Article
Neurosciences
Ruike Chen, Cong Sun, Tingting Liu, Yuhao Liao, Junyan Wang, Yi Sun, Yi Zhang, Guangbin Wang, Dan Wu
Summary: This study used fetal brain dMRI atlas to investigate the spatiotemporal pattern of white matter development, and found complex non-monotonic trends in microstructural parameters of eight white matter tracts, providing reference for diagnosing abnormal fetal white matter development.
Article
Clinical Neurology
Zeinab Sinaeifar, Mahsa Mayeli, Mahdieh Shafie, Atefe Pooyan, Giulia Cattarinussi, Mohammad Hadi Aarabi, Fabio Sambataro
Summary: This is a study that used DMRI connectometry approach to investigate white matter tracts associated with anger, while exploring potential sex differences. The results showed that the pathways associated with the limbic system and movement-related regions were involved in anger in men, while no brain pathways showed a significant relationship with anger in women.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Wasim Khan, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann
Summary: Advanced diffusion MRI was used to assess microstructural properties of normal-appearing white matter (NAWM) before it converted to white matter hyperintensities (WMHs) in ischemic stroke. The study found that NAWM converting to WMHs already exhibited changes in tissue compositions, with lower white matter-like and increased fluid-like and gray matter-like properties compared to persistent NAWM. Furthermore, the microstructural compositions were related to overall WMH burden, indicating greater fluid-like properties in NAWM vulnerable to WMH development.
Article
Psychology, Developmental
Benjamin T. Newman, James T. Patrie, T. Jason Druzgal
Summary: Puberty is a crucial period in adolescent development that affects various aspects of physiology, including the brain. This study analyzes diffusion MRI scans to examine the relationship between pubertal development and brain microstructure. The findings suggest that pubertal changes are associated with complex responses in brain tissue beyond traditional measures focusing on white matter axonal properties.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Lorna Bryant, Emilie T. McKinnon, James A. Taylor, Jens H. Jensen, Leonardo Bonilha, Christophe de Bezenac, Barbara A. K. Kreilkamp, Guleed Adan, Udo C. Wieshmann, Shubhabrata Biswas, Anthony G. Marson, Simon S. Keller
Summary: This study utilized FBI and FBWM to evaluate the diffusion properties of white matter tracts in patients with epilepsy. It was found that patients with chronic epilepsy had a widespread distribution of extra-axonal diffusivity, and those with refractory epilepsy exhibited significantly greater markers of extra-axonal diffusivity compared to nonrefractory epilepsy patients. These findings suggest that extra-axonal diffusivity alterations may serve as biomarkers of neuroinflammatory processes or reduced axonal density in epilepsy.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Giulia Berto, Daniel Bullock, Pietro Astolfi, Soichi Hayashi, Luca Zigiotto, Luciano Annicchiarico, Francesco Corsini, Alessandro De Benedictis, Silvio Sarubbo, Franco Pestilli, Paolo Avesani, Emanuele Olivetti
Summary: This study introduces a novel supervised fiber segmentation method called Classifyber, which combines information from atlases, connectivity patterns, and the geometry of fiber paths into a simple linear model. Through experiments on multiple datasets, it is demonstrated that Classifyber substantially improves segmentation quality compared to other state-of-the-art methods and is robust across diverse settings. The proposed method is provided as open-source code and a web service.
Article
Multidisciplinary Sciences
Isaac M. Adanyeguh, Francesca Branzoli, Cecile Delorme, Aurelie Meneret, Marie-Lorraine Monin, Marie-Pierre Luton, Alexandra Durr, Emanoel Sabidussi, Fanny Mochel
Summary: Huntington's disease is a fully penetrant neurodegenerative disorder with early-stage white matter damage. Fixel-based analysis (FBA) and diffusion-weighted magnetic resonance spectroscopy (DW-MRS) provided specific information about microstructural changes in the brain of HD patients. The study identified potential imaging markers and biological mechanisms underlying white matter degeneration in HD.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunxiang Zhang, Xin Zhao, Zitao Zhu, Kaiyu Wang, Brianna F. Moon, Bohao Zhang, Sayed Noman Sadat, Jinxia Guo, Jieaoxue Bao, Ding Zhang, Xiaoan Zhang
Summary: This study aimed to investigate the value of diffusion tensor imaging (DTI) combined with serum C-reactive protein (CRP) and procalcitonin (PCT) in evaluating alterations of white matter (WM) microstructure in preterm infants with necrotizing enterocolitis (NEC). The results showed that preterm infants with NEC had reduced FA values and elevated MD values in specific WM regions, and these changes were correlated with serum CRP and PCT levels. The combination of WM, CRP, and PCT showed improved performance in detecting and evaluating WM microstructure alterations in preterm infants with NEC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neuroimaging
Chiara Maffei, Natalie Gilmore, Samuel B. Snider, Andrea S. Foulkes, Yelena G. Bodien, Anastasia Yendiki, Brian L. Edlow
Summary: New techniques are needed to assess white matter integrity in individual patients with traumatic brain injury (TBI). Diffusion MRI tractography has been used to quantify white matter microstructure, but it is not commonly used in clinical settings due to the presence of focal lesions. In this study, we propose an automated tractography pipeline that successfully detected and quantified TAI in patients with acute severe TBI.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Anthony Gagnon, Gabrielle Grenier, Christian Bocti, Virginie Gillet, Andrea A. Baccarelli, Jonathan Posner, Maxime Descoteaux, Larissa Takser
Summary: Structural and functional MRI studies have explored the neuroanatomical basis of ADHD, but the anatomical ground truth remains unknown. This study used a state-of-the-art connectivity pipeline to analyze white matter connections and found that children with lower microstructural complexity and axonal density showed higher impulsive behavior. Subsection analysis revealed localized white matter alterations along each connection.
Article
Neurosciences
Katherine E. Lawrence, Zvart Abaryan, Emily Laltoo, Leanna M. Hernandez, Michael J. Gandal, James T. McCracken, Paul M. Thompson
Summary: Sex differences in white matter microstructure were examined in over 6000 children between 9 and 10 years old. Significant and replicable differences were found in both conventional and advanced diffusion-weighted imaging metrics. Boys exhibited greater diffusion metrics, while girls showed increased cell density. These findings provide an important foundation for understanding sex differences in health and disease.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Alena Stasenko, Erik Kaestner, Anny Reyes, Sanam J. Lalani, Brianna Paul, Manu Hegde, Jonathan L. Helm, Sharona Ben-Haim, Carrie R. McDonald
Summary: This study highlights that preoperative asymmetry of deep and superficial white matter structures within the temporal lobe can predict postoperative memory decline in patients with temporal lobe epilepsy. Furthermore, asymmetry of the superficial white matter is shown to be the strongest predictor in predicting and classifying memory outcomes.
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Muhamed Barakovic, Gabriel Girard, Simona Schiavi, David Romascano, Maxime Descoteaux, Cristina Granziera, Derek K. Jones, Giorgio M. Innocenti, Jean-Philippe Thiran, Alessandro Daducci
Summary: Our novel microstructure-informed tractography approach, COMMITAxSize, resolves axon diameter index estimates at the streamline level, providing invariant estimates along trajectories. By jointly estimating tissue microstructure properties and macroscopic white matter connectivity organization, our method offers a more robust estimation of axon diameter index for pathways compared to existing methods. We demonstrate the efficacy of our approach by comparing estimates with histologically-derived measurements in specific brain regions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Simona Schiavi, Po-Jui Lu, Matthias Weigel, Antoine Lutti, Derek K. Jones, Ludwig Kappos, Cristina Granziera, Alessandro Daducci
Summary: This study introduces a new method called myelin streamline decomposition (MySD), which extends convex optimization modeling to microstructure informed tractography (COMMIT), allowing the deconvolution of the actual value measured by a microstructural map on each individual streamline to recover unique bundle specific myelin fractions (BMFs).
Review
Radiology, Nuclear Medicine & Medical Imaging
Juergen Hennig, Vesa Kiviniemi, Bruno Riemenschneider, Antonia Barghoorn, Burak Akin, Fei Wang, Pierre LeVan
Summary: MREG method has evolved from a 'Gedankenexperiment' in 2005 to a fast and efficient way of measuring physiological brain activities. The method involves a stack-of-spiral trajectory for full brain coverage with high acceleration factors. Recent advances include targeted reconstruction for real-time feedback applications and time-domain principal component reconstruction for improved speed and quality.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2021)
Article
Biophysics
Salvatore Mamone, Andreas B. Schmidt, Niels Schwaderlapp, Thomas Lange, Dominik von Elverfeldt, Juergen Hennig, Stefan Gloeggler
Summary: Magnetic resonance imaging is a key technology for investigating diseases, particularly metabolic dysfunction. Understanding and monitoring metabolic changes are crucial for developing cures for various illnesses. MR methodologies are suitable for studying physiological functions within an organism.
NMR IN BIOMEDICINE
(2021)
Article
Anatomy & Morphology
Meltem Karatas, Vincent Noblet, Md Taufiq Nasseef, Thomas Bienert, Marco Reisert, Jurgen Hennig, Ipek Yalcin, Brigitte Lina Kieffer, Dominik von Elverfeldt, Laura-Adela Harsan
Summary: Researchers conducted a comparative study of brain structure and function in C57BL/6 and BALB/cJ mice using MRI technology, revealing extensive differences between the two strains, particularly in areas such as the frontal cortices and corpus callosum. Additionally, differences were observed in functional networks such as the reward-aversion circuitry and default mode network.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonia Barghoorn, Bruno Riemenschneider, Juergen Hennig, Pierre LeVan
Summary: The study shows that using SE-MREG at 3T can improve the sensitivity of BOLD activation detection by 33% to 54% compared to GE-fMRI, while also aiding in the extraction of resting-state networks. Importantly, in brain regions affected by strong susceptibility-induced magnetic field gradients, SE-MREG demonstrates significantly higher relative signal strength compared to GE-MREG.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bruno Riemenschneider, Burak Akin, Pierre LeVan, Juergen Hennig
Summary: This study aimed to balance ultra-high temporal resolution and spatial signal quality by varying sampling densities. Results showed that denser sampling reduced image blurring and off-resonance vulnerability compared to sparse sampling. The three-shot interleaved stack of spirals demonstrated higher signal-to-noise ratio and image quality.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiang Gao, Valerij G. Kiselev, Thomas Lange, Juergen Hennig, Maxim Zaitsev
Summary: An open-source spatially resolved phase graph framework is proposed for simulating arbitrary pulse sequences efficiently in three dimensions and estimating signal modulation. The framework's effectiveness is validated through several application examples showing its ability to analyze signal evolution in both frequency and spatial domain.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Clinical Neurology
Zalan Rajna, Heli Mattila, Niko Huotari, Timo Tuovinen, Johanna Kruger, Sebastian C. Holst, Vesa Korhonen, Anne M. Remes, Tapio Seppanen, Jurgen Hennig, Maiken Nedergaard, Vesa Kiviniemi
Summary: The accumulation of amyloid-beta in the brain of Alzheimer's disease patients is a key feature of the disease. Changes in cerebral haemodynamics, such as arterial impulse propagation, can predict the progression of Alzheimer's disease. The study introduced a non-invasive method to quantify the three-dimensional propagation of cardiovascular impulses in the human brain, revealing abnormalities in impulse propagation in Alzheimer's disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Juergen Hennig, Antonia Barghoorn, Shuoyue Zhang, Maxim Zaitsev
Summary: This study developed a single shot spiral turbo spin echo (TSE) sequence that can acquire artifact free images of the central nervous system with 1 mm spatial resolution at 3T.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biophysics
Mohammad Khateri, Marco Reisert, Alejandra Sierra, Jussi Tohka, Valerij G. Kiselev
Summary: Filter-exchange imaging (FEXI) is a method used for evaluating the permeability of cell membranes, relying on suppressing extracellular signals and monitoring diffusivity recovery. Monte Carlo simulations show that FEXI is sensitive to both transcytolemmal exchange and compartment geometry.
NMR IN BIOMEDICINE
(2022)
Article
Biophysics
Anders Dyhr Sandgaard, Noam Shemesh, Valerij G. Kiselev, Sune Norhoj Jespersen
Summary: The magnetic susceptibility of tissue provides information about its chemical composition and microstructural organization, but the relationship between magnetic microstructure and the measurable Larmor frequency shift is only understood for a few idealized cases. In this study, we analyzed the microstructure formed by magnetized, NMR-invisible infinite cylinders in an NMR-reporting fluid. We examined various geometries of mesoscopic Lorentz cavities and inclusions through simulations, and found that the cavity size should be approximately one order of magnitude larger than the width of the inclusions. We also derived the Larmor frequency shift for a population of cylinders with arbitrary orientation dispersion and found that it depends on the Laplace expansion coefficients p2m of the cylinders' orientation distribution function. Our work emphasizes the importance of considering microstructural organization when estimating magnetic tissue properties.
NMR IN BIOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Christopher Nelson, Andreas B. Schmidt, Isaiah Adelabu, Shiraz Nantogma, Valerij G. Kiselev, Abubakar Abdurraheem, Henri de Maissin, Soeren Lehmkuhl, Stephan Appelt, Thomas Theis, Eduard Y. Chekmenev
Summary: The feasibility of Carbon-13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C-13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1-C-13]acetate. The study successfully observed C-13 RASER signals and demonstrated its potential application on biomolecular carriers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anders Dyhr Sandgaard, Noam Shemesh, Sune Norhoj Jespersen, Valerij G. Kiselev
Summary: Estimating magnetic susceptibility using MRI relies on inverting the relationship between susceptibility and measured Larmor frequency. This study tests the impact of accounting for the constraint that Larmor frequency is only measured inside the sample and susceptibility sources should only reside inside the same sample.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Adrienne E. Campbell-Washburn, Kathryn E. Keenan, Peng Hu, John P. Mugler, Krishna S. Nayak, Andrew G. Webb, Johnes Obungoloch, Kevin N. Sheth, Juergen Hennig, Matthew S. Rosen, Najat Salameh, Daniel K. Sodickson, Joel M. Stein, Jose P. Marques, Orlando P. Simonetti
Summary: The first ISMRM Workshop on Low-Field MRI was held virtually in March 2022, discussing recent advancements in low field MRI technology and its clinical applications. With 368 registrants from 24 countries, the workshop included invited talks, abstract presentations, panel discussions, and live scanner demonstrations. The workshop emphasized the potential of low-field MRI in expanding MRI usage through cost reduction, portability, and ease of installation, as well as the challenges in overcoming SNR limitations and establishing clinical value.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Urs Wuertemberger, Daniel Erny, Alexander Rau, Jonas A. Hosp, Veysel Akguen, Marco Reisert, Valerij G. Kiselev, Jurgen Beck, Sonja Jankovic, Peter C. Reinacher, Marc Hohenhaus, Horst Urbach, Martin Diebold, Theo Demerath
Summary: The study successfully differentiated glioblastomas and brain metastases using advanced diffusion techniques and structural histopathology. Analysis of microstructural features in the contrast-enhancing tumor components served as imaging biomarkers for distinguishing these tumor entities.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Juergen Hennig
Summary: The paper details the evolution of low-field MRI from its inception to present day, focusing on the differences in research environments. In the early 90s, the lack of reasonable means to compensate for the difference in signal-to-noise ratio between 0.5 and 1.5 T resulted in the disappearance of low-field systems. However, advancements in hardware, RF receiver systems, faster gradients, flexible sampling schemes, and the integration of AI have made low-field MRI a clinically viable supplement. Additionally, ultralow-field MRI with magnets around 0.05 T has emerged as an endeavor to bring MRI to underserved communities.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
