Journal
NATURE CELL BIOLOGY
Volume 19, Issue 6, Pages 593-595Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3543
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Funding
- NCI NIH HHS [P30 CA016086] Funding Source: Medline
- NHLBI NIH HHS [R01 HL116719, R01 HL117256, R01 HL043174] Funding Source: Medline
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Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGF beta/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand-receptor signalling and flow-mediated mechanical cues.
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