Article
Clinical Neurology
Steve Simpson-Yap, Nupur Nag, Yasmine Probst, George Jelinek, Sandra Neate
Summary: The study found that better quality of diet and avoiding meat consumption were associated with reduced disability progression in people with MS. Consumption of dairy products showed mixed associations in both cross-sectional and prospective analyses.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-Ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune
Summary: This study assessed the association of HRQOL with disabilities, fatigue, and depression in Japanese subjects with MS. The results showed that HRQOL had relatively close correlations with disabilities and fatigue, and depression had an especially close relationship with HRQOL.
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Sandra Neate, Afaf Humam, Nupur Nag, George A. Jelinek, Steve Simpson-Yap
Summary: The study found a protective relationship between mastery and subsequent risk of depression in people with multiple sclerosis, suggesting it may be an intervention point for improving well-being. However, no significant associations were seen for change in fatigue, disability, or relapse number in the prospective analysis.
QUALITY OF LIFE RESEARCH
(2022)
Article
Clinical Neurology
Claudio Gasperini, Luca Prosperini, Alex Rovira, Mar Tintore, Jaume Sastre-Garriga, Carla Tortorella, Shalom Haggiag, Simonetta Galgani, Ruggero Capra, Carlo Pozzilli, Xavier Montalban, Jordi Rio
Summary: The study aimed to develop and validate a scoring system combining baseline prognostic factors and 1-year variables of treatment response to predict the long-term risk of disability accumulation in patients with RRMS. The RoAD score showed to be a useful tool in predicting the risk of reaching a disability milestone and optimizing treatment strategy for RRMS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Joanna Tarasiuk, Katarzyna Kapica-Topczewska, Agata Czarnowska, Monika Chorazy, Jan Kochanowicz, Alina Kulakowska
Summary: Fatigue and depression are common symptoms in patients with multiple sclerosis (MS). Primary fatigue and depression in MS are caused by inflammatory, oxidative/nitrosative, and neurodegenerative processes. Secondary fatigue and depression may be caused by emotional factors, sleep disorders, pain, coexisting diseases, and medication use.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Maggie Yu, George Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
Summary: A study found that dietary improvements are positively associated with health outcomes in people with multiple sclerosis (pwMS), although adhering to a specific diet can be challenging. The study suggests that ongoing adherence to a MS-specific or high-quality diet may be beneficial for reducing depression, fatigue, and disability in pwMS.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Pinar Yigit, Ayla Acikgoz, Zaur Mehdiyev, Ayfer Dayi, Serkan Ozakbas
Summary: The study found that disability and fatigue adversely affect the cognitive functions of pwMS, while depression has no significant impact. The MS-specific BICAMS test can be beneficial in assessing the cognitive state of pwMS.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Milena Sales Pitombeira, Michel Koole, Kenia R. Campanholo, Aline M. Souza, Fabio L. S. Duran, Davi J. Fontoura Solla, Maria F. Mendes, Samira L. Apostolos Pereira, Carolina M. Rimkus, Geraldo Filho Busatto, Dagoberto Callegaro, Carlos A. Buchpiguel, Daniele de Paula Faria
Summary: This study used PET imaging to investigate the characteristics of microglia activation and myelin injury in different phenotypes and disability stages of multiple sclerosis. The results showed that innate immune cell characteristics and myelin loss occurred independently in both white matter and gray matter structures, and were associated with disability.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Sam Sedaghat, Hyungseok Jang, Jiyo S. Athertya, Martin Groezinger, Jody Corey-Bloom, Jiang Du
Summary: The signal intensity variations (SIVs) of MS lesions on direct myelin imaging and standard clinical sequences were investigated as potential MRI biomarkers for disability in MS patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Robert Slusarz, Joanna Olkiewicz, Robert Bonek, Karolina Filipska, Monika Biercewicz, Adam Wisniewski
Summary: The study aimed to investigate the impact of motor disability and fatigue-related syndrome on the level of compliance with therapeutic recommendations. Prospective studies conducted among 165 multiple sclerosis patients revealed a relationship between motor disability and treatment adherence. The research showed that patients with higher disability levels demonstrated lower adherence rates, but adherence levels among patients treated with immunomodulation remained consistently high.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Inge Kirchberger, Florian Wallner, Jakob Linseisen, Philipp Zickler, Michael Ertl, Markus Naumann, Christine Meisinger
Summary: This study found that post-stroke fatigue is a common symptom, even in patients with mild impairment, and can persist over time. Prior depressive disorder and early depressive symptoms were identified as the most relevant predictors of both early and late fatigue.
FRONTIERS IN NEUROLOGY
(2022)
Review
Nutrition & Dietetics
Jose Enrique de la Rubia Orti, Maria Cuerda-Ballester, Claudia Emmanuela Sanchis-Sanchis, Jose Maria Lajara Romance, Esther Navarro-Illana, Maria Pilar Garcia Pardo
Summary: This article discusses the impact of ketogenic diet (KD) on emotional symptoms in patients with multiple sclerosis (MS). The study found that KD can improve glutamate activity and reduce central inflammation by reducing obesity, improving insulin resistance, and dyslipidemia. This improvement may alleviate functional disability and emotional disorders such as anxiety and depression by reducing extrasynaptic glutamate activity.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Marcello Moccia, Luca Fontana, Raffaele Palladino, Fabrizia Falco, Ferdinando Finiello, Mauro Fedele, Roberta Lanzillo, Liberata Reppuccia, Maria Triassi, Vincenzo Brescia Morra, Ivo Iavicoli
Summary: This study compares the differences in occupational history and early working impairments between people with multiple sclerosis (MS) and healthy workers. The results show that workers with MS are more working disabled, less exposed to workplace risks, and more limited in fitness to work compared with controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Justin Abe, Saba Jafarpour, My H. Vu, Devon O'Brien, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Kelli C. Paulsen, Laura E. Saucier, Nusrat Ahsan, Wendy G. Mitchell, Jonathan D. Santoro
Summary: The endocrine status of children with pediatric onset multiple sclerosis (POMS) is not associated with the severity of the disease or non-motor symptoms, but levels of free testosterone, cortisol, ACTH, and progesterone are abnormal in these patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Matthew Plow, Douglas D. Gunzler, Julia H. C. Chang
Summary: This study aimed to identify fatigue phenotypes in multiple sclerosis (MS) patients and examine their stability over time. The results suggest that considering the severity of fatigue experienced may be more important than considering the type of fatigue when characterizing fatigue phenotypes. Future research should explore interventions targeting environmental factors, self-efficacy, and fatigue catastrophizing to reduce the likelihood of transitioning to more severe fatigue phenotypes.
QUALITY OF LIFE RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Lipka, Eva Niess, Assunta Dal-Bianco, Gilbert J. Hangel, Paulus S. Rommer, Bernhard Strasser, Stanislav Motyka, Lukas Hingerl, Thomas Berger, Petra Hnilicova, Ema Kantorova, Fritz Leutmezer, Egon Kurca, Stephan Gruber, Siegfried Trattnig, Wolfgang Bogner
Summary: Magnetic resonance spectroscopic imaging (MRSI) allows for the assessment of metabolic alterations in multiple sclerosis (MS) that cannot be visualized using conventional magnetic resonance imaging (MRI). This study used 7 T MRSI to evaluate focal metabolic changes in MS lesions that are visible or invisible on MRI. The results showed increased mIns/tNAA levels in focal regions that were not visible on MRI, suggesting the potential of MRSI as an early biomarker in lesion development.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Clinical Neurology
Valerio Da Ros, Andrea Duggento, Armando Ugo Cavallo, Luigi Bellini, Francesca Pitocchi, Nicola Toschi, Alfredo Paolo Mascolo, Fabrizio Sallustio, Francesca Di Giuliano, Marina Diomedi, Roberto Floris, Francesco Garaci, Kamil Zelenak, Ilaria Maestrini
Summary: Machine learning applied to cone-beam CT can improve the prediction of 24-h hemorrhagic transformation in acute ischemic stroke patients undergoing endovascular thrombectomy. The study found that ML had high sensitivity but low accuracy in predicting 24-h hemorrhagic transformation.
Article
Clinical Neurology
Paul Martin Putora, Goncalo G. Almeida, Simon Wildermuth, Johannes Weber, Tobias Dietrich, Meike W. W. Vernooij, Pieter Jan van Doormaal, Lucas Smagge, Kamil Zelenak, Alexandre Krainik, Fabrice Bonneville, Luc van den Hauwe, Markus Moehlenbruch, Federico Bruno, Birgitta Ramgren, Ana Ramos-Gonzalez, Till Schellhorn, Stephan Waelti, Tim Fischer
Summary: The purpose of this study was to evaluate and compare the factors relevant to the diagnostic decision-making and imaging workup of intracerebral hemorrhages in large, specialized European centers. Expert neuroradiologists from ten centers in nine European countries were selected, and their descriptions of investigation methods were collected and compared. The findings showed that although all centers considered clinical guidelines important, there were still variations in imaging workup.
Review
Biochemistry & Molecular Biology
Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolisek
Summary: Alzheimer's disease (AD) is an incurable neurodegenerative disease characterized by perturbed cerebral perfusion and metabolism, induced proinflammatory processes, and the aggregation of amyloid beta and hyperphosphorylated Tau proteins. Various imaging methods can detect subclinical AD changes, and new insights suggest a link between brain insulin resistance and AD pathogenesis. This article discusses the use of non-neuronal imaging modalities to assess AD-related structural changes in the liver and pancreas, which may be clinically important during the prodromal phase of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neuroimaging
Lukas Meyer, Christian Paul Stracke, Maxim Bester, Kevin M. Kallmes, Kamil Zelenak, Aymeric Rouchaud, Mario Martinez-Galdamez, Pascal Jabbour, Thanh N. Nguyen, Adnan H. Siddiqui, Jens Fiehler, Susanne Gellissen
Summary: This study aims to summarize the available evidence on factors associated with aneurysm occlusion (AO) after treatment with a flow diverter (FD). The predictors with the highest impact on AO following FD treatment include aneurysm diameter, absence of branch involvement, and younger patient age.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Chemistry, Analytical
Nela Zidekova, Kristian Prso, Kristina Brisudova, Lucia Babalova, Tomas Bolek, Stefan Sivak, Egon Kurca, Juraj Mokry, Matej Samos, Vladimir Nosal, Martin Kertys
Summary: In this study, a sensitive and high throughput ultra-high-performance liquid chromatography-tandem mass spectrometry method was developed for simultaneous quantification of apixaban, dabigatran, edoxaban, and rivaroxaban in human plasma. The method was validated and found to be suitable for therapeutic drug monitoring of direct oral anticoagulants.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Biophysics
J. Oleksakova, M. Javorka, B. Czippelova, N. Mazgutova, M. Grofik, L. Babalova, P. Skacik, E. Kurca
Summary: This study aimed to assess various aspects of autonomic cardiovascular control in the very early stage of Parkinson's disease. The results showed well-preserved heart rate and blood pressure control in patients with early stage of Parkinson's disease, but subtle differences in baroreflex function and baroreflex mediated vasoconstriction response to orthostasis were observed. These findings suggest that motor signs dominate in this stage of Parkinson's disease.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Biology
Kamil Zelenak, Dusan Salat, Branislav Kolarovszki, Egon Kurca, Jana Zelenakova, Naci Kocer
Summary: A 22-year-old woman in her first pregnancy at 23 weeks of gestation had bleeding from a pial arteriovenous malformation (AVM) in the right cerebellum. The AVM was successfully treated with embolization using PHIL (precipitating hydrophobic injectable liquid). The radiation dose to the uterus was minimal, and the pregnancy resulted in a healthy baby without congenital disorders after two years.
Article
Clinical Neurology
Daniel Cierny, Dusan Dobrota, Ema Kantorova, Bibiana Malicherova, Maria Skerenova, Juraj Javor, Egon Kurca, Jan Lehotsky
Summary: The Cdx-2 gene polymorphism is not associated with the risk or progression of multiple sclerosis (MS), while the HLA-DRB1*15:01 allele is strongly associated with an increased risk of MS.
NEUROLOGICAL RESEARCH
(2023)
Article
Cell Biology
Maria Kovalska, Petra Hnilicova, Dagmar Kalenska, Marian Adamkov, Libusa Kovalska, Jan Lehotsky
Summary: This study investigates the effects of a high methionine diet on metabolic ratio and histomorphological alterations in the rat hippocampus. The results show that high methionine diet-induced hyperhomocysteinemia leads to significant changes in metabolism and tissue morphology in the hippocampus. These changes may contribute to the progression of neurodegeneration and the development of Alzheimer's disease-like pathological features.
Article
Biochemistry & Molecular Biology
Milan Grofik, Michal Cibulka, Jana Oleksakova, Stefan Sivak, Daniel Cierny, Zuzana Tatarkova, Marian Grendar, Vladimir Nosal, Robert Ruzinak, Egon Kurca, Martin Kolisek
Summary: This study analyzed the levels of oxidative stress parameters in the blood of Parkinson's disease patients and healthy controls, and found that uric acid was associated with the disease. However, these oxidative stress parameters lack predictive/diagnostic power in clinical practice.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2023)
