Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Materials Science, Multidisciplinary
Linna Sun, Qinghe Li, Yuting Guo, Xiaofeng Wu, Mingxing Han, Luzhong Zhang, Peiyuan Wang
Summary: Traumatic brain injury is a common clinical disease and current therapies are not optimal. In this study, curcumin-loaded hydrogels were developed for traumatic brain injury treatments. The hydrogels were injected into brain injury defect sites with complex anatomical structures. Real-time evaluation using MRI showed that the curcumin-loaded hydrogels can inhibit inflammation and promote nerve repair, suggesting a promising strategy for traumatic brain injury treatments.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Neurosciences
Di Li, Yan Zhang, Lina Lu, Ling Zhang, Jialing Ma, Jiaxuan Ji, Haiying Li, Gang Chen
Summary: Sec22b may play a neuroprotective role after TBI by upregulating autophagy levels, reducing cell apoptosis, neurological deficits, and blood-brain barrier permeability.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Yujian Lin, Jingjing Zhang, Dongqing Lu, Yuzheng Zhang, Jinwen Xu, Sheng Wang, Xiang Cheng, Jianbing Qin, Lei Zhang, Haoming Li, Xinhua Zhang, Wen Li
Summary: Uqcr11 overexpression can protect against oxidative stress and neuronal apoptosis in traumatic brain injury (TBI), leading to the restoration of motor, learning, and memory capabilities. It holds potential as a therapeutic target for TBI.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Min Xu, Wenhua Wang, Wei Lu, Xiaoyang Ling, Qin Rui, Haibo Ni
Summary: This study demonstrates that evodiamine (Evo) improves outcomes after traumatic brain injury (TBI) by targeting the PGK1/NRF2 signaling pathway to regulate oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Charles K. Davis, Raghu Vemuganti
Summary: Oxidative stress plays a crucial role in the pathogenesis of traumatic brain injury, leading to cell death and secondary brain damage. Antioxidant therapies show promising outcomes in reducing damage and promoting functional recovery.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Immunology
Zhongyu Wang, Zhaoyang Wang, Anqi Wang, Juan Li, Junmin Wang, Jingjing Yuan, Xin Wei, Fei Xing, Wei Zhang, Na Xing
Summary: This study aimed to investigate the mechanism of Sevo in TBI by downregulating HES1 via the FGF2/EZH2 axis. Results showed that Sevo reduced brain edema, improved neurological scores, and decreased neuronal apoptosis and autophagy in TBI rats. Upregulation of FGF2 by Sevo preconditioning increased EZH2 expression, leading to downregulation of HES1 in TBI rats.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Lilia A. Koza, Claudia Pena, Madison Russell, Alec C. Smith, Jacob Molnar, Maeve Devine, Natalie J. Serkova, Daniel A. Linseman
Summary: Successive traumatic brain injuries exacerbate neuroinflammation and oxidative stress. No therapeutics exist for populations at high risk of repetitive mild TBIs (rmTBIs). The preventative therapeutic effects of Immunocal & REG; for rmTBI and rmmTBI were explored.
Review
Biochemistry & Molecular Biology
Alice Jacquens, Edward J. Needham, Elisa R. Zanier, Vincent Degos, Pierre Gressens, David Menon
Summary: Head trauma is a common cause of disability in young adults, and cranial trauma in children has particularities in terms of epidemiology, mechanism, and physiopathology. The long-term repercussions of head trauma can be attributed to chronic neuroinflammation, a complex process involving various actors. Numerous studies have explored different anti-inflammatory therapies for traumatic brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chen Chen, Lina Lu, Jie Zhu, Xiaoyu Gu, Bofei Liu, Di Li, Gang Chen
Summary: This study investigated the role of Miro1 in secondary brain injury after TBI. The results suggest that Miro1 may play a neuroprotective role through the mitochondria trafficking pathway, potentially offering a new strategy for the treatment of TBI.
Article
Cell Biology
Wenqian Zhang, Jun Hong, Hanwen Zhang, Wencheng Zheng, Ying Yang
Summary: The study found that astrocyte-derived exosomes can protect against traumatic brain injury-induced oxidative stress and neuronal apoptosis by activating the Nrf2 signaling pathway.
Review
Biochemistry & Molecular Biology
Lars B. Dahlin
Summary: Appropriate animal models are crucial for studying the biology and physiology of neurons and other cells under normal and stress conditions. Understanding the activation of genes and factors in nerve regeneration is important for conditions like nerve injuries and neuropathy. Advanced technology and bioinformatics are necessary for a comprehensive understanding of different cell types and their behavior in neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yibin Jia, Guanyi Wang, Yuqing Ye, Enming Kang, Huijun Chen, Zishuo Guo, Xiaosheng He
Summary: TBI is a disease with high morbidity and disability worldwide, despite ongoing neural protection efforts. Due to patient heterogeneity, it is difficult to achieve satisfying results in clinic. Neuroinflammation appears since primary injury occurs, and recent studies suggest NSCs play a central role in neural regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Svetlana Demyanenko, Maria A. Pitinova, Yulia N. Kalyuzhnaya, Andrey M. Khaitin, Svetlana A. Batalshchikova, Natalya M. Dobaeva, Yulia A. Shevtsova, Kirill Goryunov, Egor Y. Plotnikov, Svetlana G. Pashkevich, Gennady T. Sukhikh, Denis N. Silachev
Summary: Peripheral nerve injury is a significant medical problem without effective treatment currently. However, the use of multipotent mesenchymal cells (MSCs)-derived extracellular vesicles (EVs) shows promise in promoting the regeneration of peripheral nerves after injury. In a rat model of sciatic nerve injury, the application of MSCs-EVs gel significantly reduced muscle atrophy and improved functional recovery. The results suggest that this therapeutic approach may be efficient for the treatment of acute peripheral nervous system injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zi-Qi Shao, Shan-Shan Dou, Jun-Ge Zhu, Hui-Qing Wang, Chun-Mei Wang, Bao-Hua Cheng, Bo Bai
Summary: Apelin-13 has neuroprotective effects against cerebral ischemia/reperfusion injury by regulating apoptosis and autophagy processes, through increasing Bcl-2/Bax ratio, reducing cleaved caspase-3 expression, modulating LC3B, p62, and Beclinl expression, and activating the PI3K/Akt/mTOR pathway. Its effects are mediated by Bcl-2 upregulation and mTOR signaling pathway activation.
NEURAL REGENERATION RESEARCH
(2021)
Correction
Biology
Havvanur Yoldas Ilktac, Gul Kiziltan, Asli Devrim Lanpir, Mehmet Ozansoy, Mehmet Y. Gunal, Sine Ozmen Togay, Ilknur Keskin, Ekrem M. Ozdemir, Ulkan Kilic
FOLIA BIOLOGICA-KRAKOW
(2022)
Article
Biochemistry & Molecular Biology
Ulkan Kilic, Birsen Elibol, Ahmet Burak Caglayan, Mustafa Caglar Beker, Merve Beker, Burcugul Altug-Tasa, Omer Uysal, Bayram Yilmaz, Ertugrul Kilic
Summary: In this study, the effects of melatonin on cell survival and apoptosis after stroke were investigated. The results showed that melatonin delayed neurological recovery and improved motor coordination. It also enhanced neuronal survival and reduced apoptosis at the cellular level. Furthermore, melatonin promoted brain remodeling and neuronal regeneration, especially in the contralateral hemisphere during the later stages of recovery.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Anne-Katrin Rohlfing, Kyra Kolb, Manuel Sigle, Melanie Ziegler, Alexander Bild, Patrick Muenzer, Jessica Sudmann, Valerie Dicenta, Tobias Harm, Mailin-Christin Manke, Sascha Geue, Marcel Kremser, Madhumita Chatterjee, Chunguang Liang, Hendrik von Eysmondt, Thomas Dandekar, David Heinzmann, Manina Guenter, Saskia Von Ungern-Sternberg, Manuela Buettcher, Tatsiana Castor, Stine Mencl, Friederike Langhauser, Katharina Sies, Diyaa Ashour, Mustafa Caglar Beker, Michael Lammerhofer, Stella E. Autenrieth, Tilman E. Schaeffer, Stefan Laufer, Paulina Szklanna, Patricia Maguire, Matthias Heikenwalder, Karin Anne Lydia Mueller, Dirk M. Hermann, Ertugrul Kilic, Ralf Stumm, Gustavo Ramos, Christoph Kleinschnitz, Oliver Borst, Harald F. Langer, Dominik Rath, Meinrad Gawaz
Summary: Platelet activation and thrombus formation play a critical role in tissue injury during ischemia/reperfusion. The absence of ACKR3 on platelets enhances platelet activation and thrombosis, exacerbating tissue damage. Activation of platelet-ACKR3 can inhibit platelet activation and thrombus formation, attenuating tissue injury.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Ahmet Burak Caglayan, Mustafa Caglar Beker, Elif Sertel Evren, Berrak Caglayan, Ulkan Kilic, Nilay Ates, Aysun Caglayan, Muhammed Furkan Dasdelen, Thorsten Roland Doeppner, Mart Saarma, Dirk Matthias Hermann, Ertugrul Kilic
Summary: CDNF and MANF, when administered after stroke, can promote neurological recovery and increase neuronal survival. They also reduce brain atrophy and glial scar formation. CDNF has the additional effect of increasing endogenous neurogenesis and promoting axonal growth.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Mustafa C. Beker, Mahmud E. Pence, Sumeyya Yagmur, Berrak Caglayan, Aysun Caglayan, Ulkan Kilic, Hayriye E. Yelkenci, Mehmet O. Altintas, Ahmet B. Caglayan, Thorsten R. Doeppner, Dirk M. Hermann, Ertugrul Kilic
Summary: Deactivation of phosphodiesterase 10A (PDE10A) dose-dependently increases neuronal survival, angiogenesis, and neurogenesis in the peri-infarct striatum, reduces astroglial scar formation and brain atrophy, and enhances motor-coordination recovery and neuronal plasticity.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Zeynep Balcikanli, Irem Culha, Pelin Dilsiz, Mehmet Serif Aydin, Nilay Ates, Mustafa Caglar Beker, Saltuk Bugra Baltaci, Halil Koc, Ahmet Yigitbasi, Mustafa Gundogar, Thorsten R. Doeppner, Dirk M. Hermann, Ertugrul Kilic
Summary: Spinal cord injury (SCI) can cause long-term neurological deficits, and the current treatments are ineffective. This study investigated the effects of lithium chloride (LiCl) on motor coordination recovery and neuroplasticity in mice with SCI. The results showed that LiCl can enhance motor coordination, reduce tissue atrophy, increase neuronal survival, and promote axonal regeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Mehmet Ozansoy, Houda Mikati, Halil Aziz Velioglu, Burak Yulug
Summary: This review investigates the role of exosomes as possible mediators between chronic systemic inflammatory diseases and Alzheimer's disease. Exosomes carry pro-inflammatory molecules generated in the periphery and target glial and neuronal cells in the central nervous system, initiating chronic neuroinflammation and contributing to Alzheimer's disease pathology.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Anatomy & Morphology
A. A. Sayin Sakul, K. B. Pence, T. Ormeci, M. Y. Gunal
Summary: This study compared the volumes of the cerebrum, cerebellum, and hippocampus in patients with isolated optic neuritis and healthy individuals using the VolBrain Online MRI Brain Volumetry System. The results showed that patients with isolated optic neuritis had lower cerebrum white matter volumes and higher volumes in certain regions of the cerebellum and hippocampus, indicating neurodegenerative changes in brain volume.
Article
Developmental Biology
Fatih Mete, Signem Eyuboglu, Ayca Vitrinel, Ulkan Kilic, Cihan Suleyman Erdogan, Ertugrul Kilic, Bayram Yilmaz
Summary: Maintenance of body temperature within physiological range is critical for the fetal and neonatal development. Hyperthermia can lead to neurobehavioral deficits in young male rats, including decreased locomotor activity, increased anxiety, and impaired motor function. These effects were more pronounced at higher temperatures. The study also found that hyperthermia caused decreased neuronal survival, increased apoptosis, and decreased cell proliferation in specific regions of the brain.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Neurosciences
Mustafa C. Beker, Fatmagul I. Aydinli, Ahmet B. Caglayan, Merve Beker, Oguzhan Baygul, Aysun Caglayan, Aurel Popa-Wagner, Thorsten R. Doeppner, Dirk M. Hermann, Ertugrul Kilic
Summary: Ischemic stroke is a leading cause of death and disability. In this study, the development of ischemic injury in young and adult mice was examined. The results showed that aging increased the brain's resilience against ischemic injury, as observed by smaller infarct area, better blood-brain barrier integrity, higher microvascular viability, neuronal survival, and stronger activation of cell survival pathways in adult mice compared to young mice. The proteome profile also differed between the aged and young brain in response to ischemic injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Gokce Gurler, Nevin Belder, Mustafa Caglar Beker, Melike Sever-Bahcekapili, Gokhan Uruk, Ertugrul Kilic, Muge Yemisci
Summary: This study reveals the presence of RFC1 protein in the inner blood-retinal barrier (BRB) and its role as an acute regulator in both normal and ischemic retinas.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Review
Biochemistry & Molecular Biology
Mihai Ruscu, Andreea Cercel, Ertugrul Kilic, Bogdan Catalin, Andrei Gresita, Dirk M. Hermann, Carmen Valeria Albu, Aurel Popa-Wagner
Summary: Ischemic stroke treatment can be improved with the use of nanomedicines, which have been shown to reduce infarct size and improve neurological function in animal models. This systematic review evaluates the efficacy of nanoparticle-based treatments for ischemic stroke and their potential impact on future therapies. The review also assesses the scientific quality of current research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Wenqiang Xin, Yongli Pan, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa-Wagner, Stefan Gerner, Sabine Huber, Ertugrul Kilic, Dirk M. Hermann, Mathias Baehr, Hagen B. Huttner, Thorsten R. Doeppner
Summary: Preconditioned extracellular vesicles (EVs) released by microglia exposed to hypoxia can reduce brain damage after ischemic stroke by regulating neuroinflammation, aquaporin 4 (AQP4) depolarization, and cerebrospinal fluid (CSF) flow. These effects are not caused by unspecific inflammatory regulation. These findings reveal the involvement of hypoxic microglia in protecting against stroke-induced brain damage through EV release.
Article
Pharmacology & Pharmacy
Ayse arzu Sakul, Sule Ayla, Mehmet evren Okur, Ayseesra Karadag, Benay Daylan, Elif Guzel, Ekrem Musa Ozdemir, Mehmet Yalcin Gunal
Summary: This study aims to investigate the antibacterial, antioxidant, and wound-healing properties of the methanolic extract of Carduus adpressus. The extract showed strong antibacterial activity against Staphylococcus aureus and Enterococcus faecalis, and moderate activity against Pseudomonas aeruginosa and Escherichia coli. It also exhibited high antioxidant activity and promoted wound healing in diabetic mice by promoting regeneration, epithelization, and angiogenesis.
JOURNAL OF RESEARCH IN PHARMACY
(2023)