Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

Chronic social stress in pigs impairs intestinal barrier and nutrient transporter function, and alters neuro-immune mediator and receptor expression

(2017) Yihang Li et al.   PLoS One

The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS)

(2016) N. Kanuri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Early life adversity in piglets induces long-term upregulation of the enteric cholinergic nervous system and heightened, sex-specific secretomotor neuron responses

(2016) J. E. Medland et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress

(2016) Emily Mackey et al.   Biology of Sex Differences

Evidence for Neuronal and Structural Changes in Submucous Ganglia of Patients With Functional Dyspepsia

(2015) Carla Cirillo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications

(2015) Calvin S. Pohl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

(2015) Giovanni Dothel et al.   GASTROENTEROLOGY

Estrogen modulates intestinal mucus physiochemical properties and protects against oxidant injury

(2015) Mark E. Diebel et al.   Journal of Trauma and Acute Care Surgery

Estrogen modulates intestinal mucus physiochemical properties and protects against oxidant injury

(2015) Mark E. Diebel et al.   Journal of Trauma and Acute Care Surgery

Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders

(2014) Z. Mujagic et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Episodic Nature of Symptoms in Irritable Bowel Syndrome

(2014) Olafur S Palsson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Conceptual frameworks and mouse models for studying sex differences in physiology and disease: Why compensation changes the game

(2014) Arthur P. Arnold   EXPERIMENTAL NEUROLOGY

Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10−/− Mice

(2013) E. M. Lennon et al.   INFLAMMATORY BOWEL DISEASES

Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease

(2013) Brittney L. McLamb et al.   PLoS One

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

(2012) J. Matricon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

(2012) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

(2012) Cristina Martínez et al.   GUT

Acute experimental stress evokes a differential gender-determined increase in human intestinal macromolecular permeability

(2012) C. Alonso et al.   NEUROGASTROENTEROLOGY AND MOTILITY

CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

(2012) Elizabeth L. Overman et al.   PLoS One

Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls

(2011) Archana S. Rao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Estrogen receptor-β signaling modulates epithelial barrier function

(2011) Mirjam Looijer-van Langen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association Between Early Adverse Life Events and Irritable Bowel Syndrome

(2011) Kara Bradford et al.   Clinical Gastroenterology and Hepatology

Leaky Gut in Patients with Diarrhea-Predominant Irritable Bowel Syndrome and Inactive Ulcerative Colitis

(2011) Krisztina Gecse et al.   DIGESTION

The role of experimental models in developing new treatments for irritable bowel syndrome

(2011) Daniel P Holschneider et al.   Expert Review of Gastroenterology & Hepatology

Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?

(2010) M. A. Adeyemo et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Organized for sex - steroid hormones and the developing hypothalamus

(2010) Kathryn M. Lenz et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome

(2010) T. K. Klooker et al.   GUT

Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

(2009) Cesare Cremon et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

(2009) Feli Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The tight junction in inflammatory disease: communication breakdown

(2009) Karen L Edelblum et al.   CURRENT OPINION IN PHARMACOLOGY

Oestradiol decreases colonic permeability through oestrogen receptor β-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells

(2009) Viorica Braniste et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

(2009) Katherine R. Groschwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Life Risk Factors That Contribute to Irritable Bowel Syndrome in Adults: A Systematic Review

(2008) Denesh K. Chitkara et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition

(2008) Arnold S Kirshenbaum et al.   BMC IMMUNOLOGY

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Long-term alterations of colonic nerve-mast cell interactions induced by neonatal maternal deprivation in rats

(2008) F. Barreau et al.   GUT

Increased Gastrointestinal Permeability and Gut Inflammation in Children with Functional Abdominal Pain and Irritable Bowel Syndrome

(2008) Robert J. Shulman et al.   JOURNAL OF PEDIATRICS