Article
Chemistry, Analytical
Xin Zhou, Hongmei Cao, Yong Zeng
Summary: In this study, a pneumatically automated microfluidic reactor device was designed to integrate analyte extraction/enrichment and DSNSA-mediated miRNA detection in a streamlined analysis workflow, achieving rapid and robust on-chip detection of miR-21 with reduced consumption of DSN enzyme. The optimized workflow demonstrated a limit-of-detection of 35 amol and has potential applications in clinical diagnosis and beyond.
Article
Nanoscience & Nanotechnology
Tomas Pinheiro, Ana C. Marques, Patricia Carvalho, Rodrigo Martins, Elvira Fortunato
Summary: The article presents a signal transduction method based on gold nanoparticles for the development of paper-based multiplex colorimetric assay devices for diabetes control, showing the potential for multiparametric colorimetric measurement.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Analytical
Somayeh Vandghanooni, Zohreh Sanaat, Raheleh Farahzadi, Morteza Eskandani, Hossein Omidian, Yadollah Omidi
Summary: Early diagnosis of cancer is crucial, and aptamer-based biosensors have been developed as reliable tools for detecting various cancer markers, increasing the chances of successful treatment.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Physical
Xiaowei Chen, A. Ghorbani, Long Quan, D. Toghraie
Summary: Sports injuries are a common problem for athletes, ranging from minor sprains to severe fractures and concussions. Microfluidic devices have shown promise in sports medicine by analyzing small samples of sweat, blood, or urine to provide real-time data on an athlete's physiological status. This information can optimize training, prevent injuries, and also contribute to the development of diagnostic and therapeutic methods for cancer and other diseases.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Multidisciplinary Sciences
Zheng Ao, Hongwei Cai, Zhuhao Wu, Liya Hu, Asael Nunez, Zhuolong Zhou, Hongcheng Liu, Maria Bondesson, Xiongbin Lu, Xin Lu, Ming Dao, Feng Guo
Summary: Researchers have developed an automated high-throughput microfluidic platform to track T cell infiltration and cytotoxicity and evaluate treatment efficacy. By screening a drug library, they identified an epigenetic drug that enhances tumor infiltration and treatment effectiveness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
David E. Reynolds, Menghan Pan, Jingbo Yang, George Galanis, Yoon Ho Roh, Renee-Tyler T. Morales, Shailesh Senthil Kumar, Su-Jin Heo, Xiaowei Xu, Wei Guo, Jina Ko
Summary: Extracellular vesicles (EVs) have emerged as a promising source of biomarkers, but current diagnostic methods face challenges. A highly sensitive double digital assay is developed, allowing for absolute quantification of single molecules from individual EVs. The technology successfully separates and detects single protein molecules from single EVs. The system is applicable for evaluating important cancer biomarkers and sheds light on EV heterogeneity and discovery of new EV subtype biomarkers.
Review
Materials Science, Multidisciplinary
David Caballero, Rui L. Reis, Subhas C. Kundu
Summary: Cancer is a global health issue causing millions of deaths annually. Highly metastatic cancers and late tumor detection present challenges in treatment. Complementary tissue-engineered approaches, such as bioengineered cancer traps, offer potential solutions for early diagnosis and treatment. These traps selectively capture and limit the spread of cancer cells, allowing for liquid biopsy and precision medicine treatments.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Qingyu Ruan, Fenxiang Zou, Yang Wang, Yingkun Zhang, Xing Xu, Xiaoye Lin, Tian Tian, Huimin Zhang, Leiji Zhou, Zhi Zhu, Chaoyong Yang
Summary: This paper presents an integrated, low-cost, and portable point-of-care (POC) device for analyzing DNA methylation, capable of detecting as low as 10 pg with a sensitivity that allows for detection down to 5% methylation level within 30 minutes. The POC platform shows great potential for the analysis of tumor-specific circulating DNA, offering advantages of portability, ease of use, high accuracy, and low cost.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Analytical
Bilge Asci Erkocyigit, Ozge Ozufuklar, Aysenur Yardim, Emine Guler Celik, Suna Timur
Summary: Microfluidics plays a crucial role in lab-on-a-chip systems, allowing for manipulation of fluid behavior and control on a small platform. Paper-based microfluidic analytical devices (muPADs) have numerous advantages, especially in cancer biomarker detection, and have the potential to improve diagnosis and treatment outcomes.
Article
Biochemistry & Molecular Biology
Fei Long, Shuo Li, Yaqi Xu, Min Liu, Xuan Zhang, Junting Zhou, Yiyi Chen, Yuan Rong, Xiangyu Meng, Fubing Wang
Summary: Early diagnosis and progression assessment are crucial for gastric cancer (GC) patients. A 10-gene panel was identified as a diagnostic biomarker for early detection of GC, showing good diagnostic performance in different cohorts. This panel not only aids in early detection, but also provides information on GC subtypes and their progression characteristics.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Lexiang Zhang, Wenzhao Li, Rokshana Parvin, XiaoChen Wang, Qihui Fan, Fangfu Ye
Summary: In this study, a simple and universal method for genotyping of exosome-derived microRNAs using nanoparticles and photothermal droplet digital polymerase chain reaction (ddPCR) is presented. This method can sensitively detect biomarkers related to prostate cancer.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yu Wu, Chunhua Wang, Pan Wang, Chao Wang, Yu Zhang, Lin Han
Summary: The study introduces a high-performance microfluidic detection platform for early detection of ovarian carcinoma using a novel panel of multiple biomarkers. Analysis of serum biomarkers in 18 ovarian cancer patients and 4 healthy persons indicates potential subgroup sorting.
Review
Chemistry, Analytical
Shreya Singh Beniwal, Paula Lamo, Ajeet Kaushik, Dionisio Lorenzo Lorenzo-Villegas, Yuguang Liu, Arunsundar Mohanasundaram
Summary: Colorectal cancer is a prevalent and potentially fatal disease, and effective diagnostic strategies are needed. Microfluidic diagnostics offer non-invasive real-time monitoring of disease progression and treatment response. Advancements in microfluidic technology and integration with artificial intelligence hold promise for accurate, efficient, and personalized strategies to improve patient outcomes and transform cancer management.
Review
Biochemistry & Molecular Biology
Cristina Herrera-Pariente, Sheyla Montori, Joan Llach, Alex Bofill, Eduardo Albeniz, Leticia Moreira
Summary: Gastric cancer is a common cancer worldwide, with early detection being crucial for improving clinical outcomes. Current screening programs are effective in high-incidence populations but not cost-effective in low-incidence populations, highlighting the need for new noninvasive biomarkers.
Review
Chemistry, Analytical
Madhusudan B. Kulkarni, Narasimha H. Ayachit, Tejraj M. Aminabhavi
Summary: Most biomarker testing is currently done in centralized laboratories, but the development of miniaturized, low-cost microdevices is expected to replace these conventional methods and allow for direct transfer of diagnostic results to a patient's smartphone. While biosensor-based approaches show promise for decentralized testing, there are still issues to be resolved for the understanding of different biomarkers. The creation of biosensors is seen as a promising solution to address the demand for quick, affordable analysis techniques in medical diagnostics.
Review
Biochemical Research Methods
Jayson V. Pagaduan, Vishal Sahore, Adam T. Woolley
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2015)
Meeting Abstract
Oncology
Michael Xiao, Roger Chu, Jayson Pagaduan, Richard A. Robison, Kim L. O'Neill
Review
Chemistry, Multidisciplinary
Jayson V. Pagaduan, Anil Bhatta, Lewis H. Romer, David H. Gracias
Article
Biochemical Research Methods
Rui Yang, Jayson V. Pagaduan, Ming Yu, Adam T. Woolley
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2015)
Article
Chemistry, Analytical
Chad I. Rogers, Jayson V. Pagaduan, Gregory P. Nordin, Adam T. Woolley
ANALYTICAL CHEMISTRY
(2011)
Article
Biochemical Research Methods
Pamela N. Nge, Weichun Yang, Jayson V. Pagaduan, Adam T. Woolley
Article
Biochemical Research Methods
Pamela N. Nge, Jayson V. Pagaduan, Ming Yu, Adam T. Woolley
JOURNAL OF CHROMATOGRAPHY A
(2012)
Article
Medical Laboratory Technology
Jayson Pagaduan, Estella Tam, Sridevi Devaraj
JOURNAL OF APPLIED LABORATORY MEDICINE
(2019)
Article
Medical Laboratory Technology
Jayson V. Pagaduan, Mahesheema Ali, Michael Dowlin, Liye Suo, Tabitha Ward, Fadel Ruiz, Sridevi Devaraj
PRACTICAL LABORATORY MEDICINE
(2018)
Article
Chemistry, Multidisciplinary
Qianru Jin, Ming Li, Beril Polat, Santosh K. Paidi, Aimee Dai, Amy Zhang, Jayson V. Pagaduan, Ishan Barman, David H. Gracias
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
