Journal
NATURE GENETICS
Volume 49, Issue 3, Pages 323-324Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3798
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Funding
- NCI NIH HHS [P30 CA045508, R01 CA190092] Funding Source: Medline
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Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.
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