Article
Biochemistry & Molecular Biology
Ioanna Tsantzali, Aikaterini Foska, Eleni Sideri, Evdokia Routsi, Effrosyni Tsomaka, Dimitrios K. Kitsos, Christina Zompola, Anastasios Bonakis, Sotirios Giannopoulos, Konstantinos I. Voumvourakis, Georgios Tsivgoulis, George P. Paraskevas
Summary: CSF biomarkers are the gold standard for AD diagnosis, but plasma biomarkers may provide an alternative method with comparable accuracy and the advantage of avoiding lumbar puncture.
Article
Clinical Neurology
Juan Lantero-Rodriguez, Cecile Tissot, Anniina Snellman, Stijn Servaes, Andrea L. L. Benedet, Nesrine Rahmouni, Laia Montoliu-Gaya, Joseph Therriault, Wagner S. S. Brum, Jenna Stevenson, Firoza Z. Z. Lussier, Gleb Bezgin, Arthur C. C. Macedo, Mira Chamoun, Sulantha S. S. Mathotaarachi, Tharick A. A. Pascoal, Nicholas J. J. Ashton, Henrik Zetterberg, Pedro Rosa Neto, Kaj Blennow
Summary: This study evaluated the concentrations of N-terminal tau fragments (NTA-tau) in cerebrospinal fluid (CSF) and plasma using a novel immunoassay (NTA) in the TRIAD cohort. The results showed that CSF and plasma NTA-tau concentrations were specifically increased in cognitively impaired A beta-positive groups and displayed stronger correlations with tau positron emission tomography (PET) than with amyloid PET and magnetic resonance imaging (MRI). NTA-tau has potential as a tau tangle biomarker in clinical settings and trials.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Antoine Leuzy, Nicholas C. Cullen, Niklas Mattsson-Carlgren, Oskar Hansson
Summary: Recent advances in CSF and blood-based biomarkers of Alzheimer's disease lesions include the introduction of fully automated assays, certified reference materials for CSF A beta 42, and a unified protocol for sample handling. These developments support the reliability and availability of biomarkers, such as A beta, P-tau, and NfL, in both CSF and blood, with potential applications in clinical practice and trials.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Le Gjerum, Birgitte Bo Andersen, Marie Bruun, Anja Hviid Simonsen, Otto Molby Henriksen, Ian Law, Steen Gregers Hasselbalch, Kristian Steen Frederiksen
Summary: The study found that cerebrospinal fluid biomarkers have a higher clinical value in supporting the diagnosis of Alzheimer's disease compared to 2-[F-18]FDG-PET, affecting diagnostic confidence and the need for ancillary investigations significantly.
Article
Immunology
Kaja Nordengen, Bjorn-Eivind Kirsebom, Grit Richter, Lene Palhaugen, Berglind Gisladottir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Brathen, Goril Rolfseng Grontvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M. Vromen, Betty M. Tijms, Pieter J. Visser, Per Selnes, Milicia G. Kramberger, Bengt Winblad, Kaj Blennow, Tormod Fladby
Summary: Brain innate immune activation is associated with Alzheimer's disease, with varying degrees of activation at different disease stages. In predementia AD, differences in immune activation levels and biomarker profiles may be related to amyloidosis and tau pathology. Changes in certain biomarkers in cerebrospinal fluid may be linked to cognitive preservation or impairment in predementia AD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Anna Lidia Wojdala, Giovanni Bellomo, Lorenzo Gaetani, Andrea Toja, Elena Chipi, Dandan Shan, Davide Chiasserini, Lucilla Parnetti
Summary: The transition from cerebrospinal fluid (CSF) to plasma provides new avenues for studying molecular phenotypes of Alzheimer's disease (AD). This study evaluated a panel of AD biomarkers in matched CSF and plasma samples, comparing their diagnostic performance and evaluating their trajectories along the AD progression. The findings suggest that a standardized panel of selected plasma markers can facilitate early AD diagnosis and monitoring of disease progression.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Anna Lidia Wojdala, Davide Chiasserini, Giovanni Bellomo, Silvia Paciotti, Lorenzo Gaetani, Federico Paolini Paoletti, Lucilla Parnetti
Summary: Phosphatidylethanolamine binding protein 1 (PEBP1) has potential as a biomarker for Alzheimer's disease (AD), but further research is needed to evaluate its diagnostic potential.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Neurosciences
Jianwei Yang, Longfei Jia, Yan Li, Qiongqiong Qiu, Meina Quan, Jianping Jia
Summary: AD research is currently at a crucial point where the molecular understanding of the disease is being translated into potential therapies, despite previous failures in drug development. Biomarkers measured in cerebrospinal fluid and blood are playing an increasingly important role in clinical trials for AD, reflecting the pathophysiological processes in the brain. Challenges in incorporating these biomarkers into trials have been acknowledged, but progress is being made to overcome these obstacles. Ongoing efforts in this area will be crucial for the development of disease-modifying treatments for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Dorota Konickova, Katerina Mensikova, Lucie Tuckova, Eva Henykova, Miroslav Strnad, David Friedecky, David Stejskal, Radoslav Matej, Petr Kanovsky
Summary: The understanding of neurodegenerative diseases has shifted in the past 20 years, from being seen as well-defined entities to complex and heterogeneous processes. Diagnosis primarily requires brain imaging techniques or invasive tests, but identifying specific proteinopathies is difficult due to overlap in clinical diagnoses. Laboratory methods to identify biomarkers are urgently needed to improve diagnosis, monitor disease progression, and evaluate treatment effects.
Article
Geriatrics & Gerontology
Min Young Chun, Hyemin Jang, Hee Jin Kim, Jun Pyo Kim, John Gallacher, Jose Antonio Allue, Leticia Sarasa, Sergio Castillo, Maria L. Pascual-Lucas, Duk Na, Sang Won Seo
Summary: This study aimed to determine whether APOE genotypes, age, and cognitive status increase the predictive performance of plasma A beta and CSF A beta levels for A beta PET positivity. The results showed that both plasma A beta and CSF A beta can accurately predict A beta PET status, especially when considering clinical information such as APOE genotype and cognitive stage, plasma A beta has better predictive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Andrea Pilotto, Marta Parigi, Giulio Bonzi, Beatrice Battaglio, Elisabetta Ferrari, Lorenza Mensi, Alberto Benussi, Salvatore Caratozzolo, Maura Cosseddu, Rosanna Turrone, Silvana Archetti, Nicholas J. Ashton, Henrik Zetterberg, Silvia Giliani, Alessandro Padovani
Summary: Plasma phosphorylated tau species levels are elevated in early stage AD and strongly related to phosphorylated tau, total tau, and amyloid in cerebrospinal fluid. These findings may support the use of plasma markers for diagnosing and prognosing AD in the early stage.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Constance Delaby, Charlotte E. Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurelie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Celine Blanc-Quintin, Merce Boada, Olivier Bousiges, Miles D. Chapman, Mari L. DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gabelle, Elisabetta Galloni, Clementine Gondolf, Frederique Grandhomme, Oriol Grau-Rivera, Melanie Hart, Takeshi Ikeuchi, Andreas Jeromin, Kensaku Kasuga, Ashvini Keshavan, Michael Khalil, Peter Koertvelyessy, Agnieszka Kulczynska-Przybik, Jean-Louis Laplanche, Piotr Lewczuk, Qiao-Xin Li, Alberto Lleo, Catherine Malaplate, Marta Marquie, Colin L. Masters, Barbara Mroczko, Leonor Nogueira, Adelina Orellana, Markus Otto, Jean-Baptiste Oudart, Claire Paquet, Federico Paolini Paoletti, Lucilla Parnetti, Armand Perret-Liaudet, Katell Peoc'h, Koen Poesen, Albert Puig-Pijoan, Isabelle Quadrio, Muriel Quillard-Muraine, Benoit Rucheton, Susanna Schraen, Jonathan M. Schott, Leslie M. Shaw, Marc Suarez-Calvet, Magda Tsolaki, Hayrettin Tumani, Chinedu T. Udeh-Momoh, Lucie Vaudran, Marcel M. Verbeek, Federico Verde, Lisa Vermunt, Jonathan Vogelgsang, Jens Wiltfang, Henrik Zetterberg, Sylvain Lehmann
Summary: This study examined the variation in quantifying cerebrospinal fluid (CSF) biomarkers for the diagnosis of Alzheimer's disease (AD) across different centers worldwide and proposed harmonized comments to address inconsistency in interpretation and reporting of results. The findings revealed similarities in (pre-)analytical procedures among centers but significant heterogeneity in cutoff definitions and report comments, leading to the identification of the most accurate and informative comments through consensus for CSF biomarker interpretation in the context of AD diagnosis. This represents the first attempt to propose harmonized reports across specialized laboratories globally involved in AD diagnosis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Anne-Brita Knapskog, Mari Aksnes, Trine Holt Edwin, Per Magne Ueland, Arve Ulvik, Evandro Fei Fang, Rannveig Sakshaug Eldholm, Nathalie Bodd Halaas, Ingvild Saltvedt, Lasse M. Giil, Leiv Otto Watne
Summary: Patients with Alzheimer's disease (AD) exhibited higher concentrations of kynurenic acid and picolinic acid than controls. Higher concentrations of kynurenic acid were associated with slower progression of AD. Potential neurotoxic kynurenines were not increased among patients with AD. Activation of the kynurenine pathway's neuroprotective branch may be an adaptive response in AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Yan-Li Wang, Jinglong Chen, Zhong-Li Du, Haoyi Weng, Yuan Zhang, Runzhi Li, Ziyan Jia, Mengfan Sun, Jiwei Jiang, Fang-Ze Wang, Jun Xu
Summary: Plasma p-tau181 levels are associated with multiple AD-associated cognitive domains and AD-related CSF biomarkers at the clinical stages of AD. Additionally, plasma p-tau181 levels are related to the change rates of cognitive decline and hippocampal atrophy. This study confirms the utility of plasma p-tau181 as a non-invasive biomarker for early detection and prediction of AD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P. De Deyn, Maria Bjerke, Guy Nagels, Charlotte E. Teunissen, Sebastiaan Engelborghs
Summary: This study examines the relationship between neuropathology and CSF biomarkers in Alzheimer's disease patients, finding that the associations are stronger and more significant with longer intervals between lumbar puncture and death. This suggests that CSF biomarkers may not be well suited for monitoring neuropathological changes at later disease stages.
Article
Clinical Neurology
Flora Gossink, Annemiek Dols, Max L. Stek, Philip Scheltens, Bas Nijmeijer, Petra Cohn Hokke, Anke Dijkstra, Fred Van Ruissen, Cora Aalfs, Yolande A. L. Pijnenburg
Summary: This study explores the lifelong behavioral and personality characteristics in bvFTD patients with C9orf72(RE) gene mutation, and identifies distinctive features during the disease course, such as excessive buying and obsessive physical exercise. The findings suggest a lifelong neuropsychiatric vulnerability in carriers of the C9orf72(RE) gene, potentially linking neurodevelopmental and neurodegenerative diseases.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Hulya Ulugut, Simone Stek, Lianne E. E. Wagemans, Roos J. Jutten, Maria Antoinette Keulen, Femke H. Bouwman, Niels D. Prins, Afina W. Lemstra, Welmoed Krudop, Charlotte E. Teunissen, Bart N. M. van Berckel, Rik Ossenkoppele, Frederik Barkhof, Wiesje M. van der Flier, Philip Scheltens, Yolande A. L. Pijnenburg
Summary: Primary progressive aphasia (PPA) is divided into three prototypical subtypes - semantic, non-fluent, and logopenic - each subtype progresses differently over time and has a relatively long disease duration.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Janina Krell-Roesch, Martin Rakusa, Jeremy A. Syrjanen, Argonde C. van Harten, Val J. Lowe, Clifford R. Jack, Walter K. Kremers, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Maria Vassilaki, Yonas E. Geda
Summary: This study examined the association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms in older non-demented adults. The results showed that lower CSF Aβ42 and higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with depression, anxiety, and other NPS.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Jetske van der Schaar, Leonie N. C. Visser, Femke H. Bouwman, Johannes C. F. Ket, Philip Scheltens, Annelien L. Bredenoord, Wiesje M. van der Flier
Summary: The study provides an overview of considerations regarding the disclosure of AD pathology before the onset of dementia, categorizing them into clinical, personal, and societal contexts. The literature on this topic is diverse and contradictory, with a focus on harmful effects.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Geriatrics & Gerontology
Merike Verrijp, Mark A. Dubbelman, Leonie N. C. Visser, Roos J. Jutten, Elke W. Nijhuis, Marissa D. Zwan, Hein P. J. van Hout, Philip Scheltens, Wiesje M. van der Flier, Sietske A. M. Sikkes
Summary: In a sample of community-based volunteers, most participants and study partners reported no significant IADL difficulties. However, differences between participant and study partner were quite prevalent, with subjective factors indicating increased report of IADL difficulties by the participant. These findings suggest that self- and study partner-report measures may not be interchangeable, and the level of awareness needs to be considered, even in cognitively healthy individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Willemijn J. Jansen, Olin Janssen, Betty M. Tijms, Stephanie J. B. Vos, Rik Ossenkoppele, Pieter Jelle Visser
Summary: This study aims to estimate the prevalence of amyloid abnormality in individuals with different cognitive statuses and examine the factors that may affect these estimates. The results show that CSF-based estimates using adjusted data-driven cutoffs were higher than PET-based estimates in individuals without dementia, suggesting that preclinical and prodromal AD may be more prevalent than previously estimated. This finding has important implications for clinical trial recruitment strategies and healthcare planning policies.
Article
Clinical Neurology
Agnetha D. Fruijtier, Jetske van der Schaar, Ingrid S. van Maurik, Marissa D. Zwan, Philip Scheltens, Femke Bouwman, Yolande A. L. Pijnenburg, Bart N. M. van Berckel, Jarith Ebenau, Wiesje M. van der Flier, Ellen M. A. Smets, Leonie N. C. Visser
Summary: This study investigated the impact of six communication strategies on amyloid disclosure in mild cognitive impairment (MCI) patients. It found that risk communication best practices resulted in the highest information recall, while recall in emotional support was better than the basic and elaborate information strategies. Risk communication best practices also led to the highest uncertainty, while teach-back and emotional support contributed to the highest evaluations of the physician and information. Overall, risk communication best practices, attending to emotions, and teach-back techniques enhance information recall and contribute to positive care evaluations for amyloid-PET results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Fiona Heeman, Denise Visser, Maqsood Yaqub, Sander Verfaillie, Tessa Timmers, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Adriaan A. Lammertsma, Sandeep S. Golla
Summary: Alzheimer's disease is characterized by reduced cerebral blood flow. This study compared the precision of different methods for measuring cerebral blood flow and found that relative blood flow methods had better repeatability than absolute blood flow methods. The high precision of relative blood flow may be due to a compensatory effect of the extraction fraction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Geriatrics & Gerontology
Eva Y. L. Tan, Niels Janssen, Ron Handels, Inez H. G. B. Ramakers, Frans R. J. Verhey, Wiesje M. van der Flier, Rene J. F. Melis, Marcel G. M. Olde Rikkert, Jos M. G. A. Schols, Marjolein E. de Vugt
Summary: The objective of this study was to investigate the health-related quality of life (HRQol) of family caregivers of individuals with mild cognitive impairment (MCI), and to explore possible determinants and differences compared to caregivers of individuals with mild dementia. The study found no significant difference in HRQoL between family caregivers of individuals with MCI and mild dementia. However, caregiver characteristics, such as being a spouse and having a lower educational level, were associated with lower HRQoL.
AGING & MENTAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J. Myers, Maryam Shoai, Itziar de Rojas, Niccolo Tesi, Henne Holstege, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price
Summary: Late-onset Alzheimer's disease has a strong genetic component, and the heritability estimates range from 38% to 66%. The APOE region and microglial-related genes play important roles in the genetic architecture of the disease.
Editorial Material
Clinical Neurology
Wiesje M. van der Flier, Betty M. Tijms
NATURE REVIEWS NEUROLOGY
(2023)
Article
Clinical Neurology
Yanaika S. S. Hok-A-Hin, Katharina Bolsewig, Daimy N. N. Ruiters, Alberto Lleo, Daniel Alcolea, Afina W. W. Lemstra, Wiesje M. M. van der Flier, Charlotte E. E. Teunissen, Marta del Campo
Summary: Our study showed that THOP1 can serve as an early specific biomarker for Alzheimer's Disease (AD). We developed THOP1 immunoassays and validated our findings in two independent cohorts.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Cell Biology
Wiesje M. van der Flier, Marjolein E. de Vugt, Ellen M. A. Smets, Marco Blom, Charlotte E. Teunissen
Summary: Alzheimer's disease is a significant healthcare challenge with no current cure. This perspective proposes a strategy to shift the focus towards the pre-dementia stages and invest in personalized medicine for diagnosis, prediction and prevention. It suggests empowering patients and the public to actively participate in managing their health and disease, and developing improved strategies for early intervention.
Article
Clinical Neurology
Jolene F. Leijenaar, Silvia Ingala, Carole H. Sudre, Henk-Jan M. M. Mutsaerts, Anna E. Leeuwis, Wiesje M. van der Flier, Philip Scheltens, Henry C. Weinstein, Frederik Barkhof, Joop van Gerven, Geert Jan Groeneveld, Niels D. Prins
Summary: In patients with VCI, a positive response to methylphenidate was associated with decreased integrity of the monoaminergic tract, while responsiveness to galantamine may be related to co-morbid AD pathology.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2022)
Article
Clinical Neurology
Jooske M. F. Boomsma, Lieza G. Exalto, Frederik Barkhof, Anna E. Leeuwis, Niels D. Prins, Philip Scheltens, Charlotte E. Teunissen, Henry C. Weinstein, Geert Jan Biessels, Wiesje M. van der Flier
Summary: This study investigated the trajectories of cognitive decline in memory clinic patients with different types of vascular brain injury, revealing the distinct impacts of lacunes and non-lacunar infarcts on cognitive functioning. It was found that different types of vascular brain injury show little differences in cognitive trajectories.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
