Journal
NEURAL REGENERATION RESEARCH
Volume 12, Issue 9, Pages 1544-1550Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.215267
Keywords
nerve regeneration; mesenchymal stem cell transplantation; adipose-derived mesenchymal stem cells; recurrent laryngeal nerve; larynx; nerve injury; functional recovery; vocal fold; cell differentiation; neural regeneration
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Funding
- National Natural Science Foundation of China [81470680, 81170901]
- Natural Science Foundation of Beijing of China [7132053]
- Beijing Health Foundation of High-level Technical Personnel in China [2014-2-004]
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Medialization thyroplasty or injection laryngoplasty for unilateral vocal fold paralysis cannot restore mobility of the vocal fold. Recent studies have shown that transplantation of mesenchymal stem cells is effective in the repair of nerve injuries. This study investigated whether adipose-derived stem cell transplantation could repair recurrent laryngeal nerve injury. Rat models of recurrent laryngeal nerve injury were established by crushing with micro forceps. Adipose-derived mesenchymal stem cells (ADSCs; 8 x 10(5)) or differentiated Schwann-like adipose-derived mesenchymal stem cells (dADSCs; 8 x 10(5)) or extracellular matrix were injected at the site of injury. At 2, 4 and 6 weeks post-surgery, a higher density of myelinated nerve fiber, thicker myelin sheath, improved vocal fold movement, better recovery of nerve conduction capacity and reduced thyroarytenoid muscle atrophy were found in ADSCs and dADSCs groups compared with the extracellular matrix group. The effects were more pronounced in the ADSCs group than in the dADSCs group. These experimental results indicated that ADSCs transplantation could be an early interventional strategy to promote regeneration after recurrent laryngeal nerve injury.
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