Article
Transplantation
Arpana Iyengar, Nivedita Kamath, Hamsa Reddy, Jyoti Sharma, Jyoti Singhal, Susan Uthup, Sudha Ekambaram, Sumithra Selvam, Anja Rahn, Dagmar-C Fischer, Mandy Wan, Rukshana Shroff
Summary: In children with chronic kidney disease, different dosing regimens of oral cholecalciferol achieved similar 25OHD concentrations without toxicity. Children with glomerular disease required higher doses of cholecalciferol compared to those with non-glomerular disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Debasish Banerjee, Nihil Chitalia, Irina Chis Ster, Evan Appelbaum, Ravi Thadhani, Juan Carlos Kaski, David Goldsmith
Summary: A study on vitamin D supplementation in stable, non-diabetic CKD patients showed no beneficial effects on left ventricular mass.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Review
Nutrition & Dietetics
Giuseppe Cianciolo, Maria Cappuccilli, Francesco Tondolo, Lorenzo Gasperoni, Fulvia Zappulo, Simona Barbuto, Francesca Iacovella, Diletta Conte, Irene Capelli, Gaetano La Manna
Summary: The text highlights the common issue of poor vitamin D status in patients with chronic kidney disease, attributing it to various factors such as uremic malnutrition, dietary restrictions, and proteinuria. Furthermore, it points out the lack of large-scale interventional studies on the non-calcemic activities of vitamin D in the literature.
Article
Cardiac & Cardiovascular Systems
Carlo Briguori, Roy O. Mathew, Zhen Huang, Kreton Mavromatis, LaTonya J. Hickson, Wei Ling Lau, Anoop Mathew, Sandeep Mahajan, David C. Wheeler, Kathleen J. Claes, Gang Chen, Fernando E. B. Nolasco, Gregg W. Stone, Jerome L. Fleg, Mandeep S. Sidhu, Frank W. Rockhold, Glenn M. Chertow, Judith S. Hochman, David J. Maron, Sripal Bangalore
Summary: The effect of treatment strategies on the timing of dialysis initiation in participants with both chronic coronary disease and advanced chronic kidney disease is explored. The study found that an initial invasive management strategy is associated with an accelerated time to initiation of maintenance dialysis for kidney failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pediatrics
Nivedita Kamath, Arpana Iyengar, Hamsa Reddy, Jyoti Sharma, Jyoti Singhal, Sudha Ekambaram, Susan Uthup, Sumithra Selvam, Mandy Wan, Anja Rahn, Dagmar Christiane-Fischer, Rukshana Shroff
Summary: This study analyzed the effects of different dosing regimens of cholecalciferol supplementation on bone biomarkers. The results showed that cholecalciferol supplementation significantly increased bone formation, and the three dosing regimens had similar effects on bone biomarkers.
PEDIATRIC NEPHROLOGY
(2023)
Review
Food Science & Technology
Radomir Reszke, Katarzyna Kilis-Pstrusinska, Jacek C. Szepietowski
Summary: Chronic kidney disease-associated itch (CKD-aI) is a common symptom that affects both adults and children, but there is limited data on the pediatric population. This narrative review aims to provide a comprehensive description of CKD-aI in children, focusing on its pathogenesis and treatment recommendations based on data extrapolated from adults.
Article
Nutrition & Dietetics
Mario Flores-Aldana, Marta Rivera-Pasquel, Armando Garcia-Guerra, Jesus Giovanni Perez-Cortes, Juan E. Barcena-Echegollen
Summary: This study aimed to assess the effect of vitamin D supplementation at different doses on serum 25(OH)D concentrations in preschool children. After three months, there was a significant increase in serum concentrations of 25(OH)D and a decrease in the prevalence of vitamin D deficiency. No adverse effects were observed.
Article
Medical Laboratory Technology
Pierre Delanaye, Antoine Lanot, Antoine Bouquegneau, Xavier Warling, Luc Radermacher, Catherine Masset, Jean-Marie Krzesinski, Olivier Moranne, Etienne Cavalier
Summary: This study aimed to investigate the necessity of monitoring 1,25-dihydroxyvitamin D levels in hemodialysis patients. The results showed that there was a significant increase in 25-hydroxyvitamin D levels in patients treated with native vitamin D, but no significant change in 1,25-dihydroxyvitamin D levels. For patients treated with active vitamin D, there were no significant changes in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels. Therefore, monitoring 1,25-dihydroxyvitamin D levels in patients newly treated with active vitamin D does not seem useful.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Review
Nutrition & Dietetics
Mattia Perazzi, Enrico Gallina, Giulia Francesca Manfredi, Filippo Patrucco, Antonio Acquaviva, Donato Colangelo, Mario Pirisi, Mattia Bellan
Summary: This paper reviews the potential role of vitamin D in the pathogenesis and management of systemic sclerosis (SSc). Pre-clinical data suggest that vitamin D and its analogs may suppress fibrogenesis, while clinical data show a high prevalence of hypovitaminosis D and osteoporosis in SSc patients, but inconsistent findings regarding the association with clinical manifestations and phenotypes of SSc.
Review
Biochemistry & Molecular Biology
Fulvia Zappulo, Maria Cappuccilli, Alessandra Cingolani, Anna Scrivo, Anna Laura Croci Chiocchini, Miriam Di Nunzio, Chiara Donadei, Marianna Napoli, Francesco Tondolo, Giuseppe Cianciolo, Gaetano La Manna
Summary: Vitamin D plays a crucial role in bone metabolism, as well as having important extra-bone effects such as glucose homeostasis and cardiovascular protection. This narrative review provides an overview of the role of vitamin D in different settings, with a special focus on chronic kidney disease and kidney transplant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Jordi Bover, Joel Gunnarsson, Philipp Csomor, Edelgard Kaiser, Giuseppe Cianciolo, Rosa Lauppe
Summary: Nutritional vitamin D supplementation has limited effect on key biomarkers related to secondary hyperparathyroidism, with the ability to increase 25(OH)D levels but not significantly reduce PTH levels, while also causing an increase in calcium levels.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Review
Nutrition & Dietetics
Thais de Oliveira e Silva Ullmann, Beatrys Juliani Ramalho, Lucas Fornari Laurindo, Ricardo Jose Tofano, Claudio Jose Rubira, Elen Landgraf Guiguer, Sandra Maria Barbalho, Uri Adrian Prync Flato, Katia Portero Sloan, Adriano Cressoni Araujo
Summary: Vitamin D supplementation is beneficial for patients with Diabetic Kidney Disease, as it reduces proteinuria and creatinine levels. More clinical trials are needed to validate this intervention.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sandro Giannini, Andrea Giusti, Salvatore Minisola, Nicola Napoli, Giovanni Passeri, Maurizio Rossini, Luigi Sinigaglia
Summary: Vitamin D plays an essential role in immune modulation and has effects on both innate and adaptive immune systems. It is implicated in the incidence and severity of various immune-mediated disorders.
Article
Hematology
Paola Ciceri, Luisa Artioli, Lorenza Magagnoli, Alessandra Barassi, Jean-Claude Alvarez, Ziad A. A. Massy, Andrea Galassi, Mario Cozzolino
Summary: This pilot study evaluated the association between serum levels of uremic retention solutes and indexes related to the MIA syndrome in dialysis patients. The results showed significant correlations between serum albumin and both phosphate and total cholesterol, as well as between total cholesterol and phosphate. The study also indicated a relationship between malnutrition and inflammation, and between inflammation and atherosclerosis/calcification.
BLOOD PURIFICATION
(2023)
Review
Pediatrics
Vanessa Shaw, Caroline Anderson, An Desloovere, Larry A. Greenbaum, Dieter Haffner, Christina L. Nelms, Fabio Paglialonga, Nonnie Polderman, Leila Qizalbash, Jose Renken-Terhaerdt, Stella Stabouli, Jetta Tuokkola, Johan Vande Walle, Bradley A. Warady, Rukshana Shroff
Summary: Proper nutritional management is crucial for children with chronic kidney disease (CKD) to maintain normal growth and development. Infants with CKD have specific nutritional needs, and inadequate nutrition can lead to growth impairment and abnormal neurodevelopment.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medical Laboratory Technology
Pierre Delanaye, Elke Schaeffner, Mario Cozzolino, Michel Langlois, Mario Plebani, Tomris Ozben, Etienne Cavalier
Summary: The EFLM recommends European laboratories to continue using the 2009 version of the CKD-EPI equation without race correction factor. The new EKFC equation, developed from European cohorts, may serve as an alternative equation for estimating GFR in Europe. Estimating equations based on cystatin C may gain popularity due to their independence of race. Reference methods like iohexol clearance for measuring GFR remain necessary in specific patients and/or situations.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Andrea Galassi, Anila Cara, Lorenza Magagnoli, Federico Maffei Faccioli, Mario Cozzolino
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Mehmet S. Sever, Raymond Vanholder, Valerie Luyckx, Kai-Uwe Eckardt, Mykola Kolesnyk, Andrzej Wiecek, Ewa Pawlowicz-Szlarska, Daniel Gallego, Rukshana Shroff, Andrej Skoberne, Ionut Nistor, Mohamed Sekkarie, Dmytro Ivanov, Edita Noruisiene, Serhan Tuglular
Summary: During conflicts, people with kidney disease may face additional threats due to medical and logistical challenges. Acute kidney injury and treatment interruptions can worsen kidney function, and limitations in dialysis and availability of immunosuppressive medications increase the risk of complications. Local preparedness, adjustments in treatment, telemedicine support, and referrals to higher-level hospitals are important measures to address these challenges.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Pediatrics
Orsolya Horvath, Attila J. Szabo, George S. Reusz
Summary: Given the wide diversity of causes of hematuria, it is essential to recognize the underlying disease. The first objective of the assessment is to determine whether the cause of the hematuria is medically significant. Differentiating the various causes of hematuria is often simple and obvious based on the clinical signs and gross appearance of the urine, but additional non-invasive investigations may be needed in some instances.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Evelien Snauwaert, Fabio Paglialonga, Johan Vande Walle, Mandy Wan, An Desloovere, Nonnie Polderman, Jose Renken-Terhaerdt, Vanessa Shaw, Rukshana Shroff
Summary: Dietary fiber is an essential part of a healthy child's diet, and children with adequate fiber intake have higher diet quality and nutrient density. However, many children, especially those with kidney diseases, do not meet the recommended fiber intake. Recent studies suggest that dietary fiber is important for children with kidney diseases, as it provides various health benefits and does not increase the risk of hyperkalemia or nutritional deficits. New studies and guidelines are needed to address dietary fiber intake in these children.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, Research & Experimental
Despina Eleftheriou, Yolanda Collaco Moraes, Cara Purvis, Molly Pursell, Marta Merida Morillas, Robin Kahn, Maria Mossberg, Filip Kucera, Robert Tulloh, Joseph F. Standing, Veronica Swallow, Rachael McCormack, Jethro Herberg, Michael Levin, Mandy Wan, Nigel Klein, Roisin Connon, Ann Sarah Walker, Paul Brogan
Summary: Kawasaki disease (KD) is an inflammatory vasculitis affecting medium-sized arteries. Recent studies in Europe have shown high coronary complications despite treatment with IVIG, highlighting the need for a reappraisal of IVIG as the sole therapy. The KD-CAAP trial aims to test the effectiveness of corticosteroid treatment in reducing CAA rates in KD patients.
Correction
Pediatrics
Orsolya Horvath, Attila J. Szabo, George S. Reusz
PEDIATRIC NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Kate Stevens, Francesca Mallamaci, Alberto Ortiz, Jordi Bover, Pierre Delanaye, Roser Torra, Mario Cozzolino
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Cem Tanriover, Sidar Copur, Ali Mutlu, Ibrahim Batuhan Peltek, Andrea Galassi, Paola Ciceri, Mario Cozzolino, Mehmet Kanbay
Summary: CKD is a major cause of premature and accelerated aging, leading to early vascular aging and arterial stiffness. Various mechanisms including oxidative stress, inflammation, advanced glycation end products, fructose, and abnormal gut microbiota contribute to the development of early aging in CKD patients. Premature vascular aging in CKD patients is a prognostic marker for mortality and cardiovascular morbidity. Therapeutic strategies can target key molecular pathways like Nrf-2, AMPK, SIRT1, and klotho.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Rheumatology
Selcan Demir, Ali Duzova, Tevfik Karagoz, Berna Oguz, Hayrettin Hakan Aykan, Ozlem Satirer, Erdal Sag, Seza Ozen, Yelda Bilginer
Summary: This study aimed to assess the risk for cardiovascular comorbidity in pediatric Behcet's disease (BD) patients, and found that BD patients with vascular involvement may have more cardiovascular risk factors. Furthermore, cardiovascular assessment should be considered in all BD patients, and ABPM may accurately define hypertension and cardiovascular risk in pediatric BD patients.
Review
Urology & Nephrology
Pantelis Sarafidis, Fotini Iatridi, Charles Ferro, Maria-Eleni Alexandrou, Beatriz Fernandez-Fernandez, Mehmet Kanbay, Francesca Mallamaci, Ionut Nistor, Patrick Rossignol, Christoph Wanner, Mario Cozzolino, Alberto Ortiz, ERBP Board
Summary: Chronic kidney disease (CKD) in individuals with type 2 diabetes is a major public health issue. Renin-angiotensin system (RAS) blockers have been the standard treatment, but their effectiveness in reducing cardiovascular events and mortality is limited. Non-steroidal mineralocorticoid receptor antagonists (MRAs) have gained interest due to their better pharmacologic profile. Finerenone, the first compound of this class, has shown promise in reducing kidney disease progression and cardiovascular outcomes in patients with type 2 diabetes.
CLINICAL KIDNEY JOURNAL
(2023)
Editorial Material
Urology & Nephrology
Lorenza Magagnoli, Mario Cozzolino, Andrea Galassi
Summary: The synthesis of fibroblast growth factor 23 (FGF-23) is induced by positive phosphate balance, while treatment options that lower phosphate levels can reduce FGF-23 levels. However, the use of FGF-23 as a guide for clinical decision-making in the context of chronic kidney disease-mineral bone disorder (CKD-MBD) remains uncertain. Additionally, the best assay for measuring FGF-23 levels, particularly in the presence of CKD and its complications, has yet to be determined.
CLINICAL KIDNEY JOURNAL
(2023)