Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Infectious Diseases
Yorinobu Maeda, Teruo Murakami
Summary: Small intestinal bacterial overgrowth (SIBO) is characterized by an increase in the number and/or alteration in the type of bacteria in the upper gastrointestinal tract, causing various bowel symptoms. SIBO can be diagnosed using microbial culture or breath tests after carbohydrate ingestion. However, these methods have limitations and risks. Urinary excretion tests using bile acid conjugates have shown potential as diagnostic substrates for SIBO. PABA-UDCA disulfate offers a simple and rapid method for evaluating SIBO. Treatments for SIBO include antibiotics, probiotics, therapeutic diets, herbal medicines, and fecal microbiota transplantation.
Article
Gastroenterology & Hepatology
Daanish A. Siddique, Claire L. Jansson-Knodell, Anita Gupta, Gage Howard, Matthew E. Bohm, Robert M. Siwiec, David E. Nelson, Andrea S. Shin, John M. Wo
Summary: This study investigated whether different types of small intestinal bacterial overgrowth (SIBO) lead to different symptoms. The study found that overgrowth of bacteria in the oropharyngeal and respiratory tract was more associated with abdominal distention, while overgrowth of bacteria in the distal small bowel and colon was more associated with iron deficiency.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Physiology
Peter Bakonyi, Attila Kolonics, Dora Aczel, Lei Zhou, Soroosh Mozaffaritabar, Kinga Molnar, Lajos Laszlo, Balazs Kutasi, Kumpei Tanisawa, Jonguk Park, Yaodong Gu, Ricardo A. Pinho, Zsolt Radak
Summary: This study investigated the possible interactions of the brain-exercise-intestine-microbiome axis. The results showed that voluntary exercise could increase endurance capacity and spatial memory, but had no significant effect on gastrointestinal motility and intestinal oxidative stress levels. Additionally, voluntary exercise increased the number of caveolae in the smooth muscles of the intestine and the relative abundance of Bifidobacteria in the microbiome, which correlated with Akt levels in the intestine.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. M. Quigley
Summary: The concept of small intestinal bacterial overgrowth (SIBO) explains the cause of maldigestion and malabsorption. With the development of diagnostic testing, the methods for diagnosing SIBO have evolved from small bowel culture to breath tests and culture-independent microbial analytics. The availability of breath tests has led to an expansion in the diagnosis of SIBO and the associated clinical symptoms. However, issues with the specificity of breath tests have raised doubts about the role of SIBO in certain clinical scenarios. The hope is to use modern molecular microbiology to study the human small intestinal microbiome in order to provide an objective basis for diagnosing SIBO.
Article
Pharmacology & Pharmacy
Huaizhu Guo, Siqi Lu, Jindong Zhang, Chen Chen, Yanlin Du, Kun Wang, Liping Duan
Summary: This study aims to evaluate the effects of berberine compared to rifaximin in SIBO patients. 180 patients will be recruited and divided into two groups for treatment, with the effectiveness and safety assessed. The findings of this study may have implications for the management of SIBO, increasing awareness among physicians and patients about long-term abdominal discomfort and excessive examination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Juan Wei, Jing Feng, Liya Chen, Zhao Yang, Hui Tao, Liuying Li, Ji Xuan, Fangyu Wang
Summary: This study revealed a high prevalence of SIBO in patients with CD and its independent association with clinical relapse in patients in remission, with SIBO and penetrating disease behavior being the main risk factors for relapse in individuals with quiescent CD.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Neha Durgam, Ankur A. Dashputre, Olga Moshkovich, Ali Rezaie, Nicholas Martinez, Pedram Enayati, James Stansbury, George Joseph
Summary: The purpose of this study was to develop and validate a new PRO instrument, the SIBO Symptom Measure (SSM) daily diary. The SSM assesses symptom severity in SIBO patients, aiming to provide a PRO tool for endpoint measurement.
QUALITY OF LIFE RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Roman Maslennikov, Vladimir Ivashkin, Irina Efremova, Elena Poluektova, Anna Kudryavtseva, George Krasnov
Summary: This study found a relationship between small intestinal bacterial overgrowth (SIBO) and gut dysbiosis in patients with cirrhosis. Patients with SIBO had higher levels of Firmicutes and Fusobacteria, and lower levels of Bacteroidetes compared to patients without SIBO. However, gut dysbiosis and SIBO are likely independent disorders in cirrhosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Anna Gudan, Dominika Jamiol-Milc, Victoria Hawrylkowicz, Karolina Skonieczna-Zydecka, Ewa Stachowska
Summary: Bacterial overgrowth in the small intestine (SIBO) is associated with non-alcoholic fatty liver disease (NAFLD). This systematic review and meta-analysis found that the prevalence of SIBO in patients with chronic non-alcoholic liver diseases can be as high as 35%, and it increases with the percentage of men in the population. However, further research is needed due to the moderate to low quality of included studies and high heterogeneity.
Article
Gastroenterology & Hepatology
Colin R. Lickwar, James M. Davison, Cecelia Kelly, Gilberto Padilla Mercado, Jia Wen, Briana R. Davis, Matthew C. Tillman, Ivana Semova, Sarah F. Andres, Goncalo Vale, Jeffrey G. McDonald, John F. Rawls
Summary: This study reveals that the combination of microbiota and high-fat diet may suppress the expression of hepatocyte nuclear factor 4 alpha, leading to the preferential activation of intestinal epithelial cell proliferation programs, which in turn affects intestinal lipid absorption, epithelial cell renewal, and systemic energy balance.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. Quigley
Summary: The concept of SIBO has undergone significant changes and challenges, with uncertainty and controversy surrounding its diagnosis. This review aims to discuss the current pathophysiology of SIBO.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2021)
Review
Pharmacology & Pharmacy
Qinyan Yao, Zihan Yu, Qingguo Meng, Jihua Chen, Yaxin Liu, Wenxuan Song, Xiangfeng Ren, Jinjie Zhou, Xin Chen
Summary: Obesity is a global public health problem with increasing occurrence worldwide. It is associated with many diseases and conditions such as NAFLD, T2DM, and IR. The gut microbiota has been recognized as an important factor in regulating host health and diseases. SIBO, a type of intestinal dysbiosis, has been found to be related to obesity and its related diseases. However, the causal relationship between SIBO and obesity and the specific mechanisms are not well understood. This review discusses the interaction between SIBO and obesity, its mechanisms, and potential interventions, aiming to discover new therapeutic targets and treatment options for obesity and its related diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xingjie Wu, Shuikuan Bei, Xi Zhou, Yu Luo, Zhibin He, Chunxu Song, Huimin Yuan, Barbara Pivato, Werner Liesack, Jingjing Peng
Summary: Cellular motility is crucial for effective colonization of the rhizosphere, and it is linked to other genetic traits. This study used metagenomics and phylogenomics to investigate the ecological significance of cellular motility for niche differentiation and the links between genetic makeup of motile bacteria and rhizosphere colonization. The results showed that genes encoding cellular motility were important predictors of bacterial niche differentiation, and highly motile genomes were more abundant in rhizosphere soil compared to bulk soil. These highly motile genomes were also enriched in beneficial traits related to carbohydrate utilization and nutrient cycling.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Surgery
Urska Novljan, Tadeja Pintar
Summary: This study evaluated the incidence of small intestinal bacterial overgrowth (SIBO) after bariatric bypass procedures and its connection with symptoms, comorbidities, and liver pathology. The results showed a alarmingly high incidence of SIBO after bariatric surgery and suggested that diagnosis cannot be based solely on specific symptoms. The study also found a correlation between SIBO and reduced response to low molecular weight heparin (LMWH) application.
Article
Substance Abuse
Maria R. Khan, Joy D. Scheidell, David L. Rosen, Amanda Geller, Laurie M. Brotman
DRUG AND ALCOHOL DEPENDENCE
(2018)
Article
Integrative & Complementary Medicine
N. Alammar, L. Wang, B. Saberi, J. Nanavati, G. Holtmann, R. T. Shinohara, G. E. Mullin
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Oncology
Celina N. Santiago, Samara Rifkin, Julia Drewes, Gerard Mullin, Emma Spence, Linda M. Hylind, Joell J. Gills, David Kafonek, David M. Cromwell, Louis La Luna, Francis Giardello, Cynthia L. Sears
Summary: Metabolic risk factors, particularly obesity and diabetes, are positively associated with colon polyps. Obesity and hypertension may increase the incidence of synch polyps, while no association was found between metabolic risk factors and the onset of SSPs.
CANCER PREVENTION RESEARCH
(2021)
Article
Psychology, Educational
Alexandra Ursache, Rebecca Robbins, Alicia Chung, Spring Dawson-McClure, Dimitra Kamboukos, Esther J. Calzada, Girardin Jean-Louis, Laurie Miller Brotman
Summary: Research indicates that sleep issues in first-grade children are related to classroom behavior and academic performance, with teacher-reported child sleepiness being associated with lower adaptive behaviors, higher problem behaviors, and lower achievement. Parent-reported bedtime resistance and disordered breathing are also predictors of lower academic achievement.
Article
Nutrition & Dietetics
Tyrus Vong, Lisa R. Yanek, Lin Wang, Huimin Yu, Christopher Fan, Elinor Zhou, Sun Jung Oh, Daniel Szvarca, Ahyoung Kim, James J. Potter, Gerard E. Mullin
Summary: This retrospective cohort study found that malnutrition in adult COVID-19 inpatients was associated with a higher likelihood of mortality and increased hospital length of stay.
Article
Psychology, Educational
Alexandra Ursache, Kathleen Kiely Gouley, Spring Dawson-McClure, R. Gabriela Barajas-Gonzalez, Esther J. Calzada, Keith S. Goldfeld, Laurie M. Brotman
Article
Education & Educational Research
Vanessa Rodriguez, S. Lynneth Solis, Bryan Mascio, Kathleen Kiely Gouley, Patricia A. Jennings, Laurie M. Brotman
EARLY EDUCATION AND DEVELOPMENT
(2020)
Article
Education & Educational Research
Natalia Rojas, Hirokazu Yoshikawa, Pamela Morris, Dimitra Kamboukos, Spring Dawson-Mcclure, Laurie Brotman
EARLY CHILDHOOD RESEARCH QUARTERLY
(2020)
Article
Psychology, Experimental
Alexandra Ursache, Spring Dawson-McClure, Jessica Siegel, Laurie Miller Brotman
COGNITION & EMOTION
(2019)
Article
Psychology, Clinical
David A. Schuberth, Yao Zheng, Dave S. Pasalich, Robert J. McMahon, Dimitra Kamboukos, Spring Dawson-McClure, Laurie Miller Brotman
JOURNAL OF ABNORMAL CHILD PSYCHOLOGY
(2019)
Review
Medicine, General & Internal
Berkeley N. Limketkai, Zipporah Iheozor-Ejiofor, Teuta Gjuladin-Hellon, Alyssa Parian, Laura E. Matarese, Kelly Bracewell, John K. MacDonald, Morris Gordon, Gerard E. Mullin
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Gerard Mullin, Linlin Fan, Suela Sulo, Jamie Partridge
Meeting Abstract
Gastroenterology & Hepatology
Julia L. Drewes, Madison McMann, Courtney Stevens, Joell L. Gills, Samara Rifkin, Emma Spence, Brent Tabisz, Amy L. Schiller, Pamela Schearer, Stacy Gerhart, David Cromwell, Marshall Bedine, Eduardo Gonzalez-Velez, Hazel Marie Galon Veloso, Gerard Mullin, David Kafonek, Louis La Luna, Linda Hylind, Francis Giardiello, Cynthia L. Sears
Meeting Abstract
Gastroenterology & Hepatology
George Kunnackal John, Lin Wang, Julie Nanavati, Rajdeep Singh, Gerard Mullin
Meeting Abstract
Gastroenterology & Hepatology
Nuha Alammar, Behnam Saberi, Julie Nanavati, Taki Shinohara, Gerald J. Holtmann, Lin Wang, Gerard Mullin