Article
Neurosciences
Jacques P. Flores-Dourojeanni, Coby van Rijt, Marleen H. van den Munkhof, Linde Boekhoudt, Mieneke C. M. Luijendijk, Louk J. M. J. Vanderschuren, Roger A. H. Adan
Summary: The study found that stimulation of VTA dopamine neurons, as well as VTA projections to NAcb core and mPFC, impaired attention but spared impulse control before the stimulus cue; additionally, activation of VTA-NAcbS increased impulsivity under longer intertrial intervals, inducing impulsive behavior, with partial replication of effects in the beginning of the ITI.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Robert Olson, Will Jiang, Mitchell Liu, Alanah Bergman, Devin Schellenberg, Benjamin Mou, Abraham Alexander, Hannah Carolan, Fred Hsu, Stacy Miller, Siavash Atrchian, Elisa Chan, Clement Ho, Islam Mohamed, Angela Lin, Tanya Berrang, Andrew Bang, Nick Chng, Quinn Matthews, Sarah Baker, Vicky Huang, Ante Mestrovic, Derek Hyde, Chad Lund, Howard Pai, Boris Valev, Shilo Lefresene, Scott Tyldesley
Summary: This study confirms that the incidence of high-grade toxic effects in the large cohort of patients receiving SABR for oligometastases is less than 5%. The lower rates of toxic effects compared to previous studies may support further enrollment in randomized phase 3 clinical trials.
Article
Biotechnology & Applied Microbiology
Fangchao Jiang, Chaebin Lee, Weizhong Zhang, Wen Jiang, Zhengwei Cao, Harrison Byron Chong, Wei Yang, Shuyue Zhan, Jianwen Li, Yong Teng, Zibo Li, Jin Xie
Summary: This study presents a streamlined radiodynamic therapy (RDT) approach using CsI(Na)@MgO nanoparticles and 5-aminolevulinic acid (5-ALA) to overcome the shallow tissue penetration issue associated with conventional photodynamic therapy (PDT) and enhance the killing effect on cancer cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Laila A. Gharzai, Ralph Jiang, David Wallington, Gavin Jones, Samuel Birer, Neil Jairath, Elizabeth M. Jaworski, Matthew R. McFarlane, Brandon A. Mahal, Paul L. Nguyen, Howard Sandler, Todd M. Morgan, Zachery R. Reichert, Joshi J. Alumkal, Rohit Mehra, Amar U. Kishan, Karim Fizazi, Susan Halabi, Edward M. Schaeffer, Felix Y. Feng, David Elliott, Robert T. Dess, William C. Jackson, Matthew J. Schipper, Daniel E. Spratt
Summary: This study comprehensively assessed the performance of commonly reported intermediate clinical endpoints in all randomized trials in localized prostate cancer, and found that metastasis-free survival is the only identified surrogate endpoint for overall survival to date.
Article
Biochemical Research Methods
Jinghua Han, Wei Yang, Yuanke Li, Jianwen Li, Fangchao Jiang, Jin Xie, Xinglu Huang
Summary: In this study, a radiosensitizing strategy for lung cancer was explored by combining DOX-encapsulated polyaspartamide nanoparticles with 5-ALA. The results showed that this combination enhanced cancer cell killing and improved tumor suppression in vivo without causing toxicity to normal tissues.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Oncology
Suzanne Dufresne, Cindy Richard, Arthur Dieumegard, Luz Orfila, Gregory Delpon, Sophie Chiavassa, Brice Martin, Laurent Rouviere, Jean-Michel Escoffre, Edward Oujagir, Baudouin Denis de Senneville, Ayache Bouakaz, Nathalie Rioux-Leclercq, Vincent Potiron, Amelie Rebillard
Summary: Physical activity is being increasingly integrated into cancer patient care to improve survival outcomes, but its specific impact on radiotherapy efficiency remains unclear. Different modalities of physical activity have varying effects on tumor growth, suggesting that the anti-cancer benefits may depend on the type of exercise.
Review
Oncology
Aoife McGovern, Nicholas Mahony, David Mockler, Neil Fleming
Summary: This study aimed to determine the effect of resistance training during adjuvant chemotherapy and radiation therapy in cancer patients on measures of lean mass and muscle strength. The results showed that resistance training significantly increased upper body strength, lower body strength, grip strength, and lean mass. The quality of included studies was moderate to high with low risk of bias.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Sahaja Acharya, Chuang Wang, Sophia Quesada, Melissa A. Gargone, Ozgur Ates, Jinsoo Uh, Matthew J. Krasin, Thomas E. Merchant, Chia-Ho Hua
Summary: This study found that offline adaptation using on-treatment MRI scans during proton therapy improved plan quality for pediatric patients, particularly for those experiencing anatomic changes. Among the 11 patients with anatomic changes, 55% exhibited significant changes in plan quality, with 7 demonstrating a significant decrease in CTV V95 and 4 showing a significant increase in dose to the brain stem and other organs.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Andrea C. Lo, Karin Dieckmann, Tanja Pelz, Eve Gallop-Evans, Rita Engenhart-Cabillic, Dirk Vordermark, Kara M. Kelly, Cindy L. Schwartz, Louis S. Constine, Kenneth Roberts, David Hodgson
Summary: Classical Hodgkin lymphoma (HL) has transformed from a fatal disease to a curable cancer over the past century, with a major focus on reducing the use of radiation therapy and chemotherapy to minimize toxicities. Treatment intensity is guided by risk category, with response to chemotherapy playing a crucial role in deciding the utilization of radiation therapy. Ongoing trials are exploring the use of immunoregulatory drugs to mitigate the toxicities of intensified chemotherapy.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Brian De, Marcus A. Florez, Ethan B. Ludmir, Moshe H. Maor, Susan L. McGovern, Mary Frances McAleer, David R. Grosshans, Eric L. Chang, Anita Mahajan, Arnold C. Paulino
Summary: This study reviewed the records of 84 patients who received spinal radiation therapy using electrons between 1983 and 2014. The results showed that long-term follow-up revealed musculoskeletal toxic effects and decreased height, while pulmonary and cardiac toxic effects were rare.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Pharmacology & Pharmacy
Yongshu Li, Bihui Huang, Zhichao Xue, Yunhua Gao, Zhenjian Zhuo
Summary: This article highlights the development of nucleic acid therapy in pediatric cancers as a potential way to improve treatment outcomes, which should attract more attention.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Health Care Sciences & Services
Chi-Hung Liu, Bing-Shen Huang, Chien-Yu Lin, Chih-Hua Yeh, Tsong-Hai Lee, Hsiu-Chuan Wu, Chien-Hung Chang, Ting-Yu Chang, Kuo-Lun Huang, Jian-Lin Jiang, Joseph Tung-Chieh Chang, Yeu-Jhy Chang
Summary: This study aimed to investigate the frequency of cervical-cranial vascular complications soon after radiation therapy (RT) among patients with head and neck cancer (HNC) and identify differences between different types of HNC. The results showed that significant carotid artery stenosis (CAS) was more frequently observed within 5 years of RT among non-nasopharyngeal carcinoma (NPC) HNC patients compared to NPC patients. It was recommended to start carotid artery surveillance earlier for non-NPC HNC patients, while vascular surveillance could be deferred to 5 years after RT completion for NPC patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Matthew R. McFarlane, Kimberly A. Hochstedler, Anna M. Laucis, Yilun Sun, Aulina Chowdhury, Martha M. Matuszak, James Hayman, Derek Bergsma, Thomas Boike, Larry Kestin, Benjamin Movsas, Inga Grills, Michael Dominello, Robert T. Dess, Caitlin Schonewolf, Daniel E. Spratt, Lori Pierce, Peter Paximadis, Shruti Jolly, Matthew Schipper
Summary: This study analyzed pneumonitis risk after radiation therapy for lung cancer using a large, prospective dataset. Comorbidity burden, smoking status, and dosimetric parameters were incorporated in an integrated risk model to guide clinicians in assessing pneumonitis risk in individual patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Christian Baeumer, Rezarta Frakulli, Jessica Kohl, Sindhu Nagaraja, Theresa Steinmeier, Rasin Worawongsakul, Beate Timmermann
Summary: The study aimed to evaluate the role of MRI-based adaptive proton therapy for children with tumors of the head and neck and base of skull. The method of transferring anatomical changes from MRIs to synthetic CTs was successfully implemented and validated. The results showed no clinically relevant deterioration in treatment planning for the studied cohort.
Article
Oncology
Tommy Jiang, Daniela Markovic, Jay Patel, Jesus E. Juarez, Ting Martin Ma, David Shabsovich, Nicholas G. Nickols, Robert E. Reiter, David Elashoff, Matthew B. Rettig, Nicholas G. Zaorsky, Daniel E. Spratt, Amar U. Kishan
Summary: This study compared different forms of radiation therapy for localized prostate cancer and found that dose escalation alone did not significantly improve 5-year outcomes, while adding long-term androgen deprivation therapy (ADT) significantly improved patient-specific mortality and distant metastasis rates.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Janice A. Zawaski, Omaima M. Sabek, Horatiu Voicu, Hon-Chiu Eastwood Leung, M. Waleed Gaber
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Biology
Solmaz F. Afshar, Janice A. Zawaski, Taeko Inoue, David A. Rendon, Arthur W. Zieske, Jyotinder N. Punia, Omaima M. Sabek, M. Waleed Gaber
RADIATION RESEARCH
(2017)
Article
Multidisciplinary Sciences
Zhijuan Cao, Adithya Balasubramanian, Steen E. Pedersen, Jonathan Romero, Robia G. Pautler, Sean P. Marrelli
SCIENTIFIC REPORTS
(2017)
Article
Behavioral Sciences
Emma C. Perez, Shaefali P. Rodgers, Taeko Inoue, Steen E. Pedersen, J. Leigh Leasure, M. Waleed Gaber
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Surgery
Christine A. Beamish, A. Osama Gaber, Solmaz F. Afshar, Daniel W. Fraga, Dale J. Hamilton, Omaima M. Sabek
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Biochemistry & Molecular Biology
Chun-An Chen, Wei Wang, Steen E. Pedersen, Ayush Raman, Michelle L. Seymour, Fernanda R. Ruiz, Anping Xia, Meike E. van der Heijden, Li Wang, Jiani Yin, Joanna Lopez, Megan E. Rech, Richard A. Lewis, Samuel M. Wu, Zhandong Liu, Fred A. Pereira, Robia G. Pautler, Huda Y. Zoghbi, Christian P. Schaaf
HUMAN MOLECULAR GENETICS
(2020)
Article
Multidisciplinary Sciences
Bibiana K. Y. Wong, Jaclyn B. Murry, Rajesh Ramakrishnan, Fang He, Alfred Balasa, Gary R. Stinnett, Steen E. Pedersen, Robia G. Pautler, Ignatia B. Van den Veyver
Review
Oncology
Alina-Andreea Zimta, Ciprian Tomuleasa, Iman Sahnoune, George A. Calin, Ioana Berindan-Neagoe
FRONTIERS IN ONCOLOGY
(2019)
Review
Cell Biology
Baoqing Chen, Junyan Li, Dongmei Chi, Iman Sahnoune, Steliana Calin, Leonard Girnita, George A. Calin
Proceedings Paper
Optics
Tien T. Tang, Janice A. Zawaski, Kathleen N. Francis, Amina A. Qutub, M. Waleed Gaber
MEDICAL IMAGING 2018: COMPUTER-AIDED DIAGNOSIS
(2018)
Article
Cardiac & Cardiovascular Systems
Taeko Inoue, Janice A. Zawaski, Vivien Sheehan, Celeste Kanne, Alireza Paikari, Caterina C. Kaffes, Poonam Sarkar, Omaima M. Sabek, M. Waleed Gaber
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2018)