Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 18, Pages 2107-2112Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1277351
Keywords
Nauclea officinalis; indole alkaloid; anti-inflammatory activity; nitric oxide production
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Funding
- National Natural Science Foundation of China [21302181, 21662011, 31660097]
- Applied Technology Research and Development and Demonstration Project of Hainan Province [ZDXM2015063]
- Key Research and Development Project of Hainan Province [ZDYF2016221]
- Program for Science and Technology plans to youth academic innovation of Hainan Association [HAST201636]
- Natural Science Foundation of Innovative Research Team Project of Hainan province [2016CXTD007]
- Natural Science Foundation of Hainan Province [20162021, 20162024]
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A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3.6 mu M. [GRAPHICS] .
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