Article
Cell Biology
Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao
Summary: The mechanism of how neuronal signaling affects brain myelination is still not well understood. Our study reveals that dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination. Neuronal Rheb cKO inhibits oligodendrocyte differentiation and myelination, with activated neuronal expression of Dlk1 gene. Neuronal Dlk1 cKO improves myelination deficit in neuronal Rheb cKO mice, indicating that activated neuronal Dlk1 expression contributes to impaired myelination caused by Rheb cKO. The effect of Rheb cKO on Dlk1 expression is mediated by mTORC1; neuronal mTor cKO, Raptor cKO, and pharmacological inhibition of mTORC1 also lead to elevated neuronal Dlk1 expression. We demonstrate that both a secreted form of DLK1 and a membrane-bound DLK1 inhibit the differentiation of cultured oligodendrocyte precursor cells into myelin protein-expressing oligodendrocytes. Furthermore, neuronal expression of Dlk1 in transgenic mice reduces the formation of mature oligodendrocytes and myelination. This study identifies Dlk1 as an inhibitor of oligodendrocyte myelination and provides a mechanism linking altered neuronal signaling with oligodendrocyte dysfunction.
Article
Neurosciences
Stefano Cataldi, Clay Lacefield, N. Shashaank, Gautam Kumar, Siham Boumhaouad, David Sulzer
Summary: This study investigates the roles of the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) in motor learning using a mouse Treadmill Training Task and photometry. The results show that as mice become more proficient at running, activity in the DMS direct pathway decreases, while direct pathway activity in the DLS remains similar throughout training. Additionally, the study demonstrates the importance of dopamine neurotransmission in efficient motor coordination learning.
Article
Biochemistry & Molecular Biology
Ze Fan, Lirong Liang, Ruixue Ma, Rougang Xie, Youyi Zhao, Ming Zhang, Baolin Guo, Tian Zeng, Danyi He, Xianghui Zhao, Hui Zhang
Summary: Maternal exposure to sevoflurane anesthesia during pregnancy can have detrimental effects on the cognitive and motor functions of offspring, possibly due to impaired myelination.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Neurosciences
Dorien A. Maas, Maria Cecilia Angulo
Summary: Enhanced neuronal activity in the healthy brain can induce new myelination and behavioral changes, showing potential for myelin repair in demyelinating disorders such as multiple sclerosis. Preclinical studies suggest that stimulating neuronal activity in demyelinated lesions can improve remyelination, but the most efficient stimulation protocols and biological mechanisms need further exploration. Clinical studies have also shown that non-invasive brain stimulation can ameliorate MS symptoms, although the exact mechanism of symptom improvement remains unclear.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lingyu Shi, Zongyi Wang, Yujiao Li, Zheng Song, Wu Yin, Bing Hu
Summary: This study reveals the critical role of chd7 in oligodendrocyte migration and myelination in zebrafish, potentially associated with CHARGE syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Assia Tiane, Melissa Schepers, Renzo Riemens, Ben Rombaut, Patrick Vandormael, Veerle Somers, Jos Prickaerts, Niels Hellings, Daniel van den Hove, Tim Vanmierlo
Summary: In this study, researchers identified Id2 and Id4 as targets of DNA methylation during the differentiation of oligodendrocyte precursor cells. Using CRISPR technology, they confirmed that methylation of Id2/Id4 could drive cell differentiation. Furthermore, they found alterations in methylation and gene expression levels of these genes in multiple sclerosis patients compared to controls.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min-Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang-Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim, Hwan Tae Park
Summary: The study found that a large population of central neurons are derived from Cnp-expressing neuroglial stem cells; conditional gene targeting using the Cnp promoter, known to be OL-specific, can induce neuron-autonomous phenotypes.
Review
Cell Biology
Tomohiro Torii, Tomohiro Miyasaka, Hiroaki Misonou
Summary: This review article discusses the presence of tau in oligodendrocytes and its potential impact on oligodendrocyte function. The study shows that the expression levels of tau significantly change in hypomyelination models and in demyelination regions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Irena Smaga
Summary: This review summarizes the current knowledge on the role of myelin-related changes in depression, as well as the relationship among maternal malnutrition, myelination, and depression. The findings suggest that myelin alterations play a significant role in the development of depression.
Article
Biochemistry & Molecular Biology
Ruyi Mei, Wanwan Qiu, Yingying Yang, Siyu Xu, Yueyu Rao, Qingxin Li, Yuhao Luo, Hao Huang, Aifen Yang, Huaping Tao, Mengsheng Qiu, Xiaofeng Zhao
Summary: This study reveals that Ddr1 is selectively upregulated in newly differentiated oligodendrocytes in the early postnatal CNS and plays a crucial role in oligodendrocyte differentiation and myelination. Ddr1 deficiency leads to compromised axonal myelination and motor dysfunction, activating the ERK pathway in the CNS. Additionally, Ddr1 is important for myelin repair after lysolecithin-induced demyelination. Overall, this study sheds light on the role of Ddr1 in myelin development and repair in the CNS and provides a novel target for treating demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Dorsa Beroukhim-Kay, Bokkyu Kim, John Monterosso, Rebecca Lewthwaite, Carolee Winstein
Summary: During skill acquisition, improved practice performance and recall of a sensorimotor skill are correlated with distinct neural activity patterns, drawing on different motor learning mechanisms. Practice performance improvement is associated with activations in the frontal orbital cortex, putamen, amygdala, and insula, while recall performance is associated with activations in the primary motor cortex, superior frontal gyrus, somatosensory cortex, angular gyrus, and parietal gyrus.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Meiling Luo, Ying Yin, Duanfang Li, Weiwei Tang, Yuan Liu, Lu Pan, Lehua Yu, Botao Tan
Summary: The bidirectional regulation of neuronal activity can effectively modulate the development of oligodendrocyte lineage cells and the remyelination process, ultimately affecting motor function recovery. Therefore, manipulation of neuronal activity is a promising avenue for the treatment of demyelination diseases in the central nervous system.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Shuang-Ling Wu, Bin Yu, Yong-Jie Cheng, Shu-Yu Ren, Fei Wang, Lan Xiao, Jing-Fei Chen, Feng Mei
Summary: Alzheimer's disease (AD) is characterized by the presence of aggregated amyloid beta-protein (Aβ). Recent evidence suggests that inadequate myelinogenesis plays a role in AD-related functional deficits. The relationship between Aβ and myelinogenesis in AD brains, however, remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Pierson Fleischer, Aamir Abbasi, Andrew W. Fealy, Nathan P. Danielsen, Ramneet Sandhu, Philip R. Raj, Tanuj Gulati
Summary: The emergent activity in cortico-cerebellar networks during the learning of a reach-to-grasp motor skill, characterized by low-frequency oscillatory (LFO) activity in the motor cortex and cerebellum, was investigated in rats. Coordinated movement-related activity was observed in the local-field potentials as the skill consolidated, specifically in rats that gained expertise in the task. The study also found coordinated spiking activity with LFOs predominantly expressed during accurate behavior in the primary motor cortex.
Review
Neurosciences
Minkyung Kang, Yao Yao
Summary: Oligodendrocytes are crucial cells in the central nervous system responsible for myelinating axons and supporting the function of neurons. The function and development of oligodendrocytes are tightly regulated by various molecules, with laminin playing a significant role in processes such as survival, migration, proliferation, differentiation, and myelination. Understanding the specific molecular targets and signaling pathways in oligodendrocyte biology may have implications for therapeutic interventions in demyelinating diseases.
Article
Neurosciences
Yasuyuki Osanai, Takeshi Shimizu, Takuma Mori, Yumiko Yoshimura, Nobuhiko Hatanaka, Atsushi Nambu, Yoshitaka Kimori, Shinsuke Koyama, Kenta Kobayashi, Kazuhiro Ikenaka
Article
Neurosciences
Takeshi Shimizu, Yasuyuki Osanai, Kenji F. Tanaka, Manabu Abe, Rie Natsume, Kenji Sakimura, Kazuhiro Ikenaka
Article
Biochemistry & Molecular Biology
Kazuo Kunisawa, Takeshi Shimizu, Itaru Kushima, Branko Aleksic, Daisuke Mori, Yasuyuki Osanai, Kenta Kobayashi, Anna M. Taylor, Manzoor A. Bhat, Akiko Hayashi, Hiroko Baba, Norio Ozaki, Kazuhiro Ikenaka
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Neurosciences
Yasuyuki Osanai, Takeshi Shimizu, Takuma Mori, Nobuhiko Hatanaka, Yoshitaka Kimori, Kenta Kobayashi, Shinsuke Koyama, Yumiko Yoshimura, Atsushi Nambu, Kazuhiro Ikenaka