Journal
NEUROIMAGE
Volume 148, Issue -, Pages 123-129Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2017.01.018
Keywords
Dopamine; Aging; Physical activity
Funding
- National Institute on Aging [R01AG044838, R00AG042596]
- National Institute on Drug Abuse [F32DA036979]
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Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18 F]fallypride, was significantly reduced in physically active adults compared to less active adults.
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