Review
Urology & Nephrology
Jimena Rey, Raymond R. Townsend
Summary: Uncontrolled hypertension remains a significant health problem despite the availability of various medications and therapies. Device-based methods that denervate the renal arteries are emerging as potential alternatives to standard antihypertensive treatments, which often require daily medication or physical activity. This review summarizes the mechanisms, efficacy, and safety of renal artery denervation, and discusses the challenges in this rapidly evolving field.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Surgery
Nisarg V. Gandhi, Dina N. Murad, Duc T. Nguyen, Edward A. Graviss, Hassan N. Ibrahim
Summary: A long-term follow-up study of 2624 normotensive kidney donors with accessory renal arteries found that the presence of accessory renal arteries did not increase the risk of hypertension, reduced eGFR, proteinuria, or cardiovascular disease.
TRANSPLANT INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study demonstrates for the first time that the selective eEF2 kinase inhibitor A484954 can induce vasodilatation by inhibiting sympathetic nerve activity-induced vasoconstriction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Transplantation
Roland E. Schmieder
Summary: Supported by clinical evidence, renal denervation is becoming an important treatment option for hypertension, particularly in hypertensive patients with chronic kidney disease. Its potential nephroprotective effects are also being studied.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Nicola Moro, Lolita Dokshokova, Induja Perumal Vanaja, Valentina Prando, Sophie Julie A. Cnudde, Anna Di Bona, Riccardo Bariani, Leonardo Schirone, Barbara Bauce, Annalisa Angelini, Sebastiano Sciarretta, Alessandra Ghigo, Marco Mongillo, Tania Zaglia
Summary: Doxorubicin is commonly used for cancer treatment, but its clinical use is limited by cardiotoxicity. Although the adverse cardiac effects of Doxorubicin are known, the underlying mechanisms are still not fully understood. Recent studies have found that Doxorubicin may not only affect cardiomyocytes but also cardiac sympathetic neurons, which are additional targets of Doxorubicin cardiotoxicity. These findings reveal a previously unrecognized effect of Doxorubicin on cardiac autonomic regulation, which plays a role in cardiac physiology and pathology, including heart failure and arrhythmias.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Hang Liu, Yidan Li, Hao Zhou, Weijie Chen, Yanping Xu, Huaan Du, Bo Zhang, Tianli Xia, Dan Li, Zhenhong Ou, Ruotian Tang, Qingsong Chen, Binyi Zhao, Yuehui Yin
Summary: This study explores the characteristics of renal autonomic innervation at different blood pressure response sites and finds that renal nerve stimulation is an effective method for identifying renal autonomic innervation. It can help determine the optimal treatment target during renal denervation by avoiding ablation of sympathetic-inhibitory areas.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Urology & Nephrology
Xin Wang, Xiaozhi Zhao, ChangWei Ji, Guangxiang Liu, Xiaogong Li, Hongqian Guo
Summary: This study investigated the effects of extensive renal artery isolation during RAPN on blood pressure in patients with poorly controlled hypertension. The results showed that RAPN can improve blood pressure control in patients with poorly controlled hypertension in the short term and reduce the use of antihypertensive medications.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Le Li, Yulong Xiong, Zhao Hu, Yan Yao
Summary: This meta-analysis found that renal denervation can reduce heart rate in patients with hypertension, especially office, 24-hour, and daytime heart rate, but it has no significant effect on nighttime heart rate. Additionally, the reduction in heart rate is closely associated with decreased blood pressure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Kristina Rodionova, Martin Hindermann, Karl Hilgers, Christian Ott, Roland E. Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, Tilmann Ditting
Summary: The study showed that low doses of an Ang II inhibitor candesartan in congestive heart failure rats can have similar effects on tubular sodium and water reabsorption as renal denervation. Additionally, decreases in renal sympathetic nerve activity induced by volume expansion were impaired in congestive heart failure rats but unaffected by candesartan.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Review
Peripheral Vascular Disease
Hui-Chun Huang, Hao-min Cheng, Yook-Chin Chia, Yan Li, Huynh Van Minh, Saulat Siddique, Apichard Sukonthasarn, Jam Chin Tay, Yuda Turana, Narsingh Verma, Kazuomi Kario, Tzung-Dau Wang
Summary: Studies have found that changes in blood pressure induced by renal nerve stimulation (RNS) before and after percutaneous renal sympathetic denervation (RDN) can be used to assess the immediate effect of RDN and predict blood pressure reductions months following the procedure.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Review
Physiology
John W. Osborn, Roman Tyshynsky, Lucy Vulchanova
Summary: Renal sympathetic and sensory nerves play crucial roles in regulating kidney function, with overactivity linked to hypertension and other cardiometabolic diseases. Clinical trials of catheter-based renal nerve ablation for treating hypertension have shown promising results, highlighting the importance of further research into how renal nerves function and can be targeted for novel therapies.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Medicine, Research & Experimental
Tales Lyra de Oliveira, Gisele Silverio Lincevicius, Caroline Gusson Shimoura, Alex Yuri Simoes-Sato, Michelle Louvaes Garcia, Cassia T. Bergamaschi, Ruy R. Campos
Summary: The study found that bilateral renal denervation (BRD) significantly improved glycemia, renal function, and sympathetic nerve activity in streptozotocin-diabetic rats. Renal nerves may play an important role in the treatment of diabetic patients.
Article
Biochemistry & Molecular Biology
Maria Sofia Vieira-Rocha, Joana Beatriz Sousa, Pilar Rodriguez-Rodriguez, Silvia Madaglena Arribas, Carmen Diniz
Summary: Sympathetic hyperinnervation may be one of the contributors to vascular remodelling and hypertension in rats exposed to undernutrition during intrauterine life.
Article
Multidisciplinary Sciences
Julian U. G. Wagner, Lukas S. Tombor, Pedro Felipe Malacarne, Lisa-Maria Kettenhausen, Josefine Panthel, Haris Kujundzic, Nivethitha Manickam, Katja Schmitz, Maria Cipca, Kathrin A. Stilz, Ariane Fischer, Marion Muhly-Reinholz, Wesley T. Abplanalp, David John, Sarajo K. Mohanta, Christian Weber, Andreas J. R. Habenicht, Giulia K. Buchmann, Stephan Angendohr, Ehsan Amin, Katharina Scherschel, Nikolaj Kloecker, Malte Kelm, Dominik Schuettler, Sebastian Clauss, Stefan Guenther, Thomas Boettger, Thomas Braun, Christian Baer, Minh-Duc Pham, Jaya Krishnan, Susanne Hille, Oliver J. Mueller, Tarik Bozoglu, Christian Kupatt, Eleonora Nardini, Selma Osmanagic-Myers, Christian Meyer, Andreas M. Zeiher, Ralf P. Brandes, Guillermo Luxan, Stefanie Dimmeler
Summary: Aging reduces nerve density in the heart and dysregulates vascular-derived neuroregulatory genes, leading to impaired cardiovascular health.
Review
Biotechnology & Applied Microbiology
Yan Huang, Zhigang He, Anne Manyande, Maohui Feng, Hongbing Xiang
Summary: This review focuses on the knowledge of nerve regeneration after heart, liver, and kidney transplantation and applies various imaging techniques to assess the prognosis of organ transplantation. The aim is to provide theories and insights into nerve regeneration in organ transplantation for clinicians and nuclear medicine researchers, and to advance imaging techniques and radiotracers as a major step forward in clinical research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Andrea Balla, Alberto Sartori, Emanuele Botteri, Mauro Podda, Monica Ortenzi, Gianfranco Silecchia, Mario Guerrieri, Ferdinando Agresta
Summary: This study investigates the knowledge and dissemination of augmented reality (AR), virtual reality (VR), and mixed reality (MR) in minimally invasive surgery (MIS) training among medical professionals in Italy. The majority of participants had no experience with these technologies, but their answers regarding their functioning were mostly correct. The participants believed that VR, AR, and MR should be used more frequently in teaching, training, and clinical activity, as they could significantly contribute to surgical training and education. However, the limited knowledge and high costs were identified as the main barriers to the widespread adoption of these technologies.
UPDATES IN SURGERY
(2023)
Article
Oncology
Benedetto Ielpo, Alessandro Anselmo, Yoshio Masuda, Mark Yeo Hao Xuan, Fernando Burdio, Vito De Blasi, Patricia Sanchez-Velazquez, Antonio Giuliani, Juan Santiago Azagra, Giuseppe Massimiliano Viola, Mauro Podda, Gianluca Pellino, Edoardo Rosso
Summary: This article introduces the superior mesenteric artery first approach in minimally invasive pancreaticoduodenectomy, and describes five different minimally invasive surgical methods. With the guidance provided, surgeons can choose the appropriate approach based on tumor location, type of minimally invasive surgery, and their own experience, thereby increasing familiarity with this complex procedure.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Benedetto Ielpo, Alessandro Anselmo, Yoshio Masuda, Mark Yeo Hao Xuan, Fernando Burdio, Vito De Blasi, Patricia Sanchez-Velazquez, Antonio Giuliani, Juan Santiago Azagra, Giuseppe Massimiliano Viola, Mauro Podda, Gianluca Pellino, Edoardo Rosso
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Benedetto Ielpo, Alessandro Anselmo, Yoshio Masuda, Mark Yeo Hao Xuan, Fernando Burdio, Vito De Blasi, Patricia Sanchez-Velazquez, Antonio Giuliani, Juan Santiago Azagra, Giuseppe Massimiliano Viola, Mauro Podda, Gianluca Pellino, Edoardo Rosso
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manuela Montanaro, Massimiliano Agostini, Lucia Anemona, Elena Bonanno, Francesca Servadei, Enrico Finazzi Agro, Anastasios D. D. Asimakopoulos, Carlo Ganini, Chiara Cipriani, Marta Signoretti, Pierluigi Bove, Francesco Rugolo, Benedetta Imperiali, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: Prostate cancer is a common and deadly cancer in men, and the current clinical tools for prognosis are insufficient. This study found that ZNF750 protein levels are reduced in prostate cancer samples, especially in metastatic samples. It also showed that nuclear expression of ZNF750 is significantly reduced in patients with metastatic cancer. The bioinformatics analysis suggests that ZNF750 expression is positively correlated with better prognosis, indicating its potential as a reliable biomarker for metastatic prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ombretta Melaiu, Gianluca Vanni, Ilaria Portarena, Chiara Adriana Pistolese, Lucia Anemona, Silvia Pomella, Roberto Bei, Oreste Claudio Buonomo, Mario Roselli, Alessandro Mauriello, Giovanni Barillari
Summary: Immune checkpoint inhibitors have limited clinical activity as monotherapy against breast cancer, and novel combinatorial strategies are being investigated to improve treatment response. The abnormal vasculature in breast cancer is associated with immune suppression and hampers drug delivery and immune cell trafficking. Combining immune checkpoint inhibitors with tumor vessel normalizing agents shows promise in enhancing antitumor immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di Daniele, Enrico Garaci, Massimiliano Caprio, David Della-Morte
Summary: This study investigated the effects of a natural mixture of polyphenols and micronutrients (A5(+)) on counteracting white adipogenesis and promoting fat browning. The results showed that A5(+) significantly reduced lipids accumulation, inhibited cellular proliferation, and decreased the release of pro-inflammatory cytokines. Additionally, A5(+) promoted fat browning and fatty acid oxidation by increasing the expression of genes related to brown adipose tissue.
Article
Health Care Sciences & Services
Alessandra Stella Caporale, Marco Nezzo, Maria Giovanna Di Trani, Alessandra Maiuro, Roberto Miano, Pierluigi Bove, Alessandro Mauriello, Guglielmo Manenti, Silvia Capuani
Summary: This study investigated the potential of Diffusion-Tensor-Imaging (DTI) in detecting microstructural changes in prostate cancer (PCa) using different diffusion weights (b-values) and diffusion lengths (l(D)). The results showed that DTI metrics were able to differentiate between benign and PCa tissue, with the best discrimination at b-values ≥ 1500 s/mm(2) and when l(D) was comparable to the size of the epithelial compartment. The strongest correlations between DTI metrics and Gleason Score (GS) were found at b = 2000 s/mm(2) and for the range 0-2000 s/mm(2).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Review
Biochemistry & Molecular Biology
Dalgisio Lecis, Gianluca Massaro, Daniela Benedetto, Marco Di Luozzo, Giulio Russo, Alessandro Mauriello, Massimo Federici, Giuseppe Massimo Sangiorgi
Summary: Atherosclerotic cardiovascular disease is a common cause of morbidity and death worldwide. It can be controlled through modulation of immune system activity and finding new treatment strategies is of common interest. This review discusses the experimental and clinical data supporting immune-based therapies, specifically vaccination strategies, for lowering cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Alessandro Anselmo, Leandro Siragusa, Paolo Brigato, Camilla Riccetti, Andrea Collini, Bruno Sensi, Giuseppe Tisone
Summary: This study compared the outcomes of primary liver transplantation (PLT) and salvage liver transplantation (SLT) for hepatocellular carcinoma (HCC) and found that PLT resulted in significantly longer disease-free survival, overall survival, and cancer-specific survival (CSS) compared to SLT. However, within the SLT group, there was no significant difference in disease-free survival between SLT-LR and SLT-RFA. These findings suggest that PLT may provide superior long-term oncological outcomes for HCC patients.
Review
Oncology
Manuel Scimeca, Valentina Rovella, Valeria Palumbo, Maria Paola Scioli, Rita Bonfiglio, Gerry Melino, Mauro Piacentini, Luigi Frati, Massimiliano Agostini, Eleonora Candi, Alessandro Mauriello
Summary: Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. Recent studies have highlighted the importance of programmed cell death mechanisms in its development and progression. Targeting these cell death pathways may increase the susceptibility of cholangiocarcinoma cells to chemotherapy and immunotherapy. However, further research is necessary to fully understand the intricacies of programmed cell death in cholangiocarcinoma and potentially identify effective therapeutic strategies.
Review
Surgery
Alessandro Anselmo, Marco Materazzo, Nicola Di Lorenzo, Bruno Sensi, Camilla Riccetti, Maria Teresa Lonardo, Marco Pellicciaro, Francesco D'Amico, Leandro Siragusa, Giuseppe Tisone
Summary: In the past few years, innovative technology and digitalization in healthcare have played a significant role in all medical fields. Different national health systems have made great efforts to manage the security and digital privacy of large amounts of data. Blockchain technology, which is a decentralized peer-to-peer distributed database, has gained popularity due to its immutable nature in various non-medical fields. The purpose of this review is to explore the potential future role of blockchain and distributed ledger technology in the organ transplantation field and its ability to address inequalities and discrimination.
TRANSPLANT INTERNATIONAL
(2023)
Article
Oncology
Anastasios D. Asimakopoulos, Filippo Annino, Gaia Colalillo, Richard Gaston, Thierry Piechaud, Alessandro Mauriello, Umberto Anceschi, Filippo Borri
Summary: Histologically, the prostatic urethra (PU) consists of the urothelium, chorion, and prostatic peri-urethral fibromuscular tissue. There is a significant variation in the distance between the chorion and prostatic glands in different regions of the PU. Additionally, PSA-expressing cells coexist with urothelial cells in the PU epithelium.
Article
Oncology
Benedetto Ielpo, Alessandro Anselmo, Yoshio Masuda, Mark Yeo Hao Xuan, Fernando Burdio, Vito De Blasi, Patricia Sanchez-Velazquez, Antonio Giuliani, Juan Santiago Azagra, Giuseppe Massimiliano Viola, Mauro Podda, Gianluca Pellino, Edoardo Rosso
Summary: This article describes the superior mesenteric artery first approach in minimally invasive pancreaticoduodenectomy, including five different minimally invasive approaches. For the first time, a comprehensive step-by-step overview of this approach is provided by a team of expert surgeons from various international institutions. The article aims to guide the choice of approach based on tumor location, type of minimally invasive approach, and the surgeon's experience, and increase familiarity with this complex procedure.
ANNALS OF SURGICAL ONCOLOGY
(2023)