Article
Oncology
Eline H. Huele, Paul W. Veenboer, Frank J. Wessels, Trudy N. Jonges, Richard P. Meijer
Summary: This study aimed to evaluate the additional value of magnetic resonance imaging (MRI) in bladder tumor staging. The results showed that mpMRI had high sensitivity and moderate specificity in differentiating non-muscle-invasive bladder cancer (NMIBC) from muscle-invasive bladder cancer (MIBC), but the diagnostic accuracy needs further improvement.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Medicine, General & Internal
Mihnea P. Dragomir, Teodor G. Calina, Eilis Perez, Simon Schallenberg, Meng Chen, Thomas Albrecht, Ines Koch, Peggy Wolkenstein, Benjamin Goeppert, Stephanie Roessler, George A. Calin, Christine Sers, David Horst, Florian Rossner, David Capper
Summary: This study developed a classifier that can differentiate between iCCAs, intrahepatic metastases of a PAAD, and normal bile duct tissue with high accuracy, which can improve the diagnosis of pancreato-biliary cancers of the liver.
Article
Medicine, General & Internal
Javier Del Aguila Mejia, Subasri Armon, Fiona Campbell, Richard Colling, Magdalena Chechlinska, Magdalena Kowalewska, Marina Pollan, Stefan Holdenrieder, Puay Hoon Tan, Ian Cree, Blanca Iciar Indave Ruiz
Summary: This study aims to fill the gaps in the evidence base of tumour classification in the field of cancer diagnosis, treatment, and patient care. By using the evidence gap map (EGM) methodology, the study will analyze the cited research in the WHO Classification of Tumours (WCT) and develop a visual evidence map to provide a summary of the existing evidence. The findings will be published and used to guide future research planning and decision-making, especially for the development of future editions of the WCT.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, Xuexin He, Chentao Jin, Xiao He, Shuang Wu, Rui Zhou, Xiaohui Zhang, Kai Zhang, Weizhong Gu, Jing Wang, Hong Zhang
Summary: Pathology is a medical specialty focused on studying the nature and causes of disease, and plays a crucial role in connecting basic research and clinical medicine. Challenges such as invasiveness and sample representativeness limitations exist in traditional pathology, while molecular imaging provides a noninvasive way to visualize and measure biological processes at the molecular level. A new pathophysiology visualization system based on molecular imaging is showing great potential in reforming pathological practice, driving improvements in trans-scale imaging, transparency, and translation processes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Computer Science, Hardware & Architecture
Jizhou Zhang, Jianan Li, Haixin Sun, Shenwang Jiang, Yuhan Zhang, Yiwen Chen, Jinhua Zhang, Tingfa Xu
Summary: This article proposes an intelligent telepathology imaging terminal system, which utilizes Fourier ptychographic microscopy to obtain images and uses a CNN model for reconstruction, achieving high-quality digital images and phase maps.
Article
Clinical Neurology
Stephen Crosier, Debbie Hicks, Edward C. Schwalbe, Daniel Williamson, Sarah Leigh Nicholson, Amanda Smith, Janet C. Lindsey, Antony Michalski, Barry Pizer, Simon Bailey, Nick Bown, Gavin Cuthbert, Stephen B. Wharton, Thomas S. Jacques, Abhijit Joshi, Steven C. Clifford
Summary: The application of advanced molecular pathology in rare tumors faces challenges such as low sample numbers and accessibility to specialized expertise. A nationwide trial on medulloblastoma demonstrated the feasibility and effectiveness of coordinated real-time centralised pathology review (CPR) in providing robust diagnostics and altering clinical management. It was found that engagement of a specialist pathologist panel was essential for achieving consensus in histological assessments.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Chuqiao Sheng, Chunfeng Yang, Yongkang Cheng, Yu-Mei Li
Summary: Primary cardiac tumors in children are extremely rare, with diverse clinical manifestations and the need for comprehensive diagnosis. However, advancements in technology have improved the treatment outlook for these tumors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Ophthalmology
Noemie Lauwers, Katleen Janssens, Michelle Mertens, Danny Mathysen, Martin Lammens, Rob J. W. de Keizer, Veva De Groot
Summary: AS-OCT and UBM measurements of tumor thickness showed significant positive correlation with HP; UBM measurements also correlated positively with HP; AS-OCT measurements only showed mild, non-significant positive correlation with HP. Both AS-OCT and UBM are useful imaging techniques for corneal and conjunctival bulbar tumors, but neither should be considered as replacements for HP.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Cell Biology
James G. Kench, Mahul B. Amin, Daniel M. Berney, Eva M. Comperat, Ian A. Cree, Anthony J. Gill, Arndt Hartmann, Santosh Menon, Holger Moch, George J. Netto, Maria R. Raspollini, Mark A. Rubin, Puay Hoon Tan, Toyonori Tsuzuki, Samra Turjalic, Theo H. van Der Kwast, Ming Zhou, John R. Srigley
Summary: The fifth edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems provides updates on the classification and prognosis assessment of prostatic carcinoma, including recognizing PIN-like carcinoma as a subtype of acinar adenocarcinoma, renaming basal cell carcinoma as adenoid cystic (basal cell) cell carcinoma, discussing grading issues in acinar adenocarcinoma, and providing more detailed coverage of intraductal carcinoma of prostate.
Review
Cell Biology
Jaclyn M. Plotzke, David J. Adams, Paul W. Harms
Summary: Recent discoveries have revealed diverse oncogenic drivers and tumour suppressor alterations in adnexal tumours, implicating various pathways and identifying novel markers.
Article
Cardiac & Cardiovascular Systems
Rishi K. Patel, Marianna Fontana, Frederick L. Ruberg
Summary: Cardiac amyloidosis (CA) is a disease characterized by the deposition of misfolded protein deposits in the myocardial interstitium, with varying degrees of severity and clinical manifestations. Contemporary therapies and imaging modalities play a crucial role in diagnosing and treating CA, leading to improved outcomes and understanding of the disease.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Review
Oncology
Ciara Conduit, Wei Hong, Felicity Martin, Benjamin Thomas, Nathan Lawrentschuk, Jeremy Goad, Peter Grimison, Nariman Ahmadi, Ben Tran, Jeremy Lewin
Summary: This study analyzed clinicopathologic features to predict the presence of necrosis/fibrosis in post-chemotherapy retroperitoneal lymph node dissection (pcRPLND). Further collaboration and research are needed to provide better treatment for patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Veterinary Sciences
Alexandra J. Malbon, Miriam Weisskopf, Lukas Glaus, Sebastian Neuber, Maximilian Y. Emmert, Christian T. Stoeck, Nikola Cesarovic
Summary: Domestic pigs are commonly used in cardiovascular research due to their similar circulatory system with humans. Only clinically healthy animals are chosen to reduce variability. Congenital heart defects like ASD in pigs could affect experimental results.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Isadora Pereira Gomes, Victor Coutinho Bastos, Leticia Martins Guimaraes, Carolina Cavalieri Gomes
Summary: Advances in molecular technologies have improved our understanding of the molecular basis of odontogenic cysts and tumors. Various mutations, such as PTCH1 mutations in odontogenic keratocyst, BRAF p.V600E in ameloblastoma, and KRAS p.G12V/R in adenomatoid odontogenic tumor, have been identified, providing insights into the dysregulation of the MAPK/ERK pathway. However, the diagnostic significance of these genetic abnormalities is still unclear, and further research is needed to elucidate their role in the pathogenesis of odontogenic cysts and tumors.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Biology
Anna Schueth, Sven Hildebrand, Iryna Samarska, Shubharthi Sengupta, Annemarie Kiessling, Andreas Herrler, Axel zur Hausen, Michael Capalbo, Alard Roebroeck
Summary: This study demonstrates the feasibility of 3D imaging of large human tissue samples using light-sheet imaging technology, providing high-resolution images for both brain and prostate cancer samples.
COMMUNICATIONS BIOLOGY
(2023)