Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 20, Pages 2413-2419Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1311890
Keywords
Secondary metabolites; cinnamic acid; Pyronema sp.; Taxus mairei
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Funding
- National Natural Science Foundation of China [31100080]
- Opening Fund of Hubei Key Laboratory of Natural Products Research and Development [2015NP02]
- Education Department of Hubei Province Key Project [D20141201]
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Ten secondary metabolites (1-10) including a new 4-hydroxycinnamic acid derivatives, methyl 2-{(E)-2-[4-(formyloxy) phenyl] ethenyl}-4methyl-3-oxopentanoate (1), and nine known compounds (2-10) were isolated from an EtOAc extract derived from a solid rice medium of endophytic fungal strain Pyronema sp. (A2-1 & D1-2). Their structures were elucidated from NMR and HRMS data. All the compounds were tested for antibacterial activity against Mycobacterium marinum ATCCBAA-535. Compounds 1, 8 and 9 exhibited moderate antibiotic activity with IC50 of 64, 43 and 32 mu M, respectively.
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