A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes

Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice

(2017) Mathias J Friedrich et al.   Nature Protocols

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression

(2016) Roberto Rangel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beautyscreen revealsPpargactivation in metastatic prostate cancer

(2016) Imran Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery

(2015) Branden S Moriarity et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RNA sequencing ofSleeping Beautytransposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

(2015) Nuri A. Temiz et al.   GENOME RESEARCH

The functional and pathologic relevance of autophagy proteases

(2015) Álvaro F. Fernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor

(2015) C. Dorr et al.   MOLECULAR CANCER RESEARCH

PTEN Functions by Recruitment to Cytoplasmic Vesicles

(2015) Adam Naguib et al.   MOLECULAR CELL

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130

(2015) Justin Joachim et al.   MOLECULAR CELL

The evolutionary history of lethal metastatic prostate cancer

(2015) Gunes Gundem et al.   NATURE

Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma

(2015) Michael B Mann et al.   NATURE GENETICS

Spatial genomic heterogeneity within localized, multifocal prostate cancer

(2015) Paul C Boutros et al.   NATURE GENETICS

Transposon mutagenesis disentangles osteosarcoma genetic drivers

(2015) Kevin B Jones   NATURE GENETICS

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

(2015) Colin S Cooper et al.   NATURE GENETICS

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

(2015) Haruna Takeda et al.   NATURE GENETICS

PTEN: Multiple Functions in Human Malignant Tumors

(2015) Michele Milella et al.   Frontiers in Oncology

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy

(2014) L. Ding et al.   CANCER RESEARCH

Integrative Analysis of FOXP1 Function Reveals a Tumor-Suppressive Effect in Prostate Cancer

(2014) Ken-ichi Takayama et al.   MOLECULAR ENDOCRINOLOGY

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

(2014) Roland Rad et al.   NATURE GENETICS

NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes

(2014) Omer An et al.   Database-The Journal of Biological Databases and Curation

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

(2013) Rachana Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

(2013) Emilie A Bard-Chapeau et al.   NATURE GENETICS

Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model

(2013) J Ai et al.   ONCOGENE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

PTEN and NF1 Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors

(2012) V. W. Keng et al.   CANCER RESEARCH

Deregulation of a Hox Protein Regulatory Network Spanning Prostate Cancer Initiation and Progression

(2012) J. L. Chen et al.   CLINICAL CANCER RESEARCH

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

(2012) Nicole C McKnight et al.   EMBO JOURNAL

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

(2011) Yvonne Tay et al.   CELL

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

(2011) George S Vassiliou et al.   NATURE GENETICS

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

(2010) R. Rad et al.   SCIENCE

Distinct genomic aberrations associated withERGrearranged prostate cancer

(2009) Francesca Demichelis et al.   GENES CHROMOSOMES & CANCER

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

(2009) Brett S Carver et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF- B activation and invasive prostate carcinoma

(2009) P. J. Fernandez-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE

Understanding PTEN regulation: PIP2, polarity and protein stability

(2008) N R Leslie et al.   ONCOGENE