Article
Medicine, Research & Experimental
Hang Liu, Yidan Li, Hao Zhou, Weijie Chen, Yanping Xu, Huaan Du, Bo Zhang, Tianli Xia, Dan Li, Zhenhong Ou, Ruotian Tang, Qingsong Chen, Binyi Zhao, Yuehui Yin
Summary: This study explores the characteristics of renal autonomic innervation at different blood pressure response sites and finds that renal nerve stimulation is an effective method for identifying renal autonomic innervation. It can help determine the optimal treatment target during renal denervation by avoiding ablation of sympathetic-inhibitory areas.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Angelica Carandina, Giulia Lazzeri, Davide Villa, Alessio Di Fonzo, Sara Bonato, Nicola Montano, Eleonora Tobaldini
Summary: Ischemic stroke is a major global cause of death and disability, with recent research focusing on the bidirectional relationship between autonomic nervous system dysfunction and acute ischemic stroke to identify prognostic factors and potential therapeutic approaches such as vagus nerve stimulation. Preclinical studies have shown promising results in terms of neuroprotection and therapeutic possibilities, indicating the potential of neuromodulation as a first-line therapeutic approach in the early management of stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Osvaldo Delbono, Anna Carolina Zaia Rodrigues, Henry Jacob Bonilla, Maria Laura Messi
Summary: Examining the neural factors involved in the decline of neuromuscular function with aging is crucial to understanding sarcopenia. The sympathetic nervous system may affect muscle composition and function by regulating skeletal muscle motor innervation. Additionally, the role of central neurons may contribute to the coordinated response of the neuromuscular system to physiological and pathological challenges across ages.
AGEING RESEARCH REVIEWS
(2021)
Review
Neurosciences
Yan-Wei Li, Wei Li, Song-Tao Wang, Yi-Nan Gong, Bao-Min Dou, Zhong-Xi Lyu, Luis Ulloa, Shen-Jun Wang, Zhi-Fang Xu, Yi Guo
Summary: This review examines the effects of acupuncture on the regulation and maintenance of the autonomic nervous system (ANS). It found that acupuncture effectively alleviates symptoms associated with ANS dysfunction, such as migraine, depression, insomnia, functional dyspepsia, and functional constipation. Acupuncture activates sensory nerve fibers, the spinal cord, and the brain, which in turn modulate autonomic functions and relieve visceral dysfunction, inflammation, and pain through efferent autonomic nerves.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Rhian Stavely, Ahmed A. Rahman, Lauren Sahakian, Monica D. Prakash, Ainsley M. Robinson, Majid Hassanzadeganroudsari, Rhiannon T. Filippone, Sarah Fraser, Rajaraman Eri, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Summary: This study used mouse models of moderate and severe colitis to investigate the relationship between autonomic and neuroimmune signaling with inflammation. The findings suggest that increased cholinergic markers may correlate with an anti-inflammatory profile in the spleen, while enhanced sympathetic signaling could be an adaptive mechanism to mitigate the progression of intestinal inflammation.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Physiology
Emily Allen, Pott Pongpaopattanakul, Reshma A. Chauhan, Kieran E. Brack, G. Andre Ng
Summary: This study aimed to investigate the effects of electrical stimulation of the vagus nerve at varying parameters on NO release and cardiac electrophysiology using the isolated innervated rabbit heart preparation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Lindsea C. Booth, Song T. Yao, Alla Korsak, David G. S. Farmer, Sally G. Hood, Daniel McCormick, Quinn Boesley, Angela A. Connelly, Stuart J. McDougall, Willian S. Korim, Sarah-Jane Guild, Svetlana Mastitskaya, Phuong Le, Anja G. Teschemacher, Sergey Kasparov, Gareth L. Ackland, Simon C. Malpas, Robin M. McAllen, Andrew M. Allen, Clive N. May, Alexander V. Gourine
Summary: This study successfully applied optogenetics for selective stimulation of vagal efferent activity in a large animal model (sheep). Viral transduction of a subset of vagal motoneurons resulted in strong axonal membrane expression of the excitatory light-sensitive ion channel ChIEF in efferent projections innervating thoracic organs and reaching beyond the diaphragm.
Article
Peripheral Vascular Disease
Annemiek F. Hoogerwaard, Ahmet Adiyaman, Mark R. de Jong, Jaap-Jan J. Smit, Jan-Evert Heeg, Boudewijn A. A. M. van Hasselt, Arif Elvan
Summary: Using renal nerve stimulation (RNS) during renal sympathetic denervation (RDN) can enhance the antihypertensive effect, leading to significant and sustained reduction in 24-hour blood pressure with fewer antihypertensive drugs at follow-up. RNS-induced blood pressure changes were correlated with 24-hour blood pressure changes at follow-up, and patients with complete denervation had significantly lower blood pressure compared to those with incomplete denervation.
Article
Clinical Neurology
Hanall Lee, Joon Ho Lee, Moon-Hyon Hwang, Nyeonju Kang
Summary: This systematic review and meta-analysis investigated the potential effects of repetitive transcranial magnetic stimulation (rTMS) protocols on cardiovascular autonomic system (ANS) control. The results showed that applying excitatory and inhibitory rTMS protocols can significantly improve cardiovascular ANS control, reducing blood pressure and heart rate changes, and significantly improving heart rate variability. These improvements were observed when applying either excitatory rTMS protocols to the left dorsolateral prefrontal cortex or inhibitory rTMS protocols to the right dorsolateral prefrontal cortex. Overall, these findings suggest that applying excitatory and inhibitory rTMS protocols on prefrontal cortical regions may be effective in improving cardiovascular ANS control.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biophysics
Jozsef C. Szeles, Stefan Kampusch, Florian Thuerk, Christian Clodi, Norbert Thomas, Severin Fichtenbauer, Christian Schwanzer, Sebastian Schwarzenberger, Christoph Neumayer, Eugenijus Kaniusas
Summary: Recent research shows that bursted pVNS can beneficially affect cardiac autonomic modulation in healthy subjects. The study found no significant difference in cardiac autonomic modulation between biphasic and triphasic stimulation, with triphasic stimulation requiring lower intensity. These findings suggest the potential for more efficient pVNS implementation.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Clinical Neurology
Marius Keute, Kathrin Machetanz, Levan Berelidze, Robert Guggenberger, Alireza Gharabaghi
Summary: This study investigated physiological candidate biomarkers for transcutaneous auricular Vagus Nerve Stimulation (taVNS) and found that taVNS had effects on heart rate and heart rate variability scores during stimulation, indicating parasympathetic activation. However, these effects were short-lived, and baseline neuro-cardiac coupling scores may predict individual responses to taVNS.
Article
Cardiac & Cardiovascular Systems
Huishan Wang, Yuji Zhang, Fangran Xin, Hui Jiang, Dengshun Tao, Yan Jin, Yuanchen He, Qiang Wang, Sunny S. Po
Summary: Injecting calcium chloride into the major atrial ganglionated plexi during isolated coronary artery bypass grafting significantly reduces the incidence of post-operative atrial fibrillation. This intervention does not impact the length of hospitalization, but it decreases the burden of atrial fibrillation and the need for antiarrhythmic medications.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Matteo Maria Ottaviani, Fabio Vallone, Silvestro Micera, Fabio A. Recchia
Summary: This article reviews the latest research progress of vagus nerve stimulation (VNS) in cardiovascular diseases and discusses avenues for therapeutic optimization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Physiology
Hongyi Duan, Xueqin Cai, Yingying Luan, Shuo Yang, Juan Yang, Hui Dong, Huihong Zeng, Lijian Shao
Summary: The intestine is composed of various types of cells that play important roles in digestion, absorption, neuroendocrine, and immune functions. The autonomic nervous system regulates cellular proliferation and function in the intestine. Understanding the distribution and function of the autonomic nervous system in the intestine could be helpful in treating intestinal diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Physiology
Andrew L. O'Brien, Julie M. West, Tiam M. Saffari, Minh Nguyen, Amy M. Moore
Summary: Peripheral nerve injuries can result in life-altering functional deficits, even with the ability of peripheral nerves to regenerate axons after injury. Advances in nerve regeneration and repair, such as electrical stimulation, gene therapy, and surgical technique advancements, are crucial for overcoming the physiological shortcomings of axonal regeneration.
Article
Surgery
Eliza R. C. Hagens, Hannah T. Kunzli, Anne-Sophie van Rijswijk, Sybren L. Meijer, R. Clinton D. Mijnals, Bas L. A. M. Weusten, E. Debby Geijsen, Hanneke W. M. van Laarhoven, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2020)
Review
Biochemistry & Molecular Biology
I. A. M. van Thiel, S. Botschuijver, W. J. de Jonge, J. Seppen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Oncology
Charlotte Stroes, Sandor Schokker, Aafke Creemers, Remco J. Molenaar, Maarten C. C. M. Hulshof, Stephanie O. van der Woude, Roel J. Bennink, Ron A. A. Mathot, Kausilia K. Krishnadath, Cornelis J. A. Punt, Rob H. A. Verhoeven, Martijn G. H. van Oijen, Geert-Jan Creemers, Grard A. P. Nieuwenhuijzen, Maurice J. C. van der Sangen, Laurens Beerepoot, Joos Heisterkamp, Maartje Los, Marije Slingerland, Annemieke Cats, Geke A. P. Hospers, Maarten F. Bijlsma, Mark I. van Berge Henegouwen, Sybren L. Meijer, Hanneke W. M. van Laarhoven
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Review
Pathology
Esther Klaver, Myrtle Van der Wel, Lucas Duits, Roos Pouw, Kees Seldenrijk, Johan Offerhaus, Mike Visser, Fiebo ten Kate, Katharina Biermann, Lodewijk Brosens, Michael Doukas, Clement Huysentruyt, Arend Karrenbeld, Gursah Kats-Ugurlu, Jaap Van der Laan, Ineke van Lijnschoten, Freek Moll, Ariadne Ooms, Jan Tijssen, Sybren Meijer, Jacques Bergman
Summary: This study evaluated the performance of pathologists from Dutch BO expert centres in 80 consecutive LGD reviews, determining their eligibility for an expert panel through independent assessment of digital slides. After group discussions and a second phase of evaluation, remaining aspirant panel members were confirmed to meet the criteria.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
S. J. M. Hoefnagel, N. Mostafavi, M. R. Timmer, C. T. Lau, S. L. Meijer, K. K. Wang, K. K. Krishnadath
Review
Gastroenterology & Hepatology
Anne S. ten Hove, Jurgen Seppen, Wouter J. de Jonge
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
James A. Hokanson, Christopher L. Langdale, Arun Sridhar, Phil Milliken, Warren M. Grill
Summary: State-dependent electrical stimulation can increase both bladder capacity and voiding efficiency by using different parameters during bladder filling and emptying, compared to continuous stimulation.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Nienke Koopman, Drosos Katsavelis, Anne S. ten Hove, Stanley Brul, Wouter J. de Jonge, Jurgen Seppen
Summary: This article discusses the production, secretion, and signaling of the monoamine serotonin (5-HT) in the intestine, as well as its effects on intestinal homeostasis and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Andrianos Tsekrekos, Michael Vieth, Nelson Ndegwa, Adrian Bateman, Jean-Francois Flejou, Heike Grabsch, Luca Mastracci, Sybren L. Meijer, Luca Saragoni, Kieran Sheahan, Jayant Shetye, Rhonda Yantiss, Lars Lundell, Sonke Detlefsen
Summary: Perioperative chemotherapy combined with surgery for locally advanced gastric cancer is increasing, with Histologic tumor regression grade (TRG) identified as an important prognostic factor. The study found that the combination of the Becker TRG system with a three-tiered grading of regression in LNs is reproducible and may add value to prognostic assessment in gastric cancer specimens.
Article
Biochemistry & Molecular Biology
Nienke Koopman, Lauren Remijas, Jurgen Seppen, Peter Setlow, Stanley Brul
Summary: Recent studies have shown that endospore forming bacteria play a significant role in gut homeostasis as both pathogens and beneficial members of the gut microbiota. This review focuses on the sporulation processes, spore properties, and germination processes within the human gut. It also explores the interaction between spore-forming bacteria and the host's immune system, highlighting the potential use of spores as delivery vehicles for therapeutics. The review concludes by discussing the therapeutic potential of spores as probiotics, vaccine vehicles, and drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sofie P. G. Henckens, Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Sybren L. Meijer, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study investigates the impact of lymph node yield after transthoracic esophagectomy on lymph node metastasis, complications, and survival in patients with esophageal adenocarcinoma. The results demonstrate that a lymph node yield of 31 or higher is associated with an increased number of positive lymph nodes, improved disease-free survival, and overall survival, without increasing morbidity.
Article
Multidisciplinary Sciences
Nienke Koopman, Pim van Leeuwen, Stanley Brul, Jurgen Seppen
Summary: This study investigated the accuracy of a widely cited story about German soldiers using camel feces to treat dysentery in North Africa during World War 2. Through literature analysis and experimentation, the study found no evidence to support this story. It also showed that the amount of Bacillus subtilis in camel feces is low, indicating that camel feces should not be mentioned in the context of the origins of fecal transplantation.
Article
Multidisciplinary Sciences
Ibrahim M. Salman, Omar Z. Ameer, Sheridan McMurray, Sarah F. Hassan, Arun Sridhar, Stephen J. Lewis, Yee-Hsee Hsieh
Summary: This study investigated the effects of low charge nerve stimulation on hypertensive rats and identified optimal stimulation parameters. Low-intensity intermittent electrical stimulation was found to be an effective method for neuromodulation of the aortic baroreceptor afferents, reducing blood pressure and minimizing hemodynamic disturbances.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
James A. Hokanson, Christopher L. Langdale, Philip H. Milliken, Arun Sridhar, Warren M. Grill
Summary: PGE(2) instilled into the bladder causes urinary urgency symptoms, and this effect is not dependent on capsaicin-sensitive pathways. Urethral relaxation/weakness and decreased compliance may contribute to urinary urgency, suggesting potential targets for new therapies for overactive bladder.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kay Diederen, Jia Li, Gillian E. Donachie, Tim G. de Meij, Dirk R. de Waart, Theodorus B. M. Hakvoort, Angelika Kindermann, Josef Wagner, Victoria Auyeung, Anje A. te Velde, Sigrid E. M. Heinsbroek, Marc A. Benninga, James Kinross, Alan W. Walker, Wouter J. de Jonge, Jurgen Seppen
SCIENTIFIC REPORTS
(2020)