Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Otorhinolaryngology
Robert C. C. Rennert, Vance L. L. Fredrickson, William T. T. Couldwell
Summary: The microscopic transsphenoidal approach is an efficient technique that provides an unobstructed corridor and expanded access. Despite the increasing use of endoscopy, current data is insufficient to definitively support the choice between endoscopic and microscopic approaches.
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
(2022)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: Transsphenoidal surgery is the standard treatment for hormone-secreting pituitary adenomas. This study proposes a novel way to classify and report surgical outcomes by integrating efficacy and safety at the patient level. The results show that surgical interventions can be presented in four categories, incorporating both efficacy and safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Yoon-Hee Choo, Youngbeom Seo, Oh-Lyong Kim
Summary: This study retrospectively analyzed the outcomes of the transsphenoidal approach for nonfunctioning pituitary adenomas treated at a single institute. The study found that the transsphenoidal approach is an effective and safe treatment, improving visual impairment and restoring endocrine function. Diabetes insipidus was the most common complication, and complete resection during surgery helped to lower the risk of recurrence.
ANNALS OF MEDICINE
(2022)
Article
Clinical Neurology
Lea M. Alhilali, Andrew S. Little, Kevin C. J. Yuen, Jae Lee, Timothy K. Ho, Saeed Fakhran, William L. White
Summary: In this study of 102 patients undergoing microscopic transsphenoidal resection of a pituitary adenoma, early postoperative MRI showed high sensitivity and specificity for detecting residual tumors, with better reliability than late postoperative MRI. Early MRI identified 4 residual tumors that were missed by intraoperative assessment and late MRI, providing important guidance for reoperation in select patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Matthew C. Findlay, Richard Drexler, Majid Khan, Kyril L. Cole, Arian Karbe, Roman Rotermund, Franz L. Ricklefs, Joerg Flitsch, Timothy R. Smith, John L. Kilgallon, Juergen Honegger, Isabella Nasi-Kordhishti, Paul A. Gardner, Zachary C. Gersey, Hussein M. Abdallah, John A. Jane, Alexandria C. Marino, Ulrich J. Knappe, Nesrin Uksul, Jamil A. Rzaev, Evgeniy V. Galushko, Ekaterina V. Gormolysova, Anatoliy V. Bervitskiy, Henry W. S. Schroeder, Marton Eoerdoegh, Marco Losa, Pietro Mortini, Ruediger Gerlach, Apio C. M. Antunes, William T. Couldwell, Karol P. Budohoski, Robert C. Rennert, Mohammed Azab, Michael Karsy
Summary: This international multicenter study compared the clinical outcomes of microsurgical and endoscopic transnasal surgery for resecting pituitary adenomas. The results showed that microsurgery had better gross total resection rates but also had more complications and hospital utilization.
Article
Endocrinology & Metabolism
Alies J. Dekkers, Friso de Vries, Amir H. Zamanipoor Najafabadi, Emmy M. van der Hoeven, Marco J. T. Verstegen, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study retrospectively assessed the healthcare costs and cost drivers in perioperative care for pituitary tumour patients. The results showed that length of hospital stay and complications were the main drivers of costs, and certain baseline features were also associated with higher costs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Clinical Neurology
Christina E. Sarris, Scott T. Brigeman, Estelle Doris, Maggie Bobrowitz, Thomas Rowe, Eva M. Duran, Griffin D. Santarelli, Ryan M. Rehl, Garineh Ovanessoff, Monica C. Rodriguez, Kajalben Buddhdev, Kevin C. J. Yuen, Andrew S. Little
Summary: After implementing a comprehensive quality improvement program for pituitary surgery patients, there were significant improvements in patient outcomes, decreased outcome variability, and enhanced hospital financial performance. Future studies may provide further insight into disease remission, patient satisfaction, and how the surgeon learning curve impacts quality efforts.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Vicki M. Butenschoen, Alexander von Werder, Stefanie Bette, Veronika Schmette, Nina Schwendinger, Bernhard Meyer, Jens Gempt
Summary: Transsphenoidal surgery is a minimally invasive treatment for pituitary adenoma, and a study found that cortisol measurements taken 6 weeks after surgery are more reliable in predicting corticotroph function compared to measurements taken 5 days postoperatively.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Ryan Delport, James King, Mendel Castle-Kirszbaum, Tony Goldschlager, Carmela Caputo, Yi Yuen Wang
Summary: This study aimed to determine if resection of pituitary adenomas via the endoscopic endo-nasal approach (EEA) improves headaches and investigate factors that may be associated with headaches in patients with pituitary adenoma. The results showed that surgery using this method can significantly improve headaches and patients with cavernous sinus invasion are more likely to experience improvement in headaches.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Hyung-Chul Lee, Hyun-Kyu Yoon, Jung Hee Kim, Yong Hwy Kim, Hee-Pyoung Park
Summary: The study suggests that preoperative steroid administration may not be necessary for patients without adrenal insufficiency undergoing endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas, as it does not affect the pituitary hormone levels postoperatively. However, further large-scale studies are needed to determine the impact of preoperative steroid administration on clinically meaningful events such as perioperative AI and postoperative 3-month ACTH deficiency in these patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Taemin Oh, Rushikesh S. Joshi, Alexander F. Haddad, Kaitlyn M. Pereira, Kevin C. Donohue, Zain Peeran, William Carson, Aarav Badani, Elaina J. Wang, Sweta Sudhir, Ankush Chandra, Saket Jain, Angad Beniwal, Jose Gurrola II, Ivan H. El-Sayed, Lewis S. Blevins Jr, Philip V. Theodosopoulos, Sandeep Kunwar, Manish K. Aghi
Summary: This study assessed the correlation between tumor volume and prolactin level in prolactinoma and its impact on surgical outcomes. The results showed a strong association between tumor volume and prolactin levels, with an increase in tumor volume leading to a significant increase in prolactin levels in patients without biochemical remission after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Iyan Younus, Mina Gerges, Theodore H. Schwartz, Rohan Ramakrishna
Summary: Patients with Medicaid insurance undergoing endonasal endoscopic transsphenoidal surgery for pituitary adenoma tend to have larger tumor diameter, longer postoperative length of stay, higher rate of complications, and increased likelihood of long-term cranial neuropathy. However, there were no statistically significant differences in baseline comorbidities, apoplexy, endocrine outcome, vision outcome, or 30-day readmission.
JOURNAL OF NEUROSURGERY
(2021)