Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Maria Siekkeri Vandikas, Kerstin Landin-Wilhelmsen, Martin Gillstedt, Amra Osmancevic
Summary: In patients with psoriasis, high levels of vitamin D-binding protein (DBP) may serve as a new inflammatory biomarker. Total 25(OH)D is a reliable measure for vitamin D status in psoriasis patients, but evaluation of free 25(OH)D levels should be considered in patients with multiple co-morbidities and/or undergoing biologic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Nurullah celik, Halef Okan Dogan, Gokmen Zararsiz
Summary: The study revealed that obese adolescents have lower levels of vitamin D compared to their nonobese peers, leading to different diagnostic cutoff values for VDD, which may result in overtreatment if the same cutoff value is used in obese adolescents.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Emma L. Watson, Thomas J. Wilkinson, Tom F. O'Sullivan, Luke A. Baker, Douglas W. Gould, Soteris Xenophontos, Matt Graham-Brown, Rupert Major, Carl Jenkinson, Martin Hewison, Andrew Philp, Alice C. Smith
Summary: The study found that vitamin D deficiency is not a prominent factor driving the loss of muscle mass in CKD patients, but may play a role in reduced exercise capacity.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Clinical Neurology
Viktor Grut, Martin Bistrom, Jonatan Salzer, Pernilla Stridh, Anna Lindam, Lucia Alonso-Magdalena, Oluf Andersen, Daniel Jons, Martin Gunnarsson, Magnus Vrethem, Johan Hultdin, Peter Sundstrom
Summary: This study found that high levels of free vitamin D3 at a young age reduce the risk of MS later in life, and also implicate a role for DBP in MS etiology.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Soren Brunak, Anders Woetmann, Niels odum, Charlotte M. Bonefeld, Carsten Geisler
Summary: This study reveals the impact of a point mutation in the DNA-binding domain of VDR on 1,25(OH)(2)D-3 signaling, with effects on VDR subcellular localization and transcriptional activity. The study also demonstrates that the expression level of wild-type VDR determines the responsiveness of T cells to 1,25(OH)(2)D-3. Additionally, the study shows that vitamin A inhibits the translocation of VDR to the nucleus and upregulation of CYP24A1 induced by 1,25(OH)(2)D-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Anne Schoen, Maren Leifheit-Nestler, Jennifer Deppe, Dagmar-Christiane Fischer, Aysun K. Bayazit, Lukasz Obrycki, Nur Canpolat, Ipek Kaplan Bulut, Karolis Azukaitis, Alev Yilmaz, Sevgi Mir, Fatos Yalcinkaya, Oguz Soylemezoglu, Anette Melk, Gabriele Stangl, Rouven Behnisch, Rukshana Shroff, Justine Bacchetta, Uwe Querfeld, Franz Schaefer, Dieter Haffner
Summary: Uraemic cardiac remodelling is associated with vitamin D and Klotho deficiency, elevated FGF23, and RAS activation. While active vitamin D can ameliorate cardiac remodelling in rats, it does not improve the cardiac phenotype in children with CKD Stages 3-5, possibly due to increased FGF23 and faster CKD progression in treated patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Article
Multidisciplinary Sciences
Khalid E. Alzahrani, Mahmoud Al-Gawati, Abdulaziz K. Assaifan, Abdullah Alodhayb, Khalid Alotaibi, Abdullah Alswieleh, Hamad Albrithen, Amal F. Alanazi
Summary: This study presents a novel approach based on microcantilever for measuring the level of vitamin D, using Bruno aptamer as a sensing layer. By measuring the changes in microcantilever deflection and frequency, the vitamin D concentration can be accurately detected with high selectivity.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Andrea Elmelid, Maria Siekkeri Vandikas, Martin Gillstedt, Amra Osmancevic, Mikael Alsterholm
Summary: Vitamin D plays an important role in skin inflammation in psoriasis, and UVB phototherapy can increase vitamin D levels. This study aimed to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and determine if free 25(OH)D correlates stronger to disease severity than total 25(OH)D. The results showed that both total and free 25(OH)D levels increased after phototherapy and were positively correlated. However, no correlations between disease severity and vitamin D levels were found.
Review
Nutrition & Dietetics
Karolina Kedzierska-Kapuza, Urszula Szczuko, Hanna Stolinska, Dimitra Rafailia Bakaloudi, Waldemar Wierzba, Malgorzata Szczuko
Summary: This review article examines the benefits and potential risks of supplementing water-soluble vitamins in the treatment of chronic kidney disease (CKD). By reducing oxidative stress and covering the increased demand and losses associated with treatment, water-soluble vitamin supplementation may improve pharmacological responses and the overall clinical condition of patients.
Article
Medicine, Research & Experimental
Raji Ramachandran Pillai, Nancy R. Premkumar, Shivanand Kattimani, Haritha Sagili, Anand Babu Wilson, Leena Sharon, Soundravally Rajendiran
Summary: The study showed that women with postpartum depressive symptoms had significantly lower serum levels of total, free, and bioavailable 25-hydroxyvitamin D compared to non-depressive women. These findings suggest a potential association between hypovitaminosis D and postpartum depression.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Valentina Aristarco, Harriet Johansson, Sara Gandini, Debora Macis, Cristina Zanzottera, Gianluca Tolva, Irene Feroce, Chiara Accornero, Bernardo Bonanni, Aliana Guerrieri-Gonzaga, Davide Serrano
Summary: This study found that SNPs of VDR and GC genes may influence breast cancer recurrence and survival in patients, particularly with major alleles of BsmI and TaqI showing lower risk of relapse.
Article
Dentistry, Oral Surgery & Medicine
Tugba Aydin, Alparslan Dilsiz, Didem Ozkal Eminoglu, Ahmet Bedreddin Sahin, Esra Laloglu, Yunus Emre Bayrakdar
Summary: This study investigates the relationship between total, free, and bioavailable 25-hydroxyvitamin D levels and periodontitis. Serum samples from 39 patients with periodontitis and 44 healthy participants were analyzed for various biomarkers. The results show that total, free, and bioavailable 25-hydroxyvitamin D levels are significantly lower in the periodontitis group, and there is a significant correlation between total 25-hydroxyvitamin D and periodontitis. Additionally, measuring free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in understanding the relationship between periodontitis and vitamin D.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Nutrition & Dietetics
Harriet Johansson, Giuseppe Spadola, Giulio Tosti, Mario Mandala, Alessandro M. Minisini, Paola Queirolo, Valentina Aristarco, Federica Baldini, Emilia Cocorocchio, Elena Albertazzi, Leonardo Zichichi, Saverio Cinieri, Costantino Jemos, Giovanni Mazzarol, Patrizia Gnagnarella, Debora Macis, Ines Tedeschi, Emanuela Omodeo Sale, Luigia Stefania Stucci, Bernardo Bonanni, Alessandro Testori, Elisabetta Pennacchioli, Pier Francesco Ferrucci, Sara Gandini
Summary: In a study involving newly resected stage II melanoma patients, adjuvant vitamin D3 significantly increased serum 25OHD levels, particularly in patients with a baseline Breslow score under 3 mm. Patients with low 25OHD levels and Breslow score >= 3 mm had shorter disease-free survival, suggesting a potential impact of vitamin D on melanoma prognosis. Larger trials with vitamin D supplementation in melanoma subjects are needed to further investigate these findings.