Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 24, Issue 12, Pages 1021-1027Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3505
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Funding
- NIGMS NIH HHS [R35 GM118156] Funding Source: Medline
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During protein synthesis, mRNA and tRNAs must be moved rapidly through the ribosome while maintaining the translational reading frame. This process is coupled to large- and small-scale conformational rearrangements in the ribosome, mainly in its rRNA. The free energy from peptide-bond formation and GTP hydrolysis is probably used to impose directionality on those movements. We propose that the free energy is coupled to two pawls, namely tRNA and EF-G, which enable two ratchet mechanisms to act separately and sequentially on the two ribosomal subunits.
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