglio, Rocco Totaro, Alessandra Lugaresi, Valeria Di Tommaso, Damiano Paolicelli, Eleonora Cocco, Maria Giovanna Marrosu, Giancarlo Comi, Massimo Filippi, Maria Trojano, Maria Pia Amato
Summary: The study found that pregnancy in women with relapses in the year before conception increases the risk of long-term disability worsening.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Roberto Furlan, Marco Salvetti
Summary: The study assessed the relationship between disease-modifying therapy (DMT) and the development of anti-SARS-CoV-2 antibodies in patients with multiple sclerosis (MS), finding that patients treated with anti-CD20 drugs had a lower likelihood of developing antibodies.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Roberto Bergamaschi, Marta Ponzano, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Massimo Filippi, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Nicola De Rossi, Giampaolo Brichetto, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Antonio Zito, Paolo Confalonieri, Girolama Alessandra Marfia, Paola Perini, Matilde Inglese, Maria Trojano, Vincenzo Brescia Morra, Enrico Pisoni, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Marco Salvetti, Maria Pia Sormani
Summary: This study explored the association between PM2.5 and the severity of COVID-19 among patients with multiple sclerosis (MS), revealing that higher concentrations of PM2.5 increased the risk of worsening COVID-19 outcomes. The role of air pollutants in influencing COVID-19 severity in MS patients warrants further investigation.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Eugenia Rota, Marco Aguggia, Paolo Immovilli, Nicola Morelli, Davide Renosio, Andrea Barbanera
Summary: This pilot study found a statistically significant decrease in ES2 latency and duration of the temporalis muscle activity after erenumab treatment in chronic female migraineurs. This suggests that ES2 may serve as a neurophysiological marker in migraine pathophysiology and that the monoclonal antibody can modulate brainstem circuits involved in migraine pathophysiology indirectly. Further research is needed to confirm this hypothesis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Maria Pia Sormani, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Massimo Filippi, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Nicola De Rossi, Giampaolo Brichetto, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Antonio Zito, Paolo Confalonieri, Girolama Alessandra Marfia, Paola Perini, Matilde Inglese, Maria Trojano, Vincenzo Brescia Morra, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Marco Salvetti
Summary: This study compares the outcomes of COVID-19 in patients with multiple sclerosis (MS) in Italy with the expected outcomes in the general population. The risk of severe events, including hospitalization, ICU admission, and death, was found to be twice as high in the MS cohort compared to the age- and sex-matched Italian population. The increased risk was primarily associated with disease severity and comorbidities, but there was also a higher risk of hospitalization in patients on anti-CD20 therapies and a lower risk in patients on interferon.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Marta Ponzano, Irene Schiavetti, Francesca Bovis, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Margherita Monti Bragadin, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Paolo Confalonieri, Paola Perini, Roberto Bergamaschi, Matilde Inglese, Maria Petracca, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Rana Karabudak, Husnu Efendi, Roberto Furlan, Marco Salvetti, Maria Pia Sormani
Summary: This study aimed to construct a score for evaluating the individual risk of severe Covid-19 in Multiple Sclerosis (MS) patients and to assess its performance. Data from MS patients infected with Covid-19 in Italy, Turkey, and South America were analyzed, and the main risk factors were identified. The score with the best performance was derived using Lasso regression and included variables such as age, sex, country, BMI, presence of comorbidities, and treatment. The score can be used as an additional tool to identify high-risk patients and promote preventive measures.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Correction
Infectious Diseases
Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D'Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, Roberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla
Article
Neurosciences
Paolo Immovilli, Elena Marchesi, Chiara Terracciano, Nicola Morelli, Veronica Bazzurri, Fabiola Magni Fico, Domenica Zaino, Emilio Terlizzi, Paola De Mitri, Stefano Vollaro, Nicola Mometto, Donata Guidetti
Summary: This study aims to assess whether COVID-19 could be a concurrent factor in the genesis and/or worsening of stroke and to provide data on COVID-19-associated stroke patients during the first pandemic wave.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Multidisciplinary Sciences
Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, Francois Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana Petrova
Summary: The specialized structure of small intestinal villus tip blood vessels is maintained by ADAMTS18(+) telocytes, which regulate the level and location of VEGFA signaling to ensure the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Francesco Patti, Clara Grazia Chisari, Simona Toscano, Pietro Annovazzi, Paola Banfi, Roberto Bergamaschi, Raffaella Clerici, Marta Zaffira Conti, Antonio Cortese, Roberta Fantozzi, Diana Ferraro, Mariano Fischetti, Maura Frigo, Maurizia Gatto, Paolo Immovilli, Stefania Leoni, Simona Malucchi, Giorgia Maniscalco, Girolama Alessandra Marfia, Damiano Paolicelli, Paola Perini, Carlo Serrati, Rocco Totaro, Gabriella Turano, Paola Valentino, Mauro Zaffaroni, Cristina Zuliani, Diego Centonze
Summary: This study aimed to evaluate the association between cognitive profile, attitude, and preferences of patients concerning treatment choice in multiple sclerosis. The results showed that more than 50% of patients chose a collaborative role in making treatment decisions, and these patients had higher cognitive abilities.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Cell Biology
Hannah F. Bradford, Liis Haljasmagi, Madhvi Menon, Thomas C. R. McDonnell, Karita Sarekannu, Martti Vanker, Part Peterson, Chris Wincup, Rym Abida, Raquel Fernandez Gonzalez, Vincent Bondet, Darragh Duffy, David A. Isenberg, Kai Kisand, Claudia Mauri
Summary: Systemic lupus erythematosus (SLE) patients often exhibit increased expression of type I interferon (IFN)-regulated genes. In our study of 501 SLE patients, we found that 73 (14%) had autoantibodies against IFN-alpha (anti-IFN-Abs). The presence of neutralizing anti-IFN-Abs in 4.2% of patients correlated with low IFN-alpha protein levels, inhibition of IFN-I downstream gene signatures, and inactive disease score. These neutralizing anti-IFN-Abs were found to play a role in controlling SLE pathogenesis, specifically in regulating B cell populations.
CELL REPORTS MEDICINE
(2023)
Article
Clinical Neurology
Nicola Morelli, Paolo Immovilli, Elena Giacopazzi, Eugenia Rota, Marco Spallazzi, Domenica Zaino, Davide Colombi, Donata Guidetti, Emanuele Michieletti
Summary: This study aimed to evaluate the diagnostic accuracy of two different CTp postprocessing algorithms (Bayesian method and oscillation index singular value decomposition) in estimating the ischemic core. The results showed that there was a higher agreement between the Bayesian algorithm and DWI in the extended window. The more accurate estimation of the ischemic core offered by the Bayesian algorithm may play a critical role in selecting patients for reperfusion therapies.
JOURNAL OF NEUROIMAGING
(2023)
Article
Linguistics
Caterina Mauri, Andrea Sanso
Summary: This paper provides a diachronic typology of heterogeneous plurals, including associative plurals and similative plurals. Based on a 110-language sample, the most recurrent sources of these two types of plurals are identified. Associative plurals develop from elements that work as set constructors, while similative plurals comprise elements with vague reference. There are also some sources that may develop into both associative and similative plurals. These differences can be explained in terms of the referential properties of the nominal bases and the discourse contexts in which the plurals are used.
LINGUISTIC TYPOLOGY
(2023)
Meeting Abstract
Clinical Neurology
I. Schiavetti, E. Signoriello, J. Frau, M. T. Ferro, L. Pasquali, G. Abbadessa, R. Iodice, G. Lus, S. Bonavita, A. Conte, D. Ferraro, P. Immovilli, M. Di Filippo, F. Ruscica, G. Cola, M. P. Sormani, A. Signori
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Clinical Neurology
Paolo Immovilli, Nicola Morelli, Chiara Terracciano, Eugenia Rota, Elena Marchesi, Stefano Vollaro, Paola De Mitri, Domenica Zaino, Veronica Bazzurri, Donata Guidetti
Summary: This article reviews the risks faced by people with multiple sclerosis (pwMS) during the COVID-19 pandemic and discusses issues related to vaccination. It proposes strategies for the clinical management of pwMS to minimize the risks associated with COVID-19.
NEUROLOGY INTERNATIONAL
(2022)
