Journal
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume 14, Issue 1, Pages 7-8Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrgastro.2016.190
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Pancreatic ductal adenocarcinoma (PDAC) is thought to develop through the stepwise accumulation of cancer gene mutations. A new study suggests that 16% of PDACs exhibit genetic rearrangements that simultaneously altered two or more cancer driver genes. These findings challenge the current models of PDAC development, but arguably remain compatible with a stepwise tumour progression.
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